Contact

• workRoom 1720 East Block, C Floor
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work+441158231008
• Marianna.Laviola@nottingham.ac.uk

Biography

I am a biomedical engineer and, in 2013, I obtained my PhD in Bioengineering at the Polytechnic University of Milan (Italy).

My research interests include the bioengineering of the respiratory and cardiovascular systems, the development of computational models of human physiology and pathology, animal models of respiratory diseases, ultrasonography of the diaphragm and opto-pletismography.

My research focusses on the development of computational simulation and mathematical modelling of the cardiopulmonary system as the primary methodology to model critically ill patients and develop personalised and optimised resuscitation and rescue strategies.

School Responsibilities:

Lead for Early Career Researchers - Injury, Inflammation and Recovery Science

Deputy Lead for PGR Student Teaching & Training - Doctoral Programmes - School of Medicine

Mentoring, coaching & tutoring

Mentor - UoN staff and students

Coach - SoM COALS programme

Tutor - SoM BMedSci students

Others

Associate Editor, IEEE Open Journal of Engineering in Medicine and Biology

Young Professional Representative (2020 -2022) - IEEE Engineering in Medicine and Biology Society (EMBS). Administrative Committee.

Teaching Summary

PGR supervision & BMedSci and PG research project supervision

"Introduction to MATLAB" - SoM PGR course

"Computational Modelling in Critical Illness" - SoM PGR course & Pluripotent Stem Cells module

Research Summary

Computational simulations and mathematical modelling of respiratory and cardiovascular systems

In silico trials

Cardiac arrest and resuscitation strategies

Apnoea and airway management in adults, pregnancy and children

Mechanical ventilation of the lungs

Selected Publications

• M. LAVIOLA, J. RAFL, M. ROZANEK, P. KUDRNA and K. ROUBIK, 2016. Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs. Exp Lung Research. Exp Lung Res. 42(2), 87-94
• M. LAVIOLA, A. ZANNINI, R. PRIORI, F. MACCHINI, E. LEVA, M. TORRICELLI, C. CERUTI and A. ALIVERTI, 2015. Thoraco-abdominal asymmetry and asynchrony in congenital diaphragmatic hernia. Ped Pulm. 50(9), 915-924
• M. LAVIOLA, J. RAFL, M. ROZANEK, P. KUDRNA and K. ROUBIK, 2015. Models of a PaO2 course during a stepwise change of Continuous Distending Pressure in HFOV. In: 2nd International Conference Mathematics and Computers in Sciences and Industry - Sliema – Malta. 66-71.
• K. ROUBIK, V. SOBOTA and M. LAVIOLA, 2015. Selection of the Baseline Frame for Evaluation of Electrical Impedance Tomography of the Lungs. In: 2nd International Conference Mathematics and Computers in Sciences and Industry – Sliema – Malta. 293-297

• View all publications

NIHR BRC Pump Priming project: "Computational modelling for optimisation and personalisation of resuscitation during critical hypotension and cardiac arrest secondary to trauma", 2023-24 PI (£5K)

University of Nottingham - Joan Browne PhD studentship: "Investigation of hypoxemia and hypercapnia during apnoea in children using a computer simulation", 2023-26 PI (UKRI PhD stipend and fees)

Fisher & Paykel Healthcare: "Nasal High Flow (NHF) for respiratory support, in silico research", 2022-26 Co-I (£75K)

WT Biomedical Vacation Scholarship: Simulation of cardiopulmonary resuscitation strategies in myocardial infarction and asphyxia using an integrated and high fidelity computational model", 2022. PI (£2K)

Animal Free Research UK: "Simulation of myocardial infarction and hypovolemic shock using an integrated and high fidelity computational model", 2021. PI (£2K)

EPRSC: "Investigating strategies for mechanical ventilation in COVID-19 via computational simulation of virtual patients", 2020-21. Researcher Co-I (£429K)

Fisher & Paykel Healthcare: "Investigating the evolution and application of Optiflow in managing obese patients in the perioperative period", 2019-22. Co-I (£76K)

NC3Rs: "Replacement of animal models of cardiac arrest and resuscitation strategies using a computer simulation", 2019-22. Co-I (£90K)

EPRSC: "Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit: Realising Industrial and Medical Applications", 2017-21. Research Co-I (£880K)

Fisher & Paykel Healthcare: "Investigating the mechanism of Optiflow-induced gas exchange and potential optimizations using high-fidelity computational modelling", 2016-2017. Named Researcher. (£110k)

Past Research

October 2013 - September 2015 (Post-doc, Czech Technical University in Prague, Czech Republic)

Investigation of gas exchanges in animal models of ARDS during conventional ventilation and high-frequency oscillatory ventilation.

January 2010 - April 2013 (PhD thesis, Politecnico di Milano, Italy)

PhD thesis: "Development of new methods for noninvasive functional assessment of the diaphragm"

• STOLADY D., LAVIOLA M. and PILLAI A., 2021. Effect of variable pre-oxygenation endpoints on safe apnoea time using high flow nasal oxygen for women in labour: a modelling investigation British Journal of Anaesthesia. 126(4), 889-895
• M. LAVIOLA, C. NIKLAS, A. DAS, D.G. BATES and J.G. HARDMAN, 2020. Airway Rescue and the Effect of Oxygen Fraction: A Computational Modelling Study. British Journal of Anaesthesia. 125(1),
• M. LAVIOLA, C. NIKLAS, H. ALAMADI, A. DAS, D.G. BATES and J.G. HARDMAN, 2019. High oxygen fraction during airway opening is key to effective airway rescue in obese subjects In: Proceeding of the 41st IEEE Engineering in Biology and Medicine Conference, Berlin, 2019.
• M. LAVIOLA, D.G. BATES and J.G. HARDMAN, 2019. Mathematical and Computational Modelling in Critical Illness. European Respiratory & Pulmonary Diseases. 5 (1), (In Press.)
• LAVIOLA M, DAS A, CHIKHANI M, BATES DG and HARDMAN JG, 2019. Computer simulation clarifies mechanisms of carbon dioxide clearance during apnoea. British Journal of Anaesthesia. 122(3), 395-401
• LAVIOLA M, PRIORI R, D'ANGELO MG and ALIVERTI A, 2018. Assessment of diaphragmatic thickness by ultrasonography in Duchenne muscular dystrophy (DMD) patients. PloS one. 13(7), e0200582
• LAVIOLA M, DAS A, CHIKHANI M, BATES DG and HARDMAN JG, 2017. Investigating the effect of cardiac oscillations and deadspace gas mixing during apnea using computer simulation. Conference proceeding : 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference. 2017, 337-340
• M. LAVIOLA, J. RAFL, M. ROZANEK, P. KUDRNA and K. ROUBIK, 2016. Models of PaO2 response to the continuous distending pressure maneuver during high frequency oscillatory ventilation in healthy and ARDS lung model pigs. Exp Lung Research. Exp Lung Res. 42(2), 87-94
• K. ROUBIK, V. SOBOTA and M. LAVIOLA, 2015. Selection of the Baseline Frame for Evaluation of Electrical Impedance Tomography of the Lungs. In: 2nd International Conference Mathematics and Computers in Sciences and Industry – Sliema – Malta. 293-297
• M. LAVIOLA, J. RAFL, M. ROZANEK, P. KUDRNA and K. ROUBIK, 2015. Models of a PaO2 course during a stepwise change of Continuous Distending Pressure in HFOV. In: 2nd International Conference Mathematics and Computers in Sciences and Industry - Sliema – Malta. 66-71.
• M. LAVIOLA, A. ZANNINI, R. PRIORI, F. MACCHINI, E. LEVA, M. TORRICELLI, C. CERUTI and A. ALIVERTI, 2015. Thoraco-abdominal asymmetry and asynchrony in congenital diaphragmatic hernia. Ped Pulm. 50(9), 915-924
• M. LAVIOLA, O. HAJNY and K. ROUBIK, 2014. Continuous distending pressure effects on variables contributing to oxygenation in healthy and ARDS model pigs during HFOV. In: International Conference of Computational Methods in Sciences and Engineering 2014 (ICCMSE) Athens - Greece. 1618. 962-966
• A. LOMAURO, M. ROMEI, R. PRIORI, M. LAVIOLA, M.G. D'ANGELO and A. ALIVERTI, 2014. Alterations of thoraco-abdominal volumes and asynchronies in patients with spinal muscle atrophy type III. Respir Physiol Neurobiol. 197(1), 1-8
• M. NOSOTTI, M. LAVIOLA, S. MARIANI, E. PRIVITERA, P. MENDOGNI, I.F. NATALONI, A. ALIVERTI and L. SANTAMBROGIO, 2013. Variations of thoraco abdominal volumes after lung transplantation measured by optoelectronic plethysmography. Transpl Proc. 45(3), 1279-1281
• A. ALIVERTI, B. UVA, M. LAVIOLA, D. BOVIO, A. LOMAURO, C. TARPERI, E. COLOMBO, B. LOOMAS, A. PEDOTTI, T. SIMILOWSKI and P. T. MACKLEM, 2010. Concomitant ventilatory and circulatory functions of the diaphragm and abdominal muscles. J Appl Physiol. 109(5), 1432-1440
• DAS A, SAFFARAN S, CHIKHANI M, SCOTT TE, LAVIOLA M., YEHYA N, LAFFEY JG, HARDMAN JG and BATES DG, In-silico modeling of COVID-19 ARDS: pathophysiological insights and potential management implications Critical Care Exploration. (In Press.)
• LAVIOLA M., NIKLAS C., DAS. A, BATES DG and HARDMAN JG, Ventilation strategies for front of neck airway rescue: an in silico study. British Journal of Anaesthesia. 126(6), 1226-1236