Friday, 01 July 2022
Ibuprofen tablets modified to survive in space have returned to earth and shown that those with added flavour survived better with less degradation than those with no added taste.
Researchers from the International Flavour Research Centre at the University of Nottingham worked with the University of Adelaide on the research that also showed that an iron oxide coating formed during tablet manufacture could protect Ibuprofen.
“Medicines taken on space missions are exposed to cosmic rays which limit their ‘space shelf life’ and can even lead to the formation of toxic substances as the drug content declines,” said the University of Adelaide’s Professor Volker Hessel, Research Director of the Andy Thomas Centre for Space Resources and Professor in the School of Chemical Engineering and Advanced Materials who led the project to send tablets into space.
“We have tested and proven countermeasures to the degrading effects of cosmic rays by sending ibuprofen tablets made in our laboratory to the International Space Station (ISS) for six months and checking them on their return.
“Four of the six ibuprofen tablets from outside the ISS, each made with a distinct formulation and protection concept, significantly decomposed to a high number of ibuprofen fragments. The tablet with highest iron oxide content in the coating showed only minor ibuprofen loss,”
A coating of iron oxide was formed under the pressure of compacting the tablets during manufacturing in the lab.
The team developed special tablet formulations of the anti-inflammatory drug that include solid, dense drug packing which alone protects the drug from damage by some of the cosmic radiation. They also modified the chemical nature of ibuprofen by complex formation of the drug with the excipients, resulting in a ‘stronger’ ibuprofen. Excipients are substances that are included in a tablet in addition to the drug component that has a variety of uses like assisting the manufacturing process or enhancing the stability of the drug.
Many flavour compounds have multiple properties in foods and pharmaceutical, offering structural and chemical benefits as well as imparting pleasant aromas or flavours, these findings could have benefits on earth as well as in space.
The tablets were sent to the ISS for six months in a partnership between the University and space technology companies Space Tango and Aegis Technologies. One batch (60 tablets) was carried inside the space station and one batch was outside the station (6 tablets) in the Materials International Space Station Experiment (MISSE) platform. They were exposed to one of the harshest environments known.
When they returned from their epic journey the space tablets were compared to a control batch of tablets left on Earth.
“But to our surprise, natural flavours, which were added to the tablets by our research partners led by Professor Ian Fisk (International Flavour Research Centre, University of Nottingham) seemed to be help stabilise the ibuprofen even when no large iron oxide content was present.
University of Adelaide researchers are continuing their investigations in the lab by using different radiation sources to test their effects on pure ibuprofen on its own as well as inside tablets.
“The results from sending tablets to the ISS shows that experiments carried out in space can provide insight for improving manufacturing on Earth,” said Professor Hessel.
“High energised photon radiation – synonymous with the cosmos’ gamma radiation – is likely to be the biggest threat to medicines in space as it’s been found to penetrate the tablets and destroy the ibuprofen.”
Story credits
More information is available from Professor Ian Fisk on Ian.Fisk@nottingham.ac.uk
Notes to editors:
About the University of Nottingham
Ranked 32 in Europe and 16th in the UK by the QS World University Rankings: Europe 2024, the University of Nottingham is a founding member of the Russell Group of research-intensive universities. Studying at the University of Nottingham is a life-changing experience, and we pride ourselves on unlocking the potential of our students. We have a pioneering spirit, expressed in the vision of our founder Sir Jesse Boot, which has seen us lead the way in establishing campuses in China and Malaysia - part of a globally connected network of education, research and industrial engagement.
Nottingham was crowned Sports University of the Year by The Times and Sunday Times Good University Guide 2024 – the third time it has been given the honour since 2018 – and by the Daily Mail University Guide 2024.
The university is among the best universities in the UK for the strength of our research, positioned seventh for research power in the UK according to REF 2021. The birthplace of discoveries such as MRI and ibuprofen, our innovations transform lives and tackle global problems such as sustainable food supplies, ending modern slavery, developing greener transport, and reducing reliance on fossil fuels.
The university is a major employer and industry partner - locally and globally - and our graduates are the second most targeted by the UK's top employers, according to The Graduate Market in 2022 report by High Fliers Research.
We lead the Universities for Nottingham initiative, in partnership with Nottingham Trent University, a pioneering collaboration between the city’s two world-class institutions to improve levels of prosperity, opportunity, sustainability, health and wellbeing for residents in the city and region we are proud to call home.
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