Contact
Biography
Kirsty is Assistant Professor of Clinical Trials at the University of Nottingham Clinical Trials Unit (NCTU) www.nctu.ac.uk. She has over 17 years' experience working in clinical research including design and delivery of randomised controlled trials, feasibility and pilot studies as well as qualitative methodology including fidelity assessment and process evaluation. She has worked in the unit since 2014 in a range of roles including Trial Manager, Senior Trial Manager and now her current Assistant Professor post. Prior to joining the NCTU she worked for the Sheffield Clinical Trials Research Unit (CTRU) in the School of Health and Related Research (ScHARR) as a Research Associate. Prior to that she worked for the Healthcare Innovation and Technology Evaluation Centre (HITEC) based at Derby Hospitals NHS Foundation Trust where she carried out systematic reviews, evidence reviews and technical evaluations of assistive technologies and medical devices for the Centre for Evidence-based Purchasing (CEP) part of the Purchasing and Supply Chain (PASA) and the National Institute for Health and Clinical Excellence (NICE).
Her main research interest is in adult and child mental health in which she is co-applicant on several large multi-centre NIHR HTA funded trials as well as smaller projects in the UK (JtD, PRIDE, STADIA, SATURN, SPARX, RE-MIND). She has a specific interest in older adults and dementia, particularly occupational therapy based interventions exploring self-management for maintaining independent living as well as mental and physical wellbeing. She also has a strong interest in fidelity assessment of complex intervention and qualitative research.
Teaching Summary
I currently lead the Qualitative Methods in Clinical Trials Course and the Online Introduction to Clinical Trials Course as part of the NCTU Short Course programme. In addition I also co-lead the… read more
Research Summary
Moppett I, Costa M, Sprange K, Karantana A, Stanworth S, James M, Partlett C, Juszczak E, Acheson A, Sugavanam A, Shah A, Sinclair R, Welch N. The clinical benefits and cost-effectiveness and safety… read more
Selected Publications
KIRSTY SPRANGE, GAIL A MOUNTAIN, KATY SHORTLAND, CLAIRE CRAIG, DANIEL BLACKBURN, PETER BOWIE, KIRSTY HARKNESS and MAGGIE SPENCER, 2015. Journeying through Dementia, a community-based self-management intervention for people aged 65 years and over: a feasibility study to inform a future trial Pilot and Feasibility Studies. 1(42), SPRANGE, KIRSTY, MOUNTAIN, GAIL A., BRAZIER, JOHN, COOK, SARAH P., CRAIG, CLAIRE, HIND, DANIEL, WALTERS, STEPHEN J., WINDLE, GILL, WOODS, ROBERT, KEETHARUTH, ANJU D., CHATER, TIM and HORNER, KATH, 2013. Lifestyle Matters for maintenance of health and wellbeing in people aged 65 years and over: study protocol for a randomised controlled trial TRIALS. 14(302), HIND, D, ROBERTS, C, SPRANGE, K, GOSSAGE-WORRALL, R, COOPER, C and WALTERS, S, 2013. Methodological, planning and implementation challenges for RCTs evaluating group interventions Trials. 14((Suppl 1)),
Current Research
Moppett I, Costa M, Sprange K, Karantana A, Stanworth S, James M, Partlett C, Juszczak E, Acheson A, Sugavanam A, Shah A, Sinclair R, Welch N. The clinical benefits and cost-effectiveness and safety of haematopoietic interventions for patients with anaemia following major emergency surgery: a phase IV, multicentre, multi-arm randomised controlled trial: Peri-op Iron and EPO Intervention Study - POP-I, NIHR Health Technology Assessment Programme. NIHR133467, Start date July 2022 (48 months), £2,146,909. Trial methodologist Co-applicant.
Sprange K, Hall C, Juszczak E, Martin J, Murray E, Gardner, Willis A, Montgomery A. REcruitment in Mental health trials: broadening the 'net', opportunities for INclusivity through online methoDs (RE-MIND Study), NIHR CTU Support Funding Award. Jan 2022 (12 months). £72,944. Lead applicant.
Papaioannou D, Sprange K, O'Cathain A, Moody G, Robling M, Corneliuse V. Recording HArms in Behavioural change Intervention Trials (RHABIT), NIHR CTU Support Funding Award. £79,015. Jan 2022 (12 months). Co-Applicant, supervisor for qualitative element.
Partlett C, Sprange K, Linsell, L, Gamble C, Julious S, Cook A. Blinding of Trial Statisticians (BOTS), NIHR CTU Support Funding Award. £67,374. Jan 2021 (18 months). Co-applicant and qualitative lead.
Ryder S, Clifton-Brown A, Enki SG, Guha IN, Hutton C, Jones K, Rennick-Egglestone S, Sprange K, Willott S, Wragg A. Does knowledge of liver fibrosis affect high risk drinking behaviour (KLIFAD)? A feasibility randomised controlled trial. NIHR Research for Patient Benefit (RfPB). NIHR201146 (26278). Start date Sept 2020 (24 months). £219,073. Trial methodology lead, expertise in trial management and delivery.
Karantana K, Costa M, Davis T, James M, Jerosch-Herold C, Montgomery A, Ogollah R, Rodrigues J, Trickett R, Sprange K, Widdowson L. POINT: A multi-centre randomised trial of surgery versus non-surgical splint treatment for proximal phalanx shaft finger fractures in adults. NIHR Health Technology Assessment Programme. NIHR127292. Start date Sept 2019 (48 months). £1,403,829. Trial methodology lead, expertise in trial management and delivery.
Hollis C, Cortese S, Hall C, James M, Jarvis C, Liang H, Malik O, Montgomery AA, Ogollah R, Sayal K, Sharma A, Sprange K and Kyriakopoulos M. Stimulant Medication for ADHD and Tics - Understanding Response versus Non-stimulants (SATURN study): a randomised trial of the clinical and cost-effectiveness of methylphenidate versus guanfacine for ADHD in children and young people with a co-existing tic disorder. NIHR Health Technology Assessment Programme. NIHR128472. Start date Oct 2021 (48 months). £1,628,868. Trial methodology lead, expertise in trial management and delivery.
Sayal K, Montgomery AA, Sprange K, James M, Thomson L, Lang A, Ewart C, Reynolds S, Marshall T, Gledhill J, Dubicka B, Bhardwaj A. STAndardised DIagnostic Assessment for children and adolescents with emotional difficulties (STADIA): a multi-centre randomised controlled trial. NIHR Health Technology Assessment Programme. 16/96/09. Start date Nov 2018 (48 months). £1,481,137. Trial methodology lead, expertise in trial management and delivery.
Mountain G, Orrell M, Bowie P, Sprange K, Walters S, Craig C, Cooper C, Berry K, Blackburn D, Moniz-Cook ED, Young T. Journeying through dementia; randomised controlled trial of clinical and cost effectiveness. NIHR Health Technology Assessment Programme. 14/140/80. Start date Sept 2015 (42 months) £2,017,925. Fidelity assessment and qualitative study lead.