Thursday, 03 August 2023
Scientists from the Universities of Nottingham and Leicester have received nearly £600,000 to research how sexual development and gene shuffling within the malaria parasite could help to control malaria transmission.
Led by Professor Rita Tewari (University of Nottingham) and Dr David Guttery (University of Leicester), the research will focus on the molecular players involved in the development and transmission of the malaria parasite - one of the biggest killers in the world.
This is a unique type of cell division in sexual cells in malaria parasites, which happens during a process called meiosis. Meiosis is a fundamental process for all sexual organisms that enables them to generate sex cells (i.e. sperm and egg cells) that then go on to fertilise and reshuffle their genes, ultimately generating off-spring.
This research could potentially uncover new targets for therapies to control the spread of malaria in animals and humans.
Dr David Guttery said: "We know that the malaria parasite shuffles genes during sexual reproduction (termed gene recombination), but what we don’t know is how it works. The funding we have received will open the door for us to discover this, and to potentially uncover new targets for therapies to control the spread of this devastating disease."
Professor Rita Tewari said: “To understand the basic machinery of cell division in malaria parasites, especially during the sexual stages of transmission, is crucial to stopping the parasite in its tracks. Controlling the transmission of this devastating disease is as important as the disease itself. We have seen this in the case of COVID.”
The research has been funded from the Biotechnology and Biological Sciences Research Council (BBSRC) and will include collaborators at the University of Leicester (Dr James Higgins), University of Nottingham (Dr Stephen Gray and Professor Levi Yant), the Francis Crick Institute (Dr Tony Holder), University of Oxford (Professors David Ferguson and Sue Vaughan) and University of Warwick (Dr Andrew Bottrill).
Image: Gene shuffling during transmission stages of the malaria parasite.
This study will complement Professor Tewari’s research on cell division in male sex cells as part of a £2.5 million European Research Council grant. To address some of the questions on meiosis, collaborators at the University of Nottingham, University of Leicester, Francis Crick Institute and University of Groningen offer their insights into Plasmodium meiosis, published in Trends in Parasitology.
The researchers highlight the process of meiosis and how it is so different in malaria parasites and discuss state-of-the-art technologies that could be used to solve the mystery of how meiosis and gene shuffling in the malaria parasite works, which could significantly and positively impact both human and animal health in the future.
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For further information, please contact Professor Rita Tewari at the University of Nottingham.
Adam Mallaby - Media Relations Manager for the Faculty of Medicine and Health Sciences (Maternity Cover)
Email: adam.mallaby@nottingham.ac.uk
Phone: 0115 748 5719
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About the University of Nottingham
Ranked 32 in Europe and 16th in the UK by the QS World University Rankings: Europe 2024, the University of Nottingham is a founding member of the Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been given the honour since 2018 – and by the Daily Mail University Guide 2024.
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the second most targeted by the UK's top employers, according to The Graduate Market in 2022 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.
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