Anaesthesia & Critical Care

Interdisciplinary Collaboration in Systems Medicine (ICSM)

Aim and expertise

We design, develop and apply pathophysiological models of human organ systems, with the aim of addressing issues of impact in critical illness and medical crisis scenarios.

The Interdisciplinary Collaboration in Systems Medicine (ICSM) simulation suite is an integrated and validated computational model of a number of organ systems, including the heart, blood vessels (and blood) and the lungs and is developed in collaboration with the School of Engineering at University of Warwick.

Medical students practising resuscitation

 

Research issues

Critical illness and medical crises are a huge drain on our society. They consume a disproportionate part of medical budgets and are tremendously disruptive to patients and their families. Due to the unpredictable nature of these issues, the heterogeneity of patients and the time critical nature of events, recruitment to clinical studies is difficult, and the results disappointingly noisy and unhelpful. There has thus developed a pressing need for a novel method to answer questions of crucial importance to these most vulnerable of patients.

What we are doing about...

  • Personalising and optimising the therapy delivered in the Intensive Care Units (ICU)
  • Obtain novel understanding of the pathophysiological state of cardiac arrest, test new cardiopulmonary resuscitation strategies and investigate clinical management strategies after cardiac arrest
  • Explore optimal rescue strategies using the Optiflow (a recent developed oxygen therapy device that delivers high-flow, humidified oxygen via nasal cannulae) in-silico obese and pregnancy subjects.
  • Prolongation of apnoea - improving the high-risk period of anaesthetic induction, and optimising gas exchange in-silico healthy and pregnancy subjects

Outcomes

Research Grants

 

Key publications

 

 

About ICSM

The ICSM group is a collaboration between researchers at the Universities of Nottingham and Warwick, led by Prof Jonathan G Hardman (Nottingham) and Prof Declan Bates (Warwick).

People

Directors

Prof. Jonathan Hardman University of Nottingham

Prof. Declan Bates University of Warwick

Assistant Professors

Dr Marianna Laviola University of Nottingham

Dr Sina Saffaran University of Warwick

PhD Students

Janan El Alouani University of Nottingham

Liam Weaver University of Warwick

Sonal Mistry University of Warwick

Hossein Shamohammadi University of Warwick

Past recent members

Dr Anup Das

Dr Clara Daudre-Vignier

Rebecca Valentine

Dr Husam Alahmadi

We collaborate with numerous NHS and international consultants in Anaesthesia and Intensive Care.

PhD opportunities

We are always keen to hear from potential graduate students with interests in biomedical engineering and systems medicine. We are also happy to support both undergraduate and postgraduate students widen their interdisciplinary research experience during degree projects or the summer vacation. Please get in touch by email to explore research ideas and determine funding opportunities.

Wellcome Biomedical Vacation Scholarship – 2024

There is an exciting opportunity for undergraduate to join our group for the next summer 2024.

Find out more about the Wellcome Scholarship for details and eligibility criteria (our project is Project 6).

 

 

Anaesthesia & Critical Care

School of Medicine
The University of Nottingham
C Floor, East Block, Queen's Medical Centre
Nottingham, NG7 2UH


telephone: +44 (0) 115 823 1009