Wednesday, 13 November 2024
New research has found that people with a genetic defect in their ability to digest sucrose eat less cake, sweets and chocolate, which could hold the key to helping the wider population to eat less sugar.
The international study, which is published in Gastroenterology, shows that genetic variations in the sucrase-isomaltase (SI) gene are associated with the intake, and preference, of sucrose-rich foods.
Scientists found that mice lacking the SI gene have a lower intake and preference for dietary sucrose, which develops rapidly and is associated with changes in the regulation of appetite hormones. This was confirmed in large population-based cohorts showing that people with genetic defects in sucrose digestion eat fewer cakes, pastries, candy, and chocolate and like foods less as their sucrose content increases.
The work provides novel genetic insights into dietary preferences and opens the possibility of targeting SI to selectively reduce sucrose intake at the population level.
The study was led by Dr. Peter Aldiss, now a group leader in the School of Medicine at the University of Nottingham, alongside Assistant Professor. Mette K Andersen, at the Novo Nordisk Foundation Centre for Basic Metabolic Research in Copenhagen and Professor Mauro D’Amato at CIC bioGUNE in Spain and LUM University in Italy. It also involves scientists internationally from Copenhagen, Greenland, Italy and Spain as part of the ‘Sucrase-isomaltase working group’.
Dr Peter Aldiss, group leader in the School of Medicine
Dr Aldiss said: “Excess calories from sugar are an established contributor to obesity and type 2 diabetes. In the UK, we consume 9-12% of our dietary intake from free sugars, such as sucrose, with 79% of the population consuming up to three sugary snacks a day. At the same time, genetic defects in sucrose digestion have been associated with irritable bowel syndrome, a common functional disorder affecting up to 10% of the population.
“Now, our study suggests that genetic variation in our ability to digest dietary sucrose may impact not only how much sucrose we eat, but how much we like sugary foods.”
The team of experts began by investigating the dietary behaviours in mice lacking the SI gene. Here, mice developed a rapid reduction in sucrose intake, and preference. This was confirmed in two large population-based cohorts involving 6,000 individuals in Greenland and 134,766 in the UK BioBank.
The team took a nutrigenetics approach to understand how genetic variation in the SI gene impacts sucrose intake and preference in humans. Strikingly, individuals with a complete inability to digest dietary sucrose in Greenland consumed significantly less sucrose-rich foods whilst individuals with a defective, partially functional SI gene in the UK, liked sucrose-rich foods less.
These findings suggest that genetic variation in our ability to digest dietary sucrose can influence our intake, and preference, for sucrose-rich foods whilst opening up the possibility of targeting SI to selectively reduce sucrose intake at the population level. In the future, understanding how defects in the SI gene act to reduce the intake, and preference, of dietary sucrose will facilitate the development of novel therapeutics to help curb population-wide sucrose intake to improve digestive and metabolic health.”
The full study can be found here.
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More information is available from Dr Peter Aldiss from the School of Medicine at peter.aldiss1@Nottingham.ac.uk
Notes to editors:
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