Monday, 07 March 2022
A new model to analyse infectious disease outbreak data has been developed by mathematicians that could be used to improve disease tracking and control.
Researchers from the University of Nottingham developed a new data-driven framework for modelling how infectious diseases spread through a population that could reduce errors in decisions made about disease control measures. Their findings have been published in PNAS.
The COVID-19 pandemic has highlighted that the ability to unravel the dynamics of the spread of infectious diseases is profoundly important for designing effective control strategies and assessing existing ones. Mathematical models of how infectious diseases spread continue to play a vital role in understanding, mitigating, and preventing outbreaks.
Dr Rowland Seymour led the study and explains: “Most of the infectious disease models contain specific assumptions about how transmission occurs within a population. These assumptions can be arbitrary, particularly when it comes to describing how transmission varies between individuals of different types or in different locations and can be lacking in appropriate biological or epidemiological justification. this can lead to erroneous scientific conclusions and misleading predictions.”
The researchers developed a data-driven framework for modelling how infectious diseases spread through a population by avoiding strict modelling assumptions which are often difficult to justify. The researchers used the method to enhance understanding of the 2001 UK Foot and Mouth outbreak in which over 6 million animals were culled with a cost to the public and private purse of over £8 billion.
The proposed methodology is very general making it applicable to a wide class of models, including those which take into account the population’s structure (e.g. households, workplaces) and individual’s characteristics (e.g. location and age).
Infectious diseases both within human and animal populations continue to pose serious health and socioeconomic risks. We have developed a suite of contemporary statistical methods that dispenses with the need for the underlying transmission assumptions of existing models. Our approach enables instead the analysis to be driven by evidence in the data and hence allowing policy makers to make data-driven decisions about controlling the spread of a disease. Our work is another tool in the fight against the spread of infectious diseases and we are excited to develop this framework further.
This work has opened several avenues for further research in this area, including improving its computationally efficiency and being applicable in real-time, i.e. when the outbreak is still ongoing. The latter is of material importance for policy makers and government authorities, so they can be responsive to the data that is emerging from the outbreak.
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More information is available from Dr Rowland Seymour at the University of Nottingham on rowland.seymour@nottingham.ac.uk
Notes to editors:
About the University of Nottingham
Ranked 32 in Europe and 16th in the UK by the QS World University Rankings: Europe 2024, the University of Nottingham is a founding member of the Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been given the honour since 2018 – and by the Daily Mail University Guide 2024.
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the second most targeted by the UK's top employers, according to The Graduate Market in 2022 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.
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