Tania Dottorini

Contact

• workBiodiscovery Institute
  University Park
  Nottingham
  NG7 2RD
  UK
• Tania.Dottorini@nottingham.ac.uk

Biography

I am Professor of Bioinformatics at the Faculty of Medicine and Health Sciences, University of Nottingham. Previously, I was a research fellow at the Imperial College London (2011 - 2016). I obtained my Ph.D. degree in Structural Biology and Bioinformatics from the University of Rome Tor Vergata.

Expertise Summary

My current research interests are in understanding the mechanisms of insurgence and propagation of antimicrobial resistance (AMR). To this purpose, in my research, I adopt a holistic One Health approach based on collecting heterogeneous data from complex, interconnected anthropogenic environments, via multi-sensing, omics (genomics, transcriptomics, proteomics, metabolomics, etc.), clinical records, population and environmental data and metadata. Within my research group, I oversee the development of big data and cloud-powered analysis solutions based on bioinformatics and AI to combine such heterogeneous information and data mine novel correlations. My goal is to identify drivers and mechanisms underlying the insurgence and spread of new genetic variants of resistant pathogens and novel AMR traits across animals, environment, humans, and food.

In addition to contributing to a better understanding of the mechanisms underlying AMR, my research aims to support the development of novel solutions to implement surveillance, monitoring, early warning, diagnostics and treatment selection.

Recent Publications

• BAKER, M., ZHANG, X., MACIEL-GUERRA, A., BABAARSLAN, K., DONG, Y., WANG, W., HU, Y., RENNEY, D., LIU, L., LI, H., HOSSAIN, M., HEEB, S., TONG, Z., PEARCY, N., ZHANG, M., GENG, Y., ZHAO, L., HAO, Z., SENIN, N., CHEN, J., PENG, Z., LI, F. and DOTTORINI, T., 2024. Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China: Nat Commun Nat Commun. 15(1), 206
• MACIEL-GUERRA, ALEXANDRE, BABAARSLAN, KUBRA, BAKER, MICHELLE, RAHMAN, AURA, HOSSAIN, MAQSUD, SADIQUE, ABDUS, ALAM, JAHIDUL, UZZAMAN, SALIM, FERDOUS RAHMAN SARKER, MOHAMMAD, SULTANA, NASRIN, ISLAM KHAN, ASHRAFUL, ARA BEGUM, YASMIN, HASSAN AFRAD, MOKIBUL, SENIN, NICOLA, HOSSAIN HABIB, ZAKIR, SHIRIN, TAHMINA, QADRI, FIRDAUSI and DOTTORINI, TANIA, 2024. Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity: Nature Communications Nature Communications. 15(1), 8231
• MACIEL-GUERRA, ALEXANDRE, BAKER, MICHELLE, HU, YUE, WANG, WEI, ZHANG, XIBIN, RONG, JIA, ZHANG, YIMIN, ZHANG, JING, KALER, JASMEET, RENNEY, DAVID, LOOSE, MATTHEW, EMES, RICHARD D, LIU, LONGHAI, CHEN, JUNSHI, PENG, ZIXIN, LI, FENGQIN and DOTTORINI, TANIA, 2023. Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock. The ISME journal. 17(1), 21-35
• SHAHD TALHOUNI, WAKKAS FADHIL, NIGEL P. MONGAN, LARA FIELD, KELLY HUNTER, SOGAND MAKHOUS, ALEXANDRE MACIEL-GUERRA, NAYANDEEP KAUR, AUSRINE NESTARENKAITE, ARVYDAS LAURINAVICIUS, BENJAMIN E. WILLCOX, TANIA DOTTORINI, IAN SPENDLOVE, ANDREW M. JACKSON, MOHAMMAD ILYAS and JUDITH M. RAMAGE, 2023. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers Front. Immunol.. 14,

• View all publications

Grants

2024-2027 Novel global One Health surveillance approach to fight AMR using Artificial Intelligence and big data mining. Principal Investigator (PI), funded by MRC - EC-JPIAMR2023-DISTOMOS-144, JPIAMR - Joint Programming Initiative on Antimicrobial Resistance (EU).

2023-2026 Monitoring the gut microbiome via AI and omics: a new approach to detect infection and AMR and to support novel therapeutics. Principal Investigator (PI), Funded by BBSRC

2023-2026 Tackling the Pandemic of antibiotic-resistant Infections: An Artificial Intelligence Approach to new druggable therapeutic targets and drug discovery. Principal Investigator (PI), Funded by MRC

2022-2024 Fighting Infection And AMR In Broiler Farming: Artificial Intelligence, Omics And Smart Sensing For Diagnostics, Forecasting, Treatment Selection And Gut Microbiome, Principal Investigator (PI), Funded by BBSRC

2021-2023 Towards Net Zero Dairy Farming through AI and Machine Vision (DAIRYVISION), Principal Investigator (PI), Funded by InnovateUK and Chinese Ministry of Science and Technology. Partners (China): NERCITA - Beijing Research Centre for Information Technology in Agriculture; HAMEI - Heilongjiang Agricultural Machinery Engineering Institute; CAU - China Agricultural University; TAH - Tianjin Jialihe Animal Husbandry Group Co. Ltd.; HDB - Harbin Wandashan Dairy Breeding Co. Ltd. Partners (UK): Peacock Technology Ltd, Harper Adams University

2020-2021 Fighting Covid-19 in Bangladeshi and Rohingya populations with endemic bacterial diarrhoea and antimicrobial resistance, Principal Investigator (PI), Funded by Research England and GCRF. Partners: North South University, IEDCR, UNICEF, ideSHi, University of Maryland (USA).

2019 - 2023 FARMWATCH: Fight AbR with Machine learning and a Wide Array of sensing TeCHnologies, Principal Investigator (PI), Funded by InnovateUK and Chinese Ministry of Science and Technology. UK partners: Nimrod Veterinary Products Ltd; Chinese partners: Key Laboratory of Food Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, New Hope Liuhe Limited Company, Dongwa Software Company)

2019-2020 CARE Bangladesh: Cholera Antibiotic REsistance in Bangladesh: big data mining and machine learning to improve diagnostics and treatment selection. Principal Investigator (PI), Funded by GCRF. Partners: North South University, Icddr,b UNICEF, BCSIR, University of Maryland (USA)

2018- 2020 Reducing, Refining and Monitoring the Impact of Antibiotic Use in the Control of Bovine Mastitis. Co-Investigator (Co-I). Funded by Innovate UK. Partners: QMMS

2017-2020 Y-Ware. "Young-stock Welfare & Performance - Decision Making Platform". Co-investigator (Co-I), Funded by Innovate UK. Partners: PrognostiX

2011-2015 EU-FP7-PEOPLE-IEF Senior Fellowship - VECTRAP. "Sex determination pathway in the malaria vector Anopheles gambiae". PI.

Current opportunities in my group:

https://www.nottingham.ac.uk/jobs/currentvacancies/ref/MED140121X1

http://jobs.nottingham.ac.uk/MED127419X2

http://jobs.nottingham.ac.uk/MED360719

http://jobs.nottingham.ac.uk/NARFB2019X71

• BAKER, M., ZHANG, X., MACIEL-GUERRA, A., BABAARSLAN, K., DONG, Y., WANG, W., HU, Y., RENNEY, D., LIU, L., LI, H., HOSSAIN, M., HEEB, S., TONG, Z., PEARCY, N., ZHANG, M., GENG, Y., ZHAO, L., HAO, Z., SENIN, N., CHEN, J., PENG, Z., LI, F. and DOTTORINI, T., 2024. Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China: Nat Commun Nat Commun. 15(1), 206
• MACIEL-GUERRA, ALEXANDRE, BABAARSLAN, KUBRA, BAKER, MICHELLE, RAHMAN, AURA, HOSSAIN, MAQSUD, SADIQUE, ABDUS, ALAM, JAHIDUL, UZZAMAN, SALIM, FERDOUS RAHMAN SARKER, MOHAMMAD, SULTANA, NASRIN, ISLAM KHAN, ASHRAFUL, ARA BEGUM, YASMIN, HASSAN AFRAD, MOKIBUL, SENIN, NICOLA, HOSSAIN HABIB, ZAKIR, SHIRIN, TAHMINA, QADRI, FIRDAUSI and DOTTORINI, TANIA, 2024. Core and accessory genomic traits of Vibrio cholerae O1 drive lineage transmission and disease severity: Nature Communications Nature Communications. 15(1), 8231
• MACIEL-GUERRA, ALEXANDRE, BAKER, MICHELLE, HU, YUE, WANG, WEI, ZHANG, XIBIN, RONG, JIA, ZHANG, YIMIN, ZHANG, JING, KALER, JASMEET, RENNEY, DAVID, LOOSE, MATTHEW, EMES, RICHARD D, LIU, LONGHAI, CHEN, JUNSHI, PENG, ZIXIN, LI, FENGQIN and DOTTORINI, TANIA, 2023. Dissecting microbial communities and resistomes for interconnected humans, soil, and livestock. The ISME journal. 17(1), 21-35
• SHAHD TALHOUNI, WAKKAS FADHIL, NIGEL P. MONGAN, LARA FIELD, KELLY HUNTER, SOGAND MAKHOUS, ALEXANDRE MACIEL-GUERRA, NAYANDEEP KAUR, AUSRINE NESTARENKAITE, ARVYDAS LAURINAVICIUS, BENJAMIN E. WILLCOX, TANIA DOTTORINI, IAN SPENDLOVE, ANDREW M. JACKSON, MOHAMMAD ILYAS and JUDITH M. RAMAGE, 2023. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers Front. Immunol.. 14,
• MICHELLE BAKER, XIBIN ZHANG, ALEXANDRE MACIEL-GUERRA, YINPING DONG, WEI WANG, YUJIE HU, DAVID RENNEY, YUE HU, LONGHAI LIU, HUI LI, ZHIQIN TONG, MEIMEI ZHANG, YINGZHI GENG, LI ZHAO, ZHIHUI HAO, JUNSHI CHEN, ZIXIN PENG, ZIXIN PENG, FENGQIN LI, FENGQIN LI and TANIA DOTTORINI, 2023. Machine learning and metagenomics reveal shared antimicrobial resistance profiles across multiple chicken farms and abattoirs in China Nature Food: Nat Food. 4(8), 707-720
• HOKIN CHI, ELLEN E GUEST, ON L HOBMAN, TANIA DOTTORINI and JONATHAN D HIRST, 2023. Predicting bioactivity of antibiotic metabolites by molecular docking and dynamics Mol Graph Model .. 123(10850),
• PENG, Z., MACIEL-GUERRA, A., BAKER, M., ZHANG, X., HU, Y., WANG, W., RONG, J., ZHANG, J., XUE, N., BARROW, P., RENNEY, D., STEKEL, D., WILLIAMS, P., LIU, L., CHEN, J., LI, F. and DOTTORINI, T., 2022. Whole genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming: PLoS Comput Biol PLoS Comput Biol. 18(3), e1010018
• WANG, W., HU, Y., BAKER, M., DOTTORINI, T., LI, H., DONG, Y., BAI, Y., FANNING, S. and LI, F., 2022. Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China: J Antimicrob Chemother J Antimicrob Chemother.
• PEARCY, N., HU, Y., BAKER, M., MACIEL-GUERRA, A., XUE, N., WANG, W., KALER, J., PENG, Z., LI, F. and DOTTORINI, T., 2021. Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms: mSystems mSystems. e0091320
• MACIEL-GUERRA, A., ESENER, N., GIEBEL, K., LEA, D., GREEN, M. J., BRADLEY, A. J. and DOTTORINI, T., 2021. Prediction of Streptococcus uberis clinical mastitis treatment success in dairy herds by means of mass spectrometry and machine-learning: Sci Rep Sci Rep. 11(1), 7736
• WANG, W., BAKER, M., HU, Y., XU, J., YANG, D., MACIEL-GUERRA, A., XUE, N., LI, H., YAN, S., LI, M., BAI, Y., DONG, Y., PENG, Z., MA, J., LI, F. and DOTTORINI, T., 2021. Whole-Genome Sequencing and Machine Learning Analysis of Staphylococcus aureus from Multiple Heterogeneous Sources in China Reveals Common Genetic Traits of Antimicrobial Resistance: mSystems mSystems. 6(3), e0118520
• O'LOUGHLIN, S. M., FORSTER, A. J., FUCHS, S., DOTTORINI, T., NOLAN, T., CRISANTI, A. and BURT, A., 2021. Ultra-conserved sequences in the genomes of highly diverse Anopheles mosquitoes, with implications for malaria vector control: G3 (Bethesda) G3 (Bethesda).
• MONAGHAN, T. M., BISWAS, R. N., NASHINE, R. R., JOSHI, S. S., MULLISH, B. H., SEEKATZ, A. M., BLANCO, J. M., MCDONALD, J. A. K., MARCHESI, J. R., YAU, T. O., CHRISTODOULOU, N., HATZIAPOSTOLOU, M., PUCIC-BAKOVIC, M., VUCKOVIC, F., KLICEK, F., LAUC, G., XUE, N., DOTTORINI, T., AMBALKAR, S., SATAV, A., POLYTARCHOU, C., ACHARJEE, A. and KASHYAP, R. S., 2021. Multiomics Profiling Reveals Signatures of Dysmetabolism in Urban Populations in Central India: Microorganisms Microorganisms. 9(7),
• ESENER, N., MACIEL-GUERRA, A., GIEBEL, K., LEA, D., GREEN, M. J., BRADLEY, A. J. and DOTTORINI, T., 2021. Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis: PLoS Comput Biol PLoS Comput Biol. 17(6), e1009108
• PENG, Z., DOTTORINI, T., HU, Y., LI, M., YAN, S., FANNING, S., BAKER, M., XU, J. and LI, F., 2021. Comparative Genomic Analysis of the Foodborne Pathogen Burkholderia gladioli pv. cocovenenans Harboring a Bongkrekic Acid Biosynthesis Gene Cluster: Front Microbiol Front Microbiol. 12, 628538
• MONAGHAN, TANYA M., DUGGAL, NIHARIKA A., ROSATI, ELISA, GRIFFIN, RUTH, HUGHES, JAMIE, ROACH, BRANDI, YANG, DAVID Y., WANG, CHRISTOPHER, WONG, KAREN, SAXINGER, LYNORA, PUCIC-BAKOVIC, MAJA, VUCKOVIC, FRANO, KLICEK, FILIP, LAUC, GORDAN, TIGHE, PADDY, MULLISH, BENJAMIN H., BLANCO, JESUS MIGUENS, MCDONALD, JULIE A. K., MARCHESI, JULIAN R., XUE, NING, DOTTORINI, TANIA, ACHARJEE, ANIMESH, FRANKE, ANDRE, LI, YINGRUI, WONG, GANE KA-SHU, POLYTARCHOU, CHRISTOS, YAU, TUNG ON, CHRISTODOULOU, NIKI, HATZIAPOSTOLOU, MARIA, WANG, MINKUN, RUSSELL, LINDSEY A. and KAO, DINA H., 2021. A Multi-Factorial Observational Study on Sequential Fecal Microbiota Transplant in Patients with Medically Refractory Clostridioides difficile Infection CELLS. 10(11),
• JAMES, V., NIZAMUDEEN, Z.A., LEA, A., DOTTORINI , T., HOLMES, T.L., JOHNSON B.B., ARKILL, K.P. and DENNING, C., 2021. Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo Stem Cells Dev. 30((24)), 1215-1227
• WANG, W., ZHAO, L., HU, Y., DOTTORINI, T., FANNING, S., XU, J. and LI, F., 2020. Epidemiological Study on Prevalence, Serovar Diversity, Multidrug Resistance, and CTX-M-Type Extended-Spectrum β-Lactamases of Salmonella spp. from Patients with Diarrhea, Food of Animal Origin, and Pets in Several Provinces of China: Antimicrob Agents Chemother Antimicrob Agents Chemother. 64(7),
• SPANKIE, T. J., HAYWOOD, A. L., DOTTORINI, T., BARROW, P. A. and HIRST, J. D., 2020. Interaction of the maturation protein of the bacteriophage MS2 and the sex pilus of the Escherichia coli F plasmid: J Mol Graph Model J Mol Graph Model. 101, 107723
• KALER, J., MITSCH, J., VÁZQUEZ-DIOSDADO, J. A., BOLLARD, N., DOTTORINI, T. and ELLIS, K. A., 2020. Automated detection of lameness in sheep using machine learning approaches: novel insights into behavioural differences among lame and non-lame sheep: R Soc Open Sci R Soc Open Sci. 7(1), 190824
• GOULDING, L. V., YANG, J., JIANG, Z., ZHANG, H., LEA, D., EMES, R. D., DOTTORINI, T., PU, J., LIU, J. and CHANG, K. C., 2020. Thapsigargin at Non-Cytotoxic Levels Induces a Potent Host Antiviral Response that Blocks Influenza A Virus Replication: Viruses Viruses. 12(10),
• IZQUIERDO A, FAHRENBERGER M, FAHRENBERGER M, BENEDICT MQ, BENEDICT MQ, CATTERUCCIA F, EMES RD and DOTTORINI T, 2019. Evolution of gene expression levels in the male reproductive organs of Anopheles mosquitoes. Life Sci Alliance. 2(1):e201800191,
• PROBERT, C., DOTTORINI, T., SPEAKMAN, A., HUNT, S., NAFEE, T., FAZELI, A., WOOD, S., BROWN, J. E. and JAMES, V., 2019. Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis: Oncogene Oncogene. 38(10), 1751-1763
• VÁZQUEZ-DIOSDADO, J. A., MIGUEL-PACHECO, G. G., PLANT, B., DOTTORINI, T., GREEN, M. and KALER, J., 2019. Developing and evaluating threshold-based algorithms to detect drinking behavior in dairy cows using reticulorumen temperature: J Dairy Sci J Dairy Sci. 102(11), 10471-10482
• PITA-BARBOSA, A., RICACHENEVSKY, F. K., WILSON, M., DOTTORINI, T. and SALT, D. E., 2019. Transcriptional plasticity buffers genetic variation in zinc homeostasis: Sci Rep Sci Rep. 9(1), 19482
• WALTON, EMILY, CASEY, CHRISTY, MITSCH, JURGEN, VÁZQUEZ-DIOSDADO, JORGE A., YAN, JUAN, DOTTORINI, TANIA, ELLIS, KEITH A., WINTERLICH, ANTHONY and KALER, JASMEET, 2018. Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour Royal Society Open Science. 5(2),
• CONG, WEI, DOTTORINI, TANIA, KHAN, FARAZ, EMES, RICHARD D., ZHANG, FU-KAI, ZHOU, CHUN-XUE, HE, JUN-JUN, ZHANG, XIAO-XUAN, ELSHEIKHA, HANY M. and ZHU, XING-QUAN, 2018. Acute Toxoplasma Gondii Infection in Cats Induced Tissue-Specific Transcriptional Response Dominated by Immune Signatures Frontiers in Immunology. 9, 2403
• TIAN, A. L., LU, M., CALDERÓN-MANTILLA, G., PETSALAKI, E., DOTTORINI, T., TIAN, X., WANG, Y., HUANG, S. Y., HOU, J. L., LI, X., ELSHEIKHA, H. M. and ZHU, X. Q., 2018. A recombinant Fasciola gigantica 14-3-3 epsilon protein (rFg14-3-3e) modulates various functions of goat peripheral blood mononuclear cells: Parasit Vectors Parasit Vectors. 11(1), 152
• WALTON, E., CASEY, C., MITSCH, J., VÁZQUEZ-DIOSDADO, J. A., YAN, J., DOTTORINI, T., ELLIS, K. A., WINTERLICH, A. and KALER, J., 2018. Evaluation of sampling frequency, window size and sensor position for classification of sheep behaviour: R Soc Open Sci R Soc Open Sci. 5(2), 171442
• ESENER, N., GREEN, M. J., EMES, R. D., JOWETT, B., DAVIES, P. L., BRADLEY, A. J. and DOTTORINI, T., 2018. Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning: Sci Rep Sci Rep. 8(1), 17517
• MANSBRIDGE, N., MITSCH, J., BOLLARD, N., ELLIS, K., MIGUEL-PACHECO, G. G., DOTTORINI, T. and KALER, J., 2018. Feature Selection and Comparison of Machine Learning Algorithms in Classification of Grazing and Rumination Behaviour in Sheep: Sensors (Basel) Sensors (Basel). 18(10),
• ESENER, N., GREEN, M. J., EMES, R. D., JOWETT, B., DAVIES, P. L., BRADLEY, A. J. and DOTTORINI, T., 2018. Discrimination of contagious and environmental strains of Streptococcus uberis in dairy herds by means of mass spectrometry and machine-learning: Sci Rep Sci Rep. 8(1), 17517
• HALL, A. B., PAPATHANOS, P. A., SHARMA, A., CHENG, C., AKBARI, O. S., ASSOUR, L., BERGMAN, N. H., CAGNETTI, A., CRISANTI, A., DOTTORINI, T., FIORENTINI, E., GALIZI, R., HNATH, J., JIANG, X., KOREN, S., NOLAN, T., RADUNE, D., SHARAKHOVA, M. V., STEELE, A., TIMOSHEVSKIY, V. A., WINDBICHLER, N., ZHANG, S., HAHN, M. W., PHILLIPPY, A. M., EMRICH, S. J., SHARAKHOV, I. V., TU, Z. J. and BESANSKY, N. J., 2016. Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes: Proc Natl Acad Sci U S A Proc Natl Acad Sci U S A. 113(15), E2114-23
• NEAFSEY, D. E., WATERHOUSE, R. M., ABAI, M. R., AGANEZOV, S. S., ALEKSEYEV, M. A., ALLEN, J. E., AMON, J., ARCA, B., ARENSBURGER, P., ARTEMOV, G., ASSOUR, L. A., BASSERI, H., BERLIN, A., BIRREN, B. W., BLANDIN, S. A., BROCKMAN, A. I., BURKOT, T. R., BURT, A., CHAN, C. S., CHAUVE, C., CHIU, J. C., CHRISTENSEN, M., COSTANTINI, C., DAVIDSON, V. L., DELIGIANNI, E., DOTTORINI, T., DRITSOU, V., GABRIEL, S. B., GUELBEOGO, W. M., HALL, A. B., HAN, M. V., HLAING, T., HUGHES, D. S., JENKINS, A. M., JIANG, X., JUNGREIS, I., KAKANI, E. G., KAMALI, M., KEMPPAINEN, P., KENNEDY, R. C., KIRMITZOGLOU, I. K., KOEKEMOER, L. L., LABAN, N., LANGRIDGE, N., LAWNICZAK, M. K., LIRAKIS, M., LOBO, N. F., LOWY, E., MACCALLUM, R. M., MAO, C., MASLEN, G., MBOGO, C., MCCARTHY, J., MICHEL, K., MITCHELL, S. N., MOORE, W., MURPHY, K. A., NAUMENKO, A. N., NOLAN, T., NOVOA, E. M., O'LOUGHLIN, S., ORINGANJE, C., OSHAGHI, M. A., PAKPOUR, N., PAPATHANOS, P. A., PEERY, A. N., POVELONES, M., PRAKASH, A., PRICE, D. P., RAJARAMAN, A., REIMER, L. J., RINKER, D. C., ROKAS, A., RUSSELL, T. L., SAGNON, N., SHARAKHOVA, M. V., SHEA, T., SIMAO, F. A., SIMARD, F., SLOTMAN, M. A., SOMBOON, P., STEGNIY, V., STRUCHINER, C. J., THOMAS, G. W., TOJO, M., TOPALIS, P., TUBIO, J. M., UNGER, M. F., VONTAS, J., WALTON, C., WILDING, C. S., WILLIS, J. H., WU, Y. C., YAN, G., ZDOBNOV, E. M., ZHOU, X., CATTERUCCIA, F., CHRISTOPHIDES, G. K., COLLINS, F. H., CORNMAN, R. S., CRISANTI, A., DONNELLY, M. J., EMRICH, S. J., FONTAINE, M. C., GELBART, W., HAHN, M. W., HANSEN, I. A., HOWELL, P. I., KAFATOS, F. C., KELLIS, M., LAWSON, D., LOUIS, C., LUCKHART, S., MUSKAVITCH, M. A., RIBEIRO, J. M., RIEHLE, M. A., SHARAKHOV, I. V., TU, Z., ZWIEBEL, L. J. and BESANSKY, N. J., 2015. Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes: Science Science. 347(6217), 1258522
• CANAVESE, M., DOTTORINI, T. and CRISANTI, A., 2015. VEGF and LPS synergistically silence inflammatory response to Plasmodium berghei infection and protect against cerebral malaria: Pathog Glob Health Pathog Glob Health. 109(6), 255-65
• DOTTORINI, T., PERSAMPIERI, T., PALLADINO, P., BAKER, D. A., SPACCAPELO, R., SENIN, N. and CRISANTI, A., 2013. Regulation of Anopheles gambiae male accessory gland genes influences postmating response in female: FASEB J FASEB J. 27(1), 86-97
• DOTTORINI, T., PALLADINO, P., SENIN, N., PERSAMPIERI, T., SPACCAPELO, R. and CRISANTI, A., 2013. CluGene: A Bioinformatics Framework for the Identification of Co-Localized, Co-Expressed and Co-Regulated Genes Aimed at the Investigation of Transcriptional Regulatory Networks from High-Throughput Expression Data: PLoS One PLoS One. 8(6), e66196
• DOTTORINI, T., PERSAMPIERI, T., PALLADINO, P., SPACCAPELO, R. and CRISANTI, A., 2012. Silencing of the Hsf gene, the transcriptional regulator of A. gambiae male accessory glands, inhibits the formation of the mating plug in mated females and disrupts their monogamous behaviour: Pathog Glob Health Pathog Glob Health. 106(7), 405-12
• ALDRICH, C., MAGINI, A., EMILIANI, C., DOTTORINI, T., BISTONI, F., CRISANTI, A. and SPACCAPELO, R., 2012. Roles of the amino terminal region and repeat region of the Plasmodium berghei circumsporozoite protein in parasite infectivity: PLoS One PLoS One. 7(2), e32524
• DOTTORINI, TANIA, SENIN, NICOLA, MAZZOLENI, GIORGIO, MAGNUSSON, KALLE and CRISANTI, ANDREA, 2011. Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis BMC BIOINFORMATICS. 12,
• SPACCAPELO, R., AIME, E., CATERBI, S., ARCIDIACONO, P., CAPUCCINI, B., DI CRISTINA, M., DOTTORINI, T., RENDE, M., BISTONI, F. and CRISANTI, A., 2011. Disruption of plasmepsin-4 and merozoites surface protein-7 genes in Plasmodium berghei induces combined virulence-attenuated phenotype: Sci Rep Sci Rep. 1, 39
• MAGNUSSON, K., MENDES, A. M., WINDBICHLER, N., PAPATHANOS, P. A., NOLAN, T., DOTTORINI, T., RIZZI, E., CHRISTOPHIDES, G. K. and CRISANTI, A., 2011. Transcription regulation of sex-biased genes during ontogeny in the malaria vector Anopheles gambiae: PLoS One PLoS One. 6(6), e21572
• DOTTORINI, T., SOLE, G., NUNZIANGELI, L., BALDRACCHINI, F., SENIN, N., MAZZOLENI, G., PROIETTI, C., BALACI, L. and CRISANTI, A., 2011. Serum IgE reactivity profiling in an asthma affected cohort: PLoS One PLoS One. 6(8), e22319
• DOTTORINI, T., SENIN, N., MAZZOLENI, G., MAGNUSSON, K. and CRISANTI, A., 2011. Gepoclu: a software tool for identifying and analyzing gene positional clusters in large-scale gene expression analysis: BMC Bioinformatics BMC Bioinformatics. 12, 34
• SPACCAPELO, R., JANSE, C. J., CATERBI, S., FRANKE-FAYARD, B., BONILLA, J. A., SYPHARD, L. M., DI CRISTINA, M., DOTTORINI, T., SAVARINO, A., CASSONE, A., BISTONI, F., WATERS, A. P., DAME, J. B. and CRISANTI, A., 2010. Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria: Am J Pathol Am J Pathol. 176(1), 205-17
• SPACCAPELO, R., JANSE, C. J., CATERBI, S., FRANKE-FAYARD, B., BONILLA, J. A., SYPHARD, L. M., DI CRISTINA, M., DOTTORINI, T., SAVARINO, A., CASSONE, A., BISTONI, F., WATERS, A. P., DAME, J. B. and CRISANTI, A., 2010. Plasmepsin 4-deficient Plasmodium berghei are virulence attenuated and induce protective immunity against experimental malaria: Am J Pathol Am J Pathol. 176(1), 205-17
• LOW, W., MORTLOCK, A., PETROVSKA, L., DOTTORINI, T., DOUGAN, G. and CRISANTI, A., 2007. Functional cell permeable motifs within medically relevant proteins: J Biotechnol J Biotechnol. 129(3), 555-64
• DOTTORINI, T., NICOLAIDES, L., RANSON, H., ROGERS, D. W., CRISANTI, A. and CATTERUCCIA, F., 2007. A genome-wide analysis in Anopheles gambiae mosquitoes reveals 46 male accessory gland genes, possible modulators of female behavior: Proc Natl Acad Sci U S A Proc Natl Acad Sci U S A. 104(41), 16215-20
• PASCALE, A., GUSEV, P. A., AMADIO, M., DOTTORINI, T., GOVONI, S., ALKON, D. L. and QUATTRONE, A., 2004. Increase of the RNA-binding protein HuD and posttranscriptional up-regulation of the GAP-43 gene during spatial memory: Proc Natl Acad Sci U S A Proc Natl Acad Sci U S A. 101(5), 1217-22
• DOTTORINI, T., VAUGHAN, C. K., WALSH, M. A., LOSURDO, P. and SOLLAZZO, M., 2004. Crystal structure of a human VH: requirements for maintaining a monomeric fragment: Biochemistry Biochemistry. 43(3), 622-8
• COZZINI, P. and DOTTORINI, T., 2004. Is it possible docking and scoring new ligands with few experimental data? Preliminary results on estrogen receptor as a case study: Eur J Med Chem Eur J Med Chem. 39(7), 601-9
• DE LUCA, A., SCHIRINZI, A., BUCCINO, A., BOTTILLO, I., SINIBALDI, L., TORRENTE, I., CIAVARELLA, A., DOTTORINI, T., PORCIELLO, R., GIUSTINI, S., CALVIERI, S. and DALLAPICCOLA, B., 2004. Novel and recurrent mutations in the NF1 gene in Italian patients with neurofibromatosis type 1. Hum Mutat. 23(6), 629
• CONTI, E., DOTTORINI, T., SARKOZY, A., TILLER, G. E., ESPOSITO, G., PIZZUTI, A. and DALLAPICCOLA, B., 2003. A novel PTPN11 mutation in LEOPARD syndrome. Hum Mutat. 21(6), 654
• FERLIN, A., SIMONATO, M., BARTOLONI, L., RIZZO, G., BETTELLA, A., DOTTORINI, T., DALLAPICCOLA, B. and FORESTA, C., 2003. The INSL3-LGR8/GREAT ligand-receptor pair in human cryptorchidism: J Clin Endocrinol Metab J Clin Endocrinol Metab. 88(9), 4273-9
• PIZZUTI, A., FLEX, E., DI BONAVENTURA, C., DOTTORINI, T., EGEO, G., MANFREDI, M., DALLAPICCOLA, B. and GIALLONARDO, A. T., 2003. Epilepsy with auditory features: a LGI1 gene mutation suggests a loss-of-function mechanism: Ann Neurol Ann Neurol. 53(3), 396-9
• DIGILIO, M. C., CONTI, E., SARKOZY, A., MINGARELLI, R., DOTTORINI, T., MARINO, B., PIZZUTI, A. and DALLAPICCOLA, B., 2002. Grouping of multiple-lentigines/LEOPARD and Noonan syndromes on the PTPN11 gene: Am J Hum Genet Am J Hum Genet. 71(2), 389-94
• EFTHYMIADIS, A., DOTTORINI, T. and JANS, D. A., 1998. A novel system to quantitate nuclear-cytoplasmic flux in vivo: kinetics of signal-dependent nuclear protein export: Arch Biochem Biophys Arch Biochem Biophys. 355(2), 254-61
• JAMES, VICTORIA, NIZAMUDEEN, ZUBAIR A, LEA, DANIEL, DOTTORINI, TANIA, HOLMES, TERRI L, JOHNSON, BENJAMIN B, ARKILL, KENTON P, DENNING, CHRIS and SMITH, JAMES G W, 1800. Transcriptomic Analysis of Cardiomyocyte Extracellular Vesicles in Hypertrophic Cardiomyopathy Reveals Differential snoRNA Cargo. Stem cells and development. 30(24), 1215-1227
• WANG, WEI, HU, YUE, BAKER, MICHELLE, DOTTORINI, TANIA, LI, HUI, DONG, YINPING, BAI, YAO, FANNING, SEAMUS and LI, FENGQIN, 1800. Novel SCCmec type XV (7A) and two pseudo-SCCmec variants in foodborne MRSA in China. The Journal of antimicrobial chemotherapy.