Contact

• workRoom A25, Academic Rheumatology Clinical Sciences Building
  Nottingham City Hospital
  Hucknall Road
  Nottingham
  NG5 1PB
  UK
• work0115 823 1942
• dan.mcwilliams@nottingham.ac.uk

Expertise Summary

Pain researcher, specialising in pain mechanisms in musculoskeletal conditions. Interests in central mechanisms of pain, analysis of longitudinal data, quantitiative sensory testing, questionnaire development/validation, inflammatory arthritis, osteoarthritis and biobanking.

Research Summary

Pain research and epidemiological data analysis in musculoskeletal disorders (ORCID ID, orcid.org/0000-0002-0581-1895).

Part of the Pain Centre Versus Arthritis and the NIHR Nottingham Biomedical Research Centre (Musculoskeletal Research Area).

Recent Publications

• GEORGOPOULOS, V., AKIN-AKINYOSOYE, K., SMITH, S., MCWILLIAMS, D. F., HENDRICK, P. and WALSH, D. A., 2022. An observational study of centrally facilitated pain in individuals with chronic low back pain: Pain Rep Pain Rep. 7(3), e1003
• GEORGOPOULOS, V., SMITH, S., MCWILLIAMS, D. F., STEULTJENS, M. P. M., WILLIAMS, A., PRICE, A., VALDES, A. M., VINCENT, T. L., WATT, F. E. and WALSH, D. A., 2022. Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD): Osteoarthritis Cartilage Osteoarthritis Cartilage.
• GWINNUTT, J. M., NORTON, S., HYRICH, K. L., LUNT, M., COMBE, B., RINCHEVAL, N., RUYSSEN-WITRAND, A., FAUTREL, B., MCWILLIAMS, D. F., WALSH, D. A., NIKIPHOROU, E., KIELY, P., YOUNG, A., CHIPPING, J. R., MACGREGOR, A. and VERSTAPPEN, S. M. M., 2022. Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis: Rheumatology (Oxford) Rheumatology (Oxford).
• IFESEMEN, O. S., MCWILLIAMS, D. F., NORTON, S., KIELY, P. D. W., YOUNG, A. and WALSH, D. A., 2022. Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network: Rheumatology (Oxford) Rheumatology (Oxford). 61(9), 3737-3745

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• GEORGOPOULOS, V., AKIN-AKINYOSOYE, K., SMITH, S., MCWILLIAMS, D. F., HENDRICK, P. and WALSH, D. A., 2022. An observational study of centrally facilitated pain in individuals with chronic low back pain: Pain Rep Pain Rep. 7(3), e1003
• GEORGOPOULOS, V., SMITH, S., MCWILLIAMS, D. F., STEULTJENS, M. P. M., WILLIAMS, A., PRICE, A., VALDES, A. M., VINCENT, T. L., WATT, F. E. and WALSH, D. A., 2022. Harmonising knee pain patient-reported outcomes: a systematic literature review and meta-analysis of Patient Acceptable Symptom State (PASS) and individual participant data (IPD): Osteoarthritis Cartilage Osteoarthritis Cartilage.
• GWINNUTT, J. M., NORTON, S., HYRICH, K. L., LUNT, M., COMBE, B., RINCHEVAL, N., RUYSSEN-WITRAND, A., FAUTREL, B., MCWILLIAMS, D. F., WALSH, D. A., NIKIPHOROU, E., KIELY, P., YOUNG, A., CHIPPING, J. R., MACGREGOR, A. and VERSTAPPEN, S. M. M., 2022. Exploring the disparity between inflammation and disability in the 10-year outcomes of people with rheumatoid arthritis: Rheumatology (Oxford) Rheumatology (Oxford).
• IFESEMEN, O. S., MCWILLIAMS, D. F., NORTON, S., KIELY, P. D. W., YOUNG, A. and WALSH, D. A., 2022. Fatigue in early rheumatoid arthritis: data from the Early Rheumatoid Arthritis Network: Rheumatology (Oxford) Rheumatology (Oxford). 61(9), 3737-3745
• KOUSHESH, S., SHAHTAHERI, S. M., MCWILLIAMS, D. F., WALSH, D. A., SHEPPARD, M. N., WESTABY, J., HAYBATOLLAHI, S. M., HOWE, F. A. and SOFAT, N., 2022. The osteoarthritis bone score (OABS): a new histological scoring system for the characterisation of bone marrow lesions in osteoarthritis: Osteoarthritis Cartilage Osteoarthritis Cartilage. 30(5), 746-755
• IFESEMEN, ONOSI S., MCWILLIAMS, DANIEL F., FERGUSON, EAMONN, WAKEFIELD, RICHARD, AKIN-AKINYOSOYE, KEHINDE, WILSON, DEBORAH, PLATTS, DOROTHY, LEDBURY, SUSAN and WALSH, DAVID A., 2021. Central Aspects of Pain in Rheumatoid Arthritis (CAP-RA): protocol for a prospective observational study BMC RHEUMATOLOGY. 5(1),
• ASO, K., SHAHTAHERI, S. M., MCWILLIAMS, D. F. and WALSH, D. A., 2021. Association of subchondral bone marrow lesion localization with weight-bearing pain in people with knee osteoarthritis: data from the Osteoarthritis Initiative: Arthritis Res Ther Arthritis Res Ther. 23(1), 35
• MCWILLIAMS, D. F., THANKARAJ, D., JONES-DIETTE, J., MORGAN, R., IFESEMEN, O. S., SHENKER, N. G. and WALSH, D. A., 2021. The efficacy of systemic glucocorticosteroids for pain in rheumatoid arthritis: a systematic literature review and meta-analysis: Rheumatology (Oxford) Rheumatology (Oxford). 61(1), 76-89
• MILLAR B, MCWILLIAMS DF, ABHISHEK A, AKIN-AKINYOSOYE K, AUER DP, CHAPMAN V, DOHERTY M, FERGUSON E, GLADMAN JRF, GREENHAFF P, STOCKS J, VALDES AM and WALSH DA, 2020. Investigating musculoskeletal health and wellbeing; a cohort study protocol. BMC musculoskeletal disorders. 21(1), 182
• AKIN-AKINYOSOYE, K., SARMANOVA, A., FERNANDES, G. S., FROWD, N., SWAITHES, L., STOCKS, J., VALDES, A., MCWILLIAMS, D. F., ZHANG, W., DOHERTY, M., FERGUSON, E. and WALSH, D. A., 2020. Baseline self-report 'central mechanisms' trait predicts persistent knee pain in the Knee Pain in the Community (KPIC) cohort OSTEOARTHRITIS AND CARTILAGE. 28(2), 173-181
• ASO, K., SHAHTAHERI, S. M., HILL, R., WILSON, D., MCWILLIAMS, D. F., NWOSU, L. N., CHAPMAN, V and WALSH, D. A., 2020. Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats OSTEOARTHRITIS AND CARTILAGE. 28(9), 1245-1254
• MCWILLIAMS, D. F., DAWSON, O., YOUNG, A., KIELY, P. D., FERGUSON, E. and WALSH, D. A., 2019. Discrete trajectories of resolving and persistent pain in people with rheumatoid arthritis despite undergoing treatment for inflammation: Results from three UK cohorts: J Pain J Pain. 20(6), 716-727 (In Press.)
• KOJI ASO, MOHSEN SHAHTAHERI, DEBORAH WILSON, ROGER HILL, DANIEL MCWILLIAMS and DAVID WALSH, 2019. Associations of symptomatic knee OA with histopathologic features in subchondral bone Arthritis and Rheumatology. 71(6), 916-924
• MCWILLIAMS, DANIEL F., DAWSON, OLIVIA, YOUNG, ADAM, KIELY, PATRICK D. W., FERGUSON, EAMONN and WALSH, DAVID A., 2019. Discrete Trajectories of Resolving and Persistent Pain in People With Rheumatoid Arthritis Despite Undergoing Treatment for Inflammation: Results From Three UK Cohorts JOURNAL OF PAIN. 20(6), 716-727
• MCWILLIAMS, DF, RAHMAN, S, JAMES, RE, FERGUSON, E, KIELY, P and YOUNG, A, 2019. Disease activity flares and pain flares in an early rheumatoid arthritis inception cohort; characteristics, antecedents and sequelae BMC Rheumatology. 3, 49
• WALSH DA and MCWILLIAMS DF, 2019. In: CGRP and Painful Pathologies Other than Headache.
• AKIN-AKINYOSOYE K, FROWD N, MARSHALL L, STOCKS J, FERNANDES G, VALDES A, MCWILLIAMS DF, ZHANG W, DOHERTY M, FERGUSON E and WALSH DA, 2018. Traits associated with central pain augmentation in the Knee Pain in the Community (KPIC) cohort. Pain. 159(6), 1035-1044
• MCWILLIAMS DF, KIELY PDW, YOUNG A, JOHARATNAM N and WILSON D, 2018. Interpretation of DAS28 and its components in the assessment of inflammatory and non-inflammatory aspects of rheumatoid arthritis BMC Rheumatology. 2, 8
• PAPOU A, HUSSAIN S, MCWILLIAMS D, ZHANG W and DOHERTY M, 2017. Responsiveness of SF-36 Health Survey and Patient Generated Index in people with chronic knee pain commenced on oral analgesia: analysis of data from a randomised controlled clinical trial. Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation. 26(3), 761-766
• CARPENTER L, NORTON S, NIKIPHOROU E, JAYAKUMAR K, MCWILLIAMS DF, RENNIE KL, DIXEY J, KIELY P, WALSH DA, YOUNG A and , 2017. Reductions in radiographic progression in early RA over 25-years: Changing contribution from RF in 2 multi-centre UK inception cohorts. Arthritis care & research. 69(12), 1809-17
• FERNANDES GS, BHATTACHARYA A, MCWILLIAMS DF, INGHAM SL, DOHERTY M and ZHANG W, 2017. Risk prediction model for knee pain in the Nottingham community: a Bayesian modelling approach. Arthritis research & therapy. 19(1), 59
• MCWILLIAMS, D. F. and WALSH, D. A., 2017. Pain mechanisms in rheumatoid arthritis CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 35(5), S94-S101
• MCWILLIAMS DF, MARSHALL M, JAYAKUMAR K, DOHERTY S, DOHERTY M, ZHANG W, KIELY PD, YOUNG A and WALSH DA, 2016. Erosive and osteoarthritic structural progression in early rheumatoid arthritis Rheumatology (Oxford).
• MCWILLIAMS DF, FERGUSON E, YOUNG A, KIELY PD and WALSH DA, 2016. Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data. Arthritis research & therapy. 18(1), 295
• MCWILLIAMS DF and WALSH DA, 2016. Factors predicting pain and early discontinuation of tumour necrosis factor-α-inhibitors in people with rheumatoid arthritis: results from the British society for rheumatology biologics register. BMC Musculoskeletal Disorders. 17, 337
• KELLY, S., CHAPMAN, R. J., WOODHAMS, S., SAGAR, D. R., TURNER, J., BURSTON, J. J., BULLOCK, C., PATON, K., HUANG, J., WONG, A., MCWILLIAMS, D. F., OKINE, B. N., BARRETT, D. A., HATHWAY, G. J., WALSH, D. A. and CHAPMAN, V., 2015. Increased function of pronociceptive TRPV1 at the level of the joint in a rat model of osteoarthritis pain ANNALS OF THE RHEUMATIC DISEASES. 74(1), 252-259
• JOHARATNAM, N., MCWILLIAMS, D. F., WILSON, D., WHEELER, M., PANDE, I. and WALSH, D. A., 2015. A cross sectional study of pain sensitivity, disease activity assessment, mental health and fibromyalgia status in rheumatoid arthritis: Arthritis Res Ther Arthritis Res Ther. 17(1), 11
• WALSH, D. A. and MCWILLIAMS, D. F., 2014. Mechanisms, impact and management of pain in rheumatoid arthritis: Nat Rev Rheumatol Nat Rev Rheumatol. 10(10), 581-592
• MCWILLIAMS, D. F., VARUGHESE, S., YOUNG, A., KIELY, P. D. and WALSH, D. A., 2014. Work disability and state benefit claims in early rheumatoid arthritis: the ERAN cohort: Rheumatology (Oxford) Rheumatology (Oxford). 53(3), doi: 10.1093/rheumatology/ket373
• MCWILLIAMS, D. F., MUTHURI, S., MUIR, K. R., MACIEWICZ, R. A., ZHANG, W. and DOHERTY, M., 2014. Self-reported adult footwear and the risks of lower limb osteoarthritis: the GOAL case control study: BMC Musculoskelet Disord BMC Musculoskelet Disord. 15(1), 308
• MCWILLIAMS, D. F., KIELY, P. D., YOUNG, A. and WALSH, D. A., 2013. Baseline factors predicting change from the initial DMARD treatment during the first 2 years of rheumatoid arthritis: experience in the ERAN inception cohort: BMC Musculoskelet Disord BMC Musculoskelet Disord. 14, 153
• MCWILLIAMS DF, ZHANG W, MANSELL JS, KIELY PDW, YOUNG A and WALSH DA, 2012. Predictors of change in bodily pain in early rheumatoid arthritis: an inception cohort study. Arthritis care & research. 64(10), 1505-13
• WALSH, D. A., VERGHESE, P., COOK, G. J., MCWILLIAMS, D. F., MAPP, P. I., ASHRAF, S. and WILSON, D., 2012. Lymphatic vessels in osteoarthritic human knees: Osteoarthritis Cartilage Osteoarthritis Cartilage. doi: 10.1016/j.joca.2012.01.012,
• WALSH, D. A. and MCWILLIAMS, D. F., 2012. Pain in rheumatoid arthritis: Curr Pain Headache Rep Curr Pain Headache Rep. 16(6), 509-17
• SUOKAS, A. K., WALSH, D. A., MCWILLIAMS, D. F., CONDON, L., MORETON, B., WYLDE, V., ARENDT-NIELSEN, L. and ZHANG, W., 2012. Quantitative sensory testing in painful osteoarthritis: a systematic review and meta-analysis: Osteoarthritis Cartilage Osteoarthritis Cartilage. 20(10), 1075-85
• MCWILLIAMS DF, LEEB BF, MUTHURI SG, DOHERTY M and ZHANG W, 2011. Occupational risk factors for osteoarthritis of the knee: a meta-analysis. Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 19(7), 829-39
• ZHANG, W., MCWILLIAMS, D.F., INGHAM, S.L., DOHERTY, S.A., MUTHURI, S., MUIR, K.R. and DOHERTY, M., 2011. Nottingham knee osteoarthritis risk prediction models Annals of the Rheumatic Diseases. 70(9), 1599-1604
• MUTHURI SG, MCWILLIAMS DF, DOHERTY M and ZHANG W, 2011. History Of Knee Injuries And Knee Osteoarthritis: A Meta-Analysis Of Observational Studies. Osteoarthritis And Cartilage / Oars, Osteoarthritis Research Society. 19(11), 1286-93
• HOLLIDAY KL, MCWILLIAMS DF, MACIEWICZ RA, MUIR KR, ZHANG W and DOHERTY M, 2011. Lifetime Body Mass Index, Other Anthropometric Measures Of Obesity And Risk Of Knee Or Hip Osteoarthritis In The Goal Case-Control Study. Osteoarthritis And Cartilage / Oars, Osteoarthritis Research Society. 19(1), 37-43
• INGHAM SL, ZHANG W, DOHERTY SA, MCWILLIAMS DF, MUIR KR and DOHERTY M, 2011. Incident Knee Pain In The Nottingham Community: A 12-Year Retrospective Cohort Study. Osteoarthritis And Cartilage / Oars, Osteoarthritis Research Society. 19(7), 847-52
• MCWILLIAMS, D.F., DOHERTY, S.A., JENKINS, W.D., MACIEWICZ, R.A., MUIR, K.R., ZHANG, W. and DOHERTY, M., 2010. Mild acetabular dysplasia and risk of osteoarthritis of the hip: a case control study Annals of the Rheumatic Diseases. 69(10), 1774-1778
• MCWILLIAMS DF, DOHERTY S, MACIEWICZ RA, MUIR KR, ZHANG W and DOHERTY M, 2010. Self-Reported Knee And Foot Alignments In Early Adult Life And Risk Of Osteoarthritis. Arthritis Care & Research. 62(4), 489-95
• WALSH DA, MCWILLIAMS DF, TURLEY MJ, DIXON MR, FRANSÈS RE, MAPP PI and WILSON D, 2010. Angiogenesis And Nerve Growth Factor At The Osteochondral Junction In Rheumatoid Arthritis And Osteoarthritis. Rheumatology (Oxford, England). 49(10), 1852-61
• FRANSÈS RE, MCWILLIAMS DF, MAPP PI and WALSH DA, 2010. Osteochondral Angiogenesis And Increased Protease Inhibitor Expression In Oa. Osteoarthritis And Cartilage / Oars, Osteoarthritis Research Society. 18(4), 563-71
• WALSH DA, YOUSEF A, MCWILLIAMS DF, HILL R, HARGIN E and WILSON D, 2009. Evaluation Of A Photographic Chondropathy Score (Pcs) For Pathological Samples In A Study Of Inflammation In Tibiofemoral Osteoarthritis. Osteoarthritis And Cartilage / Oars, Osteoarthritis Research Society. 17(3), 304-12
• MAPP PI, AVERY PS, MCWILLIAMS DF, BOWYER J, DAY C, MOORES S, WEBSTER R and WALSH DA, 2008. Angiogenesis In Two Animal Models Of Osteoarthritis. Osteoarthritis And Cartilage / Oars, Osteoarthritis Research Society. 16(1), 61-9
• WALSH, D A, BONNET, C S, TURNER, E L, WILSON, D, SITU, M and MCWILLIAMS, D F, 2007. Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis. Osteoarthritis and Cartilage. 15(7), 743-51
• SURI S, GILL SE, MASSENA DE CAMIN S, WILSON D, MCWILLIAMS DF and WALSH DA, 2007. Neurovascular Invasion At The Osteochondral Junction And In Osteophytes In Osteoarthritis. Annals Of The Rheumatic Diseases. 66(11), 1423-8
• HARRIS, J.C., GILLIAM, A.D., MCKENZIE, A.J., EVANS, S.A., GRABOWSKA, A.M., CLARKE, P.A., MCWILLIAMS, D.F. and WATSON, S.A., 2004. The biological and therapeutic importance of gastrin gene expression in pancreatic adenocarcinomas Cancer Research. 64(16), 5624-5631
• SEEGERS, H.C., AVERY, P.S., MCWILLIAMS, D.F., HAYWOOD, L. and WALSH, D.A., 2004. Combined effect of bradykinin B₂ and neurokinin-1 receptor activation on endothelial cell proliferation in acute synovitis FASEB Journal. 18(6), 762-764
• MCKAIG, B.C., MCWILLIAMS, D., WATSON, S.A. and MAHIDA, Y.R., 2003. Expression and regulation of tissue inhibitor of metalloproteinase-1 and matrix metalloproteinases by intestinal myofibroblasts in inflammatory bowel disease American Journal of Pathology. 162(4), 1355-1360
• HAYWOOD, L., MCWILLIAMS, D.F., PEARSON, C.I., GILL, S.E., GANESAN, A., WILSON, D. and WALSH, D.A., 2003. Inflammation and angiogenesis in osteoarthritis. Arthritis & Rheumatism. 48(8), 2173-2177
• WATSON, S A, MORRIS, T M, MCWILLIAMS, D F, HARRIS, J, EVANS, S, SMITH, A and CLARKE, P A, 2002. Potential role of endocrine gastrin in the colonic adenoma carcinoma sequence. British Journal of Cancer. 87(5), 567-73
• MCWILLIAMS, D. F., GRIMES, S. and WATSON, S. A., 2001. Antibodies raised against the extracellular tail of the CCKB/gastrin receptor inhibit gastrin-stimulated signalling Regulatory Peptides. VOL 99(NUMBER 2-3), 157-161
• WATSON, S A, ROBINSON, K E, MCWILLIAMS, D, MICHAELI, D, SMITH, A M and ROBINSON, G, 2000. Transforming growth factor-alpha-mediated growth pathways in human gastro-intestinal cell lines in relation to the gastrin autocrine pathway. International Journal of Cancer. 87(1), 20-8
• MCWILLIAMS DF, WATSON SA, CROSBEE DM, MICHAELI D and SETH R, 1998. Coexpression Of Gastrin And Gastrin Receptors (Cck-B And Delta Cck-B) In Gastrointestinal Tumour Cell Lines. Gut. 42(6), 795-8