Stan Heptinstall

Contact

• workSouth Block
  Queen's Medical Centre
  Nottingham
  NG7 2UH
  UK
• work0115 823 1013
• fax0115 823 1017
• stan.heptinstall@nottingham.ac.uk

Biography

Born in Bolton, schooled in Lytham St Annes, BSc and PhD gained at University of Newcastle upon Tyne, employed at University of Nottingham for 40 years, now retired from full-time employment at the University. Director of Platelet Solutions, Ltd, a spinout company of the University of Nottingham.

Expertise Summary

For many years I was engaged in research to identify how blood cells, especially platelets, are involved in the control of bleeding (haemostasis) and in forming blood clots which result in heart attacks, strokes and similar negative outcomes (thrombosis).The research involves finding means through which thrombosis can be avoided. I am a director of a University of Nottingham spin-out company Platelet Solutions Ltd which produces products for use in platelet function testing.

Teaching Summary

After many years of teaching undergraduates and postgraduates at the University of Nottingham I now do less of this. I still deliver the odd lecture when invited to do so.

Research Summary

My main interest is in the contribution of blood cells, especially platelets, to haemostasis and thrombosis, and the development and testing of appropriate pharmacological or dietary interventions.… read more

Selected Publications

• HEPTINSTALL, S, 2013. Antiplatelet Agents: Current and Novel. In: FERRO, A and GARCIA, DA, eds., Antiplatelet and Anticoagulation Therapy Springer. 1-44

• View all publications

Life is about doing the best you can within the environment that you find yourself in. It is also about being compassionate and caring and encouraging others. If we all did that the world would be a better place.

Current Research

My main interest is in the contribution of blood cells, especially platelets, to haemostasis and thrombosis, and the development and testing of appropriate pharmacological or dietary interventions. Investigations of platelet function are performed using a wide range of experimental approaches. There is a particular interest in development of tests of platelet function that are easy to use and therefore are available for widespread use in healthcare. A spin-out company Platelet Solutions Ltd has been formed to facilitate this.

Past Research

My past research is best appreciated through a glance at my publications.

Future Research

Although I am now retired from full-time academic work I do continue to maintain an interest in current developments and still contribute ideas to ongoing research at the University of Nottingham. Also I continue to be a director of the spin-out company Platelet Solutions Ltd.

• HEPTINSTALL S, 2017. James G. White MD, 1929-2016. Platelets. 28(1), 103-105
• BATH PM, APPLETON JP, BERIDZE M, CHRISTENSEN H, DINEEN RA, DULEY L, ENGLAND TJ, HEPTINSTALL S, JAMES M, KRISHNAN K, MARKUS HS, POCOCK S, RANTA A, ROBINSON TG, FLAHERTY K, SCUTT P, VENABLES GS, WOODHOUSE LJ and SPRIGG N, 2016. Baseline characteristics of the 3096 patients recruited into the 'Triple Antiplatelets for Reducing Dependency after Ischemic Stroke' trial. International journal of stroke : official journal of the International Stroke Society. (In Press.)
• HEPTINSTALL S, 2016. A story of cooperation and friendship in Europe with good outcomes. Platelets. 27(6), 495
• ALGAHTANI M and HEPTINSTALL S, 2016. Novel strategies for assessing platelet reactivity. Future cardiology. 13(1), 33-47
• KEELER BD, SIMPSON JA, FOX SC, STAVROU CL, BRIGGS RA, PATEL P, HEPTINSTALL S and ACHESON AG, 2015. An observational study investigating the effect of platelet function on outcome after colorectal surgery. International journal of surgery (London, England). 17, 28-33
• KRISHNAN K, BERIDZE M, CHRISTENSEN H, DINEEN R, DULEY L, HEPTINSTALL S, JAMES M, MARKUS HS, POCOCK S, RANTA A, ROBINSON T, NIKOLA N, VENABLES G and BATH P, 2015. Safety and efficacy of intensive vs. guideline antiplatelet therapy in high-risk patients with recent ischemic stroke or transient ischemic attack: rationale and design of the Triple Antiplatelets for Reducing Dependency after Ischaemic Stroke (TARDIS) trial (ISRCTN47823388). International journal of stroke : official journal of the International Stroke Society. 10(7), 1159-65
• DOVLATOVA N, LORDKIPANIDZÉ M, LOWE GC, DAWOOD B, MAY J, HEPTINSTALL S, WATSON SP, FOX SC and THE UK GAPP STUDY GROUP, 2014. Evaluation of a whole blood remote platelet function test for the diagnosis of mild bleeding disorders. Journal of thrombosis and haemostasis : JTH. (In Press.)
• THOMAS MR, WIJEYERATNE YD, MAY JA, JOHNSON A, HEPTINSTALL S and FOX SC, 2014. A platelet P-selectin test predicts adverse cardiovascular events in patients with acute coronary syndromes treated with aspirin and clopidogrel. Platelets. (In Press.)
• GLENN JR, DOVLATOVA N, WHITE AE, DHILLON K, HEPTINSTALL S and FOX SC, 2014. 'VASPFix' for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists. Thrombosis and haemostasis. 111(3), 539-48
• HEPTINSTALL, S, 2013. Antiplatelet Agents: Current and Novel. In: FERRO, A and GARCIA, DA, eds., Antiplatelet and Anticoagulation Therapy Springer. 1-44
• FOX SC, MAY JA, JOHNSON A, HERMANN D, STRIETER D, HARTMAN D and HEPTINSTALL S, 2013. Effects on platelet function of an EP3 receptor antagonist used alone and in combination with a P2Y12 antagonist both in-vitro and ex-vivo in human volunteers. Platelets. 24(5), 392-400
• HEPTINSTALL S, 2013. How important is it to keep taking the aspirin? Thrombosis and haemostasis. 110(6), 1108-9
• IYÚ, D., GLENN, J.R., WHITE, A.E., JOHNSON, A., HEPTINSTALL, S. and FOX, S.C., 2012. The role of prostanoid receptors in mediating the effects of PGE3 on human platelet function Thrombosis and Haemostasis. 107(4), 797-799
• GLENN JR, WHITE AE, IYU D and HEPTINSTALL S, 2012. PGE(2) reverses G(s)-mediated inhibition of platelet aggregation by interaction with EP3 receptors, but adds to non-G(s)-mediated inhibition of platelet aggregation by interaction with EP4 receptors. Platelets. 23(5), 344-51
• WIJEYERATNE YD, JOSHI R and HEPTINSTALL S, 2012. Ticagrelor: a P2Y12 antagonist for use in acute coronary syndromes Clinical Pharmacology (Expert review). 5(3), 257-269
• HEPTINSTALL S, 2012. Platelet activation by an extracellular adherence protein from Staphylococcus aureus acting via modulation of sulfhydryl groups on platelets. Arteriosclerosis, thrombosis, and vascular biology. 32(8), 1751-2
• WIJEYERATNE YD, JOSHI R and HEPTINSTALL S, 2012. Ticagrelor: a P2Y12 antagonist for use in acute coronary syndromes. Expert review of clinical pharmacology. 5(3), 257-69
• IYU, D., GLENN, J.R., WHITE, A.E., FOX, S.C. and HEPTINSTALL, S., 2011. Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y₁₂ antagonist Arteriosclerosis, Thrombosis and Vascular Biology. 31(2), 416-422
• IYÚ, D., JÜTTNER, M., GLENN, J.R., WHITE, A.E., JOHNSON, A.J., FOX, S.C. and HEPTINSTALL, S., 2011. PGE₁ and PGE₂ modify platelet function through different prostanoid receptors Prostaglandins and Other Lipid Mediators. 94(1-2), 9-16
• IYÚ, D., GLENN, J.R., WHITE, A.E., FOX, S.C., GIEZEN, H. VAN, NYLANDER, S. and HEPTINSTALL, S., 2011. Mode of action of P2Y12 antagonists as inhibitors of platelet function Thrombosis and Haemostasis. 105(1), 96-106
• IYÚ D, GLENN JR, WHITE AE, FOX SC, DOVLATOVA N and HEPTINSTALL S, 2011. P2Y(12) And EP3 Antagonists Promote The Inhibitory Effects Of Natural Modulators Of Platelet Aggregation That Act Via cAMP. Platelets. 22(7), 504-15
• WIJEYERATNE YD and HEPTINSTALL S, 2011. Anti-Platelet Therapy: ADP Receptor Antagonists. British Journal Of Clinical Pharmacology. 72(4), 647-57
• IYU, D., GLENN, J.R., WHITE, A.E., JOHNSON, A.J., FOX, S.C. and HEPTINSTALL, S., 2010. The role of prostanoid receptors in mediating the effects of PGE₂ on human platelet function Platelets. 21(5), 329-342
• HEPTINSTALL S, SPAULDING C, DANSER J, HALVORSEN S, JAMES S, TUOMILEHTO J, HOHNLOSER S, LEFÈVRE T, CARMELIET P and GITTENBERGER-DE GROOT AC, 2010. Photofeature: European cardiovascular researchers on holiday and outside of work Circulation. 122(7), f40-f42
• MAHAJAN R and HEPTINSTALL S, 2010. Should critical care patients receive or remain on treatment with antiplatelet drugs? Critical Care Medicine. 38(1), 298-300
• SAMAMA MM, KUNITADA S, OURSIN A, DEPASSE F and HEPTINSTALL S, 2010. Comparison of a direct Factor Xa inhibitor, edoxaban, with dalteparin and ximelagatran: A randomised controlled trial in healthy elderly adults. Thrombosis Research. 126(4), e286-293
• FOX SC, MAY JA, SHAH A, NEUBERT U and HEPTINSTALL S, 2009. Measurement of platelet P-selectin for remote testing of platelet function during treatment with clopidogrel and/or aspirin. Platelets. 20(4), 250-9
• HEPTINSTALL, S., FOX, S.C., MAY, J.A., HERMANN, D., STREITER, D. and HARTMAN, D., 2009. EP3 receptor blockade and platelet function in man Journal of Thrombosis and Haemostasis. 7(Supplement 2), OC-MO-100
• DOVLATOVA, N., WIJEYERATNE, Y.D., FOX, S.C., MANOLOPOULOS, P., JOHNSON, A.J., WHITE, A.E., LATIF, L., RALEVIC, V. and HEPTINSTALL, S., 2009. Detection of P2Y14 receptor protein on platelets and investigation of the role of P2Y14 in platelet function. J Thromb Haemostas. Supplement 2, WE-045
• FOX, S.C., MAY, J.A., SHAH, A., NEUBERT, U. and HEPTINSTALL, S., 2009. Assessment of clopidogrel and aspirin therapy using remote platelet testing. J Thromb Haemostas. 7(Supplement 2), WE-755
• IYU, D and HEPTINSTALL, S., 2009. Harnessing the antiplatelet effects of prostaglandin E2 by EP3 receptor blockade. J Thromb Haemost. 7(Supplement 2), MO-101
• STOREY, ROBERT F, MELISSA THORNTON, S, LAWRANCE, RACHAEL, HUSTED, STEEN, WICKENS, MARK, EMANUELSSON, HÅKAN, CANNON, CHRISTOPHER P, HEPTINSTALL, STAN and ARMSTRONG, MARTIN, 2009. Ticagrelor yields consistent dose-dependent inhibition of ADP-induced platelet aggregation in patients with atherosclerotic disease regardless of genotypic variations in P2RY12, P2RY1, and ITGB3. Platelets. 20(5), 341-8
• VISIOLI, FRANCESCO, BERNAERT, HERWIG, CORTI, ROBERTO, FERRI, CLAUDIO, HEPTINSTALL, STAN, MOLINARI, ENRICO, POLI, ANDREA, SERAFINI, MAURO, SMIT, HENK J, VINSON, JOE A, VIOLI, FRANCESCO and PAOLETTI, RODOL, 2009. Chocolate, lifestyle, and health. Critical Reviews in Food Science and Nutrition. 49(4), 299-312
• HEPTINSTALL S, IYU D, MANOLOPOULOS P, GLENN JR, WHITE AE, JOHNSON A, DOVLATOVA N, FOX SC, MAY JA, HERMANN D and MAGNUSSON O, 2008. DG-041 inhibits the EP3 prostanoid receptor--a new target for inhibition of platelet function in atherothrombotic disease. Platelets. 19(8), 605-13
• MAY JA, FOX SC, GLENN JR, CRAXFORD S and HEPTINSTALL S, 2008. Platelet function reduces significantly during the morning. Platelets. 19(7), 556-8
• MANOLOPOULOS, P., GLENN, J.R., FOX, S.C., MAY, J.A., DOVLATOVA, N.L., TANG, S.-W., THOMAS, N.R., RALEVIC, V. and HEPTINSTALL, S., 2008. Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y₁ and P2Y₁₂ receptors: a new finding that may influence the design of anti-thrombotic agents Platelets. 19(2), 134-145
• GLENN JR, WHITE AE, JOHNSON AJ, FOX SC, MYERS B and HEPTINSTALL S, 2008. Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Platelets. 19(1), 59-69
• JOHNSON, A, DOVLATOVA, N and AND HEPTINSTALL, H., 2008. Multiple electrode aggregometry and P2Y12 antagonists Thrombosis and Haemostasis. 99(6), 1127-1129
• DOVLATOVA, N.L., JAKUBOWSKI, J.A., SUGIDACHI, A. and HEPTINSTALL, S., 2008. The reversible P2Y₁₂antagonist cangrelor influences the ability of the active metabolites of clopidogrel and prasugrel to produce irreversible inhibition of platelet function Journal of Thrombosis and Haemostasis. 6(7), 1153-1159
• DOVLATOVA, N., WIJEYERATNE, Y.D., FOX, S.C., MANOLOPOULOS, P., JOHNSON, A.J., WHITE, A.E., LATIF, M.L., RALEVIC, V. and HEPTINSTALL, S., 2008. Detection of P2Y14 protein in platelets and investigation of the role of P2Y14 in platelet function in comparison with the EP3 receptor Thrombosis and Haemostasis. 100(2), 261-270
• DOVLATOVA N, WIJEYERATNE YD, FOX SC, MANOLOPOULOS P, JOHNSON AJ, WHITE AE, LATIF ML, RALEVIC V and HEPTINSTALL S, 2008. Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor. Thrombosis and haemostasis. 100(2), 261-70
• JOHNSON A, DOVLATOVA N and HEPTINSTALL S, 2008. Multiple electrode aggregometry and P2Y(12) antagonists. Thrombosis and haemostasis. 99(6), 1127-9
• HEPTINSTALL, S., FOX, S., GLENN, J., JOHNSON, A., WHITE, A., HATZINOCOLAU, M., PINK, A., STAFFORD, N., BEHAN, M., DOLAN, G. and AND MYERS, B., 2007. Leucocytes influence platelet aggregation more than you think Platelets. 18(1), 77-78
• WHITE AE, GLENN JR, FOX SC, JOHNSON A, MYERS B and HEPTINSTALL S, 2007. Reduced platelet aggregation to ADP and ATP in patients with leucocytosis is due to enhanced rates of adenine nucleotide metabolism mediated by the NTPDase CD39 Platelets. 18(1), 100
• FOX SC, MAY JA and HEPTINSTALL S, 2007. Quantitation of endothelial microparticles in plasma samples is impaired by chylomicrons following ingestion of a fatty meal Platelets. 18(1), 85-86
• HEPTINSTALL, S, MYERS, B, FOX, S.C, GLENN, J.R and JOHNSON, A.J. AND WHITE, A.E., 2007. Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Thrombosis Research. 120(Supplement 2), S153-S154
• HEPTINSTALL, S, MYERS, B, FOX, S.C, GLENN, J.R, JOHNSON, A.J and AND WHITE, A.E., 2007. Raised levels of CD39 in leucocytosis result in marked inhibition of ADP-induced platelet aggregation via rapid ADP hydrolysis. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-W-356
• XAVIER, R, WHITE, A, FOX, S, WILCOX, R and AND HEPTINSTALL, S., 2007. Enhanced platelet aggregation and activation under conditions of hypothermia Thrombosis and Haemostasis. 98(6), 1266-1275
• FOX, S.C, MAY, J.A and AND HEPTINSTALL, S., 2007. Measurement of endothelial microparticles in blood is impaired if chylomicrons are present after a fatty meal. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-526
• MAY, J.A, FOX, S.C, HEPTINSTALL, S and AND KWIK-URIBE, C., 2007. Effects of a flavanol-rich cocoa beverage on platelet and leucocyte function in man. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-T-685
• XAVIER, R, WHITE, A, FOX, S and AND HEPTINSTALL, S., 2007. Platelet aggregation is enhanced under conditions of hypothermia. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-320
• STOREY, R.F, HUSTED, S, HARRINGTON, R.A, HEPTINSTALL, S, WILCOX, R.G, PETERS, G, WICKENS, M, EMANUELSSON, H, GURBEL, P, GRANDE, P and AND CANNON, C.P., 2007. Inhibition of Platelet Aggregation by AZD6140, A Reversible Oral P2Y12 Receptor Antagonist, Compared with Clopidogrel in Patients with Acute Coronary Syndromes. Journal of the American College of Cardiology. 50(19), 1852-1856 (In Press.)
• WIJEYERATNE, Y.D, WHITE, A.E, RALEVIC, V and AND HEPTINSTALL, S., 2007. Comparison of the effects of the P2Y14 receptor agonist UDP-glucose and the EP3 receptor agonist sulprostone on platelet function. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-W-280
• XAVIER RG, WHITE AE, FOX SC, WILCOX RG and HEPTINSTALL S, 2007. Enhanced platelet aggregation and activation under conditions of hypothermia. Thrombosis and haemostasis. 98(6), 1266-75
• WIRE, R, MAY, J.A, HEPTINSTALL, S, CHEN, D, LU,Y and AND ZHAO, L., 2007. Heteroclitin D, A component of plants of the Kadsura species inhibits paf-induced platelet aggregation, P-selectin expression and platelet-leucocyte conjugate formation. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-344
• DOVLATOVA, N.L, JAKUBOWSKI, J.A, SUGIDACHI, A and AND HEPTINSTALL, S., 2007. Competition between reversible and irreversible P2Y12 antagonists and its influence on ADP-mediated platelet activation. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-340
• STOREY, R., HARRINGTON, R, A., HUSTED, S., HEPTINSTALL, S., WILCOX, R., GURBEL, A., GRANDE, P., WICKENS, M., PETERS, G., EMANUELSSON, H. and CANNON, C., 2007. AZD6140 Suppresses Platelet Aggregation in Clopidogrel-Treated Patients Even in Those With High Aggregation Levels JACC. 49(9 (Supplement A)),
• HEPTINSTALL, S, ANDERS, R, GURNEY, M, HERMANN, D and AND HARTMAN, D., 2007. EP3 receptors - a new target for inhibition of platelet aggregation and platelet-leucocyte conjugate formation. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-W-273
• HEPTINSTALL, S, ANDERS, R, GURNEY, M, HERMANN, D and AND HARTMAN, D., 2007. EP3 Receptors: A new target for inhibition of platelet function in inflammatory thrombotic disease. Arteriosclerosis Thrombosis and Vascular Biology. 27(e109),
• STOREY RF, HUSTED S, HARRINGTON RA, HEPTINSTALL S, WILCOX RG, PETERS G, WICKENS M, EMANUELSSON H, GURBEL P, GRANDE P and CANNON CP, 2007. Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromes. Journal of the American College of Cardiology. 50(19), 1852-6
• MANOLOPOULOS, P, IYU ESPINOSA, D, ANDERS, B, GURNEY, M, HERMANN, D, HARTMAN, D and AND HEPTINSTALL, S., 2007. Platelet EP3 receptors as targets for antithrombotic agents - comparison of DG-041 with aspirin and AR-C69931. Journal of Thrombosis and Haemostasis: JTH. 5(Supplement 2), P-S-345
• HEPTINSTALL, S., FOX, S., GLENN, J., JOHNSON, A., WHITE, A., HATZINOCOLAU, M., PINK, A., STAFFORD, N., BEHAN, M., DOLAN, G. and MYERS, B., 2006. Effects of blood leucocytes on platelet aggregation - a review of recent studies on leucocytes, adenine nucleotide metabolism and CD39 Seminars in Cardiology. 12(2), 43-54
• HEPTINSTALL, STAN, GLENN, JACQUELINE R, JOHNSON, ANDREW, MYERS, BETHAN, WHITE, ANN E and ZHAO, LIAN, 2006. Leukocytosis, vascular disease, and adenine nucleotide metabolism. Arteriosclerosis, Thrombosis, and Vascular Biology. 26(2), e22-3
• HEPTINSTALL S, MAY JA, FOX SC, KWIK-URIBE C and ZHAO L, 2006. Cocoa flavanols and platelet and leukocyte function: recent in vitro and ex vivo studies in healthy adults. Journal of cardiovascular pharmacology. 47 Suppl 2, S197-205; discussion S206-9
• ZHAO, LIAN, GRAY, LAURA, LEONARDI-BEE, JO, WEAVER, CHRIS S, HEPTINSTALL, STAN and BATH, PHILIP M W, 2006. Effect of aspirin, clopidogrel and dipyridamole on soluble markers of vascular function in normal volunteers and patients with prior ischaemic stroke. Platelets. 17(2), 100-4
• HUSTED, S., EMANUELSSON, H., HEPTINSTALL, S., SANDSET, P.M., WICKENS, M. and PETERS, G., 2006. Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y₁₂ antagonist AZD6140 with aspirin in patients with atherosclerosis: a double-blind comparison to clopidogrel with aspirin European Heart Journal. 27(9), 1038-1047
• HEPTINSTALL, S., FOX, S.C., GLENN, J.R., JOHNSON, A., WHITE, A.E., DOLAN, G. and MYERS, B., 2006. Blood leucocytes are mobile modulators of adenine metabolism and play an important role in determining the effects of adenine nucleotides on platelet function. Purinergic Signalling. 2, 137
• HEPTINSTALL, S., GLENN, J.R., JOHNSTON, A., WHITE, A. and MYERS, B., 2006. Leucocytes, leucocytosis and adenine nucleotide metabolism. Platelets. 17, 115
• HEPTINSTALL, S., MANOLOPOULOS, M., GLENN, J.R., FOX, S.C., MAY, J.A., DOVLATOVA, N., TANG, S-W., BAUER, N., HESSE, M., THOMAS, N.R. and RALEVIC, V., 2006. Acyl derivatives of coenzyme A inhibit ADP-induced platelet function via antagonism at P2Y1 and P2Y12 receptors. Purinergic Signalling. 2, 92-93
• STOREY R.F., HUSTED S, HARRINGTON R.A., HEPTINSTALL S., WILCOX R.G. and ET AL., 2006. AZD6140 Yields greater inhibition of platelet aggregation than clopidogrel in patients with acute coronary syndromes without previous clopidogrel treatment. In: 204 (A821)
• HEPTINSTALL, S, 2006. Variable therapeutic effectiveness of clopidogrel in acute coronary syndromes. Journal of Thrombosis and Haemostasis: JTH. 4(3), 539-41
• GLENN JR, WHITE AE, JOHNSON AJ, FOX SC, BEHAN MW, DOLAN G and HEPTINSTALL S, 2005. Leukocyte count and leukocyte ecto-nucleotidase are major determinants of the effects of adenosine triphosphate and adenosine diphosphate on platelet aggregation in human blood. Platelets. 16(3-4), 159-70
• STOREY RF, MAY JA and HEPTINSTALL S, 2005. Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin Thrombosis Research. VOL 115(NUMBER 4), 301-307
• BEHAN MW, FOX SC, HEPTINSTALL S and STOREY RF, 2005. Inhibitory effects of P2Y12 receptor antagonists on TRAP-induced platelet aggregation, procoagulant activity, microparticle formation and intracellular calcium responses in patients with acute coronary syndromes Platelets. 16(2), 73-80
• HEPTINSTALL, S., JOHNSON, A., GLENN, J.R. and WHITE, A.E., 2005. Adenine nucleotide metabolism in human blood - important roles for leukocytes and erythrocytes. Journal of Thrombosis and Haemostasis. 3(10), 2331-2339
• HEPTINSTALL,S., TANG,S., MANOLOPOULOS,P., FOX,S., MAY,J., GLENN,J. and RALEVIC,V., 2005. Derivatives of coenzymes A inhibit platelet aggregation via efects at P2Y1 and P2Y12 receptors. In: 20th Congress of the International Society on Thrombosis & Haemostasis. OR334
• ZHAO, L., SPRIGG, N., HEPTINSTALL, S. and BATH, P., 2005. Effects of granulocyte-colony stimulating factor on platelets and leukocyte function in whole blood in vitro. In: International Society of Thrombosis & Haemostasis. P02373
• FOX, S.C., MANOLOPOULOS, P., MAY, J.A. and HEPTINSTALL, S., 2005. Platelet aggregation, microparticle formation and platelet-leukocyte conjugate formation induced by combinations of 5-HT and epinephrine are inhibited by Sarpogrelate and BP-984 In: International Society Thrombosis & Haemostasis, Sydney, Australia. PO2149
• MAY, J., ZHAO, L. and HEPTINSTALL, S., 2005. Dietary flavanols - Effects on platelets and leukocytes. In: International Society of Thrombosis & Haemostasis. PO953
• BATH, P.M.W., ZHAO, L. and HEPTINSTALL, S., 2005. Current status of stroke prevention in patients with atrial fibrillation European Heart Journal supplements. 7(Supplement C), C12-18
• MANOLOPOULOS, P., FOX, S.C. and HEPTINSTALL, S., 2005. Involvement of P2Y1 and P2Y12 receptors in platelet responses to adenosine diphosphate and thrombin receptor activating peptide. In: International Society of Thrombosis & Haemostasis, Sydney 2005. PO1498
• STOREY, ROBERT F, MAY, JANE A and HEPTINSTALL, STAN, 2005. Potentiation of platelet aggregation by heparin in human whole blood is attenuated by P2Y12 and P2Y1 antagonists but not aspirin. Thrombosis Research. 115(4), 301-7
• HEPTINSTALL, S., 2005. The recent history of platelets in thrombosis and other disorders.. In: Wellcome Witnesses to the Twentieth Century Medicine 23.
• FOX, S.C., BEHAN, M.W.H and HEPTINSTALL, S., 2004. Inhibition of ADP-induced intracellular Ca²⁺ responses and platelet aggregation by the P2Y₁₂ receptor antagonists AR-C69931MX and clopidogrel is enhanced by prostaglandin E₁ Cell Calcium. 35(1), 39-46
• FOX SC, SASAE R, JANSON S, MAY JA and HEPTINSTALL S, 2004. Quantitation of platelet aggregation and microaggregate formation in whole blood by flow cytometry. Platelets. 15(2), 85-93
• HEPTINSTALL S, TANG SW, MANOLOPOULOS P, FOX SC, MAY J, GLENN J, RALEVIC V., 2004. N0204-003 inhibits ADP-induced platelet function via antagonism at P2Y1 and In: Platelets. 493
• FOX SC, SIEBERT D, MCMAHON A, MAY J, SPANGENBERG P, HEPTINSTALL S, 2004. Inhibitory effect of physical exercise on platelet aggregation in whole blood may be through In: Platelets. 490
• FOX SC, MAY JA, MANOLOPOULOS P, HEPTINSTALL S, 2004. P2Y1 and P2Y12 purinergic receptor involvement in platelet responses induced by collagen and TRAP In: Platelets. 364
• FOX SC, MAY JA, MANOLOPOULOS P, HEPTINSTALL S, 2004. P2Y1 and P2Y12 purinergic receptor involvement in platelet responses induced by collagen and TRAP In: Platelets. 364
• MANOLOPOULOS P, FOX SC, HEPTINSTALL S., 2004. Involvement of P2Y1 and P2Y12 purinergic receptors in platelet responses to the combination of Adenosine Diphosphate and Thrombin Receptor Activating Peptide In: Platelets. 502
• FOX SC, MANOLOPOULOS P, MAY J, HEPTINSTALL S, 2004. Studies on the effects of sarpogrelate and its active metabolite BP-984 on 5-HT-induced platelet activation In: Platelets. 490
• ZHAO, LIAN, BATH, PHILIP, LöSCHE, WOLFGANG and HEPTINSTALL, STAN, 2004. Platelet-monocyte interaction and GPIIb/IIIa blockade. Thrombosis and Haemostasis. 92(4), 888-90
• ZHAO, L., BATH, P.M., MAY, J., LOSCHE, W. and HEPTINSTALL, S., 2004. Correction. Platelets. 15, 63-63
• HEPTINSTALL, STAN, GLENN, JACKIE R, MAY, JANE A, STOREY, ROBERT F and WILCOX, ROBERT G, 2004. Clopidogrel resistance. Catheterization and Cardiovascular Interventions. 63(3), 397-8
• WILLMOT, MARK, ZHAO, LIAN, HEPTINSTALL, STAN and BATH, PHILIP, 2004. Triple antiplatelet therapy for secondary prevention of recurrent ischemic stroke. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association. 13(3), 138-40
• ZHAO, LIAN, BATH, PHILIP M W, MAY, JANE, LÃƑ¶SCHE, WOLFGANG and HEPTINSTALL, STAN, 2004. P-selectin, tissue factor and CD40 ligand expression on platelet-leucocyte conjugates in the presence of a GPIIb/IIIa antagonist. Platelets. 14(7-8), 473-80
• MAY, J. A. and HEPTINSTALL, S., 2004. Effects of Anticoagulants Used During Blood Collection on Human Platelet Function Methods in Molecular Biology. VOL 272, 3-12
• MAY, JANE A and HEPTINSTALL, STANLEY, 2004. Effects of anticoagulants used during blood collection on human platelet function. Methods in Molecular Biology. 272, 3-11
• ZHAO, L., BATH, P. M. W., FOX, S., MAY, J., JUDGE, H., LOSCHE, W. and HEPTINSTALL, S., 2003. The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions Current Medical Research and Opinion. VOL 19(PART 3), 178-186
• STAFFORD, N.P., PINK, A.E., WHITE, A.E., GLENN, J.R. and HEPTINSTALL, S., 2003. Mechanisms involved in adenosine triphosphate-induced platelet aggregation in whole blood. Arteriosclerosis, Thrombosis, and Vascular Biology. 23(10), 1928-1933
• EVANS, P.A., HEPTINSTALL, S., CROWHURST, E.C., DAVIES, T., GLENN, J.R., MADIRA, W., DAVIDSON, S.J., BURMAN, J.F., HOSKINSON, J. and STRAY, C.M., 2003. Prospective double-blind randomized study of the effects of four intravenous fluids on platelet function and hemostasis in elective hip surgery. Journal of Thrombosis and Haemostasis. 1(10), 2140-8
• ZHAO, LIAN, BATH, PHILIP M W, FOX, SUE, MAY, JANE, JUDGE, HEATHER, LÖSCHE, WOLFGANG and HEPTINSTALL, STAN, 2003. The effects of GPIIb-IIIa antagonists and a combination of three other antiplatelet agents on platelet-leukocyte interactions. Current Medical Research and Opinion. 19(3), 178-86
• EVANS, P A, CROWHURST, E C, GLENN, J A, DAVIES, T and HEPTINSTALL, S, 2003. Can the effects of clinical reperfusion fluids on platelet aggregation in vitro predict the effects of administration of such fluids in a clinical study ex vivo? Platelets. 14(4), 253-7
• FOX SC, JUDGE HM, ALLEN BR and HEPTINSTALL, S., 2002. Platelet aggregation and intracellular calcium mobilisation responses are enhanced by cyclosporin A but not by pimecrolimus (SDZ ASM 981) Platelets. 13(4), 213-218
• SCHOLZ, THOMAS, ZHAO, LIAN, TEMMLER, UTA, BATH, PHILIP, HEPTINSTALL, STAN and LöSCHE, WOLFGANG, 2002. The GPIIb/IIIa antagonist eptifibatide markedly potentiates platelet-leukocyte interaction and tissue factor expression following platelet activation in whole blood in vitro. Platelets. 13(7), 401-6
• STOREY, R. F., JUDGE, H. M., WILCOX, R. G. and HEPTINSTALL, S., 2002. Inhibition of ADP-induced P-selectin Expression and Platelet-Leukocyte Conjugate Formation by Clopidogrel and the P2Y~1~2 Receptor Antagonist AR-C69931MX but not Aspirin Thrombosis and Haemostasis. VOL 88(PART 3), 488-494
• STOREY, ROBERT F, WILCOX, ROBERT G and HEPTINSTALL, STAN, 2002. Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease. Platelets. 13(7), 407-13
• STOREY, R. F., WILCOX, R. G. and HEPTINSTALL, S., 2002. Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart disease Platelets. VOL 13(PART 7), 407-414
• SCHOLZ, THOMAS, TEMMLER, UTA, KRAUSE, SIEGFRIED, HEPTINSTALL, STAN and LöSCHE, WOLFGANG, 2002. Transfer of tissue factor from platelets to monocytes: role of platelet-derived microvesicles and CD62P. Thrombosis and Haemostasis. 88(6), 1033-8
• FOX, S. C., JUDGE, H. M., ALLEN, B. R. and HEPTINSTALL, S., 2002. Platelet aggregation and intracellular calcium mobilisation responses are enhanced by cyclosporin A but not by pimecrolimus (SDZ ASM 981) Platelets. VOL 13(PART 4), 213-218
• DAVIES, A R, JUDGE, H M, MAY, J A, GLENN, J R and HEPTINSTALL, S, 2002. Interactions of platelets with Synthocytes, a novel platelet substitute. Platelets. 13(4), 197-205
• STOREY, ROBERT F, JUDGE, HEATHER M, WILCOX, ROBERT G and HEPTINSTALL, STAN, 2002. Inhibition of ADP-induced P-selectin expression and platelet-leukocyte conjugate formation by clopidogrel and the P2Y12 receptor antagonist AR-C69931MX but not aspirin. Thrombosis and Haemostasis. 88(3), 488-94
• ZHAO, L, BATH, P and HEPTINSTALL, S, 2001. Effects of combining three different antiplatelet agents on platelets and leukocytes in whole blood in vitro. British Journal of Pharmacology. 134(2), 353-8
• STOREY, R. F., NEWBY, L. J. and HEPTINSTALL, S., 2001. Effects of P2Y~1 and P2Y~1~2 receptor antagonists on platelet aggregation induced by different agonists in human whole blood Platelets. VOL 12(PART 7), 443-447
• STOREY, R F, NEWBY, L J and HEPTINSTALL, S, 2001. Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole blood. Platelets. 12(7), 443-7
• STOREY, R F, SANDERSON, H M, WHITE, A E, MAY, J A, CAMERON, K E and HEPTINSTALL, S, 2000. The central role of the P(2T) receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity. British journal of haematology. 110(4), 925-34
• STOREY, R. F., SANDERSON, H. M., WHITE, A. E., MAY, J. A., CAMERON, K. E. and HEPTINSTALL, S., 2000. The central role of the P~2~T receptor in amplification of human platelet activation, aggregation, secretion and procoagulant activity British Journal of Haematology. VOL 110(PART 4), 925-934
• NATARAJAN, P, MAY, J A, SANDERSON, H M, ZABE, M, SPANGENBERG, P and HEPTINSTALL, S, 2000. Effects of cytochalasin H, a potent inhibitor of cytoskeletal reorganisation, on platelet function. Platelets. 11(8), 467-76
• STOREY, R F and HEPTINSTALL, S, 1999. Laboratory investigation of platelet function. Clinical and Laboratory Haematology. 21(5), 317-29
• COLE, A T, HUDSON, N, LIEW, L C, MURRAY, F E, HAWKEY, C J and HEPTINSTALL, S, 1999. Protection of human gastric mucosa against aspirin-enteric coating or dose reduction? Alimentary Pharmacology and Therapeutics. 13(2), 187-93
• TAYLOR, J E, PORTER, C, HEPTINSTALL, S, MCLAREN, M and BELCH, J J, 1999. Increased platelet activation in renal transplant patients. Platelets. 10(4), 223-7
• STOREY, R F, MAY, J A, WILCOX, R G and HEPTINSTALL, S, 1999. A whole blood assay of inhibition of platelet aggregation by glycoprotein IIb/IIIa antagonists: comparison with other aggregation methodologies. Thrombosis and haemostasis. 82(4), 1307-11
• BROWN, N, MAY, J A, WILCOX, R G, ALLAN, L M, WILSON, A M, KIFF, P S and HEPTINSTALL, S, 1999. Comparison of antiplatelet activity of microencapsulated aspirin 162.5 Mg (Caspac XL), with enteric coated aspirin 75 mg and 150 mg in patients with atherosclerosis. British Journal of Clinical Pharmacology. 48(1), 57-62
• STOREY, R. F., MAY, J. A., WILCOX, R. G. and HEPTINSTALL, S., 1999. A Whole Blood Assay of Inhibition of Platelet Aggregation by Glycoprotein IIb/IIIa Antagonists: Comparison with other Aggregation Methodologies Thrombosis and Haemostasis. VOL 82(NUMBER 4), 1307-1311
• PEIRCE, N S, FORSTER, C D, HEPTINSTALL, S and MACDONALD, I A, 1999. Unexpected changes in the catecholamine content of platelets and plasma during exercise. Platelets. 10(5), 312-8
• HEPTINSTALL S, WHITE AE, EDWARDS N, PASCOE J, SANDERSON HM, FOX SC and HENDERSON RA, 1998. Differential effects of three radiographic contrast media on platelet aggregation and degranulation: implications for clinical practice? British Journal of Haematology. 103(4), 1023-30
• LOWE,K.C., EDWARDS,C.M. and HEPTINSTALL,S., 1998. Anti-thrombotic effects of Pluronic^® F-68 in human whole blood in vitro Experimental Biology Online. 3(Supplement 1998 SEB Annual Meeting Abstracts of papers - York 22-27 March), A6.19
• STOREY, R F, WILCOX, R G and HEPTINSTALL, S, 1998. Differential effects of glycoprotein IIb/IIIa antagonists on platelet microaggregate and macroaggregate formation and effect of anticoagulant on antagonist potency. Implications for assay methodology and comparison of different antagonists. Circulation (Baltimore). 98(16), 1616-21
• SANDERSON, H M, FOX, S C, ROBBINS, R A, LÖSCHE, W, SPANGENBERG, P and HEPTINSTALL, S, 1998. Role of GPIIb-IIIa in platelet-monocyte and platelet-neutrophil conjugate formation in whole blood. Platelets. 9(3-4), 245-50
• GLENN, J R and HEPTINSTALL, S, 1998. Evidence that adenosine diphosphate can activate adenylate cyclase via conversion to adenosine in platelet-rich plasma containing magnesium. Thrombosis and Haemostasis. 80(2), 321-5
• LÖSCHE, W, REDLICH, H, KRAUSE, S, HEPTINSTALL, S and SPANGENBERG, P, 1998. Activation of leukocytes in whole blood samples by N-formyl-methionyl-leucyl-phenylalanine (FMLP) enhances platelet aggregability but not platelet P-selectin exposure and adhesion to leukocytes. Platelets. 9(3-4), 219-21
• VICKERS, J, LÖSCHE, W, DÖPEL, E, HEPTINSTALL, S, STEIN, G and SPANGENBERG, P, 1998. Measurement of platelet activation and adhesion to leukocytes during haemodialysis. Platelets. 9(3-4), 261-4
• MAY, J A, RATAN, H, GLENN, J R, LÖSCHE, W, SPANGENBERG, P and HEPTINSTALL, S, 1998. GPIIb-IIIa antagonists cause rapid disaggregation of platelets pre-treated with cytochalasin D. Evidence that the stability of platelet aggregates depends on normal cytoskeletal assembly. Platelets. 9(3-4), 227-32
• EDWARDS, C M, HEPTINSTALL, S and LOWE, K C, 1998. Pluronic F-68 inhibits agonist-induced platelet aggregation in human whole blood in vitro. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 26(5-6), 441-7
• EVANS, P A, GLENN, J R, HEPTINSTALL, S and MADIRA, W, 1998. Effects of gelatin-based resuscitation fluids on platelet aggregation. British Journal of Anaesthesia. 81(2), 198-202
• EDWARDS, C M, HEPTINSTALL, S and LOWE, K C, 1997. Effects of the co-polymer surfactant, Pluronic F-68, on platelet aggregation in human whole blood. Artificial Cells, Blood Substitutes, and Immobilization Biotechnology. 25(5), 493-9
• EDWARDS, C M, LOWE, K C, HEPTINSTALL, S, LUCAS, P, TRABELSI, H and CAMBON, A, 1997. Novel fluoro-surfactants for perfluorochemical emulsification. Effects on aggregation of human platelets in vitro and possible applications as anti-thrombotic agents. Advances in Experimental Medicine and Biology. 428, 489-93
• REDLICH, H, VICKERS, J, LÖSCHE, W, HEPTINSTALL, S, KEHREL, B and SPANGENBERG, P, 1997. Formation of platelet-leukocyte conjugates in whole blood. Platelets. 8(6), 419-25
• EVANS, P A, MADIRA, W, RIYATT, M S, ERRINGTON, M and HEPTINSTALL, S, 1997. Changes in plasma ionised calcium within 24 hours of trauma in patients infused with the calcium containing colloid Haemaccel during fluid resuscitation. Journal of Accident and Emergency Medicine. 14(2), 73-5
• MAY JA, HEPTINSTALL S, COLE AT and HAWKEY CJ, 1997. Platelet responses to several agonists and combinations of agonists in whole blood: a placebo controlled comparison of the effects of a once daily dose of plain aspirin 300 mg, plain aspirin 75 mg and enteric coated aspirin 300 mg, in man. Thrombosis research. 88(2), 183-92
• YUSUF, S W, SANDERSON, H, HEPTINSTALL, S, NURDEN, A T, WENHAM, P W and HOPKINSON, B R, 1996. ADP-induced P-selectin expression on platelets as a predictor of successful thrombolysis. Blood Coagulation and Fibrinolysis. 7(2), 266-9
• EDWARDS, C M, MAY, J A, HEPTINSTALL, S and LOWE, K C, 1996. Effects of pluronic F-68 (poloxamer 188) on platelet aggregation in human whole blood. Thrombosis Research. 81(4), 511-2
• MAY, J. A., HEPTINSTALL, S. and SPANGENBERG, P., 1996. Changes in the composition of the platelet cytoskeleton in response to ADP: effects of MK-852 and ARL 66096 Blood Coagulation and Fibrinolysis. VOL 7(NUMBER SUP//2), 221-224
• HORN, E H, HARDY, E, COOPER, J, HEPTINSTALL, S and RUBIN, P C, 1996. Platelet reactivity in vitro in relation to thromboxane in healthy pregnancy. Thrombosis and Haemostasis. 75(2), 346-51
• SANDERSON, H M, HEPTINSTALL, S, VICKERS, J and LöSCHE, W, 1996. Studies on the effects of agonists and antagonists on platelet shape change and platelet aggregation in whole blood. Blood Coagulation and Fibrinolysis. 7(2), 245-8
• LöSCHE, W, DRESSEL, M, KRAUSE, S, REDLICH, H, SPANGENBERG, P and HEPTINSTALL, S, 1996. Contact-induced modulation of neutrophil elastase secretion and phagocytic activity by platelets. Blood Coagulation and Fibrinolysis. 7(2), 210-3
• MAY JA, HEPTINSTALL S and SPANGENBERG P, 1996. Changes in the composition of the platelet cytoskeleton in response to adp: effects of mk-852 and arl 66096. Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis. 7(2), 221-4
• GLENN JR, SPANGENBERG P and HEPTINSTALL S, 1996. Actin polymerization and depolymerization in relation to platelet shape change, aggregation and disaggregation. Platelets. 7(1-2), 23-7
• HEPTINSTALL S, 1996. Efficacy of dipyridamole as prophylaxis for stroke and the added value of dipyridamole in combination with aspirin. Platelets. 7(1-2), 7-8
• MAY JA, GLENN JR, SPANGENBERG P and HEPTINSTALL S, 1996. The composition of the platelet cytoskeleton following activation by adp: effects of various agents that modulate platelet function. Platelets. 7(3), 159-68
• HEPTINSTALL, S, GLENN, J R, LöSCHE, W and SPANGENBERG, P, 1995. ADP-induced platelet aggregation and actin polymerization. Involvement of GpIIb/IIIa and the effect of Mg2+. Seminars in thrombosis and hemostasis.. 21(2), 137-45
• ARMSTRONG, R, MAY, J A, LöSCHE, W and HEPTINSTALL, S, 1995. Factors that contribute to spontaneous platelet aggregation and streptokinase-induced aggregation in whole blood. Thrombosis and Haemostasis. 73(2), 297-303
• HEPTINSTALL, S, MAY, J A, GLENN, J R, SANDERSON, H M, DICKINSON, J P and WILCOX, R G, 1995. Effects of ticlopidine administered to healthy volunteers on platelet function in whole blood. Thrombosis and Haemostasis. 74(5), 1310-5
• HORN, E. H., COOPER, J. A., HARDY, E. and HEPTINSTALL, S., 1995. Longitudinal studies of platelet cyclic AMP during healthy pregnancy and pregnancies at risk of pre-eclampsia Clinical Science. VOL 89(NUMBER 1), 91
• HORN EH, COOPER JA, HARDY E, HEPTINSTALL S and RUBIN PC, 1995. Longitudinal studies of platelet cyclic amp during healthy pregnancy and pregnancies at risk of pre-eclampsia. Clinical science (london, england : 1979). 89(1), 91-9
• HARDY E, HEPTINSTALL S, RUBIN PC and HORN EH, 1995. Original article: effects of raised extracellular magnesium on platelet reactivity. Platelets. 6(6), 346-53
• HARDY E, GLENN J, HEPTINSTALL S, RUBIN PC and HORN EH, 1995. Magnesium modifies the responses of platelets to inhibitory agents which act via cAMP. Thrombosis and haemostasis. 74(4), 1132-7
• LOUDEN KA, BROUGHTON PIPKIN F, HEPTINSTALL S, FOX SC, TUOHY P, O'CALLAGHAN C, MITCHELL JR and SYMONDS EM, 1994. Neonatal platelet reactivity and serum thromboxane B2 production in whole blood: the effect of maternal low dose aspirin. British Journal of Obstetrics and Gynaecology. 101(3), 203-8
• ANDREWS, R, MAY, J A, VICKERS, J and HEPTINSTALL, S, 1994. Inhibition of platelet aggregation by transdermal glyceryl trinitrate. British Heart Journal. 72(6), 575-9
• HEPTINSTALL S, 1994. Antiplatelet therapy and vascular disease. Platelets. 5(1), 1-2
• FOX SC, KILBY MD, SANDERSON HM and HEPTINSTALL S, 1994. Investigations on spontaneous aggregation and platelet responses to streptokinase and to adrenaline during pregnancy. Platelets. 5(3), 139-44
• GLENN J, SPANGENBERG P and HEPTINSTALL S, 1994. Platelet-platelet contact and thromboxane a(2) contribute to actin polymerization in platelets stimulated with adp. Platelets. 5(2), 84-9
• LONSDALE, R. J., HEPTINSTALL, S., WESTBY, J. C. and BERRIDGE, D. C., 1993. A Study of the Use of the Thromboxane A~2 Antagonist, Sulotroban, in Combination with Streptokinase for Local Thrombolysis in Patients with Recent Peripheral Arterial Occlusions: Clinical Effects, Platelet Function and Fibrinolytic Parameters Thrombosis and Haemostasis. VOL 69(NUMBER 2), 103
• LONSDALE RJ, HEPTINSTALL S, WESTBY JC, BERRIDGE DC, WENHAM PW, HOPKINSON BR and MAKIN GS, 1993. A study of the use of the thromboxane a2 antagonist, sulotroban, in combination with streptokinase for local thrombolysis in patients with recent peripheral arterial occlusions: clinical effects, platelet function and fibrinolytic parameters. Thrombosis and haemostasis. 69(2), 103-11, 123
• GROENEWEGEN, W A, KNIGHT, D W and HEPTINSTALL, S, 1992. Progress in the medicinal chemistry of the herb feverfew. Progress in medicinal chemistry.. 29, 217-38
• MARLES, R J, KAMINSKI, J, ARNASON, J T, PAZOS-SANOU, L, HEPTINSTALL, S, FISCHER, N H, CROMPTON, C W, KINDACK, D G and AWANG, D V, 1992. A bioassay for inhibition of serotonin release from bovine platelets. Journal of natural products.. 55(8), 1044-56
• HEPTINSTALL, S, GLENN, J and SPANGENBERG, P, 1992. Changes in G-actin after platelet activation in platelet rich plasma. Thrombosis and Haemostasis. 68(6), 727-30
• LOUDEN, K A, BROUGHTON PIPKIN, F, SYMONDS, E M, TUOHY, P, O'CALLAGHAN, C, HEPTINSTALL, S, FOX, S and MITCHELL, J R, 1992. A randomized placebo-controlled study of the effect of low dose aspirin on platelet reactivity and serum thromboxane B2 production in non-pregnant women, in normal pregnancy, and in gestational hypertension. British Journal of Obstetrics and Gynaecology. 99(5), 371-6
• HEPTINSTALL, S, AWANG, D V, DAWSON, B A, KINDACK, D, KNIGHT, D W and MAY, J, 1992. Parthenolide content and bioactivity of feverfew (Tanacetum parthenium (L.) Schultz-Bip.). Estimation of commercial and authenticated feverfew products. Journal of Pharmacy and Pharmacology. 44(5), 391-5
• LOUDEN KA, BROUGHTON PIPKIN F, HEPTINSTALL S, FOX SC, MITCHELL JR and SYMONDS EM, 1991. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. British Journal of Obstetrics and Gynaecology. 98(12), 1239-44
• LöSCHE, W, VICKERS, J, MAY, J and HEPTINSTALL, S, 1991. The platelet aggregating activity of 2,3-diphosphoglycerate may be caused by ADP impurity. Thrombosis Research. 61(2), 175-7
• GRAY, S J and HEPTINSTALL, S, 1991. Interactions between prostaglandin E2 and inhibitors of platelet aggregation which act through cyclic AMP. European Journal of Pharmacology. 194(1), 63-70
• SPANGENBERG, P, HEPTINSTALL, S, CRAWFORD, J and TILL, U, 1991. Measurements of the G-/F-actin equilibrium in ADP-stimulated human platelets. Acta histochemica. Supplementband.. 41, 181-6
• HORN, E H, COOPER, J, HARDY, E, HEPTINSTALL, S and RUBIN, P C, 1991. A cross-sectional study of platelet cyclic AMP in healthy and hypertensive pregnant women. Clinical Science. 80(6), 549-58
• LOUDEN KA, BROUGHTON PIPKIN F, HEPTINSTALL S, FOX SC, MITCHELL JR and SYMONDS EM, 1990. A longitudinal study of platelet behaviour and thromboxane production in whole blood in normal pregnancy and the puerperium. British Journal of Obstetrics and Gynaecology. 97(12), 1108-14
• MAY, J, LOESCHE, W and HEPTINSTALL, S, 1990. Glucose increases spontaneous platelet aggregation in whole blood. Thrombosis Research. 59(3), 489-95
• KILBY, M D, BROUGHTON PIPKIN, F, COCKBILL, S, HEPTINSTALL, S and SYMONDS, E M, 1990. A cross-sectional study of basal platelet intracellular free calcium concentration in normotensive and hypertensive primigravid pregnancies. Clinical Science. 78(1), 75-80
• GROENEWEGEN, W A and HEPTINSTALL, S, 1990. A comparison of the effects of an extract of feverfew and parthenolide, a component of feverfew, on human platelet activity in-vitro. Journal of Pharmacy and Pharmacology. 42(8), 553-7
• KRAUSE, S, ARESE, P, HEPTINSTALL, S and LöSCHE, W, 1990. Influence of substances affecting cell sulfhydryl/disulfide status on adherence of human monocytes. Arzneimittel-Forschung.. 40(6), 689-92
• PATTRICK, M, HEPTINSTALL, S and DOHERTY, M, 1989. Feverfew in rheumatoid arthritis: a double blind, placebo controlled study. Annals of the Rheumatic Diseases. 48(7), 547-9
• GLUSA, E, BEVAN, J and HEPTINSTALL, S, 1989. Verapamil is a potent inhibitor of 5-HT-induced platelet aggregation. Thrombosis Research. 55(2), 239-245
• TILL, U, BERGMANN, I, BREDDIN, K, HEPTINSTALL, S, LöSCHE, W, MAZUROV, A and PESCARMONA, G, 1989. Sulfhydryl/disulfide-status of blood platelets--a target for pharmacological intervention? Progress in clinical and biological research.. 301, 341-5
• LöSCHE, W, MICHEL, E, LULL, K, KREUTZFELD, B, HEPTINSTALL, S and TILL, U, 1989. [The effect of high glucose concentrations on the osmotic and mechanical resistance of human erythrocytes] Zeitschrift für medizinische Laboratoriumsdiagnostik.. 30(2), 124-7
• KRAUSE, S, MICHEL, E, BRACHMANN, P, LöSCHE, W, HEPTINSTALL, S and TILL, U, 1989. [Cellular chemiluminescence of activated phagocytes of whole blood] Folia haematologica (Leipzig, Germany : 1928). 116(6), 955-65
• HEPTINSTALL, S, COCKBILL, S R, BURGESS-WILSON, M E and JONES, E W, 1988. Studies on platelets before and after stroke in a patient with essential thrombocythaemia. British medical journal (Clinical research ed.). 296(6632), 1298-9
• COCKBILL, S R, BURMESTER, H B and HEPTINSTALL, S, 1988. Pseudo grey platelet syndrome--grey platelets due to degranulation in blood collected into EDTA. European Journal of Haematology. 41(4), 326-33
• LOESCHE, W, MAZUROV, A V, VOYNO-YASENETSKAYA, T A, GROENEWEGEN, W A, HEPTINSTALL, S and REPIN, V S, 1988. Feverfew--an antithrombotic drug? Folia haematologica (Leipzig, Germany : 1928). 115(1-2), 181-4
• LOESCHE, W, GROENEWEGEN, W A, KRAUSE, S, SPANGENBERG, P and HEPTINSTALL, S, 1988. Effects of an extract of feverfew (Tanacetum parthenium) on arachidonic acid metabolism in human blood platelets. Biomedica biochimica acta.. 47(10-11), S241-3
• VOYNO-YASENETSKAYA, T A, LOESCHE, W, GROENEWEGEN, W A, HEPTINSTALL, S, REPIN, V S and TILL, U, 1988. Effects of an extract of feverfew on endothelial cell integrity and on cAMP in rabbit perfused aorta. Journal of Pharmacy and Pharmacology. 40(7), 501-2
• MURPHY, J J, HEPTINSTALL, S and MITCHELL, J R, 1988. Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet. 2(8604), 189-92
• HEPTINSTALL, S, GROENEWEGEN, W A, SPANGENBERG, P and LöSCHE, W, 1988. Inhibition of platelet behaviour by feverfew: a mechanism of action involving sulphydryl groups. Folia haematologica (Leipzig, Germany : 1928). 115(4), 447-9
• LöSCHE, W, BEVAN, J, MICHEL, E, HEPTINSTALL, S and TILL, U, 1988. [Effect of high glucose concentrations on spontaneous aggregation of human blood platelets] Zeitschrift für medizinische Laboratoriumsdiagnostik.. 29(1), 55-8
• HEPTINSTALL, S and BEVAN, J, 1988. How can we inhibit 5-HT-induced platelet aggregation and why should we bother? Folia haematologica (Leipzig, Germany : 1928). 115(4), 475-8
• JOHNSTON, G.I. and HEPTINSTALL, S., 1988. Identity of saturable calcium-binding sites on blood platelets and their involvement in platelet aggregation. Thrombosis and Haemostasis. 59, 54-61
• LöSCHE, W, MICHEL, E, HEPTINSTALL, S, KRAUSE, S, GROENEWEGEN, W A, PESCARMONA, G P and THIELMANN, K, 1988. Inhibition of the behaviour of human polynuclear leukocytes by an extract of Chrysanthemum parthenium. Planta medica.. 54(5), 381-4
• HEPTINSTALL, S, 1988. Feverfew--an ancient remedy for modern times? Journal of The Royal Society of Medicine. 81(7), 373-4
• BURGESS-WILSON, M E, COCKBILL, S R, JOHNSTON, G I and HEPTINSTALL, S, 1987. Platelet aggregation in whole blood from patients with Glanzmann's thrombasthenia. Blood. 69(1), 38-42
• HEPTINSTALL, S, GROENEWEGEN, W A, SPANGENBERG, P and LOESCHE, W, 1987. Extracts of feverfew may inhibit platelet behaviour via neutralization of sulphydryl groups. Journal of Pharmacy and Pharmacology. 39(6), 459-65
• HEPTINSTALL, S, 1987. Haematology, ethnography, and thrombosis. British medical journal (Clinical research ed.). 294(6563), 3-4
• BURGESS-WILSON, M.E., COCKBILL, S.R., JOHNSTON, G.I. and HEPTINSTALL, S., 1987. Platelet aggregation in whole blood from patients with Glanzmann's thrombasthenia. Blood. 69, 38-42
• LöSCHE, W, MAZUROV, A V, HEPTINSTALL, S, GROENEWEGEN, W A, REPIN, V S and TILL, U, 1987. An extract of feverfew inhibits interactions of human platelets with collagen substrates. Thrombosis Research. 48(5), 511-8
• MAURICE, P D, ALLEN, B R, HEPTINSTALL, S and BATHER, P C, 1986. Arachidonic acid metabolism by peripheral blood cells in psoriasis. British Journal of Dermatology. 114(5), 553-66
• BEVAN, J and HEPTINSTALL, S, 1986. Effects of combinations of 5-hydroxytryptamine receptor antagonists on 5-HT-induced human platelet aggregation. Naunyn-Schmiedeberg's Archives of Pharmacology. 334(4), 341-5
• BURGESS-WILSON, M E, MORRISON, R and HEPTINSTALL, S, 1986. Spontaneous platelet aggregation in heparinised blood during pregnancy. Thrombosis Research. 41(3), 385-93
• SILLS, T, COWLEY, A J and HEPTINSTALL, S, 1986. Aspirin and dazoxiben as inhibitors of platelet behaviour: modification of their effects by agents that alter cAMP production. Thrombosis Research. 42(1), 91-8
• SILLS, T and HEPTINSTALL, S, 1986. Effects of a thromboxane synthetase inhibitor and a cAMP phosphodiesterase inhibitor, singly and in combination, on platelet behaviour. Thrombosis and Haemostasis. 55(3), 305-8
• PEACOCK, I, HAWKINS, M and HEPTINSTALL, S, 1986. Platelet behaviour in non-insulin-dependent diabetes--influence of vascular complications, treatment and metabolic control. Thrombosis and Haemostasis. 55(3), 361-5
• GROENEWEGEN, W A, KNIGHT, D W and HEPTINSTALL, S, 1986. Compounds extracted from feverfew that have anti-secretory activity contain an alpha-methylene butyrolactone unit. Journal of Pharmacy and Pharmacology. 38(9), 709-12
• HEPTINSTALL, S, FOX, S, CRAWFORD, J and HAWKINS, M, 1986. Inhibition of platelet aggregation in whole blood by dipyridamole and aspirin. Thrombosis Research. 42(2), 215-23
• GROENEWEGEN, W A and HEPTINSTALL, S, 1986. Amounts of feverfew in commercial preparations of the herb. Lancet. 1(8471), 44-5
• BEVAN, J and HEPTINSTALL, S, 1985. Serotonin-induced platelet aggregation in whole blood and the effects of ketanserin and mepyramine. Thrombosis Research. 38(2), 189-94
• MORRISON, R, CRAWFORD, J, MACPHERSON, M and HEPTINSTALL, S, 1985. Platelet behaviour in normal pregnancy, pregnancy complicated by essential hypertension and pregnancy-induced hypertension. Thrombosis and Haemostasis. 54(3), 607-11
• HEPTINSTALL, S, WHITE, A, WILLIAMSON, L and MITCHELL, J R, 1985. Extracts of feverfew inhibit granule secretion in blood platelets and polymorphonuclear leucocytes. Lancet. 1(8437), 1071-4
• COWLEY, A J, JONES, E W, CARTER, A J, HANLEY, S P and HEPTINSTALL, S, 1985. The effects of dazoxiben, an inhibitor of thromboxane synthetase, on cold-induced forearm vasoconstriction and platelet behaviour in different individuals. British Journal of Clinical Pharmacology. 19(1), 1-8
• ANDREWS, N P, BROUGHTON PIPKIN, F and HEPTINSTALL, S, 1985. Blood platelet behaviour in mothers and neonates. Thrombosis and Haemostasis. 53(3), 428-32
• CARTER, A J and HEPTINSTALL, S, 1985. Platelet aggregation in whole blood: the role of thromboxane A2 and adenosine diphosphate. Thrombosis and Haemostasis. 54(3), 612-6
• GRAY, S J and HEPTINSTALL, S, 1985. The effects of PGE2 and CL 115,347, an antihypertensive PGE2 analogue, on human blood platelet behaviour and vascular contractility. European Journal of Pharmacology. 114(2), 129-37
• JOHNSTON, G I, HEPTINSTALL, S and LöSCHE, W, 1985. Effects of diamide and iodoacetamide on the expression of the glycoprotein IIb/IIIa complex on blood platelets. Biochemical and Biophysical Research Communications. 127(3), 822-7
• COWLEY, A J, HEPTINSTALL, S and MITCHELL, J R, 1985. Similarity between platelet and blood-vessel reactivity. Lancet. 2(8447), 154-5
• LöSCHE, W, BURGESS-WILSON, M, MICHEL, E, HEPTINSTALL, S and TILL, U, 1985. Diamide induces reversible aggregation of human blood platelets. Thrombosis Research. 40(6), 869-74
• COWLEY, A J, HEPTINSTALL, S and HAMPTON, J R, 1985. Effects of prostacyclin and of the stable prostacyclin analogue ZK 36374 on forearm blood flow and blood platelet behaviour in man. Thrombosis and Haemostasis. 53(1), 90-4
• JOHNSTON, G I, HEPTINSTALL, S, ROBINS, R A and PRICE, M R, 1984. The expression of glycoproteins on single blood platelets from healthy individuals and from patients with congenital bleeding disorders. Biochemical and Biophysical Research Communications. 123(3), 1091-8
• COWLEY, A J, STAINER, K, COCKBILL, S and HEPTINSTALL, S, 1984. Correlation between platelet behaviour and cold-induced vasoconstriction in man, and the effects of epoprostenol infusion. Clinical Science. 67(5), 511-4
• HEPTINSTALL, S, 1984. Properties of blood platelets that may be relevant to atherogenesis. VASA. Zeitschrift für Gefässkrankheiten. Journal for vascular diseases.. 13(4), 343-9
• BURGESS-WILSON, M E, GREEN, S, HEPTINSTALL, S and MITCHELL, J R, 1984. Spontaneous platelet aggregation in whole blood: dependence on age and haematocrit. Lancet. 2(8413), 1213
• HEPTINSTALL S and FOX SC, 1983. Human blood platelet behaviour after inhibition of thromboxane synthetase. British Journal of Clinical Pharmacology. 15 Suppl 1, 31S-37S
• JONES, E W, COCKBILL, S R, COWLEY, A J, HANLEY, S P and HEPTINSTALL, S, 1983. Effects of dazoxiben and low-dose aspirin on platelet behaviour in man. British Journal of Clinical Pharmacology. 15 Suppl 1, 39S-44S
• BEVAN, J and HEPTINSTALL, S, 1983. Effects of ketanserin and mepyramine on platelet aggregation and on the uptake of 5-hydroxytryptamine into platelets. Thrombosis Research. 30(5), 415-23
• MULLEY, G P, HEPTINSTALL, S, TAYLOR, P M and MITCHELL, J R, 1983. ADP-induced platelet release reaction in acute stroke. Thrombosis and Haemostasis. 50(2), 524-6
• BILLETT, E, HANLEY, S, HEPTINSTALL, S and MAYER, R J, 1983. Monoamine oxidase activity in diabetes. Diabetes. 32(2), 130-3
• FOX SC, BURGESS-WILSON M, HEPTINSTALL S and MITCHELL JR, 1982. Platelet aggregation in whole blood determined using the Ultra-Flo 100 Platelet Counter. Thrombosis and Haemostasis. 48(3), 327-9
• HANLEY, S P, BEVAN, J, COCKBILL, S R and HEPTINSTALL, S, 1982. A regimen for low-dose aspirin? British medical journal (Clinical research ed.). 285(6351), 1299-302
• BURNHAM, W R, HEPTINSTALL, S, COCKBILL, S R and HARRISON, S, 1982. Blood platelet behaviour during infusion of an Intralipid-based intravenous feeding mixture. Postgraduate Medical Journal. 58(677), 152-5
• HANLEY, S P, BEVAN, J, COCKBILL, S R and HEPTINSTALL, S, 1981. Differential inhibition by low-dose aspirin of human venous prostacyclin synthesis and platelet thromboxane synthesis. Lancet. 1(8227), 969-71
• HEPTINSTALL, S, BEVAN, J, COCKBILL, S R, HANLEY, S P and PARRY, M J, 1980. Effects of a selective inhibitor of thromboxane synthetase on human blood platelet behaviour. Thrombosis Research. 20(2), 219-30
• HEPTINSTALL, S, MULLEY, G P, TAYLOR, P M and MITCHELL, J R, 1980. Platelet-release reaction in myocardial infarction. British medical journal.. 280(6207), 80-1
• TAYLOR, P M and HEPTINSTALL, S, 1980. The abilities of human blood platelets to bind extracellular calcium and to be aggregated by adenosine diphosphate are related. British Journal of Haematology. 46(1), 115-22
• HEPTINSTALL, S, 1980. Platelet behaviour and vascular disease. Artery.. 8(5), 448-56
• COCKBILL, S.R., HEPTINSTALL, S. and TAYLOR, P.M., 1979. A comparison of the abilities of acetylsalicylic acid, flurbiprofen and indomethacin to inhibit the release reaction and prostaglandin synthesis in human blood platelets. British Journal of Pharmacology. 67, 73-78
• HEPTINSTALL, S and TAYLOR, P M, 1979. The effects of citrate and extracellular calcium ions on the platelet release reaction induced by adenosine diphosphate and collagen. Thrombosis and Haemostasis. 42(2), 778-93
• COCKBILL, S R and HEPTINSTALL, S, 1978. A method for estimating prostaglandin synthetase activity in blood platelets and the extent of its pharmacological inhibition [proceedings] Journal of Physiology. 276, 15P-16P
• HEPTINSTALL, S and TAYLOR, P M, 1978. The influence of anticoagulants and extracellular divalent cations on blood platelet behaviour [proceedings] Journal of Physiology. 276, 25P-26P
• WHITE, A M and HEPTINSTALL, S, 1978. Contribution of platelets to thrombus formation. British Medical Bulletin. 34(2), 123-8
• TAYLOR, P M and HEPTINSTALL, S, 1978. Cyclic nucleotide phosphodiesterase activity and the platelet release reaction. Thrombosis and Haemostasis. 39(2), 550-1
• HEPTINSTALL, S and MULLEY, G P, 1977. Adenosine diphosphate induced platelet aggregation and release reaction in heparinized platelet rich plasma and the influence of added citrate. British Journal of Haematology. 36(4), 565-71
• HEPTINSTALL, S., 1976. The use of a chelating ion-exchange resin to evaluate the effects of the extracellular calcium concentration on adenosine diphosphate induced aggregation of human blood platelets. Thrombosis and Haemostasis. 36, 208-220
• ADAMS, J, HEPTINSTALL, S and MITCHELL, J R, 1975. A six-channel automated platelet aggregometer. Thrombosis et diathesis haemorrhagica.. 34(3), 821-4
• ARCHIBALD, A R, BADDILEY, J and HEPTINSTALL, S, 1973. The alanine ester content and magnesium binding capacity of walls of Staphylococcus aureus H grown at different pH values. Biochimica et Biophysica Acta. 291(3), 629-34
• ARCHIBALD, A R, BADDILEY, J, HECKELS, J E and HEPTINSTALL, S, 1971. Further studies on the glycerol teichoic acid of walls of Staphylococcus lactis I3. Location of the phosphodiester groups and their susceptibility to hydrolysis with alkali. Biochemical Journal. 125(1), 353-9
• ARCHIBALD, A R and HEPTINSTALL, S, 1971. The teichoic acids of Micrococcus sp. 24. Biochemical Journal. 125(1), 361-3
• HEPTINSTALL, S, ARCHIBALD, A R and BADDILEY, J, 1970. Teichoic acids and membrane function in bacteria. Nature. 225(5232), 519-21
• ARCHIBALD, A R, BADDILEY, J and HEPTINSTALL, S, 1969. The distribution of the glucosyl substituents along the chain of the teichoic acid in walls of Lactobacillus buchneri N.C.I.B. 8007. Biochemical Journal. 111(2), 245-6
• ARCHIBALD, A R, BADDILEY, J, BUTTON, D, HEPTINSTALL, S and STAFFORD, G H, 1968. Ocuurrence of polymers containing N-acetylglucosamine-1-phosphate in bacterial walls. Nature. 219(156), 855-6