Research issues
Diabetes, stroke, chronic kidney disease and peripheral vascular disease are some of the UK more prevalent, chronic and life threatening disease. Underpinning all of these, and other, pathologies is vascular dysfunction.
What we are doing about...
a) Investigating the impact of remote ischaemic conditioning following ischaemic stroke
b) Assessing the effects of G-CSF and other colony stimulating factors in promoting stroke recovery through generation of haematopoietic stem cells
c) Studying the role of the endocannabinoid system and cannabinoids in blood-brain-barrier dysfunction and the potential therapeutic effects of cannabinoid supplementation
a) Investigating new therapeutics in the treatment of vascular and metabolic dysfunction associated with diabetes in preclinical models, healthy volunteers and clinical trials
b) Novel therapeutics, dietary and exercise aspects for the management of obese patients with diabetes
c) Exploring the vascular impact of human and analogue insulin
d) Epidemiological and population studies investigating safety, efficacy and treatment strategies in diabetes and non diabetes cohort using retrospective database analysis – THIN / CPRD
e) Clinical trials for the management of foot ulcers in patients with diabetes
3. Vascular calcification
a) Exploring the role of hydrogen sulphide in vascular calcification associated with ageing and CKD
b) Investigation the effects of bone derived hormones (particularly osteocalcin) and factors on body systems and how these might be manipulated to reduce disease, including vascular disease and calcification
c) Investigating the effects of drugs and hormones on bone physiology, with a particular emphasis on leptin, endocannabinoids, and drugs for treating obesity, diabetes and osteoporosis
Current projects
- Remote ischaemic conditioning after stroke trial (ReCAST)
- A systematic review and meta-analysis of cannabinoids and experimental stroke
- Using a BBB model to identify new molecules that prevent increased permeability in ischaemia/reperfusion
- Identifying the mechanisms of action of the endocannabinoid system in the vasculature of human volunteers and how this is altered by disease states
- Investigation on the effects of combination glucose lowering therapy and the impact of antidiabetic therapy-induced weight gain on cardiovascular outcomes in patients with type 2 diabetes
- Observational study to investigate the effectiveness of Humalog mix-50 insulin in people with diabetes
- Investigation on the effects of short-term energy restriction on liver lipid, metabolism and inflammatory status in severely obese adults
Outcomes
Our research is published in leading peer-reviewed journals.
ENGLAND, T.J., BATH, P.M.W., ABAEI, M., AUER, D. and JONES, D.R.E., 2013. Hematopoietic stem cell (CD34+) uptake of superparamagnetic iron oxide is enhanced by but not dependent on a transfection agent. Cytotherapy: Journal of Cell Therapy. 15(3), 384-390
BATH P, SPRIGG N and ENGLAND T, 2013. Colony stimulating factors (including erythropoietin, granulocyte colony stimulating factor and analogues) for stroke. Cochrane Database of Systematic Reviews. Doi: 10.1002/14651858.CD005207.pub4
ENGLAND, T.J., ABAEI, M., AUER, D.P., LOWE, J., JONES, D.R.E., SARE, G., WALKER, M. and BATH, P.M.W.,2012. Granulocyte-colony stimulating factor for mobilizing bone marrow stem cells in subacute stroke: the Stem Cell Trial Of Recovery Enhancement After Stroke 2 Randomized Controlled Trial Stroke. 43(2), 405-411
More publications under individual members' profiles.