Developmental cardiogenesis and angiogenesis
One of the key areas of our research into cardiovascular disease is the study of cardiogenesis and angiogenesis. As a team of experienced, multidisciplinary researchers, we’re working to understand normal and abnormal heart development, as well as explore how the heart ages.
We’re advancing clinical understanding of the healthy and ageing heart in both humans and animals, including furthering our understanding of the key roles that cardiogenesis, angiogenesis and vascular disorders play in these processes.
Our aim is to improve prevention, diagnosis and treatment of these cardiovascular conditions, ultimately prolonging and saving lives.
Spotlight project
Understanding heart disease in humans and dogs
One in three people will be diagnosed with a heart condition during their lives, so understanding these problems is vital for human health and wellbeing. Our research team is working with researchers and clinicians in hospitals and laboratories all over the world in order to understand how cardiomyopathies and other heart diseases happen.
By looking at genetic mutations and their effects on the heart, we can understand how to diagnose and ultimately treat these conditions. Not only does this impact on human lives, but we can use what we find to understand whether animals are affected by the same mutations.
In canine breeds, cardiomyopathy affects up to 50% of the population. This decreases lifespan and disrupts the day-to-day life of both dogs and their owners. So, in addition to working on human heart disease, the Nottingham Canine Health Genomics group (led by Nigel Mongan, Catrin Rutland, Mark Dunning and Malcolm Cobb) works with thousands of owners and their dogs to understand the genetic links to heart disease, how the heart changes and how lifestyle impacts cardiovascular problems.
Read more about this project