Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: KAY, ALASDAIR G., LONG, GRACE, TYLER, GEORGE, STEFAN, ANDREI, BROADFOOT, STEPHEN J., PICCININI, ANNA M., MIDDLETON, JIM and KEHOE, OKSANA, 2017. Mesenchymal Stem Cell-Conditioned Medium Reduces Disease Severity and Immune Responses in Inflammatory Arthritis SCIENTIFIC REPORTS. 7,

Content: SCHWEHM C, KELLAM B, GARCES AE, HILL SJ, KINDON ND, BRADSHAW TD, LI J, MACDONALD SJ, ROWEDDER JE, STODDART LA and STOCKS MJ, 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C-C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase δ (PI3Kδ) Inhibitors. Journal of medicinal chemistry. 60(4), 1534-1554

Content: ZAPOTOCZNA, M., MURRAY, E.J., HOGAN, S., O'GARA, J.P., CHHABRA, S.R., CHAN, W.C., O'NEILL, E. and WILLIAMS, P., 2017. 5-Hydroxyethyl-3-tetradecanoyltetramic acid represents a novel treatment for intravascular catheter infections due to Staphylococcus aureus Journal of Antimicrobial Chemotherapy. 72(3), 744-753

Content: SCHWEHM, CAROLIN, KELLAM, BARRIE, GARCES, AIMIE E., HILL, STEPHEN J., KINDON, NICHOLAS D., BRADSHAW, TRACEY D., LI, JIN, MACDONALD, SIMON J. F., ROWEDDER, JAMES E., STODDART, LEIGH A. and STOCKS, MICHAEL J., 2017. Design and Elaboration of a Tractable Tricyclic Scaffold To Synthesize Druglike Inhibitors of Dipeptidyl Peptidase-4 (DPP-4), Antagonists of the C–C Chemokine Receptor Type 5 (CCR5), and Highly Potent and Selective Phosphoinositol-3 Kinase $delta$ (PI3K$delta$) Inhib Journal of Medicinal Chemistry. acs.jmedchem.6b01801

Content: PANDUGA V, STOCKS MJ and BOSQUILLON C, 2017. Ipratropium is 'luminally recycled' by an inter-play between apical uptake and efflux transporters in Calu-3 bronchial epithelial cell layers. International journal of pharmaceutics. (In Press.)

Content: KINDON, NICHOLAS, ANDREWS, GLEN, BAXTER, ANDREW, CHESHIRE, DAVID, HEMSLEY, PAUL, JOHNSON, TIMOTHY, LIU, YU-ZHEN, MCGINNITY, DERMOT, MCHALE, MARK, METE, ANTONIO, REUBERSON, JAMES, ROBERTS, BRYAN, STEELE, JOHN, TEOBALD, BARRY, UNITT, JOHN, VAUGHAN, DEBORAH, WALTERS, IAIN and STOCKS, MICHAEL J., 2017. Discovery of AZD-2098 and AZD-1678, Two Potent and Bioavailable CCR4 Receptor Antagonists ACS Medicinal Chemistry Letters. acsmedchemlett.7b00315

Content: KINDON N, DAVIS A, DOUGALL I, DIXON J, JOHNSON T, WALTERS I, THOM S, MCKECHNIE K, MEGHANI P and STOCKS MJ, 2017. From UTP to AR-C118925, the discovery of a potent non nucleotide antagonist of the P2Y2 receptor. Bioorganic & medicinal chemistry letters. 27(21), 4849-4853

Content: TAREK ABOUL-FADL, AHMED S. M. ABORAIA, ABU-BAKER M. ABDEL-AAL, MOHAMMED K. ABDEL-HAMID, WESAM S. QAYED, OLA M. F. ABOU-GHADIR, RANA M. IBRAHIM, MARIAM E. I. ABDEL-RASOUL, MOSTAFA A. HASSAN, NOHA G. M. FEKRY, HEND A.A. ABD EL-WAHAB and ADEL F. YOUSSEF, 2017. Novel synthetic inhibitors of eosinophils with potential anti-asthmatic activity In: 4th International Congress on Drug Discovery, Designing and Development, Chicago, Illinois, USA, November 2-3, 2017.

Content: CINI, MELCHIOR, BRADSHAW, TRACEY D. and WOODWARD, SIMON, 2017. Using titanium complexes to defeat cancer: the view from the shoulders of titans CHEMICAL SOCIETY REVIEWS. 46(4), 1040-1051

Content: SOO, HSIEN-CHUEN, CHUNG, FELICIA FEI-LEI, LIM, KUAN-HON, YAP, VERONICA ALICIA, BRADSHAW, TRACEY D., HII, LING-WEI, TAN, SI-HOEY, SEE, SZE-JIA, TAN, YUEN-FEN, LEONG, CHEE-ONN and MAI, CHUN-WAI, 2017. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway PLOS ONE. 12(1),

Content: CHUNG, FELICIA FEI-LEI, TAN, PERRY FAITH TZE MING, RAJA, VIJAY JOSEPH, TAN, BOON-SHING, LIM, KUAN-HON, KAM, TOH-SEOK, HII, LING-WEI, TAN, SI HOEY, SEE, SZE-JIA, TAN, YUEN-FEN, WONG, LI-ZHE, YAM, WAI KEAT, MAI, CHUN WAI, BRADSHAW, TRACEY D. and LEONG, CHEE-ONN, 2017. Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1) SCIENTIFIC REPORTS. 7,

Content: LUZZANI GA, CALLERO MA, KURUPPU AI, TRAPANI V, FLUMIAN C, TODARO L, BRADSHAW TD and LOAIZA PEREZ AI, 2017. In Vitro Antitumor Effects of AHR Ligands Aminoflavone (AFP 464) and Benzothiazole (5F 203) in Human Renal Carcinoma Cells. Journal of cellular biochemistry. 118(12), 4526-4535

Content: SALEH, MAYSAA M., LAUGHTON, CHARLES A., BRADSHAW, TRACEY D. and MOODY, CHRISTOPHER J., 2017. Development of a series of bis-triazoles as G-quadruplex ligands (vol 7, pg 47297, 2017) RSC ADVANCES. 7(77), 49056-49056

Content: ELIZABETH YURIEV*, SOM NAIDU, LUKE S. SCHEMBRI and JENNIFER L. SHORT, 2017. Scaffolding the development of problem-solving skills in chemistry: guiding novice students out of dead ends and false starts Chemistry Education and Research Practice. 18, 486-504

Content: LINDA ÅKERBLADH, LUKE S. SCHEMBRI, MATS LARHED and LUKE R. ODELL*, 2017. Palladium(0)-Catalyzed Carbonylative One-Pot Synthesis of N-Acylguanidines The Journal of Organic Chemistry. 82(23), 12520–12529

Publications