School of Pharmacy

Publications in the Biomolecular Science and Medicinal Chemistry Division

Publications

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LUCEY, MARIE J, CHEN, DONGSHENG, LOPEZ-GARCIA, JORGE, HART, STEPHEN M, PHOENIX, FLADIA, AL-JEHANI, RAJAI, ALAO, JOHN P, WHITE, ROGER, KINDLE, KARIN B, LOSSON, RéGINE, CHAMBON, PIERRE, PARKER, MALCOLM G, SCHäR, PRIMO, HEERY, DAVID M, BULUWELA, LAKJAYA and ALI, SIMAK, 2005. T:G mismatch-specific thymine-DNA glycosylase (TDG) as a coregulator of transcription interacts with SRC1 family members through a novel tyrosine repeat motif. Nucleic Acids Research. 33(19), 6393-404

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KONTOPIDIS, G., WU, S.-Y., ZHELEVA, D.I., TAYLOR, P., MCINNES, C., LANE, D.P., FISCHER, P.M. and WALKINSHAW, M.D., 2005. Structural and biochemical studies of human proliferating cell nuclear antigen complexes provide a rationale for cyclin association and inhibitor design Proceedings of the National Academy of Sciences of the United States of America. 102(6), 1871-1876

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FISCHER, P.M. and GIANELLA-BORRADORI, A., 2005. Recent progress in the discovery and development of cyclin-dependent kinase inhibitors. Expert Opinion on Investigational Drugs. 14(4), 457-477

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FISCHER, P.M., 2005. Protein-protein interactions in drug discovery Drug Design Reviews Online. 2(3), 179-207

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KRYSTOF, V., MCNAE, I.W., WALKINSHAW, M.D., FISCHER, P.M., MÜLLER, P., VOJTESEK, B., ORSÁG, M., HAVLÍCEK, L. and STRNAD, M., 2005. Antiproliferative activity of olomoucine II, a novel 2,6,9-trisubstituted purine cyclin-dependent kinase inhibitor. Cellular and Molecular Life Sciences. 62(15), 1763-1771

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MCINNES, C., MEZNA, M. and FISCHER, P.M., 2005. Progress in the discovery of polo-like kinase inhibitors. Current Topics in Medicinal Chemistry. 5(2), 181-197

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RAYNAUD, F.I., WHITTAKER, S.R., FISCHER, P.M., MCCLUE, S., WALTON, M.I., BARRIE, S.E., GARRETT, M.D., ROGERS, P., CLARKE, S.J., KELLAND, L.R., VALENTI, M., BRUNTON, L., ECCLES, S., LANE, D.P. and WORKMAN, P., 2005. In vitro and in vivo pharmacokinetic-pharmacodynamic relationships for the trisubstituted aminopurine cyclin-dependent kinase inhibitors olomoucine, bohemine and CYC202 Clinical Cancer Research. 11(13), 4875-4887

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MCINNES, C. and FISCHER, P.M., 2005. Strategies for the design of potent and selective kinase inhibitors. Current Pharmaceutical Design. 11(14), 1845-1863

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NUTLEY, B.P., RAYNAUD, F.I., WILSON, S.C., FISCHER, P.M., HAYES, A., GODDARD, P.M., MCCLUE, S.J., JARMAN, M., LANE, D.P. and WORKMAN, P., 2005. Metabolism and pharmacokinetics of the cyclin-dependent kinase inhibitor R-roscovitine in the mouse. Molecular Cancer Therapeutics. 4(1), 125-139

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UHRINOVA, S., UHRIN, D., POWERS, H., WATT, K., ZHELEVA, D., FISCHER, P.M., MCINNES, C. and BARLOW, P.N., 2005. Structure of free MDM2 N-terminal domain reveals conformational adjustments that accompany p53-binding. Journal of Molecular Biology. 350(3), 587-598

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DEKKER, LODEWIJK V, DANIELS, ZOE, HICK, CAROLINE, ELSEGOOD, KATHRYN, BOWDEN, SARAH, SZESTAK, TADGE, BURLEY, J RUSSELL, SOUTHAN, ANDY, CRONK, DAVID and JAMES, IAIN F, 2005. Analysis of human Nav1.8 expressed in SH-SY5Y neuroblastoma cells. European Journal of Pharmacology. 528(1-3), 52-8

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BROWN, SEAN G, THOMAS, ALISON, DEKKER, LODEWIJK V, TINKER, ANDREW and LEANEY, JOANNE L, 2005. PKC-delta sensitizes Kir3.1/3.2 channels to changes in membrane phospholipid levels after M3 receptor activation in HEK-293 cells. American Journal of Physiology: Cell Physiology. 289(3), C543-56

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RENAULT, MARIE-ANGE, JALVY, SANDRA, POTIER, MYLèNE, BELLOC, ISABELLE, GENOT, ELISABETH, DEKKER, LODEWIJK V, DESGRANGES, CLAUDE and GADEAU, ALAIN-PIERRE, 2005. UTP induces osteopontin expression through a coordinate action of NFkappaB, activator protein-1, and upstream stimulatory factor in arterial smooth muscle cells. Journal of Biological Chemistry. 280(4), 2708-13

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DEKKER,L.V. and CRONK,D., 2005. Nav1.8 as a drug target for pain. In: COWARD,K. and BAKER,M.D., eds., Sodium channels, pain and analgesia Birkhäuser Publishing Ltd, Basel, CHE. 123-144
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School of Pharmacy

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