Systematic reviews on eczema
March 2021: This resource is now archived and no longer being updated.
We recommend the Epistemonikos database as a comprehensive, searchable database of systematic reviews. The L.OVE Platform provides an alternative source for atopic dermatitis systematic reviews, browsable by topic.
This page is a mapping by topic of systematic reviews on eczema (atopic eczema) published since the 2000 HTA Systematic review of treatments for atopic eczema. The systematic reviews were found in the searches for our Annual Evidence Updates and CEBD Evidence Updates. Links are given to the PubMed abstract, or the original publication if not in PubMed.
Atopic eczema (© CEBD)
Copyright © 2021 The University of Nottingham, on behalf of the Centre of Evidence Based Dermatology. ALL RIGHTS RESERVED.
Please reference this resource (as a web page citation) if you use it for research or publications.
Epidemiology and aetiology
Aetiology, genetic risk factors & biomarkers
Risk factors - maternal & prenatal (see also "Maternal diet" under Prevention)
2021 Childhood vaccination and allergy: A systematic review and meta-analyses
2021 Neonatal jaundice, phototherapy and childhood allergic diseases: an updated systematic review and meta-analysis
2020 A systematic review of eczematous eruptions in patients receiving biologic therapy
2020 A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia
2020 The effect of water hardness on atopic eczema and skin barrier function: A systematic review and meta-analysis
2020 Oral mycobiome identification in atopic dermatitis, leukemia, and HIV patients - a systematic review
2020 Social and psychosocial effects on atopic eczema symptom severity - a scoping review of observational studies published from 1989 - 2019
2020 The relationship of prenatal antibiotic exposure and infant antibiotic administration with childhood allergies: a systematic review
2020 Bidirectional relationship between atopic dermatitis and inflammatory bowel disease: a systematic review and meta-analysis
2020 Association between atopic dermatitis and risk of autism spectrum disorder: A systematic review and meta-analysis
2020 Association of early viral lower respiratory infections and subsequent development of atopy, a systematic review and meta-analysis of cohort studies
2020 Genetics and epigenetics of atopic dermatitis: An updated systematic review
2020 Association of ABO blood groups with allergic diseases: a scoping review
2020 Phenotypic switch to eczema in patients receiving biologics for plaque psoriasis: a systematic review
2020 The bidirectional association between inflammatory bowel disease and atopic dermatitis: A systematic review and meta-analysis
2019 How does parental history of atopic disease predict the risk of atopic dermatitis in a child? - a systematic review and meta-analysis
2019 What is the evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis? - A systematic review
2019 The impact of airborne pollution on atopic dermatitis-A literature review
2019 VDR gene polymorphisms and allergic diseases: evidence from a meta-analysis
2019 Timing of cow's milk or cow's milk formula introduction to the infant diet and atopic risk in children: A systematic review and meta-analysis
2019 Transforming growth factor beta in human milk and allergic outcomes in children: a systematic review
2019 Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review
2019 Infant milk-feeding practices and food allergies, allergic rhinitis, atopic dermatitis, and asthma throughout the life span: a systematic review
2019 Research letter: Association of acetaminophen exposure with increased risk of eczema in children: A meta-analysis
2019 Micronutrients in atopic dermatitis: A systematic review
2019 Atopic dermatitis and autoimmunity: the occurrence of autoantibodies and their association with disease severity
2019 Zinc and atopic dermatitis: a systematic review and meta-analysis
2019 [Air pollution and atopic eczema : Systematic review of findings from environmental epidemiological studies] (in German)
2018 Role of the gut microbiota in atopic dermatitis: a systematic review
2018 Greenspace and atopic sensitization in children and adolescents-A systematic review
2018 Association between the age of solid food introduction and eczema; a systematic review and a meta-analysis
2018 Is atopic dermatitis associated with obesity? A systematic review of observational studies
2018 Atopic dermatitis and alcohol use: A meta-analysis and systematic review
2017 Environmental risk factors for development of atopic dermatitis: a systematic review
2017 Systematic review and meta-analysis of human skin diseases due to particulate matter
2017 Association of very preterm birth with decreased risk of eczema: A systematic review and meta-analysis
2017 Early life antibiotic exposure increases the risk of developing allergic symptoms later in life: A meta-analysis
2017 Association between atopic manifestations and eosinophilic esophagitis: A systematic review and meta-analysis
2017 Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis
2017 Overview of systematic reviews in allergy epidemiology
2016 Timing of allergenic food introduction to the infant diet and risk of allergic or autoimmune disease: A systematic review and meta-analysis
2016 Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis
2016 Association of atopic dermatitis with smoking: A systematic review and meta-analysis
2016 Environmental factors associated with altered gut microbiota in children with eczema: A systematic review
2016 A systematic review of vigorous physical activity in eczema
2016 The march from early life food sensitization to allergic disease: a systematic review and meta-analyses of birth cohort studies
2016 Intestinal microbiota and allergic diseases: A systematic review
2016 The association between phthalate exposure and atopic dermatitis with a discussion of phthalate induced secretion of interleukin-1β and thymic stromal lymphopoietin
2015 Interrelationships between atopic disorders in children: A meta-analysis based on ISAAC questionnaires
2015 Twin studies of atopic dermatitis: interpretations and applications in the filaggrin era
2015 Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis
2015 Association between atopic dermatitis and autism spectrum disorders: a systematic review
2015 The influence of childhood traffic-related air pollution exposure on asthma, allergy and sensitization: a systematic review and a meta-analysis of birth cohort studies
2015 A systematic review of socioeconomic position in relation to asthma and allergic diseases
2015 Association of vitiligo and alopecia areata with atopic dermatitis: A systematic review and meta-analysis
2015 Exposure to 'farming' and objective markers of atopy: a systematic review and meta-analysis
2015 Factors that predict remission of infant atopic dermatitis: a systematic review
2015 Volatile organic compounds and risk of asthma and allergy: a systematic review
2014 Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta-analysis
2014 CD14 polymorphisms, microbial exposure and allergic diseases: a systematic review of gene-environment interactions
2014 Birth weight and atopic dermatitis: systematic review and meta-analysis
2014 Guidelines of care for the management of atopic dermatitis: section 1. Diagnosis and assessment of atopic dermatitis (AAD guideline)
2013 Pet exposure and risk of atopic dermatitis at the pediatric age: a meta-analysis of birth cohort studies
2013 Does early life exposure to antibiotics increase the risk of eczema? A systematic review
2013 Obesity - a promoter of allergy?
2012 Impact of ambient temperature on children's health: a systematic review
2012 Exposure to cats: update on risks for sensitization and allergic diseases
2012 Caesarean section delivery and atopic dermatitis - meta-analysis of observational studies 
2011 Association between biomarker-quantified antioxidant status during pregnancy and infancy and allergic disease during early childhood: a systematic review
2011 Association between domestic mould and mould components, and asthma and allergy in children: A systematic review
2011 Atopic dermatitis and the hygiene hypothesis revisited
2011 Respiratory and allergic health effects of dampness, mold, and dampness-related agents: a review of the epidemiologic evidence
2010 Is there a rural/urban gradient in the prevalence of eczema? A systematic review
2008 A bidirectional relationship between psychosocial factors and atopic disorders: a systematic review and meta-analysis
2008 Caesarean delivery and risk of atopy and allergic disease: meta-analyses
2007 Atopic eczema in under 12s: diagnosis and management (NICE guideline)
2007 The role of furry pets in eczema: a systematic review
2007 The role of the intestinal microbiota in the development of atopic disorders
2006 What causes worsening of eczema? A systematic review
2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?
2004 No epidemiological evidence for infant vaccinations to cause allergic disease
1998 Health effects of passive smoking. 5. Parental smoking and allergic sensitisation in children
Diagnosis, evaluation & outcomes
Disease impact & treatment cost-effectiveness
Prevention
2021 Effect of folic acid intake on infant and child allergic diseases: Systematic review and meta-analysis
2021 Prepregnancy BMI, gestational weight gain and risk of childhood atopic dermatitis: A systematic review and meta-analysis
2020 Dietary factors during pregnancy and atopic outcomes in childhood: a systematic review from the European Academy of Allergy and Clinical Immunology
2019 Effect of probiotic supplementation in pregnant women: A meta-analysis of randomized controlled trials
2019 Systematic review and meta-analysis on the use of probiotic supplementation in pregnant mother, breastfeeding mother and infant for the prevention of atopic dermatitis in children
2019 [Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis] (in Chinese)
2018 Prenatal vitamin D status and respiratory and allergic outcomes in childhood: A meta-analysis of observational studies
2018 Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis
2017 Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies
2017 Prenatal intake of vitamins and allergic outcomes in the offspring: A systematic review and meta-analysis
2017 Overview of systematic reviews in allergy epidemiology
2016 Omega-3 Fatty Acids and Maternal and Child Health: An Updated Systematic Review
2016 Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis
2016 Maternal vitamin D status and childhood asthma, wheeze and eczema: a systematic review and meta-analysis
2016 Omega-3 long-chain PUFA intake during pregnancy and allergic disease outcomes in the offspring: a systematic review and meta-analysis of observational studies and randomized controlled trials
2016 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics
2015 Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood (Cochrane Review)
2015 Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis
2015 Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials
2015 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics
2014 Does maternal diet during pregnancy and lactation affect outcomes in offspring? A systematic review of food-based approaches
2014 Maternal folate exposure in pregnancy and childhood asthma and allergy: a systematic review
2013 Diet and allergic diseases among population aged 0 to 18 years: myth or reality?
2012 Maternal dietary antigen avoidance during pregnancy or lactation, or both, for preventing or treating atopic disease in the child (Cochrane Review)
2012 Impact of maternal supplementation with probiotics during pregnancy on atopic eczema in childhood - a meta-analysis
2012 Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis
2012 The impact of vitamin D in pregnancy on extraskeletal health in children: A systematic review
2011 The effect of perinatal omega-3 fatty acid supplementation on inflammatory markers and allergic diseases: a systematic review
2011 Overview of Reviews. The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews
2011 BMJ Clinical Evidence - Eczema
2011 Management of atopic eczema in primary care (SIGN guideline)
2010 Diagnosing and managing common food allergies: a systematic review
2010 Prevalence, natural history, diagnosis, and treatment of food allergy: a systematic review of the evidence
2008 Systematic review and evidence-based consensus guideline on prevention of allergy and atopic eczema of the German Network on Allergy Prevention (ABAP)
2002 Complementary/alternative medicine in dermatology: evidence-assessed efficacy of two diseases and two treatments
2000 Systematic review of treatments for atopic eczema
Dietary & supplements (for prevention)
2020 The role of probiotics in the prevention and treatment of atopic dermatitis in children: an updated systematic review and meta-analysis of randomized controlled trials
2019 Effect of omega-3 fatty acids supplementation during childhood in preventing allergic disease: A systematic review and meta-analysis
2019 Systematic review and meta-analysis on the use of probiotic supplementation in pregnant mother, breastfeeding mother and infant for the prevention of atopic dermatitis in children
2019 Timing of cow's milk or cow's milk formula introduction to the infant diet and atopic risk in children: A systematic review and meta-analysis
2019 Health benefits of yogurt among infants and toddlers aged 4 to 24 months: a systematic review
2019 Complementary feeding and food allergy, atopic dermatitis/eczema, asthma, and allergic rhinitis: a systematic review
2019 Health benefits of yogurt among infants and toddlers aged 4 to 24 months: a systematic review
2019 The role of oral vitamins and supplements in the management of atopic dermatitis: a systematic review
2019 [Effect of probiotic supplementation during pregnancy and infancy in preventing atopic dermatitis in children: a Meta analysis] (in Chinese)
2018 Probiotic supplementation for prevention of atopic dermatitis in infants and children: A systematic review and meta-analysis
2018 Infant formulas containing hydrolysed protein for prevention of allergic disease (Cochrane Review)
2018 Lactobacillus rhamnosus GG in the primary prevention of eczema in children: A systematic review and meta-analysis
2018 Partially hydrolyzed whey infant formula: Literature review on effects on growth and the risk of developing atopic dermatitis in infants from the general population
2018 Association between the age of solid food introduction and eczema; a systematic review and a meta-analysis
2018 Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis
2018 The effects of early life polyunsaturated fatty acids and ruminant trans fatty acids on allergic diseases: A systematic review and meta-analysis
2017 A partially hydrolyzed 100% whey formula and the risk of eczema and any allergy: an updated meta-analysis
2017 Prebiotics for the prevention of allergies: a systematic review and meta-analysis of randomized controlled trials
2017 Vitamin D supplementation in primary allergy prevention: systematic review of randomized and non-randomized studies
2017 Overview of systematic reviews in allergy epidemiology
2016 Omega-3 fatty acids and maternal and child health: An updated systematic review
2016 Polyunsaturated fatty acid supplementation in infancy for the prevention of allergy
2016 Fish intake during pregnancy or infancy and allergic outcomes in children: a systematic review and meta-analysis
2016 Timing of allergenic food introduction to the infant diet and risk of allergic or autoimmune disease: A systematic review and meta-analysis
2016 Synbiotics for prevention and treatment of atopic dermatitis: a meta-analysis of randomized clinical trials
2016 Hydrolysed formula and risk of allergic or autoimmune disease: systematic review and meta-analysis
2016 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Prebiotics
2015 Probiotics and primary prevention of atopic dermatitis: a meta-analysis of randomized controlled studies
2015 Long-term effect of early-life supplementation with probiotics on preventing atopic dermatitis: A meta-analysis
2015 Probiotics for prevention of atopic diseases in infants: systematic review and meta-analysis
2015 Probiotics for the prevention of allergy: a systematic review and meta-analysis of randomized controlled trials
2015 World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics
2014 Comparative probiotic strain efficacy in the prevention of eczema in infants and children: a systematic review and meta-analysis
2014 The importance of allergen avoidance in high risk infants and sensitized patients: a meta-analysis study
2013 Prebiotics in infants for prevention of allergy (Cochrane Review)
2013 Meta-analysis of probiotics and/or prebiotics for the prevention of eczema
2013 Effect of nutrient supplementation on atopic dermatitis in children: a systematic review of probiotics, prebiotics, formula, and fatty acids
2013 Diet and allergic diseases among population aged 0 to 18 years: myth or reality?
2013 The use of prebiotics during the first year of life for atopy prevention and treatment
2012 [Preventative effects of probiotics for infantile eczema and atopic eczema: A systematic review] (in Chinese)
2012 Probiotics supplementation during pregnancy or infancy for the prevention of atopic dermatitis: a meta-analysis
2012 [Meta-analysis of probiotics preventing allergic diseases in infants] (in Chinese)
2012 Are organic foods safer or healthier than conventional alternatives? A systematic review
2011 Overview of Reviews. The prevention of eczema in infants and children: an overview of Cochrane and non-Cochrane reviews
2011 Supplementation of infant formula with probiotics and/or prebiotics: A systematic review and comment by the ESPGHAN committee on nutrition
2011 Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review
2011 BMJ Clinical Evidence - Eczema
2011 Management of atopic eczema in primary care (SIGN guideline)
2011 Nutrients and foods for the primary prevention of asthma and allergy: systematic review and meta-analysis
2010 Nutrition-related health effects of organic foods: a systematic review
2010 [Meta analysis of lactic acid bacteria as probiotics for the primary prevention of infantile eczema] (in Chinese)
2010 Meta-analysis of the evidence for a partially hydrolyzed 100% whey formula for the prevention of allergic diseases
2010 Diagnosing and managing common food allergies: a systematic review
2010 Prevalence, natural history, diagnosis, and treatment of food allergy: a systematic review of the evidence
2010 Partially hydrolyzed 100% whey protein infant formula and reduced risk of atopic dermatitis: a meta-analysis
2010 Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature
2009 Omega 3 and 6 oils for primary prevention of allergic disease: systematic review and meta-analysis
2008 Meta-analysis of clinical trials of probiotics for prevention and treatment of pediatric atopic dermatitis
2008 Systematic review and evidence-based consensus guideline on prevention of allergy and atopic eczema of the German Network on Allergy Prevention (ABAP)
2008 Probiotics for the treatment or prevention of atopic dermatitis: a review of the evidence from randomized controlled trials
2007 Probiotics in infants for prevention of allergic disease and food hypersensitivity (Cochrane Review)
2007 The efficacy of amino acid-based formulas in relieving the symptoms of cow's milk allergy: a systematic review
2006 Formulas containing hydrolysed protein for prevention of allergy and food intolerance in infants (Cochrane Review)
2006 Soy formula for prevention of allergy and food intolerance in infants (Cochrane Review)
2006 Systematic review of the relationship between early introduction of solid foods to infants and the development of allergic disease
2005 Atopic dermatitis and the 'hygiene hypothesis': too clean to be true?
2005 A systematic review of the role of hydrolyzed infant formulas in allergy prevention
2001 Prospective cohort studies using hydrolysed formulas for allergy prevention in atopy-prone newborns: a systematic review
2000 Systematic review of treatments for atopic eczema
Aeroallergen reduction (for prevention)
Topical treatments
Topical calcineurin inhibitors
Systemic treatments
Systemic immune modulators (conventional, non-biologic)
Systemic biologic therapies
New small molecule systemic therapies
Immunotherapy/desensitisation
Anti-histamine/anti-allergic
Dietary & supplements (for treatment)
Other systemic treatments
Other treatments
Psychological & educational
Aeroallergen reduction (for treatment)
Bathing & water softeners
Complementary & alternative therapies