Tuesday, 19 March 2024
Experts at the University of Nottingham are joining forces with Stand Against MND and the MND Association, to carry out research to better understand motor neurone disease (MND) mechanisms – the biochemical processes that go wrong – in order to speed up the race to find new treatments.
MND affects up to 5,000 adults in the UK at any one time. Signals from specialised nerve cells called motor neurones gradually stop reaching the muscles, causing them to weaken, stiffen and waste. MND is life-shortening with currently no cure.
In this project, scientists from the University are targeting specialised cells, called astrocytes, that work to keep motor neurones healthy. By using RNA therapies to make astrocytes work more effectively, the hope is they will be able to better protect malfunctioning motor neurones.
The research has been made possible thanks to funding from Stand Against MND.
Sam Perkins is Co-Founder and Trustee of Stand Against MND. He said: “Following my MND diagnosis back in 2019 I was determined to do anything I could to make a difference. To now be at a point where we have raised almost £250,000 is incredible, and I’m so grateful to everyone who has fundraised and donated to Stand Against MND. In recognition of the fact that much of our fundraising is done locally, we felt investing in the MND research base in Nottingham was the right thing to do. We are also directing funds to other early career researchers across the UK, trying to increase the number of scientists working on understanding this disease, for the benefit of patients in the future.
“When we founded Stand Against MND in early 2020 it was difficult to know what sort of impact we might have, so launching a partnership like this with the support of the University of Nottingham and the MND Association gives me an immense sense of pride. It wouldn’t be possible without our supporters and my carers, so a massive thank you has to go out to them.”
The donation from Stand Against MND is also directed towards supporting early career researchers, developing the next generation of MND research leaders.
The announcement comes within weeks of International Day of Women and Girls in Science and includes support for a second PhD studentship to be awarded by Sam Perkins and his charity to talented, female early career researcher, Hannah Bailey.
Professor Rob Layfield
Hannah, the successful recipient of the Stand Against MND Studentship funded in collaboration with the MND Association, from the School of Life Sciences at the University, said: “I’m incredibly grateful to Sam Perkins at Stand Against MND and all who have fundraised for this generous support. This PhD studentship, also thanks to the MND Association, allows me to benefit from excellent training, materials and guidance. Thanks to this I feel incredibly supported in starting my career in MND research, and hope to make valuable contributions to our understanding and treatment of MND.”
Dr Brian Dickie MBE, Director of Research at the MND Association said: “This significant donation from Sam Perkins and Stand Against MND represents countless hours of fundraising efforts by so many. We at the MND Association are incredibly grateful that Sam has chosen to donate these funds to further MND research. We’re delighted to see the PhD studentship has been named after Sam’s charity Stand Against MND, as it honours his drive, determination and dedication to help researchers make those important discoveries, which will take us closer to effective therapies and eventually a cure. We continue to be inspired by Sam, and thank him for everything he is doing to support our work.”
Sam’s funding comes on top of recent support from the MND Association to the University of Nottingham team for a further project that seeks to understand how problems in astrocytes themselves might be a critical driver in MND.
Professor Rob Layfield, from the School of Life Sciences at the University, said: “This generous support from Sam Perkins at Stand Against MND, alongside that of the MND Association, is so important as it not only helps us build the critical mass to ensure that the University of Nottingham continues to part of the international effort to beat MND, but it also ensures that the most talented young scientists have the opportunity to start a career in MND research. Sam reminds us why we do what we do."
Story credits
More information is available from Professor Rob Layfield in the School of Life Sciences at the University of Nottingham at robert.layfield@nottingham.ac.uk
Notes to editors:
About the University of Nottingham
Ranked 32 in Europe and 16th in the UK by the QS World University Rankings: Europe 2024, the University of Nottingham is a founding member of the Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been given the honour since 2018 – and by the Daily Mail University Guide 2024.
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the second most targeted by the UK's top employers, according to The Graduate Market in 2022 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.
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