Novel approach yields new insights into the causes of pre-eclampsia

 Study into the causes and, potentially, prevention of this hypertension could help to reduce the burden it places on the NHS. In the past five years, the number of prescriptions of ACE inhibitors and angiotensin receptor blockers has risen to 13.4 million.

The Cambridge findings unexpectedly revealed a fine-tuning mechanism in angiotensinogen that is responsive to changes in tissue oxygen. The Nottingham contribution has been in showing how this change — from a less active to a more active form — occurs in the human body as well as the test-tube.

Professor Fiona Broughton Pipkin of the Department of Obstetrics and Gynaecology, University of Nottingham, has been studying angiotensin in normal and pre-eclamptic pregnancy for 30 years.

Pre-eclampsia — new high blood pressure and kidney problems in pregnancy — affects about one woman in 20 in the UK during pregnancy, and often needs premature delivery. In its most serious form it is one of the two most important causes of maternal death in the UK, and worldwide kills at least 55,000 pregnant women per year. It is one of the ‘oxidative stress’ diseases, and probably originates in the placenta, or afterbirth.

Professor Broughton Pipkin said: “We decided that examining the ratio of the two forms of angiotensinogen in plasma from pre-eclamptic women and those with normal blood pressure would be an excellent test of the hypothesis that this mechanism could contribute to high blood pressure.

“We sent coded samples to Cambridge and were thrilled when we broke the code to find that the results fitted our prediction beautifully. They also fit with the changes in the placenta in pre-eclampsia. This is an absolutely novel approach, which is providing new insights into what goes wrong in pre-eclampsia.

“The collaboration is continuing and expanding, and we hope very much to get rapid grant funding”.

The work was supported by British Heart Foundation (BHF), the Wellcome Trust, the Isaac Newton Trust, and the Medical Research Council (MRC).

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Please note: the Nottingham team who worked on the research is currently at the International Society for the Study of Hypertension in Pregnancy World Congress in Melbourne, Australia, and has limited availability.

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