Wednesday, 29 January 2020
An eminent philanthropist and three time cancer survivor Dr James Hull has joined forces with six universities, including the University of Nottingham, to investigate why cancer returns in some people and not others.
Focusing on patients who have had successful treatment of advanced cancer and in whom the cancer has not reoccurred for at least five years, researchers from the University of Nottingham, University of Surrey, University of Oxford, Cardiff University, Swansea University, University of Manchester, and Royal Surrey County Hospital, as part of the Continuum Long-term Survivor study, will undertake non-invasive investigations of each individuals’ immune systems and tumour cells to identify any unique features which could explain why they have remained cancer free.
Figures from Cancer Research UK indicate that there are around 363,000 new cancer cases in the UK every year. It is likely that a high percentage of those diagnosed will have a reoccurrence of the disease within two years of finishing treatment however why cancer returns in some patients and not others remains a mystery to physicians.
Researchers believe that these patients may have proteins on the surface of their tumours which their immune system mistakes as an infection and subsequently destroys the tumour as if fighting an infection. Findings from this study could help revolutionise immunotherapy treatment by targeting different proteins on cancer cells, potentially eliminating cancer recurrence in patients.
We are particularly excited to be part of the Continuum family as it allows us understand why some patients respond very well to treatment and become long term cancer survivors. As part of this project we have already identified novel targets and unique immune receptors which we believe may be important in the long term survival of several cancer patients. We can now use these receptors to target these proteins in other less fortunate cancer patients. We also integrate closely with other Continuum members from other Universities who are focusing on other aspects of cancer biology in long term cancer survivors.
James Hull, philanthropist and CEO and Founder of Continuum Life Sciences, a cancer research company which is striving to find a cure for cancer and who has made this study possible with numerous financial awards to the universities mentioned, said: “I am very grateful to be a cancer survivor and wholeheartedly thank all those involved in my treatment journey. I want to find out everything we can about this devastating illness to spare future generations the difficulties I have gone through in my fight against cancer. Bringing together the best cancer experts in the country and equipping them with the resources they need is one way I can do this and I am very excited to see what they uncover.”
Recruitment for this innovative study remains open. If you have had an aggressive, locally advanced and/or metastatic cancer which resolved completely with treatment and have remained free of the disease without maintenance treatment for 5 years or longer we would like to talk to you.
Please email cltsstudy@continuumlifesciences.com or alternatively call on the free phone number 0800 144 8488. .
Story credits
More information is available from Professor Lindy Durrant at lindy.durrant@nottingham.ac.uk
Notes to editors:
About the University of Nottingham
Ranked 32 in Europe and 16th in the UK by the QS World University Rankings: Europe 2024, the University of Nottingham is a founding member of the Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been given the honour since 2018 – and by the Daily Mail University Guide 2024.
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the second most targeted by the UK's top employers, according to The Graduate Market in 2022 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.
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