"I am an academic clinical fellow and clinical radiology trainee. My research interest is to use advanced neuroimaging techniques to understand the mechanisms of dementia and develop novel imaging biomarkers in the diagnosis, prediction and monitoring of disease progression of dementia."According to the latest evidence, up to 40% of dementia cases globally could be potentially prevented or delayed by addressing twelve risk factors in our day-to-day lives. Modifying these risk factors may directly mitigate dementia pathology or boost brain resilience that may be reflected by improved brain ageing. Over the last decade, advanced computational models were developed from large normative MRI cohort data to enable individual estimation of one’s ‘brain age’ that compared to one’s actual chronological determines the 'brain age gap’, an increasingly popular marker of brain health. The aim of this study is to investigate the independent and cumulative effect of various dementia risk factors on brain ageing and cognitive performance in the UK Biobank cohort.
"Additionally, we will explore the potential biological mechanisms by examining how much of the relationship between risk factors and cognitive performance is influenced by the brain age gap. We believe that a clearer understanding of the impact of epidemiologically determined dementia risk factors on brain health and ageing has potential to inform the design of more effective targeted interventions and will also offer objective outcome assessment by tracking their effects on brain ageing."
For more information about Professor Rob Dineen and to contact them for queries about ACF and CL research opportunities, please visit their staff profile on the School of Medicine website.
University of NottinghamMedical School Nottingham, NG7 2UH
Contacts: Call 0115 823 0031 ext.30031 or please see our 'contact us' page for further details