Publications in the Biomolecular Science and Medicinal Chemistry Division

Content: KAIRA, BUBACARR G., SLATER, ALEXANDRE, MCCRAE, KEITH R., DREVENY, INGRID, SUMYA, UMMAY, MUTCH, NICOLA J., SEARLE, MARK and EMSLEY, JONAS, 2020. Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery BLOOD. 136(14), 1685-1697

Content: GUNNELL, EMMA A., AL-NOORI, ALAA, MUHSEN, USAMA, DAVIES, CLARE C., DOWDEN, JAMES and DREVENY, INGRID, 2020. Structural and biochemical evaluation of bisubstrate inhibitors of protein arginine N-methyltransferases PRMT1 and CARM1 (PRMT4) BIOCHEMICAL JOURNAL. 477(4), 787-800

Content: SOUKARIEH, FADI, LIU, RUILING, ROMERO, MANUEL, ROBERSTON, SHAUN N, RICHARDSON, WILLIAM, LUCANTO, SIMONE, OTON, EDUARD VICO, QUDUS, NAIM RUHUL, MASHABI, ALAA, GROSSMAN, SCOTT, ALI, SADIQUR, SOU, TOM'AS, KUKAVICA-IBRULJ, IRENA, LEVESQUE, ROGER C, BERGSTR'OM, CHRISTEL A S, HALLIDAY, NIGEL, MISTRY, SHAILESH N, EMSLEY, JONAS, HEEB, STEPHAN, WILLIAMS, PAUL, C'AMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm Grown Pseudomonas aeruginosa Frontiers in Chemistry. 8, 204

Content: GROSSMAN, SCOTT, SOUKARIEH, FADI, RICHARDSON, WILLIAM, LIU, RUILING, MASHABI, ALAA, EMSLEY, JONAS, WILLIAMS, PAUL, CAMARA, MIGUEL and STOCKS, MICHAEL J, 2020. Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR. European Journal of Medicinal Chemistry. 208, 112778

Content: SOU, T., SOUKARIEH, F., WILLIAMS, P., STOCKS, M.J., C'AMARA, M. and BERGSTR'OM, C.A.S., 2020. Model-Informed Drug Discovery and Development in Pulmonary Delivery: Biopharmaceutical Pharmacometric Modeling for Formulation Evaluation of Pulmonary Suspensions ACS Omega.

Content: GOH JY, O'SULLIVAN SE, SHORTALL SE, ZORDAN N, PICCININI AM, POTTER HG, FONE KCF and KING MV, 2020. Gestational poly(I:C) attenuates, not exacerbates, the behavioral, cytokine and mTOR changes caused by isolation rearing in a rat 'dual-hit' model for neurodevelopmental disorders. Brain, behavior, and immunity.

Content: AMBRA VESTRI, AMANDA K. PEARCE, ROBERT CAVANAGH, IOANNA D. STYLIARI, CARLOS SANDERS, BENOIT COUTURAUD, SILVIA SCHENONE, VINCENZO TARESCO, RASMUS R. JAKOBSEN, STEVEN M. HOWDLE, FRANCESCA MUSUMECI and DOMENICO SAGNELLI, 2020. Starch/Poly(glycerol-adipate) Nanocomposites: A Novel Oral Drug Delivery Device Coatings.

Content: ENGLEZOU, GEORGIA, KORTSEN, KRISTOFFER, PACHECO, ANA A. C., CAVANAGH, ROBERT, LENTZ, JOACHIM C., KRUMINS, EDUARDS, SANDERS-VELEZ, CARLOS, HOWDLE, STEVEN M., NEDOMA, ALISYN J. and TARESCO, VINCENZO, 2020. 2-Methyltetrahydrofuran (2-MeTHF) as a versatile green solvent for the synthesis of amphiphilic copolymers via ROP, FRP, and RAFT tandem polymerizations JOURNAL OF POLYMER SCIENCE.

Content: PRIEBBENOW DL, LEAVER DJ, NGUYEN N, CLEARY B, LAGIAKOS HR, SANCHEZ J, XUE L, HUANG F, SUN Y, MUJUMDAR P, MUDUDUDDLA R, VARGHESE S, TEGUH S, CHARMAN SA, WHITE KL, SHACKLEFORD DM, KATNENI K, CUELLAR M, STRASSER JM, DAHLIN JL, WALTERS MA, STREET IP, MONAHAN BJ, JARMAN KE, JOUSSET SABROUX H, FALK H, CHUNG MC, HERMANS SJ, DOWNER NL, PARKER MW, VOSS AK, THOMAS T and BAELL JB, 2020. Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents. Journal of medicinal chemistry. 63(9), 4655-4684

Content: LANE JR, ABRAMYAN AM, ADHIKARI P, KEEN AC, LEE KH, SANCHEZ J, VERMA RK, LIM HD, YANO H, JAVITCH JA and SHI L, 2020. Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism. eLife. 9,

Content: GREEN, JACK P., SWANTON, TESSA, MORRIS, LUCY, V, EL-SHARKAWY, LINA Y., COOK, JAMES, YU, SHI, BESWICK, JAMES, ADAMSON, ANTONY D., HUMPHREYS, NEIL E., BRYCE, RICHARD, FREEMAN, SALLY, LAWRENCE, CATHERINE and BROUGH, DAVID, 2020. LRRC8A is essential for hypotonicity-, but not for DAMP-induced NLRP3 inflammasome activation ELIFE. 9,

Content: SWANTON, TESSA, BESWICK, JAMES A., HAMMADI, HALAH, MORRIS, LUCY, WILLIAMS, DANIEL, DE CESCO, STEPHANE, EL-SHARKAWY, LINA, YU, SHI, GREEN, JACK, DAVIS, JOHN B., LAWRENCE, CATHERINE B., BROUGH, DAVID and FREEMAN, SALLY, 2020. Selective inhibition of the K+ efflux sensitive NLRP3 pathway by Cl- channel modulation CHEMICAL SCIENCE. 11(43), 11720-11728

Content: SOFIE YE, RAFAEL W. HARTMANN, MARCUS SÖDERSTRÖM, MOHAMMAD A. AMIN, BOBO SKILLINGHAUG, LUKE S. SCHEMBRI* and LUKE R. ODELL*, 2020. Turning Information Dissipation into Dissemination: Instagram as a Communication Enhancing Tool during the COVID-19 Pandemic and Beyond Journal of Chemical Education. 97(9), 3217-3222

Content: SLOAN, T.J., MURRAY, E., YOKOYAMA, M., MASSEY, R.C., CHAN, W.C., BONEV, B.B. and WILLIAMS, P., 2019. Timing is everything – impact of naturally occurring Staphylococcus aureus AgrC cytoplasmic domain adaptive mutations on auto-induction Journal of Bacteriology. 201(20), e00409-19

Content: CI DE MATTEIS, MD RANDALL, EJ HARVEY, AP MORRIS, GS WINKLER and HF BOARDMAN, 2019. An integrated dyspepsia module for first year pharmacy students; a flexible and generic template for integrating science with clinical and professional practice American Journal of Pharmaceutical Education. 83, 108-118

Publications