Project Title: Multi-scale platform for imaging sodium gradients in the placenta cells
Supervisors: Raheela Khan, Dr Galina Pavlovskaya
Studies will use the human placenta as our experimental model in light of its well-characterised Na-dependent functions and abundant expression of sodium channels. Advances and refinement of powerful biophysical (23Na NMR, cryo-EM, crystallography, imaging) and physiological (whole-cell electrophysiology, single-channel recording, Na fluorophore assays) techniques spanning high-resolution structural studies and molecular membrane physiology through to whole-cell analyses will ultimately yield a well‑rounded, systematic interpretation of Na dynamics that has potential translational value in a range of conditions including pregnancy, hypertension and cancer.
For further details and applications please see:
https://www.nottingham.ac.uk/bbdtp/available-projects/molecules-cells-and-organisms/medicine/2017-18-khan-pavlovskaya-scott.aspx
or contact Raheela.Khahn@nottingham.ac.uk