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Publications in the Biomolecular Science and Medicinal Chemistry Division

Publications

Content: HARRIS, S A., GAVATHIOTIS, E., SEARLE, M S., OROZCO, M. and LAUGHTON, C A., 2001. Cooperativity in drug-DNA recognition: a molecular dynamics study Journal of the American Chemical Society. 123(50), 12658-12663

Content: BOSTOCK-SMITH, C E, HARRIS, S A, LAUGHTON, C A and SEARLE, M A, 2001. Induced fit DNA recognition by a minor groove binding analogue of Hoechst 33258: fluctuations in DNA A tract structure investigated by NMR and molecular dynamics simulations. Nucleic Acids Research. 29(3), 693-702

Content: CHAN, D C, LAUGHTON, C A, QUEENER, S F and STEVENS, M F, 2001. Structural studies on bioactive compounds. 34. Design, synthesis, and biological evaluation of triazenyl-substituted pyrimethamine inhibitors of Pneumocystis carinii dihydrofolate reductase. Journal of Medicinal Chemistry. 44(16), 2555-64

Content: BRADSHAW, T.D., BROWNE, H.L., HUTCHINSON, I., LAUGHTON, C.A., LEONG, C.O., OBRIEN, S., STEVENS, M.F., TRAPANI, V. and WESTWELL, A.D., 2001. Mechanistic studies and evaluation of clinical markers for phortress, a new agent for clinical trials British Journal of Cancer. 85, 272

Content: CHHABRA, S. R., PAREKH, H., KHAN, A. N., BYCROFT, B. W. and KELLAM, B., 2001. A Dde-based carboxy linker for solid-phase synthesis Tetrahedron Letters. VOL 42(PART 11), 2189-2192

Content: PAREKH, H., CHHABRA, S.R., BYCROFT, B.W. and KELLAM, B., 2001. Synthesis, evaluation and solid-phase applications of a Dde-based carboxy linker In: American Peptide Symposium. 145

Content: WARD, P., CHHABRA, S.R. and KELLAM, B., 2001. Nsuper^α-Dmc protected amino acids: Hydrogenolysis and acid stable acceptors for α-glycosyl-1-O-amino acid synthesis In: American Peptide Symposium. P204

Content: COLLINS, H M, MORRIS, T M and WATSON, S A, 2001. Spectrum of matrix metalloproteinase expression in primary and metastatic colon cancer: relationship to the tissue inhibitors of metalloproteinases and membrane type-1-matrix metalloproteinase. British Journal of Cancer. 84(12), 1664-70

Content: JENNINGS, C. R., GUO, L., COLLINS, H. M. and BIRCHALL, J. P., 2001. Matrix metalloproteinases 2 and 9 in otitis media with effusion Clinical Otolaryngology and Allied Sciences. VOL 26(PART 6), 491-494

Content: HEERY, D.M., HOARE, S., HUSSAIN, S., PARKER, M.G. and SHEPPARD, H., 2001. Core LXXLL motif sequences in CREB-binding protein, SRC1, and RIP140 define affinity and selectivity for steroid and retinoid receptors Journal of Biological Chemistry. 276(9), 6695-6702

Content: SHEPPARD, H.M., HARRIES, J.C., HUSSAIN, S., BEVAN, C. and HEERY, D.M., 2001. Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1 Molecular and Cellular Biology. 21(1), 39-50

Content: LE DOUARIN, B, HEERY, D M, GAUDON, C, VOM BAUR, E and LOSSON, R, 2001. Yeast two-hybrid screening for proteins that interact with nuclear hormone receptors. Methods in Molecular Biology. 176, 227-48

Content: WANG, S., MCCLUE, S.J., FERGUSON, J.R., HULL, J.D., STOKES, S., PARSONS, S., WESTWOOD, R. and FISCHER, P.M., 2001. Synthesis and configuration of the cyclin-dependent kinase inhibitor roscovitine and its enantiomer Tetrahedron Asymmetry. VOL 12(NUMBER 20), 2891-2894

Content: FISCHER, P.M., KRAUSZ, E. and LANE, D.P., 2001. Cellular delivery of impermeable effector molecules in the form of conjugates with peptides capable of mediating membrane translocation. Bioconjugate Chemistry. 12(6), 825-841

Content: FISCHER, P.M., 2001. Recent advances and new directions in the discovery and development of cyclin-dependent kinase inhibitors. Current Opinion in Drug Discovery & Development. 4(5), 623-634

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