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Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function Nature Genetics. 43(11), 1082-1090 BLAKEY JD and HALL IP, 2011. Current Progress In Pharmacogenetics. British Journal Of Clinical Pharmacology. 71(6), 824-31 SILVERMAN EK, VESTBO J, AGUSTI A, ANDERSON W, BAKKE PS, BARNES KC, BARR RG, BLEECKER ER, BOEZEN HM, BURKART KM, CELLI BR, CHO MH, COOKSON WOC, CROXTON T, DALEY D, DEMEO DL, GAN W, GARCIA-AYMERICH J, HALL IP, HANSEL NN, HERSH CP, KALSHEKER N, KILEY JP, KIM WJ, LAMBRECHTS D, LEE S, LITONJUA AA, LOMAS DA, LONDON SJ, NISHIMURA M, NØRDESTGAARD BG, O'DONNELL CJ, POSTMA DS, PUHAN MA, TESFAIGZI Y, TOBIN MD, VOGELMEIER C, WILK JB, WOUTERS E, YOUNG RP, ZIEGLER-HEITBROCK L, MACNEE W and CRAPO JD, 2011. Opportunities And Challenges In The Genetics Of Copd 2010: An International Copd Genetics Conference Report. Copd. 8(2), 121-35 FOLEY, S., GARSED, K., SINGH, G., DUROUDIER, N.P., SWAN, C., HALL, I.P., ZAITOUN, A., BENNETT, A., MARSDEN, C., HOLMES, G., WALLS, A. and SPILLER, R.C., 2011. Impaired uptake of serotonin by platelets from patients with irritable bowel syndrome correlates with duodenal immune activation Gastroenterology. 140(5), 1434-1443.e1 OBEIDAT M, WAIN LV, SHRINE N, KALSHEKER N, SOLER ARTIGAS M, REPAPI E, BURTON PR, JOHNSON T, RAMASAMY A, ZHAO JH, ZHAI G, HUFFMAN JE, VITART V, ALBRECHT E, IGL W, HARTIKAINEN A, POUTA A, CADBY G, HUI J, PALMER LJ, HADLEY D, MCARDLE WL, RUDNICKA AR, BARROSO I, LOOS RJF, WAREHAM NJ, MANGINO M, SORANZO N, SPECTOR TD, GLÄSER S, HOMUTH G, VÖLZKE H, DELOUKAS P, GRANELL R, HENDERSON J, GRKOVIC I, JANKOVIC S, ZGAGA L, POLAŠEK O, RUDAN I, WRIGHT AF, CAMPBELL H, WILD SH, WILSON JF, HEINRICH J, IMBODEN M, PROBST-HENSCH NM, GYLLENSTEN U, JOHANSSON Å, ZABOLI G, MUSTELIN L, RANTANEN T, SURAKKA I, KAPRIO J, JARVELIN M, HAYWARD C, EVANS DM, KOCH B, MUSK AW, ELLIOTT P, STRACHAN DP, TOBIN MD, SAYERS I, HALL IP and SPIROMETA CONSORTIUM, 2011. A comprehensive evaluation of potential lung function associated genes in the spirometa general population sample. Plos one. 6(5), e19382 SINGH, SHAILENDRA R, BILLINGTON, CHARLOTTE K, SAYERS, IAN and HALL, IAN P, 2010. Can lineage specific markers be identified to characterize mesenchyme-derived cell populations in the human airways? American journal of physiology. Lung cellular and molecular physiology. REPAPI, E., SAYERS, I., WAIN, L.V., BURTON, P.R., JOHNSON, T., OBEIDAT, M., ZHAO, J.H., RAMASAMY, A., ZHAI, G., VITART, V., HUFFMAN, J.E., IGL, W., ALBRECHT, E., DELOUKAS, P. and HENDERSON, J., 2010. Genome-wide association study identifies five loci associated with lung function Nature Genetics. 42(1), 36-44 BROOK, B.S., PEEL, S.E., HALL, I.P., POLITI, A.Z., SNEYD, J., BAI, Y., SANDERSON, M.J. and JENSEN, O.E., 2010. A biomechanical model of agonist-initiated contraction in the asthmatic airway Respiratory Physiology & Neurobiology. 170(1), 44-58 HALAPI E, GUDBJARTSSON DF, JONSDOTTIR GM, BJORNSDOTTIR US, THORLEIFSSON G, HELGADOTTIR H, WILLIAMS C, KOPPELMAN GH, HEINZMANN A, BOEZEN HM, JONASDOTTIR A, BLONDAL T, GUDJONSSON SA, JONASDOTTIR A, THORLACIUS T, HENRY AP, ALTMUELLER J, KRUEGER M, SHIN HD, UH S, CHEONG HS, JONSDOTTIR B, LUDVIKSSON BR, LUDVIKSDOTTIR D, GISLASON D, PARK C, DEICHMANN K, THOMPSON PJ, WJST M, HALL IP, POSTMA DS, GISLASON T, KONG A, JONSDOTTIR I, THORSTEINSDOTTIR U and STEFANSSON K, 2010. A Sequence Variant On 17Q21 Is Associated With Age At Onset And Severity Of Asthma. European Journal Of Human Genetics : Ejhg. 18(8), 902-8 CORTIJO J, MILARA J, MATA M, DONET E, GAVARA N, PEEL SE, HALL IP and MORCILLO EJ, 2010. Nickel Induces Intracellular Calcium Mobilization And Pathophysiological Responses In Human Cultured Airway Epithelial Cells. Chemico-Biological Interactions. 183(1), 25-33 SAYERS,, HAWLEY,, STEWART,, BILLINGTON,, HENRY,, LEIGHTON-DAVIES,, CHARLTON, and HALL,, 2009. Pharmacogenetic characterization of indacaterol, a novel beta(2)-adrenoceptor agonist. British journal of pharmacology.
BLAKEY, J D, SAYERS, I, RING, S M, STRACHAN, D P and HALL, I P, 2009. Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort. Thorax. 64(5), 381-7 DUROUDIER, NATHALIE P, STRACHAN, DAVID P, BLAKEY, JOHN D and HALL, IAN P, 2009. Association of the cysteinyl leukotriene receptor 1 gene with atopy in the British 1958 birth cohort. The Journal of allergy and clinical immunology. 124(3), 566-72, 572.e1-3 STEWART,, HALL,, PARKER,, MOFFATT,, WARDLAW,, CONNOLLY,, RUSE, and SAYERS,, 2009. PLAUR polymorphisms and lung function in UK smokers. BMC Medical Genetics. 10(1), 112
BARTON, S.J., KOPPELMAN, G.H., VONK, J.M., BROWNING, C.A., NOLTE, I.M., STEWART, C.E., BAINBRIDGE, S., MUTCH, S., ROSE-ZERILLI, M.J., POSTMA, D.S., MANIATIS, N., HENRY, A.P., HALL, I.P., HOLGATE, S.T., TIGHE, P., HOLLOWAY, J.W. and SAYERS, I., 2009. PLAUR polymorphisms are associated with asthma, PLAUR levels, and lung function decline Journal of Allergy and Clinical Immunology. 123(6), 1391-1400.e17 BEGHÉ, B, HALL, I P, PARKER, S G, MOFFATT, M F, WARDLAW, A, CONNOLLY, M J, FABBRI, L M, RUSE, C and SAYERS, I, 2009. Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy.
GUDBJARTSSON, D.F., BJORNSDOTTIR, U.S., HALAPI, E., HELGADOTTIR, A., SULEM, P., JONSDOTTIR, G.M., THORLEIFSSON, G., HELGADOTTIR, H., STEINTHORSDOTTIR, V., STEFANSSON, H., WILLIAMS, C., HUI, J., BEILBY, J., WARRINGTON, N.M., JAMES, A., PALMER, L.J., KOPPELMAN, G.H., HEINZMANN, A., KRUEGER, M., BOEZEN, H.M., WHEATLEY, A., ALTMULLER, J., SHIN, H.D., UH, S.-T., CHEONG, H.S., JONSDOTTIR, B., GISLASON, D., PARK, C.-S., RASMUSSEN, L.M., PORSBJERG, C., HANSEN, J.W., BACKER, V., WERGE, T., JANSON, C., JÖNSSON, U.-B., NG, M.C.Y., CHAN, J., SO, W.Y., MA, R., SHAH, S.H., GRANGER, C.B., QUYYUMI, A.A., LEVEY, A.I., VACCARINO, V., REILLY, M.P., RADER, D.J., WILLIAMS, M.J.A., RIJ, A.M. VAN, JONES, G.T., TRABETTI, E., MALERBA, G., PIGNATTI, P.F., BONER, A., PESCOLLDERUNGG, L., GIRELLI, D., OLIVIERI, O., MARTINELLI, N., LUDVIKSSON, B.R., LUDVIKSDOTTIR, D., EYJOLFSSON. G.I., ARNAR, D., THORGEIRSSON, G., DEICHMANN, K., THOMPSON, P.J., WJST, M., HALL, I.P., POSTMA, D.S., GISLASON, T., GULCHER, J., KONG, A., JONSDOTTIR, I., THORSTEINSDOTTIR, U. and STEFANSSON, K., 2009. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics. 41(3), 342-347 BILLINGTON, CHARLOTTE K, LE JEUNE, IVAN R, YOUNG, KENNETH W and HALL, IAN P, 2008. A major functional role for phosphodiesterase 4D5 in human airway smooth muscle cells. American journal of respiratory cell and molecular biology. 38(1), 1-7
DENHAM, SAMUEL, KOPPELMAN, GERARD H, BLAKEY, JOHN, WJST, MATTHIAS, FERREIRA, MANUEL A, HALL, IAN P and SAYERS, IAN, 2008. Meta-analysis of genome-wide linkage studies of asthma and related traits. Respiratory Research. 9, 38 PEEL SE, LIU B and HALL IP, 2008. Orai And Store-Operated Calcium Influx In Human Airway Smooth Muscle Cells. American Journal Of Respiratory Cell And Molecular Biology. 38(6), 744-9 HALL IP, 2008. Natriuretic Peptides And Asthma: Is There A Connection? Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology. 38(7), 1068-70 SINGH SR and HALL IP, 2008. Airway Myofibroblasts And Their Relationship With Airway Myocytes And Fibroblasts. Proceedings Of The American Thoracic Society. 5(1), 127-32 PANETTIERI RA, KOTLIKOFF MI, GERTHOFFER WT, HERSHENSON MB, WOODRUFF PG, HALL IP, BANKS-SCHLEGEL S and NATIONAL HEART, LUNG, AND BLOOD INSTITUTE, 2008. Airway Smooth Muscle In Bronchial Tone, Inflammation, And Remodeling: Basic Knowledge To Clinical Relevance. American Journal Of Respiratory And Critical Care Medicine. 177(3), 248-52 LIU, B, FREYER, A.M and HALL, I.P, 2007. Bradykinin activates calcium-dependent potassium channels in cultured human airway smooth muscle cells. American Journal of Physiology: Lung Cellular and Molecular Physiology. 292(4), L898-907 HIDALGO-BASTIDA LA, BARRY JJA, EVERITT NM, ROSE FRAJ, BUTTERY LD, HALL IP, CLAYCOMB WC and SHAKESHEFF KM, 2007. Cell adhesion and mechanical properties of a flexible scaffold for cardiac tissue engineering. Acta biomaterialia. 3(4), 457-62 DUROUDIER, NATHALIE P, SAYERS, IAN, CASTAGNA, CHARLOTTE CARABOTT, FENECH, ANTHONY G, HALAPI, EVA, SWAN, CAROLINE and HALL, IAN P, 2007. Functional Polymorphism and Differential Regulation of CYSLTR1 Transcription in Human Airway Smooth Muscle and Monocytes. Cell biochemistry and biophysics. 47(1), 119-30 HALL, I P and SAYERS, I, 2007. Pharmacogenetics and asthma: false hope or new dawn? European Respiratory Journal. 29(6), 1239-45 SMITH, NATALIE, BROWNING, CLAUDIA A, DUROUDIER, NATHALIE, STEWART, CERI, PEEL, SAMANTHA, SWAN, CAROLINE, HALL, IAN P and SAYERS, IAN, 2007. Salmeterol and cytokines modulate inositol-phosphate signalling in human airway smooth muscle cells via regulation at the receptor locus. Respiratory Research. 8, 68 TAYLOR DR and HALL IP, 2007. Adrb2 Polymorphisms And Beta2 Agonists. Lancet. 370(9605), 2075-6 CLAYTON, J.A., RODGERS, S., BLAKEY, J., AVERY, A. and HALL, I.P., 2006. Thiazide diuretic prescription and electrolyte abnormalities in primary care British Journal of Clinical Pharmacology. 61(1), 87-95 HALL, I.P., BLAKEY, J.D., AL BALUSHI, K.A., WHEATLEY, A., SAYERS, I., PEMBREY, M.E., RING, S.M., MCARDLE, W.L. and STRACHAN, D.P., 2006. β2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study Lancet. 368(9537), 771-779 SWAN, C., RICHARDS, S.A., DUROUDIER, N.P., SAYERS, I. and HALL, I.P., 2006. Alternative promoter use and splice variation in the human histamine H1 receptor gene American Journal of Respiratory Cell and Molecular Biology. 35(1), 118-126 HORAN, M, NEWSWAY, V., YASMIN,, LEWIS, M.D., EASTER, T.E., REES, D.A., MAHTO, A., MILLAR, D.S., PROCTER, A.M., SCANLON, M.F., WILKINSON, I.B., HALL, I.P., WHEATLEY, A., BLAKEY, J., BATH, P.M.W., COCKCROFT, J.R., KRAWCZAK, M. and COOPER, D.N., 2006. Genetic variation at the growth hormone (GH1) and growth hormone receptor (GHR) loci as a risk factor for hypertension and stroke. Human Genetics. 119(5), 527-540 CLAYTON, J.A., LE JEUNE, I.R. and HALL, I.P., 2006. Severe hyponatraemia in medical in-patients: aetiology, assessment and outcome QJM (Quarterly Journal of Medicine). 99(8), 505-511 DURCAN, N., COSTELLO, R.W., MCLEAN, W.G., BLUSZTAJN, J., MADZIAR, B., FENECH, A.G., HALL, I.P., GLEICH, G.J., MCGARVEY, L. and WALSH, M.-T., 2006. Eosinophil-mediated cholinergic nerve remodeling American Journal of Respiratory Cell and Molecular Biology. 34(6), 775-786 GREEN, R.H., BRIGHTLING, C.E., MCKENNA, S., HARGADON, B., NEALE, N., PARKER, D., RUSE, C., HALL, I.P. and PAVORD, I.D., 2006. Comparison of asthma treatment given in addition to inhaled corticosteroids on airway inflammation and responsiveness European Respiratory Journal. 27(6), 1144-1151 HALL, IAN P, 2006. Pharmacogenetics of asthma. Chest. 130(6), 1873-8 BLAKEY, J., HALAPI, E., BJORNSDOTTIR, U.S., WHEATLEY, A., KRISTINSSON, S., UPMANYU, R., STEFANSSON, K., HAKONARSON, H. and HALL, I.P., 2005. Contribution of ADAM33 polymorphisms to the population risk of asthma Thorax. 60(4), 274-276 GOH, G., SELF, T., BARBADILLO MUÑOZ, M.D., HALL, I.P., YOUNG, L. and DENNING, C., 2005. Molecular and phenotypic analyses of human embryonic stem cell-derived cardiomyocytes: opportunities and challenges for clinical translation Thrombosis and Haemostasis. 94(4), 728-737 SAYERS, I. and HALL, I.P., 2005. Pharmacogenetic approaches in the treatment of asthma Current Allergy & Asthma Reports. 5(2), 101-108 HALL, I.P. and BLAKEY, J.D., 2005. Genetic association studies in Thorax Thorax. 60(5), 357-359 HALL, I.P., 2005. Pharmacogenetics and ethnicity: more complexities of personalized prescribing American Journal of Respiratory and Critical Care Medicine. 171(6), 535-536 FREYER, A.M., BILLINGTON, C.K., PENN, R.B. and HALL, I.P., 2004. Extracellular matrix modulates β2-adrenergic receptor signaling in human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 31(4), 440-445 WADSWORTH, S.J., FREYER, A.M., CORTELING, R.L. and HALL, I.P., 2004. Biosynthesized matrix provides a key role for survival signaling in bronchial epithelial cells American Journal of Physiology: Lung Cellular and Molecular Physiology. 286(3), L596-L603 FENECH, A.G., BILLINGTON, C.K., SWAN, C., RICHARDS, S., HUNTER, T., EBEJER, M.J., FELICE, A.E., ELLUL-MICALLEF, R. and HALL, I.P., 2004. Novel polymorphisms influencing transcription of the human CHRM2 gene in airway smooth muscle American Journal of Respiratory Cell and Molecular Biology. 30(5), 678-686 CORTELING, R.L., LI, S., GIDDINGS, J., WESTWICK, J., POLL, C. and HALL, I.P., 2004. Expression of transient receptor potential C6 and related transient receptor potential family members in human airway smooth muscle and lung tissue. American Journal of Respiratory Cell and Molecular Biology. 30(2), 145-154 SABROE, I., WHYTE, M.K.B., WILSON, A.G., DOWER, S.K., HUBBARD, R. and HALL, I.P., 2004. Toll-like receptor (TLR) 4 polymorphisms and COPD Thorax. 59(1), 81
HALL, I.P., 2004. The β-agonist controversy revisited Lancet. 363(9404), 183 LEE, D.K., CURRIE, G.P., HALL, I.P., LIMA, J.J. and LIPWORTH, B.J., 2004. The arginine-16 b2-adrenoceptor polymorphism predisposes to bronchoprotective subsensitivity in patients treated with formoterol and salmeterol British Journal of Clinical Pharmacology. 57(1), 68-75 BILLINGTON, C.K., PENN, R.B., GONCHAROVA, E.A., IRANI, C., VOROTNIKOV, A.V., TKACHUK, V.A., KRYMSKAYA, V.P., PANETTIERI, R.A., PASCUAL, R.M., HAWKINS, M.L. and HALL, I.P., 2003. Signalling and regulation of G protein-coupled receptors in airway smooth muscle cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration m3 muscarinic acetylcholine receptor regulation in the airway Interleukin-1beta a Respiratory Research. 4(1), 2 GONCHAROVA, E.A., BILLINGTON, C., IRANI, C., VOROTNIKOV, A.V., TKACHUK, V.A., PENN, R.B., KRYMSKAYA, V.P., PANETTIERI, R.A., PASCUAL, R.M., HAWKINS, M.L. and HALL, I.P., 2003. Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration m3 muscarinic acetylcholine receptor regulation in the airway interleukin-1β and rhinovirus sensitize adenylyl cyclase in human airway smooth-muscle cells American Journal of Respiratory Cell and Molecular Biology. 29(1), 19-27 DEWAR, J.C. and HALL, I.P., 2003. Personalised prescribing for asthma - is pharmacogenetics the answer? Journal of Pharmacy and Pharmacology. 55(3), 279-289 KOTLIKOFF, M. and HALL, I.P., 2003. Hypertension: beta testing Journal of Clinical Investigation. 112(5), 654-655 LE JEUNE, I.R., SHEPHERD, M., VAN HEEKE, G., HOUSLAY, M.D. and HALL, I.P., 2002. Cyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells: identification and characterization of a novel PDE4D5 promoter Journal of Biological Chemistry. 277(39), 35980-35989 WHEATLEY, A.P., BOLLAND, D.J., HEWITT, J.E., DEWAR, J.C. and HALL, I.P., 2002. Identification of the autoantigen SART-1 as a candidate gene for the development of atopy Human Molecular Genetics. 11(18), 2143-2146 BILLINGTON, C. K. and PENN, R. B., 2002. m3 muscarinic Acetylcholine Receptor Regulation in the Airway American Journal of Respiratory Cell and Molecular Biology. VOL 26(PART 3), 269-272
FOWLER, S.J., HALL, I.P., WILSON, A.M., WHEATLEY, A.P. and LIPWORTH, B.J., 2002. 5-Lipoxygenase polymorphism and in-vivo response to leukotriene receptor antagonists European Journal of Clinical Pharmacology. 58(3), 187-190 FENECH, A. and HALL, I.P., 2002. Pharmacogenetics of asthma British Journal of Clinical Pharmacology. 53(1), 3-15 FREYER, A.M., JOHNSON, S.R. and HALL, I.P., 2001. Effects of growth factors and extracellular matrix on survival of human airway smooth muscle cells. American Journal of Respiratory Cell and Molecular Biology. 25(5), 569-576 BILLINGTON, C.K., PASCUAL, R.M., HAWKINS, M.L., PENN, R.B. and HALL, I.P., 2001. Interleukin-1β and rhinovirus sensitize adenylyl cyclase in human airway smooth-muscle cells American Journal of Respiratory Cell and Molecular Biology. 24(5), 633-639
CHO, S.H., HALL, I.P., WHEATLEY, A., DEWAR, J., ABRAHA, D., DEL MUNDO, J., LEE, H. and OH, C.K., 2001. Possible role of the 4G/5G polymorphism of the plasminogen activator inhibitor 1 gene in the development of asthma Journal of Allergy and Clinical Immunology. 108(2), 212-214 PASCUAL, R.M., BILLINGTON, C.K., HALL, I.P., PANETTIERI, R.A., FISH, J.E., PETERS, S.P. and PENN, R.B., 2001. Mechanisms of cytokine effects on G protein-coupled receptor-mediated signaling in airway smooth muscle American Journal of Physiology. Lung Cellular and Molecular Physiology. 281(6), L1425-35
HALL, I.P., 2001. Chronic lung disease - Instut Pasteur Euroconference Drugs. 4(9), 1021-1024
HOLLOWAY, J.W., LONJOU, C., BEGHE, B., PENG, Q., GAUNT, T.R., GOMES, I., HALL, I.P., DEWAR, J.C., WILKINSON, J. and THOMAS, N.S., 2001. Linkage analysis of the 5q31-33 candidate region for asthma in 240 UK families Genes and Immunity. 2(1), 20-24 FENECH, A.G., EBEJER, M.J., FELICE, A.E., ELLUL-MICALLEF, R. and HALL, I.P., 2001. Mutation screening of the muscarinic M~2 and M~3 receptor genes in normal and asthmatic subjects British Journal of Pharmacology. 133(1), 43-48 BROWN, J.K., JONES, C.A., ROONEY, L.A., CAUGHEY, G.H. and HALL, I.P., 2001. Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions American Journal of Physiology. 282(2), L197-206
LONJOU, C., BARNES, K., CHEN, H., COOKSON, W.O.C.M., DEICHMANN, K.A., HALL, I.P., HOLLOWAY, J.W., LAITINEN, T., PALMER, L.J. and WJST, M., 2000. A first trial of retrospective collaboration for positional cloning in complex inheritance: Assay of the cytokine region on chromosome 5 by the Consortium on Asthma Genetics (COAG) Proceedings of the National Academy of Sciences of the United States of America. 97(20), 10942-10947 SCOTT, M.G.H., SWAN, C., WHEATLEY, A.P. and HALL, I.P., 1999. Identification of' novel polymorphisms within the promoter region of the human ~2 adrenergic receptor gene British Journal of Pharmacology. 126(4), 841-844 TAN, S., HALL, I.P., DEWAR, J., DOW, E. and LIPWORTH, B., 1997. Association between ~2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics Lancet. 350(9083), 995-999