Contact

• workWest Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 924 9924 xt 84739
• msadm9@exmail.nottingham.ac.uk

Biography

Trained in Neurosurgery in Edinburgh , Nottingham and Paris.

Consultant Adult and Paediatric Neurosurgeon in Nottingham since 2003.

Training Programme Director for Neurosurgery, Health Education East Midlands.

Current Chairman of British Paediatric Neurosurgery Group

Research Summary

Local PI for BASICS study

Brain Tissue Velocimetry by Ultrasound for assessment of Intracranial Pressure

Ongoing analysis of use of antibiotic impregnated EVDs.

Tissue and molecular heterogeneity in glial tumours.

Drug delivery to brain tumours, including intracavity treatments and intrathecal regimes.

SIOP Ependymoma II study

Recent Publications

• RAHMAN CV, SMITH SJ, MORGAN PS, LANGMACK KA, CLARKE PA, RITCHIE AA, MACARTHUR DC, ROSE FR, SHAKESHEFF KM, GRUNDY RG and RUMAN RAHMAN, 2013. Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PloS one. 8(10), e77435
• SMITH S.J., TILLY H., WARD J.H., MACARTHUR D.C., LOWE J., COYLE B. and GRUNDY R.G., 2012. CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma Acta Neuropathologica. 124(1), 99-110
• SMITH, S.J., WILSON, M., WARD, J.H., RAHMAN, C.V., PEET, A.C., MACARTHUR, D.C., ROSE, F.R.A.J., GRUNDY, R.G. and RAHMAN, R., 2012. Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition PLoS One. 7(12), e52335
• BARROW, J., ADAMOWICZ-BRICE, M., CARTMILL, M., MACARTHUR, D., LOWE, J., ROBSON, K., BRUNDLER, M.A., WALKER, D.A., COYLE, B. and GRUNDY, R., 2011. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas Neuro-oncology. 13(2), 212-222

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Past Research

Stanhope Fellow in Academic Radiology , Nottingham 2001-2002 , Doctor of Medicine Thesis in "Multimodality MRI Imaging of Glial Tumours" including work with T1 TurboFLASH perfusion imaging, tensor diffusion imaging and multivoxel spectroscopy.

Neuroendoscopic management of hydrocephalus and brain tumours.

Analysis of results of surgery for UKCCSG / SIOP Ependymoma studies.

Correlative clinical and radiological studies of paediatric postoperative posterior fossa syndrome

CCLG Functional Imaging Group- Collaborator in CRUK funded multicentre programme

Local PI for Rescue ICP study.

Future Research

Clinical Utility of Low Field Intraoperative MRI

• RAHMAN CV, SMITH SJ, MORGAN PS, LANGMACK KA, CLARKE PA, RITCHIE AA, MACARTHUR DC, ROSE FR, SHAKESHEFF KM, GRUNDY RG and RUMAN RAHMAN, 2013. Adjuvant chemotherapy for brain tumors delivered via a novel intra-cavity moldable polymer matrix. PloS one. 8(10), e77435
• SMITH S.J., TILLY H., WARD J.H., MACARTHUR D.C., LOWE J., COYLE B. and GRUNDY R.G., 2012. CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma Acta Neuropathologica. 124(1), 99-110
• SMITH, S.J., WILSON, M., WARD, J.H., RAHMAN, C.V., PEET, A.C., MACARTHUR, D.C., ROSE, F.R.A.J., GRUNDY, R.G. and RAHMAN, R., 2012. Recapitulation of tumor heterogeneity and molecular signatures in a 3D brain cancer model with decreased sensitivity to histone deacetylase inhibition PLoS One. 7(12), e52335
• BARROW, J., ADAMOWICZ-BRICE, M., CARTMILL, M., MACARTHUR, D., LOWE, J., ROBSON, K., BRUNDLER, M.A., WALKER, D.A., COYLE, B. and GRUNDY, R., 2011. Homozygous loss of ADAM3A revealed by genome-wide analysis of pediatric high-grade glioma and diffuse intrinsic pontine gliomas Neuro-oncology. 13(2), 212-222
• DAVIS, E.E., PITCHFORD, N.J., JASPAN, T., MACARTHUR, D. and WALKER, D., 2011. Effects of hydrocephalus after cerebellar tumor: a case-by-case approach Pediatric Neurology. 44(3), 193-201
• SMITH SJ, LONG A, BARROW JH, MACARTHUR DC, COYLE B, GRUNDY RG and CHILDREN'S CANCER AND LEUKAEMIA GROUP BIOLOGICAL STUDIES COMMITTEE, 2011. Pediatric High-Grade Glioma: Identification Of Poly(Adp-Ribose) Polymerase As A Potential Therapeutic Target. Neuro-Oncology. 13(11), 1171-7
• SHARP MC and MACARTHUR DC, 2011. An unusual presentation of colloid cyst--implications for lifestyle advice. British journal of neurosurgery. 25(2), 284-5
• DAVIS, EMMA E., PITCHFORD, NICOLA J., JASPAN, TIM, MCARTHUR, DONALD and WALKER, DAVID, 2010. Development of cognitive and motor function following cerebellar tumour injury sustained in early childhood CORTEX. 46(7), 919-932
• SMITH SJ, UGHRATDAR I and MACARTHUR DC, 2009. Never go to sleep on undrained pus: a retrospective review of surgery for intraparenchymal cerebral abscess. British journal of neurosurgery. 23(4), 412-7
• PEET AC, ARVANITIS TN, AUER DP, DAVIES NP, HARGRAVE D, HOWE FA, JASPAN T, LEACH MO, MACARTHUR D, MACPHERSON L, MORGAN PS, NATARAJAN K, PAYNE GS, SAUNDERS D, GRUNDY RG and CCLG FUNCTIONAL IMAGING GROUP, 2008. The value of magnetic resonance spectroscopy in tumour imaging. Archives of disease in childhood. 93(9), 725-7
• SMITH SJ, BODDU S and MACARTHUR DC, 2007. Atypical meningiomas: WHO moved the goalposts? British journal of neurosurgery. 21(6), 588-92
• MAXWELL M, SENEVIRATNE M, MACARTHUR D and VEALE P, 2007. Parental feedback surveys should be used more widely for monitoring the quality of pediatric care. Paediatric anaesthesia. 17(3), 297-8
• SHASTRI-HURST, N, TSEGAYE, M, ROBSON, D K, LOWE, J S and MACARTHUR, D C, 2006. Stereotactic brain biopsy: An audit of sampling reliability in a clinical case series. British Journal of Neurosurgery. 20(4), 222-6
• BUXTON N, MACARTHUR D, ROBERTSON I and PUNT J, 2003. Neuroendoscopic third ventriculostomy for failed shunts. Surgical neurology. 60(3), 201-3; discussion 203-4
• YAP C, MACARTHUR DC and HOPE DT, 2002. 'Mind the gap': resorption of a bone flap stored subcutaneously for 6 months. British journal of neurosurgery. 16(5), 523-4
• MACARTHUR DC, BUXTON N, PUNT J, VLOEBERGHS M and ROBERTSON IJA, 2002. The role of neuroendoscopy in the management of brain tumours. British journal of neurosurgery. 16(5), 465-70
• MACARTHUR DC and BUXTON N, 2001. The management of brain tumours. Journal of the Royal College of Surgeons of Edinburgh. 46(6), 341-8
• MACARTHUR DC, PUNT JA, SPENCER M, DOUGLAS DL, WHITE BD and HOLLAND IM, 2001. Neurological deterioration years after closure of myelomeningocoele - 'the second lesion'. Spinal cord. 39(1), 11-4
• MACARTHUR DC, ROBERTSON IJ and PUNT JA, 2000. Third ventricular cysts and membranes unsuspected on conventional CT and MRI. British journal of neurosurgery. 14(5), 455-7
• WHITTLE IR, MACARTHUR DC, MALCOLM GP, LI M, WASHINGTON K and IRONSIDE JW, 1998. Can experimental models of rodent implantation glioma be improved? A study of pure and mixed glioma cell line tumours. Journal of neuro-oncology. 36(3), 231-42
• MACARTHUR DC, NIXON SJ and AITKEN RJ, 1998. Avoidable deaths still occur after large bowel surgery. Scottish Audit of Surgical Mortality, Royal College of Surgeons of Edinburgh. The British journal of surgery. 85(1), 80-3
• MACARTHUR DC and PRICE RF, 1997. Minor head injury. Journal of neurosurgery. 87(3), 485-6
• MACARTHUR DC, GRIEVE DC, THOMPSON AM, GREIG JD and NIXON SJ, 1997. Herniography for groin pain of uncertain origin. The British journal of surgery. 84(5), 684-5
• VISWANATHAN R, MACARTHUR DC and WHITTLE IR, 1994. Nail gun injury to the brain: an unusual case of suicide. Scottish medical journal. 39(3), 83