Contact
Biography
Education:
- DPhil in Physiology, Anatomy and Genetics - Neurosciences (University of Oxford, 2011)
- MRes in Biomedical Research (Imperial College, 2007)
- MSc in Bioengineering (SupAgro, 2007)
Research positions:
- Assistant Professor (University of Nottingham, 2023-present)
- Anne McLaren Fellow (University of Nottingham, 2020-2023)
- Honorary Research Fellow/Visiting Researcher (University of Oxford, 2018-2019)
- Postdoctoral Research Assistant (University of Oxford, 2013-2018)
- Postdoctoral Fellow (Mount Sinai School of Medicine, New York, 2011-2013)
Expertise Summary
The Finelli lab explores the multiple facets of the neurodegenerative process using a wide range of molecular and cellular approaches, as well as transcriptomics, metabolomics and proteomics. Their main research centers around the role of oxidative and nitrosative stresses and redox mechanisms in the pathophysiology of neurodegenerative conditions including Alzheimer's disease, amyotrophic lateral sclerosis, and frontotemporal dementia.
Research Summary
Dr Mattéa Finelli established her group in January 2020 at the University of Nottingham Biodiscovery Institute. The Finelli lab aims to advance our understanding of the molecular mechanisms… read more
Recent Publications
MONAGHAN TM, UGUN-KLUSEK A, FINELLI M, GURNANI P, CHAKRABARTI L, KAO D, ALEXANDER C and POLYTARCHOU C, 2023. Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut. CASTROFLORIO E, DEN HOED J, SVISTUNOVA D, FINELLI MJ, CEBRIAN-SERRANO A, CORROCHANO S, BASSETT AR and DAVIES B, 2021. The Ncoa7 locus regulates V-ATPase formation and function, neurodevelopment and behaviour. Cellular and molecular life sciences. 78(7), 3503-3524 FENEBERG E, GORDON D, THOMPSON AG, FINELLI MJ, DAFINCA R, CANDALIJA A, CHARLES PD, MÄGER I, WOOD MJ, FISCHER R, KESSLER BM, GRAY E, TURNER MR and TALBOT K, 2020. An ALS-linked mutation in TDP-43 disrupts normal protein interactions in the motor neuron response to oxidative stress Neurobiology of disease.
Current Research
Dr Mattéa Finelli established her group in January 2020 at the University of Nottingham Biodiscovery Institute. The Finelli lab aims to advance our understanding of the molecular mechanisms underlying neurodegenerative disease and to develop and test new therapeutic strategies for these disorders.
In particular, the Finelli lab explores the proteins present in the human brain and how these proteins change in neurodegenerative diseases including Alzheimer's disease and motor neuron disease. They also develop new tools to promote the use of stem cell technology for improved disease modeling and drug testing.
The Finelli lab uses a combination of stem cell technology, gene editing, cell phenotyping, quantitative and redox proteomics, recombinant protein- and cell-based functional assays and in vitro drug screening.
More details can be found on the Finelli lab website.
Dr Mattéa Finelli is Deputy Director of the Centre for Dementia, and founder and Project Leader of the International Network of Neurodegenerative Disease Research (part of the Global Alliance of Medical Excellence Network) and of the International Dementia Network (part of Universitas 21).