Contact

• workDivision of Child Health, Obstetrics and Gynaecology
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 970 9102
• fax0115 970 9241
• donald.macarthur@nuh.nhs.uk

Research Summary

Surgical management of brain tumours- including image guided surgery, neuroendoscopy, delivery of gene therapy and intracavitary chemotherapy

Tumour banking

Perfusion MR imaging of brain tumours

MR Spectroscopy of brain tumours

Postoperative imaging of tumours

Long term sequelae and quality of life issues after surgery

Recent Publications

• SMITH S.J., TILLY H., WARD J.H., MACARTHUR D.C., LOWE J., COYLE B. and GRUNDY R.G., 2012. CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma Acta Neuropathologica. 124(1), 99-110
• SMITH, S.J., WILSON, M., WARD, J.H., RAHMAN, C.V., PEET, A.C., MACARTHUR, D.C., ROSE, F.R.A.J., GRUNDY, R.G. and RAHMAN, R., 2012. Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition PLoS One. 7(12), e52335
• BARROW, J., ADAMOWICZ-BRICE, M., CARTMILL, M., MACARTHUR, D., LOWE, J., ROBSON, K., BRUNDLER, M.A., WALKER, D.A., COYLE, B. and GRUNDY, R., 2011. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas Neuro-oncology. 13(2), 212-222
• DAVIS, E.E., PITCHFORD, N.J., JASPAN, T., MACARTHUR, D. and WALKER, D., 2011. Effects of hydrocephalus after cerebellar tumor: a case-by-case approach Pediatric Neurology. 44(3), 193-201

• View all publications

Kalkunte R, Macarthur D, Morton R. Glioblastoma in a boy with Fragile X; an unusual case of neuroprotection. Archives of Disease in Childhood (epub ahead of April 2007).

Maxwell M, Seneviratne M, Macarthur D, Veale P (2007). Parental feedback surveys should be used more widely for monitoring the quality of paediatric care. Paediatric Anaesthesia 17: 297-298.

Shastri-Hurst N, Tsegaye M, Robson DK, Lowe JS & Macarthur DC (2006). Stereotactic brain biopsy : an audit of sampling reliability in a clinical case series. British Journal of Neurosurgery 20: 222-226 (2006)

Becker J, Sivakumar G, Auer D, Macarthur DC, Jaspan T (2006). Post-operative imaging of paediatric brain tumours. Should the protocol be changed? British Neurosurgical Research Group, Hurstwood Park.

Buxton N, Macarthur D, Robertson I, Punt J (2003). Neuroendoscopic third ventriculostomy for failed shunts. Surgical Neurology 60: 201-204.

Macarthur DC, Morgan P, Martel A, Byrne PO, Moody AR (2002). Can Gliomas be graded using multimodality MRI? British Journal of Neurosurgery 16: 407.

• SMITH S.J., TILLY H., WARD J.H., MACARTHUR D.C., LOWE J., COYLE B. and GRUNDY R.G., 2012. CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma Acta Neuropathologica. 124(1), 99-110
• SMITH, S.J., WILSON, M., WARD, J.H., RAHMAN, C.V., PEET, A.C., MACARTHUR, D.C., ROSE, F.R.A.J., GRUNDY, R.G. and RAHMAN, R., 2012. Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition PLoS One. 7(12), e52335
• BARROW, J., ADAMOWICZ-BRICE, M., CARTMILL, M., MACARTHUR, D., LOWE, J., ROBSON, K., BRUNDLER, M.A., WALKER, D.A., COYLE, B. and GRUNDY, R., 2011. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas Neuro-oncology. 13(2), 212-222
• DAVIS, E.E., PITCHFORD, N.J., JASPAN, T., MACARTHUR, D. and WALKER, D., 2011. Effects of hydrocephalus after cerebellar tumor: a case-by-case approach Pediatric Neurology. 44(3), 193-201
• SMITH SJ, LONG A, BARROW JH, MACARTHUR DC, COYLE B, GRUNDY RG and CHILDREN'S CANCER AND LEUKAEMIA GROUP BIOLOGICAL STUDIES COMMITTEE, 2011. Pediatric High-Grade Glioma: Identification Of Poly(Adp-Ribose) Polymerase As A Potential Therapeutic Target. Neuro-Oncology. 13(11), 1171-7
• SHARP MC and MACARTHUR DC, 2011. An unusual presentation of colloid cyst--implications for lifestyle advice. British journal of neurosurgery. 25(2), 284-5
• DAVIS, E.E., PITCHFORD, N.J., JASPAN, T., MCARTHUR, D. and WALKER, D., 2010. Development of cognitive and motor function following cerebellar tumour injury sustained in early childhood Cortex. 46(7), 919-932
• MESSAHEL B, ASHLEY S, SARAN F, ELLISON D, IRONSIDE J, PHIPPS K, COX T, CHONG WK, ROBINSON K, PICTON S, PINKERTON CR, MALLUCCI C, MACARTHUR D, JASPAN T, MICHALSKI A, GRUNDY RG and CHILDREN'S CANCER LEUKAEMIA GROUP BRAIN TUMOUR COMMITTEE, 2009. Relapsed Intracranial Ependymoma In Children In The Uk: Patterns Of Relapse, Survival And Therapeutic Outcome. European Journal Of Cancer (Oxford, England : 1990). 45(10), 1815-23
• SMITH SJ, UGHRATDAR I and MACARTHUR DC, 2009. Never go to sleep on undrained pus: a retrospective review of surgery for intraparenchymal cerebral abscess. British journal of neurosurgery. 23(4), 412-7
• KALKUNTE R, MACARTHUR D and MORTON R, 2009. Glioblastoma in a boy with fragile X: an unusual case of neuroprotection. BMJ case reports. 2009,
• CLAYTON,, VLOEBERGHS,, JASPAN,, WALKER,, MACARTHUR, and GRUNDY,, 2008. Intrathecal chemotherapy delivered by a lumbar-thecal catheter in metastatic medulloblastoma: a case illustration. Acta neurochirurgica.
• PEET AC, ARVANITIS TN, AUER DP, DAVIES NP, HARGRAVE D, HOWE FA, JASPAN T, LEACH MO, MACARTHUR D, MACPHERSON L, MORGAN PS, NATARAJAN K, PAYNE GS, SAUNDERS D, GRUNDY RG and CCLG FUNCTIONAL IMAGING GROUP, 2008. The value of magnetic resonance spectroscopy in tumour imaging. Archives of disease in childhood. 93(9), 725-7
• SMITH SJ, BODDU S and MACARTHUR DC, 2007. Atypical meningiomas: WHO moved the goalposts? British journal of neurosurgery. 21(6), 588-92
• KALKUNTE R, MACARTHUR D and MORTON R, 2007. Glioblastoma in a boy with fragile X: an unusual case of neuroprotection. Archives of disease in childhood. 92(9), 795-6
• MAXWELL M, SENEVIRATNE M, MACARTHUR D and VEALE P, 2007. Parental feedback surveys should be used more widely for monitoring the quality of pediatric care. Paediatric anaesthesia. 17(3), 297-8
• SHASTRI-HURST, N, TSEGAYE, M, ROBSON, D K, LOWE, J S and MACARTHUR, D C, 2006. Stereotactic brain biopsy: An audit of sampling reliability in a clinical case series. British Journal of Neurosurgery. 20(4), 222-6
• RAMASWAMY R, MACARTHUR D and WHITE BD, 2004. Vascular threat in base of skull fractures. British journal of neurosurgery. 18(2), 197-8
• BUXTON N, MACARTHUR D, ROBERTSON I and PUNT J, 2003. Neuroendoscopic third ventriculostomy for failed shunts. Surgical neurology. 60(3), 201-3; discussion 203-4
• YAP C, MACARTHUR DC and HOPE DT, 2002. 'Mind the gap': resorption of a bone flap stored subcutaneously for 6 months. British journal of neurosurgery. 16(5), 523-4
• MACARTHUR DC, BUXTON N, PUNT J, VLOEBERGHS M and ROBERTSON IJA, 2002. The role of neuroendoscopy in the management of brain tumours. British journal of neurosurgery. 16(5), 465-70
• MACARTHUR, D. C., BUXTON, N., VLOEBERGHS, M. and PUNT, J., 2001. The effectiveness of neuroendoscopic interventions in children with brain tumours Child's Nervous System. VOL 17(PART 10), 589-594
• MACARTHUR DC and BUXTON N, 2001. The management of brain tumours. Journal of the Royal College of Surgeons of Edinburgh. 46(6), 341-8
• BUXTON N, HO KJ, MACARTHUR D, VLOEBERGHS M, PUNT J and ROBERTSON I, 2001. Neuroendoscopic third ventriculostomy for hydrocephalus in adults: report of a single unit's experience with 63 cases. Surgical neurology. 55(2), 74-8
• MACARTHUR DC, PUNT JA, SPENCER M, DOUGLAS DL, WHITE BD and HOLLAND IM, 2001. Neurological deterioration years after closure of myelomeningocoele - 'the second lesion'. Spinal cord. 39(1), 11-4
• MACARTHUR DC, ROBERTSON IJ and PUNT JA, 2000. Third ventricular cysts and membranes unsuspected on conventional CT and MRI. British journal of neurosurgery. 14(5), 455-7
• BUXTON, N, MACARTHUR, D, MALLUCCI, C, PUNT, J and VLOEBERGHS, M, 1998. Neuroendoscopic third ventriculostomy in patients less than 1 year old. Pediatric Neurosurgery. 29(2), 73-6
• BUXTON, N, MACARTHUR, D, MALLUCCI, C, PUNT, J and VLOEBERGHS, M, 1998. Neuroendoscopy in the premature population. Child's Nervous System. 14(11), 649-52
• WHITTLE IR, MACARTHUR DC, MALCOLM GP, LI M, WASHINGTON K and IRONSIDE JW, 1998. Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. Journal of neuro-oncology. 36(3), 231-42
• MACARTHUR DC, NIXON SJ and AITKEN RJ, 1998. Avoidable deaths still occur after large bowel surgery. Scottish Audit of Surgical Mortality, Royal College of Surgeons of Edinburgh. The British journal of surgery. 85(1), 80-3
• MACARTHUR DC and PRICE RF, 1997. Minor head injury. Journal of neurosurgery. 87(3), 485-6
• MACARTHUR DC, GRIEVE DC, THOMPSON AM, GREIG JD and NIXON SJ, 1997. Herniography for groin pain of uncertain origin. The British journal of surgery. 84(5), 684-5
• KENNEDY RL, HARRISON RF, BURTON AM, FRASER HS, HAMER WG, MACARTHUR D, MCALLUM R and STEEDMAN DJ, 1997. An artificial neural network system for diagnosis of acute myocardial infarction (AMI) in the accident and emergency department: evaluation and comparison with serum myoglobin measurements. Computer methods and programs in biomedicine. 52(2), 93-103
• VISWANATHAN R, MACARTHUR DC and WHITTLE IR, 1994. Nail gun injury to the brain: an unusual case of suicide. Scottish medical journal. 39(3), 83