Biodiscovery Institute Publications

All BDI principal investigators (past and recent) on each publication are highlighted in bold. The same publications appear under each PI that is an author on it.

Cinzia Allegrucci

Atallah NM, Haque M, Quinn C, Toss MS, Makhlouf S, Ibrahim A, Green AR, Alsaleem M, Rutland CS, Allegrucci C,Mongan NP, Rakha E. Characterisation of luminal and triple-negative breast cancer with HER2 Low protein expression. Eur J Cancer, 2023, 113371. doi.org/10.1016/j.ejca.2023.113371

Ghannam SF, Rutland CS, Allegrucci C,Mongan NP, Rakha E. Defining invasion in breast cancer: the role of basement membrane. J Clin Pathol., 2023, 76(1):11-18. doi.org/10.1136/jcp-2022-208584

Ghannam SF, Rutland CS, Allegrucci C, Mongan NP, Rakha E. Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? Histopathology, 2023, 83(3):376-393. doi.org/10.1111/his.14939

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C,James VH, Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E, Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Front Genet., 2023, 13:1096071. doi.org/10.3389/fgene.2022.1096071

Idrisova KF, Zeinalova AK, Masgutova GA, Bogov AA, Allegrucci C, Syromiatnikova VY, Salafutdinov II, Garanina EE, Andreeva DI, Kadyrov AA, Rizvanov AA, Masgutov RF. Application of neurotrophic and proangiogenic factors as therapy after peripheral nervous system injury. Neural Regen Res., 2022, 17(6):1240-1247. doi.org/10.4103/1673-5374.327329

Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S,Allegrucci C,James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, Mongan NP, Jeyapalan JN. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front Endocrinol, (Lausanne), 2022, 13:1006101. doi.org/10.3389/fendo.2022.1006101

Ponomarev A, Gilazieva Z, Solovyeva V, Allegrucci C, Rizvanov A. Intrinsic and Extrinsic Factors Impacting Cancer Stemness and Tumor Progression. Cancers (Basel), 2022, 14(4):970. doi.org/10.3390/cancers14040970

Mahmoud R, Ordóñez-Morán P, Allegrucci C. Challenges for Triple Negative Breast Cancer Treatment: Defeating Heterogeneity and Cancer Stemness. Cancers (Basel), 2022, 14(17):4280. doi.org/10.3390/cancers14174280

Kenton Arkill

Da Vitoria Lobo M, Bates DO, Arkill KP, Hulse RP. Measurement of solute permeability in the mouse spinal cord. Journal of Neuroscience Methods, 2023, 393:109880. doi.org/10.1016/j.jneumeth.2023.109880

Pope I, Tanner H, Masia F, Payne L, Arkill KP, Mantell J, Langbein W, Borri P, Verkade P. Correlative light-electron microscopy using small gold nanoparticles as single probes. Light Sci Appl., 2023, 2(1):80. doi.org/10.1038/s41377-023-01115-4

Gomez NE, James V,Arkill KP, Nizamudeen ZA, Onion D, Fairclough LC. PBMC derived extracellular vesicles in a smoking-related inflammatory disease model. Eur. J. Immunol., 2023, 53: 2250143. doi.org/10.1002/eji.202250143

James JR, Ashworth JC, Abuhantash M, Grundy M, Seedhouse CH, Curd J, Arkill KP, Wright AJ, Merry CLR, Thompson A. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. Int. J. Mol. Sci., 2023, 24(4), 4235. doi.org/10.3390/ijms24044235

Wijesinghe SN, Anderson J, Brown TJ, Nanus DE, Housmans B, Green JA, Hackl M, Choi KK, Arkill KP, Welting T, James V, Jones SW and Peffers MJ. The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence. Front. Mol. Biosci., 2022, 9:971621. doi.org/10.3389/fmolb.2022.971621

Arkill KP, Michel CC, Rider EVM. et al. John squire and endothelial glycocalyx structure: an unfinished story. J Muscle Res Cell Motil., 2023, 44, 217–223. doi.org/10.1007/s10974-022-09629-x

Malhi NK, Allen CL, Stewart E, Horton KL, Riu F, Batson J, Amoaku W, Morris JC, Arkill KP, Bates DO. Serine/arginine rich protein kinase-1 (SRPK1) inhibition for the treatment of diabetic retinopathy. Am. J. Physiol. - Heart Circ. Physiol., 2022, 332:H1014-H1027. doi.org/10.1152/ajpheart.00001.2022

Qiu Y, Buffonge S, Ramnath R, Jenner S, Fawaz S, Arkill KP, Neal CR, Verkade P, White SJ, Hezzell M, Salmon AHJ, Suleiman MS, Welsh GI, Foster RR, Madeddu P, Satchell, SC. Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function Diabetologia, 2022, 65:879–894. doi.org/10.1007/s00125-022-05650-4

Jennifer Ashworth

Jones S, Ashworth JC, Meakin M, Collier P, Probert C, Ritchie AA, Merry CLR, Grabowska AM. Application of a 3D Hydrogel-Based Model to Replace Use of Animals for Passaging Patient-Derived Xenografts. In vitro models, 2023, 2:99–111. doi.org/10.1007/s44164-023-00048-x

James JR, Curd J, Ashworth JC, Abuhantash, Grundy M, Seedhouse CH, Arkill KP, Wright AJ, Merry CLR, Thompson A. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. Int J Mol Sci., 2023, 24(4):4235. doi: 10.3390/ijms24044235

Mendonca T, Lis-Slimak K, Matheson AB, Smith MG, Akosua BA-A, Ashworth JC, Cavanagh R, Paterson L, Dalgarno PA, Alexander C, Tassieri M, Merry CLR, Wright AJ. OptoRheo: Simultaneous In Situ Micro-Mechanical Sensing and Imaging of Live 3D Biological Systems. Commun. Biol., 2023, 6(1):463. doi:10.1038/s42003-023-04780-8

Steve Atkinson

Yang R, Atkinson S, Chen Z, Cui Y, Du Z, Han Y, Sebbane F, Slavin P, Song Y, Yan Y, Wu Y, Xu L, Zhang C, Zhang Y, Hinnebusch BJ, Stenseth NC, Motin VL. Yersinia pestis and Plague: some knowns and unknowns. Zoonoses (Burlingt)., 2023, 3(1):5. doi.org/10.15212/zoonoses-2022-0040

Fell HG, Jones M, Atkinson S, Stenseth NC, Algar AC. The role of reservoir species in mediating plague's dynamic response to climate. R Soc Open Sci., 2023, 10(5):230021. doi.org/10.1098/rsos.230021

Wiechmann A, Garcia V, Elton L, Williams P,Atkinson S. Reciprocal regulation of NagC and quorum sensing systems and their roles in hmsHFRS expression and biofilm formation in Yersinia pseudotuberculosis. Microbiology (Reading), 2023, 169(10). doi.org/10.1099/mic.0.001397

Fell HG, Osborne OG, Jones MD, Atkinson S, Tarr S, Keddie SH, Algar AC. Biotic factors limit the invasion of the plague pathogen (Yersinia pestis) in novel geographical settings. Global Ecol Biogeogr., 2022, 31(4), 672-684. doi.org/10.1111/geb.13453

David Bates

Manabile MA, Hull R, Khanyile R, Molefi T, Damane BP, Mongan NP,Bates DO, Dlamini Z. Alternative Splicing Events and Their Clinical Significance in Colorectal Cancer: Targeted Therapeutic Opportunities. Cancers (Basel)., 2023, 15(15):3999. doi.org/10.3390/cancers15153999

Marva G, Ünsal S, Benest AV,Bates DO,Ordóñez-Morán P. Novel Approach to Measure Transepithelial Electrical Resistance in Intestinal Cells. Methods Mol Biol., 2023, 2650:35-42. doi.org/10.1007/978-1-0716-3076-1_3

Dlamini Z, Khanyile R, Molefi T, Damane BP, Bates DO, Hull R. Genomic Interplay between Neoneurogenesis and Neoangiogenesis in Carcinogenesis: Therapeutic Interventions. Cancers (Basel), 2023, 15(6):1805. doi.org/10.3390/cancers15061805

Lobo MEDV, Bates DO,Arkill KP, Hulse RP. Measurement of solute permeability in the mouse spinal cord. J Neurosci Methods, 2023, 393:109880. doi.org/10.1016/j.jneumeth.2023.109880

Balasubramanian B, Yacqub-Usman K, Venkatraman S, Myint KZ, Juengsamarn J, Sarkhampee P, Lertsawatvicha N, Sripa J, Kuakpaetoon T, Suriyonplengsaeng C, Wongprasert K, Grabowska AM,Bates DO, Janvilisri T, Tohtong R. Targeting FGFRs Using PD173074 as a Novel Therapeutic Strategy in Cholangiocarcinoma. Cancers (Basel), 2023, 15(9):2528. doi.org/10.3390/cancers15092528

Alalwany RH, Hawtrey T, Morgan K, Morris JC, Donaldson LF, Bates DO. Vascular endothelial growth factor isoforms differentially protect neurons against neurotoxic events associated with Alzheimer's disease. Front Mol Neurosci., 2023, 16:1181626. doi.org/10.3389/fnmol.2023.1181626

Malhi NK, Bates DO, Arkill KP, Allen CL. Noninvasive Measurement of Retinal Microvascular Permeability During Loss of Endothelial Quiescence. Methods Mol Biol., 2022, 2441:135-156. doi.org/10.1007/978-1-0716-2059-5_11

Bhalla SR, Riu F, Machado MJC, Bates DO. Measurement of Revascularization in the Hind Limb After Experimental Ischemia in Mice. Methods Mol Biol., 2022, 2441:105-113. doi.org/10.1007/978-1-0716-2059-5_9

Malhi NK, Allen CL, Stewart E, Horton KL, Riu F, Batson J, Amoaku W, Morris JC, Arkill KP, Bates DO. Serine-arginine-rich protein kinase-1 inhibition for the treatment of diabetic retinopathy. Am J Physiol Heart Circ Physiol., 2022, 322(6):H1014-H1027. doi.org/10.1152/ajpheart.00001.2022

Supradit K, Boonsri B, Duangdara J, Thitiphatphuvanon T, Suriyonplengsaeng C, Kangsamaksin T, Janvilisri T, Tohtong R, Yacqub-Usman K, Grabowska AM,Bates DO, Wongprasert K. Inhibition of serine/arginine-rich protein kinase-1 (SRPK1) prevents cholangiocarcinoma cells induced angiogenesis. Toxicol In Vitro., 2022, 82:105385. doi.org/10.1016/j.tiv.2022.105385

Da Vitoria Lobo ME, Weir N, Hardowar L, Al Ojaimi Y, Madden R, Gibson A, Bestall SM, Hirashima M, Schaffer CB, Donaldson LF, Bates DO, Hulse RP. Hypoxia-induced carbonic anhydrase mediated dorsal horn neuron activation and induction of neuropathic pain. Pain, 2022, 163(11):2264-2279. doi.org/10.1097/j.pain.0000000000002627

Basera A, Hull R, Demetriou D, Bates DO, Kaufmann AM, Dlamini Z, Marima R. Competing Endogenous RNA (ceRNA) Networks and Splicing Switches in Cervical Cancer: HPV Oncogenesis, Clinical Significance and Therapeutic Opportunities. Microorganisms, 2022, 10(9):1852. doi.org/10.3390/microorganisms10091852

Nizamundeen ZA, ElSaboni L, Vetch G, Karim J, Neal CR, Allen CL, Bates DO,Arkill KP. Transmission Electron Microscopy of Endothelium. Methods Mol Biol., 2022, 2441:95-103. doi.org/10.1007/978-1-0716-2059-5_8

Green KR, Beazley-Long N, Lynch AP, Allen CL, Bates DO, Benest AV. Quantification of Angiogenesis in Laser Choroidal Neovascularization. Methods Mol Biol., 2022, 2441:223-231. doi.org/10.1007/978-1-0716-2059-5_17

Sueca-Comes M, Rusu EC, Grabowska AM,Bates DO. Looking Under the Lamppost: The Search for New Cancer Targets in the Human Kinome. Pharmacol Rev., 2022, 74(4):1136-1145. doi.org/10.1124/pharmrev.121.000410

Andrew Benest

Marva G, Ünsal S, Benest AV, Bates DO, Ordóñez-Morán P. Novel Approach to Measure Transepithelial Electrical Resistance in Intestinal Cells. Methods Mol Biol., 2023, 2650:35-42. doi.org/10.1007/978-1-0716-3076-1_3

Mortara L, Benest AV, Derosa L, Chouaib S, Ribatti D. Editorial: The intricate innate immune-cancer cell relationship in the context of tumor angiogenesis, immunity and microbiota: The angiogenic switch in the tumor microenvironment as a key target for immunotherapies. Front Immunol., 2022, 13:1045074. doi.org/10.3389/fimmu.2022.1045074

Jenkins HH, Lopez AAT, Tarantini FS, Tomlin H, Scales D, Lee IN, Wu S, Hyde R, Lis-Slimak K, Byaruhanga T, Thompson JL, Pijuan-Galito S, Doolan L, Kaneko K, Gwynne P, Reffin C, Park E, Dey J, Hill J, Arendt-Tranholm A, Stroud A, Petrie M, Denning C,Benest AV*,Seedhouse C*. Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva. Sci Rep., 2022, 12(1):11553. *denotes equal contribution. doi.org/10.1038/s41598-022-15616-6

Tarantini FS, Wu S, Jenkins H , Tellechea Lopez A, Tomlin H, Hyde R, Lis-Slimak K , Thompson JL, Pijuan-Galito S Scales D, Kaneko K , Dey J, Park E, Hill J, Lee I, Doolan L, Tranholm AA, Seedhouse C, Denning C, Benest AV. Direct RT-qPCR Assay for the Detection of SARS-CoV-2 in Saliva Samples. Methods Protoc., 2022 5(2), 25. doi.org/10.3390/mps5020025

Green KR, Beazley Long N, Lynch AP, Allen CL, Benest AV. Quantification of pathological angiogenesis using laser induced choroidal neovascularisation. Methods Mol Biol., 2022, 2441:223-231. doi.org/10.1007/978-1-0716-2059-5_17

Tabrizi ZB, Green KR, Lynch AP, Ahmed NS, Beazley-Long N, Benest AV. Simple Gene Knockdown in Endothelial Cells Using Short Interfering RNA Oligonucleotides. Methods Mol Biol., 2022, 2441:251-255. doi.org/10.1007/978-1-0716-2059-5_19

Benest AV. 2022. Angiogenesis: methods and protocol. First Edition. Springer-Nature. ISBN 1064-3745

Ben Blount

Blount BA, Lu X, Driessen MRM, Jovicevic D, Sanchez MI, Ciurkot K, Zhao Y, Lauer S, McKiernan RM, Gowers G-OF, Sweeney F, Fanfani V, Lobzaev E, Palacios-Flores K, Walker RSK, Hesketh A, Cai J, Oliver SG, Cai Y, Stracquadanio G, Mitchell LA, Bader JS, Boeke JD, Ellis T. Synthetic yeast chromosome XI design provides a testbed for the study of extrachromosomal circular DNA dynamics. Cell Genomics, 2023, 3:100418. doi.org/10.1016/j.xgen.2023.100418 

Xu X, Meier F, Blount BA, Pretorius IS, Ellis T, Paulsen IT, Williams TC. Trimming the genomic fat: minimising and re-functionalising genomes using synthetic biology. Nat Commun., 2023, 14 (1), 1984. doi.org/10.1038/s41467-023-37748-7 

Blount BA. Synthetic bacterial genome upgraded for viral defence and biocontainment. Nature, 2023, 615 (7953), 592-594. doi.org/10.1038/d41586-023-00702-0 

Schindler D, Walker RSK, Jiang S, Brooks AN, Wang Y, Müller CA, Cockram C, Luo Y, García A, Schraivogel D, Mozziconacci J, Blount BA, Cai J, Ogunlana L, Liu W, Jönsson K, Abramczyk D, Garcia-Ruiz E, Turowski TW, Swidah R, Ellis T, Antequera F, Shen Y, Nieduszynski CA, Koszul R, Dai J, Steinmetz LM, Boeke JD, Cai Y. (2022). Design, Construction, and Functional Characterization of a tRNA Neochromosome in Yeast. bioRxiv, 2022.10.03.510608. doi.org/10.1101/2022.10.03.510608 

Dan Booth

Malavasi EL, Ghosh A, Booth DG, Zagnoni M, Sherman DL, Brophy PJ. Dynamic early clusters of nodal proteins contribute to node of Ranvier assembly during myelination of peripheral neurons. Elife, 2021, 10:e68089. doi.org/10.7554/elife.68089

Booth DG, Kozar N, Bradley S, Meijer D. Characterizing the molecular etiology of arthrogryposis multiplex congenita in patients with LGI4 mutations. Glia, 2021, 69(11):2605-2617. doi.org/10.1002/glia.24061

Tracey Bradshaw

Kuruppu AI, Turyanska L, Bradshaw TD, Manickam S, Galhena BP, Paranagama P, De Silva R. Apoferritin and Dps as drug delivery vehicles: some selected examples in oncology. Biochimica et Biophysica Acta, 2022, 1866 (2). doi.org/10.1016/j.bbagen.2021.130067

Brookes A, Ji L, Bradshaw TD,Stocks M, Gray D, Butler J, Gershkovich P. Is Oral Lipid-Based Delivery Systems for Drug Targeting to the Brain Feasible? European J Pharmaceutics and Biopharmaceutics, 2022, 172, 112-122. doi.org/10.1016/j.ejpb.2022.02.004

Sousa A, Bradshaw TD, Ribeiro D, Fernandes E, Freitas M. Pro-inflammatory effects of silver nanoparticles in the intestine. Arch Toxicol., 2022, 96, 1551–1571.

doi.org/10.1007/s00204-022-03270-w

Abuzaid H, Abdelrazig S, Ferreira L, Collins HM, Kim D-H, Lim K-H, Kam T-S, Turyanska L, Bradshaw TD. Apoferritin-encapsulated Jerantinine A for transferrin receptor targeting and enhanced selectivity in breast cancer therapy. ACS Omega, 2022, 7, 25, 21473–21482. doi.org/10.1021/acsomega.2c00997

Mehmood H, Musa M, Woodward S, Hossan MS, Bradshaw TD, Haroon M, Nortcliffe A, Akhtar T. Design and Synthesis of selective anticancer 4-cyanophenyl substituted thiazoll-2-ylhydrazones. RSC Adv., 2022, 12, 34126-34141. doi.org/10.1039/D2RA03226K

Saleh MM, Abuarqoub DA, Hammad AM, Hossan MS, Ahmed N, Aslam N, Naser AY, Moody CJ, Laughton CA,Bradshaw TD. In Vitro Anticancer Properties of Novel Bis-Triazoles. Current Issues in Molecular Biology, 2023; 45(1):175-196. doi.org/10.3390/cimb45010014

Humphreys J, Malagreca F, Hume PA, Davies ES, Argent SP, Bradshaw TD, Amabilino DB. Highly electron deficient diketopyrrolopyrroles. Chem Commun (Camb)., 2023, 59(12):1613-1616. doi.org/10.1039/d2cc06770f

Brookes A, Jewell A, Feng W, Bradshaw TD, Butler J, Gershkovich P. Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain. Int J Pharmaceutics, 2023, 635:122651. doi.org/10.1016/j.ijpharm.2023.122651

Summers HS, Lewis W, Williams HEL,Bradshaw TD, Moody CJ, Stevens MFG. Discovery of new imidazotetrazinones with potential to overcome tumor resistance. Eur J Med Chem., 2023, 257:115507. doi.org/10.1016/j.ejmech.2023.115507

Jack Bryant

Bryant JA, Staunton KA, Doherty HM, Alao MB, Ma X, Morcinek-Orlowska J, Goodall ECA, Gray J, Milner M, Cole JA, de Cogan F, Knowles TJ, Glinkowska, Moradigaravand D, Henderson IR, Banzhaf M. Bam complex associated proteins in Escherichia coli are functionally linked to peptidoglycan biosynthesis, membrane fluidity and DNA replication. bioRxiv, 2023.07.05.547807. doi.org/10.1101/2023.07.05.547807

Watson R, Maxwell M, Dunn S, Brooks A, Jiang L, Hill HJ, Williams G, Kotowska A, Nikoi ND, Stamataki Z, Banzhaf M, Scurr D, Bryant JA, de Cogan F. Development of biocide coated polymers and their antimicrobial efficacy. Nano Select., 2023, 4(7):442-453. doi.org/10.1002/nano.202300005

Sroczyk EA, Bryant JA, de Cogan F, Knapczyk-Korczak J, Marzec MM, Szewczyk PK, Banzhaf M, Stachewicz U. Modification of electrospun PI membranes with active chlorine for antimicrobial skin patches applications. Applied Surface Science, 2022, 592:153302. doi.org/10.1016/j.apsusc.2022.153302

Goodall ECA, Morris FC, McKeand SA, Sullivan R, Warner IA, Sheehan E, Boelter G, Icke C, Cunningham AF, Cole JA, Banzhaf M, Bryant JA, Henderson IR. LI-Detector: a Method for Curating Ordered Gene-Replacement Libraries. Microbiol Spectr., 2022, 10(4):e0083322. doi.org/10.1128/spectrum.00833-22

Boelter G, Bryant JA, Doherty H, Wotherspoon P, Alodaini D, Ma X, Alao MB, Moynihan PJ, Moradigaravand D, Glinkowska M, Knowles TJ, Henderson IR, Banzhaf M. The lipoprotein DolP affects cell separation in Escherichia coli, but not as an upstream regulator of NlpD. Microbiology, 2022, 168(5). doi.org/10.1099/mic.0.001197

Bryant JA, Riordan L, Watson R, Nikoi ND, Trzaska W, Slope L, Tibbatts C, Alexander MR, Scurr DJ, May RC, de Cogan F. Developing Novel Biointerfaces: Using Chlorhexidine Surface Attachment as a Method for Creating Anti-Fungal Surfaces. Glob Chall., 2022, 6(5):2100138. doi.org/10.1002/gch2.202100138

Watson R, Oldfield M, Bryant JA, Riordan L, Hill HJ, Watts JA, Alexander MR, Cox MJ, Stamataki Z, Scurr DJ, de Cogan F. Efficacy of antimicrobial and anti-viral coated air filters to prevent the spread of airborne pathogens. Sci Rep., 2022, 12(1):2803. doi.org/10.1038/s41598-022-06579-9

Freire CA, Silva RM, Ruiz RC, Pimenta DC, Bryant JA, Henderson IR, Barbosa AS, Elias WP. Secreted Autotransporter Toxin (Sat) Mediates Innate Immune System Evasion. Front. Immunol., 2022, 13. doi.org/10.3389/fimmu.2022.844878

Lee Buttery

Moise S, Dolcetti L, Dazzi F, Roach P, Buttery L, MacNeil S, Medcalf N. Assessing the immunosuppressive activity of alginate-encapsulated mesenchymal stromal cells on splenocytes. Artif Cells Nanomed Biotechnol., 2022, 50(1):168-176. doi.org/10.1080/21691401.2022.2088547

Ramis J, Middlewick R, Pappalardo F, Cairns JT, Stewart ID, John AE, Naveed SU, Krishnan R, Miller S, Shaw DE, Brightling CE, Buttery L,Rose F, Jenkins G, Johnson SR, Tatler AL. Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling. Eur Respir J., 2022, 60(1):2004361. doi.org/10.1183/13993003.04361-2020

Miguel Cámara

Soukarieh F, Gurnani P, Romero M, Halliday N, Stocks M, Alexander C, Cámara M. Design of quorum sensing inhibitor-polymer conjugates to penetrate Pseudomonas aeruginosa biofilms. ACS Macro Letters, 2023, 12(3):314-319. doi.org/10.1021/acsmacrolett.2c00699

Dubern J-F, Romero M, Prochnow AM, Messina M, Trampari E, Naghra-van Gijzel H, Chan K-G, Carabelli AM, Barraud N, Lazenby J, Chen Y, Robertson S, Malone JG, Williams P, Heeb S,Cámara M. ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa. NPJ Biofilms Microbiomes, 2022, 8(1):64. doi.org/10.1038/s41522-022-00325-9

Weng Chan

Williams P, Hill P, Bonev B, Chan WC. Quorum-sensing, intra- and inter-species competition in the staphylococci. Microbiology, 2023, 169(8), 001381. doi.org/10.1099/mic.0.001381

Bardelang P, Murray EJ, Blower I, Zandomeneghi S, Goode A, Hussain R, Kumari D, Siligardi G, Inoue K, Luckett J, Doutch J, Emsley J, Chan WC, Hill P, Williams P, Bonev BB. Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Front Chem., 2023, 11, 1113885. doi.org/10.3389/fchem.2023.1113885

Taylor M, Simoes F, Smith J, Genapathy S, Canning A, Lledos M, Chan WC, Denning C, Scurr DJ, Steven RT, Spencer SJ, Shard AG, Alexander MR, Zelzer M. Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. Surf Interface Anal., 2022, 54(4), 417-432. doi.org/10.1002/sia.7052

Murray EJ, Dubern J-F, Chan WC, Chhabra SR, Williams P. A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin. Cell Chem Biol., 2022, 29(7), 1187-1199. doi.org/10.1016/j.chembiol.2022.02.007

Yan Chen

Larsen M, Olstad CF, Koch HW, Martiniussen MA, Hoff SR, Lund-Hanssen H, Solli HS, Mikalsen KØ, Auensen S, Nygård J, Lång K, Chen Y, Hofvind S. AI Risk Score on Screening Mammograms Preceding Breast Cancer Diagnosis. Radiology, 2023, 309(1):e230989. doi.org/10.1148/radiol.230989

Chen Y, Taib A, Darker I, James J. Performance of a Breast Cancer Detection AI Algorithm using the Personal Performance in Mammographic Screening Scheme. Radiology, 2023, 308(3). doi.org/10.1148/radiol.223299

Partridge G.J.W., Taib A.G., Phillips, P. Chen Y, et al. Take a break: should breaks be enforced during digital breast tomosynthesis reading sessions? Eur Radio., 2023. doi.org/10.1007/s00330-023-10086-4

Lam S, Bai C, Baldwin D, Chen Y, Connolly C, de Koning H, Heuvelmans MA, Hu P, Kazerooni EA, Lancaster HL, Langs G, McWilliams A, Osarogiagbon RU, Oudkerk M, Peters M, Robbins HA, Sahar L, Smith RA, Triphuridet N, Field J. Current and Future Perspectives on CT Screening for Lung Cancer: A Road Map for 2023-2027 from the IASLC. Journal of Thoracic Oncology, 2023, S1556-0864(23)00687-1. doi.org/10.1016/j.jtho.2023.07.019

Hovda T, Sagstad S, Larsen M, Chen Y, Hofvind S. Screening outcome for interpretation by the first and second reader in a population-based mammographic screening program with independent double reading. Acta Radiologica, 2023, 1-8. doi.org/10.1177/02841851231176272

Michalopoulou E, Clauser P, Gilbert F, Pijnappel R, Mann R, Baltzer P, Chen Y, Fallenberg E. A survey by the European Society of Breast Imaging on radiologists’ preferences regarding Quality Assurance measures of image interpretation in screening and diagnostic mammography. Eur Radio., 2023. doi.org/10.1007/s00330-023-09973-7

O'Dowd E, Lee RW, Akram A, Bartlett E, Bradley S, Brain K, Callister M, Chen Y, et al. Defining the Road Map to a UK National Lung Cancer Screening Programme. Lancet Oncol., 2023, 24(5):e207-e218. doi.org/10.1016/s1470-2045(23)00104-3

Chen Y, Sudin E, Partridge G, Taib A, Darker I., et al. Measuring Reader Fatigue in the Interpretation of Screening Digital Breast Tomosynthesis. Br J Radiol., 2023, 96(1143):20220629. doi.org/10.1259/bjr.20220629

Su G., Lin J, Chen Y, et al. Radiomics features for assessing tumor-infiltrating lymphocytes correlate with molecular traits of triple-negative breast cancer. J Transl Med., 2022, 20, 471. doi.org/10.1186/s12967-022-03688-x

Chen Y, James J, Michalopoulou E, Darker I, Jenkins J. Performance of radiologists and radiographers in double reading mammograms: the UK breast screening programme. Radiology, 2022, 306(1):102-109. doi.org/10.1148/radiol.212951

Chen Y, Sudin E, Sergeant M, Partridge G, et al. Digital pathology: the effect of experience on visual search behavior. J Med Imaging, 2022, 9(3), 035501. doi.org/10.1117/1.jmi.9.3.035501

Rachel Clifford

Rajasekar P, Hall RJ, Binaya KC, Mahapatra PS, Puppala SP, Thakker D, MacIsaac JL, Lin D, Kobor M, Bolton CE, Sayers I, Hall IP, Clifford RL. Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation. Environ Pollut., 2023, 337:122561. doi.org/10.1016/j.envpol.2023.122561

Beth Coyle

Jackson HK, Mitoko C, Linke F, Macarthur D, Kerr ID, Coyle B. Extracellular Vesicles Potentiate Medulloblastoma Metastasis in an EMMPRIN and MMP-2 Dependent Manner. Cancers (Basel), 2023, 15(9):2601. doi.org/10.3390/cancers15092601

Taylor L, Wade PK, Johnson JEC, Aldighieri M, Morlando S, Di Leva G, Kerr ID, Coyle B. Drug Resistance in Medulloblastoma Is Driven by YB-1, ABCB1 and a Seven-Gene Drug Signature. Cancers, 2023, 15(4):1086. doi.org/10.3390/cancers15041086

Linke F, Johnson JEC, Kern S, Bennett CD, Lourdusamy A, Lea D, Clifford SC, Merry CLR, Stolnik S, Alexander MR, Peet AC, Scurr DJ, Griffiths RL, Grabowska AM, Kerr ID, Coyle B. Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. Acta Neuropathol Commun., 2023, 11(1):6. doi.org/10.1186/s40478-022-01496-4

Roper SJ, Coyle B. Establishing an in vitro 3D spheroid model to study medulloblastoma drug response and tumour dissemination. Current Protocols in Toxicology, 2022. DOI: doi.org/10.1002/cpz1.357

Madhumita Dandapani

Neves R, DeDiosPerez B, Panek R, Jagani S, Wilne S, Mahendra Bhatt J., …Dineen RA. Development of cancer surveillance guidelines in ataxia telangiectasia: A Delphi‐based consensus survey of international experts. Cancer Med., 2023, 12(13):14663-14673. doi: doi.org/10.1002/cam4.6075

Neves R, Perez BDD, Tindall T, Fernandez N.S, Panek R, Wilne S, …Glazebrook C. Whole-body MRI for cancer surveillance in ataxia–telangiectasia: A qualitative study of the perspectives of people affected by A-T and their families. Health Expect., 2023, 26(3):1358-1367. doi.org/10.1111/hex.13756

Butler A, Meijer L, Liu J, Chohan M, Jalloh I, Macarthur D, …Dandapani M. Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours. Childs Nerv Syst., 2023, 39(6):1537-1544.

doi.org/10.1007/s00381-023-05872-w

Bishop E, Dimitrova M, Froggatt A, Estevez-Cebrero M, Storer LCD, Mussai F, …Dandapani M. Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion. Biomed Res Int., 2022, 2022:9008685. doi.org/10.1155/2022/9008685

Campbell E, Aquilina K, Dandapani, M, Walker D, Rahman, R. EPCT-03. Working together to accelerate the preclinical to clinical translation of drug delivery systems for children’s brain tumours. Neuro Oncol., 2022, 24(Suppl 1): i36. doi.org/10.1093%2Fneuonc%2Fnoac079.131

Woodward A, Amugi L, Patel K, Kilpatrick C, Kim D, Dandapani M. EPEN-21. Developing a sensitive method for detection of minimal residual disease in ependymoma using metabolomic analysis of cerebrospinal fluid. Neuro Oncol., 2022, 24(Suppl 1): i43. doi.org/10.1093%2Fneuonc%2Fnoac079.719

Lodewijk Dekker

Alblihy A, Ali R, Algethami M, Ritchie AA, Shoqafi A, Alqahtani S, Mesquita KA, Toss MS, Ordóñez-Morán P, Jeyapalan JN, Dekker L, Salerno M, Hartsuiker E, Grabowska AM, Rakha EA, Mongan NP, Madhusudan S. Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. Int J Mol Sci., 2023, 24(13):10966. doi.org/10.3390/ijms241310966

Chris Denning

Hall C, Law JP, Reyat JS, Cumberland MJ, Hang S, Vo NTN, Raniga K, Weston CJ, O'Shea C, Townend JN, Gehmlich K, Ferro CJ, Denning C, Pavlovic D. Chronic activation of human cardiac fibroblasts in vitro attenuates the reversibility of the myofibroblast phenotype. Sci Rep.,2023, 13(1):12137. doi.org/10.1038/s41598-023-39369-y

Blake H, Somerset S, Mahmood I, Mahmood N, Corner J, Ball JK, Denning C. Workforce Experiences of a Rapidly Established SARS-CoV-2 Asymptomatic Testing Service in a Higher Education Setting: A Qualitative Study. Int J Environ Res Public Health, 2022, 19(19):12464. doi.org/10.3390/ijerph191912464

Jenkins HH, Lopez AA, Tarantini FS, Tomlin H, Scales D, Lee I, Wu S, Hyde R, Lis-Slimak K, Byaruhanga T, Thompson JL, Pijuan-Galito S, Doolan L, Kaneko K, Gwynne P, Reffin C, Park E, Dey J, Hill J, Arendt-Tranholm A, Stroud A, Petrie M, Denning C,Benest AV, Seedhouse C. Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from human saliva. Sci Rep., 2022,12(1):11553. doi.org/10.1038/s41598-022-15616-6

Tarantini FS, Wu S, Jenkins H, Lopez AT, Tomlin H, Hyde R, Lis-Slimak K, Thompson JL, Pijuan-Galitó S, Scales D, Kaneko K, Dey J, Park E, Hill J, Lee I, Doolan L, Arendt-Tranholm A, Denning C,Seedhouse C, Benest AV. Direct RT-qPCR assay for the detection of SARS-CoV-2 in saliva samples. Methods Protoc., 2022, 5(2):25. doi.org/10.3390/mps5020025

Raniga K, Vo NTN, Denning C. Differentiation and Characterization of Human Pluripotent Stem Cell-Derived Cardiac Endothelial Cells for In Vitro Applications. Methods Mol Biol., 2022, 2441:339-348. doi.org/10.1007/978-1-0716-2059-5_27

James Dixon

Intini C, Blokpoel Ferreras L, Casey S, Dixon JE, Gleeson JP, O'Brien FJ. An Innovative miR‐activated Scaffold for the Delivery of a miR‐221 Inhibitor to Enhance Cartilage Defect Repair. Adv Ther., 2023, 2200329. doi.org/10.1002/adtp.202200329

Simpson LA, Crowley D, Forey T, Acosta H, Ferjentsik Z, Chatfield J, Payne A, Simpson BS, Redwood C, Dixon JE, Holmes N, Sang F, Alberio R, Loose M, Johnson AD. NANOG is required to establish the competence for germ-layer differentiation in the basal tetrapod axolotl. PLoS Biol., 2023, 21(6):e3002121. doi.org/10.1371/journal.pbio.3002121

Rehmani S, McLaughlin CM, Eltaher HM, Moffett RC, Flatt PR, Dixon JE. Orally-delivered insulin-peptide nanocomplexes enhance transcytosis from cellular depots and improve diabetic blood glucose control. J Control Release, 2023, 360:93-109. doi.org/10.1016/j.jconrel.2023.06.006

Eltaher HM, Blokpoel Ferreras LA, Jalal AR, Dixon JE. Direct contact-mediated non-viral gene therapy using thermo-sensitive hydrogel-coated dressings. Biomater Adv., 2022, 143:213177. doi.org/10.1016/j.bioadv.2022.213177

Power RN, Cavanagh BL, Dixon JE, Curtin CM, O'Brien FJ. Development of a Gene-Activated Scaffold Incorporating Multifunctional Cell-Penetrating Peptides for pSDF-1α Delivery for Enhanced Angiogenesis in Tissue Engineering Applications. Int J Mol Sci., 2022, 23(3):1460. doi.org/10.3390/ijms23031460

Ingrid Dreveny

Maurer SK, Mayer MP, Ward SJ, Boudjema S, Halawa M, Zhang J, Caulton SG, Emsley J, Dreveny I. Ubiquitin specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity. J Biol Chem., 2023, 28:105300. doi.org/10.1016/j.jbc.2023.105300

Ducker C, French S, Pathak M, Taylor H, Sainter A, Askem W, Dreveny I, Santana AEG, Pickett JA, Oldham NJ. Characterisation of geranylgeranyl diphosphate synthase from the sandfly Lutzomyia longipalpis. Insect Biochem Mol Biol., 2023,161:104001. doi.org/10.1016/j.ibmb.2023.104001

Li C, Barroeta AB, Wong SS, Kim HJ, Pathak M, Dreveny I, Meijers JCM, Emsley J. Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites. J Thromb Haemost., 2023, 21(9):2378-2389.doi.org/10.1016/j.jtha.2023.03.042

Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J. Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science, 2023, 379(6636):996-1003. doi.org/10.1126/science.abm3452

Spiliotopoulos A, Maurer SK, Tsoumpeli MT, Bonfante JAF, Owen JP, Gough KC, Dreveny I. Next-Generation Phage Display to Identify Peptide Ligands of Deubiquitinases. Methods Mol. Bio., 2023, 2591:189-218 doi.org/10.1007/978-1-0716-2803-4_12

Jin Q, Gutierrez Diaz B, Pieters T, Zhou Y, Narang S, Fijalkwoski I, Borin C, Van Laere J, Payton M, Cho BK, Han C, Sun L, Serafin V, Yacu G, Von Loocke W, Basso G, Veltri G, Dreveny I, Ben-Sahra I, Goo YA, Safgren SL, Tsai YC, Bornhauser B, Suraneni PK, Gaspar-Maia A, Kandela I, Van Vlierberghe P, Crispino JD, Tsirigos A, Ntziachristos P. Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia. Sci Adv., 2022, 8(49):eabq8437. doi.org/10.1126/sciadv.abq8437

Lindy Durrant

Houvast RD, van Duijvenvoorde M, Chua J, Vankemmelbeke M, Durrant LG, Inderson A, van Hooft JE, Mieog JSD, Bonsing BA, Sier CFM, Crobach ASLP, Vahrmeijer AL, Kuppen PJK. Prediction of Biomarker Expression on Primary Pancreatic Ductal Adenocarcinoma Tissues Using Fine-Needle Biopsies: Paving the Way for a Patient-Tailored Molecular Imaging Approach. Mol Diagn Ther., 2023, 27(2):261-273. doi.org/10.1007/s40291-022-00635-w

Choudhury RH, Daniels I, Vaghela P, Atabani S, Kirk T, Symonds P, Cook KW, Al-Omari A, Weston D, Shah S, Hutchinson D, Paston SJ, Metheringham RL, Brentville VA, Durrant LG. Immune responses to citrullinated and homocitrullinated peptides in healthy donors are not restricted to the HLA SE shared allele and can be selected into the memory pool. Immunology, 2023, 169(4):467-486. doi.org/10.1111/imm.13645

Chua JX, Durrant LG, Chok YL, Lai OM. Susceptibility to SARS-CoV-2 omicron following ChAdOx1 nCoV-19 and BNT162b2 versus CoronaVac vaccination. iScience, 2022, 25(11):105379 doi.org/10.1016/j.isci.2022.105379

Brentville VA, Symonds P, Chua J, Skinner A, Daniels I, Cook KW, Koncarevic S, Martinez-Pinna R, Shah S, Choudhury RH, Vaghela P, Weston D, Al-Omari A, Davis J, Durrant LG. Citrullinated glucose-regulated protein 78 is a candidate target for melanoma immunotherapy. Front Immunol., 2022, 13:1066185 doi.org/10.3389/fimmu.2022.1066185

Choudhury RH, Symonds P, Paston SJ, Daniels I, Cook KW, Gijon M, Metheringham RL, Brentville VA, Durrant LG. PAD-2-mediated citrullination of nucleophosmin provides an effective target for tumor immunotherapy. J Immunother Cancer, 2022, 10(2):e003526. doi.org/10.1136/jitc-2021-003526

Cook K, Xue W, Atabani S, Symonds P, Al Omari A, Daniels I, Shah S, Choudhury RH, Weston D, Metheringham R, Brentville V, Durrant L. Vaccine Can Induce CD4-Mediated Responses to Homocitrullinated Peptides via Multiple HLA-Types and Confer Anti-Tumor Immunity. Front Immunol., 2022, 13:873947. doi.org/10.3389/fimmu.2022.873947

Gijon M, Metheringham RL, Toss MS, Paston SJ, Durrant LG. The Clinical and Prognostic Significance of Protein Arginine Deiminases 2 and 4 in Colorectal Cancer. Pathobiology, 2022, 89(1):38-48. doi.org/10.1159/000518414

Michelakos T, Kontos F, Kurokawa T, Cai L, Sadagopan A, Krijgsman D, Weichert W, Durrant LG, Kuppen PJK, R Ferrone C, Ferrone S. Differential role of HLA-A and HLA-B, C expression levels as prognostic markers in colon and rectal cancer. J Immunother Cancer, 2022, 10(3):e004115. doi.org/10.1136/jitc-2021-004115

Isioma Egbuniwe

Egbuniwe IU, Harris RJ, Nakamura M, Nestle FO, Akbar AN, Karagiannis SN, Lacy KE. B Lymphocytes Accumulate and Proliferate in Human Skin at Sites of Cutaneous Antigen Challenge. J Invest Dermatol., 2022, 142(3 Pt A):726-731.e4. doi.org/10.1016/j.jid.2021.06.038

Guo F, Estévez-Vázquez O, Benedé-Ubieto R, Maya-Miles D, Zheng K, Gallego-Durán R, Rojas Á, Ampuero J, Romero-Gómez M, Philip K, Egbuniwe IU, Chen C, Simon J, Delgado TC, Martínez-Chantar ML, Sun J, Reissing J, Bruns T, Lamas-Paz A, Moral MGD, Woitok MM, Vaquero J, Regueiro JR, Liedtke C, Trautwein C, Bañares R, Cubero FJ, Nevzorova YA. A Shortcut from Metabolic-Associated Fatty Liver Disease (MAFLD) to Hepatocellular Carcinoma (HCC): c-MYC a Promising Target for Preventative Strategies and Individualized Therapy. Cancers (Basel), 2021, 31;14(1):192. doi.org/10.3390/cancers14010192

Boonsri B, et al. Effect of Combining EGFR Tyrosine Kinase Inhibitors and Cytotoxic Agents on Cholangiocarcinoma Cells. Cancer Res Treat., 2021, 53(2):457-470. doi.org/10.4143/crt.2020.585

Jonas Emsley

Markham-Lee Z, Morgan NV, Emsley J. Inherited ADAMTS13 mutations associated with Thrombotic Thrombocytopenic Purpura: a short review and update. Platelets, 2023, 34(1):2138306. doi.org/10.1080/09537104.2022.2138306

Bardelang P, Murray EJ, Blower I, Zandomeneghi S, Goode A, Hussain R, Kumari D, Siligardi G, Inoue K, Luckett J, Doutch J, Emsley J,Chan WC, Hill P, Williams P, Bonev BB. Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Front Chem., 2023, 11:1113885. doi.org/10.3389/fchem.2023.1113885

Maurer SK, Mayer MP, Ward SJ, Boudjema S, Halawa M, Zhang J, Caulton SG, Emsley J,Dreveny I. Ubiquitin specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity. J Biol Chem., 2023, 105300. doi.org/10.1016/j.jbc.2023.105300

Damaskinaki FN, Jooss NJ, Martin EM, Clark JC, Thomas MR, Poulter NS, Emsley J,Kellam B, Watson SP, Slater A. Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization. J Thromb Haemost., 2023, 21(2):317-328 doi.org/10.1016/j.jtha.2022.11.002

Li C, Barroeta AB, Wong SS, Kim HJ, Pathak M, Dreveny I, Meijers JCM, Emsley J. Structures of factor XI and prekallikrein bound to domain 6 of high-molecular weight kininogen reveal alternate domain 6 conformations and exosites. J Thromb Haemost., 2023, 21(9):2378-2389. doi.org/10.1016/j.jtha.2023.03.042

Mohammed BM, Sun MF, Cheng Q, Litvak M, McCrae KR, Emsley J, McCarty OJT, Gailani D. High-molecular-weight kininogen interactions with the homologs prekallikrein and factor XI: importance to surface-induced coagulation. J Thromb Haemost., 2023, S1538-7836(23)00729-8. doi.org/10.1016/j.jtha.2023.09.027

Kearney KJ, Spronk HMH, Emsley J, Key NS, Philippou H. Plasma Kallikrein as a Forgotten Clotting Factor. Semin Thromb Hemost., 2023, Apr 18. doi.org/10.1055/s-0043-57034

Mailer RK, Rangaswamy C, Konrath S, Emsley J, Renné T. An update on factor XII-driven vascular inflammation. Biochim Biophys Acta Mol Cell Res., 2022, 1869(1):119166. doi.org/10.1016/j.bbamcr.2021.119166

Mattea Finelli

Monaghan TM, Ugun-Klusek A, Finelli MJ, Gurnani P, Chakrabarti L, Kao D, Alexander C, Polytarchou C. Connecting inflammatory bowel and neurodegenerative diseases: microRNAs as a shared therapeutic intervention. Gut, 2023, gutjnl-2022-327301. doi.org/10.1136/gutjnl-2022-327301

Castroflorio E, den Hoed J, Svistunova D, Finelli MJ, Cebrian-Serrano A, Corrochano S, Bassett AR, Davies B, Oliver PL. The Ncoa7 locus regulates V-atpase formation and function, neurodevelopment and behaviour. Cell Mol Life Sci., 2021, Apr;78(7):3503-3524. doi.org/10.1007/s00018-020-03721-6

Hester Franks

Atallah E, Welsh SJ, O'Carrigan B, Oshaughnessy A, Dolapo I, Kerr AS, Kucharczak J, Lee C, Crooks C, Hicks A, Chimakurthi CR, Rao A, Franks H, Patel PM, Aithal GP. Incidence, risk factors and outcomes of checkpoint inhibitor-induced liver injury: a 10-year real-world retrospective cohort study. JHEP Reports, 2023. 5(10):100851. doi: 10.1016/j.jhepr.2023.100851

Barnes E, Hillier-Moses G, Murray H, Stevinson C, Franks HA, Gossage L. Evaluation of the MOVE Online Exercise Programme for Young People Aged 13-30. Supportive Care in Cancer, 2023, 31 (7):377. doi.org/10.1007/s00520-023-07758-8

Cocking D, Damion RA, Franks H, Jaconelli M, Wilkinson D, Brook M, Auer DP, Bowtell R. Deuterium brain imaging at 7T during D2O dosing. Magn Reson Med., 2023, 89(4) 1514-1521. doi: 10.1002/mrm.29539

Kevin Gaston

Reolizo LM, Williams H, Wadey K, Frankow A, Li Z, Gaston K,Jayaraman PS, Johnson JL, George SJ. Arterioscler Thromb Vasc Biol., 2023, 43(3):456-473. doi.org/10.1161/atvbaha.122.318367

Bello RO, Willis-Powell L, James O, Sharma A, Marsh E, Ellis L, Gaston K, Siddiqui Y. Does Human Papillomavirus Play a Causative Role in Prostate Cancer? A Systematic Review Using Bradford Hill’s Criteria. Cancers (Basel), 2023, 15(15):3897. doi.org/10.3390/cancers15153897

Borkosky SS, Fassolari M, Campos-León K, Rossi AH, Salgueiro M, Pascuale CA, Martínez RP, Gaston K, de Prat Gay G. Biomolecular Condensation of the Human Papillomavirus E2 Master Regulator with p53: Implications in Viral Replication. J Mol Biol., 2023, 435(16):167889. doi.org/10.1016/j.jmb.2022.167889

Pavel Gershkovich

Chu Y, Wong A, Chen H, Ji L, Qin C, Feng W, Stocks MJ, Gershkovich P. Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport. Eur J Pharm Biopharm., 2023, S0939-6411(23)00228-X. doi.org/10.1016/j.ejpb.2023.08.015

Muresan P, Woodhams S, Smith F, Taresco V, Shah J, Wong M, Chapman V, Smith S, Hathway G, Rahman R,Gershkovich P, Marlow M. Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain. Nanomedicine, 2023, 49:102664. doi.org/10.1016/j.nano.2023.102664

Brookes A, Jewell A, Feng W, Bradshaw TD, Butler J, Gershkovich P. Oral lipid-based formulations alter delivery of cannabidiol to different anatomical regions in the brain. Int J Pharm., 2023, 635:122651. doi.org/10.1016/j.ijpharm.2023.122651

Muresan P, McCrorie P, Smith F, Vasey C, Taresco V, Scurr DJ, Kern S, Smith S,Gershkovich P, Rahman R, Marlow M. Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site. Eur J Pharm Biopharm., 2023,182:53-61. doi.org/10.1016/j.ejpb.2022.11.016

Han S, Trevaskis N, Gershkovich P, Kagan L.Editorial: Lymphatic delivery and targeting of drugs, vaccines, and imaging agents. Front Pharmacol., 2022, 13:1011778. doi.org/10.3389/fphar.2022.1011778

Feng W, Qin C, Abdelrazig S, Bai Z, Raji M, Darwish R, Chu Y, Ji L, Gray DA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol. Int J Pharm., 2022, 624:121947. doi.org/10.1016/j.ijpharm.2022.121947

Jewell A, Brookes A, Feng W, Ashford M, Gellert P, Butler J, Fischer PM, Scurr DJ, Stocks MJ, Gershkovich P. Distribution of a highly lipophilic drug cannabidiol into different lymph nodes following oral administration in lipidic vehicle. Eur J Pharm Biopharm., 2022, 174:29-34. doi.org/10.1016/j.ejpb.2022.03.014

Sulaiman S, Gershkovich P, Hoad CL, Calladine M, Spiller RC, Stolnik S, Marciani L. Application of In Vivo MRI Imaging to Track a Coated Capsule and Its Disintegration in the Gastrointestinal Tract in Human Volunteers. Pharmaceutics, 2022, 14(2):270. doi.org/10.3390/pharmaceutics14020270

Brookes A, Ji L, Bradshaw TD, Stocks M, Gray D, Butler J, Gershkovich P. Is oral lipid-based delivery for drug targeting to the brain feasible? Eur J Pharm Biopharm., 2022, 172:112-122. doi.org/10.1016/j.ejpb.2022.02.004

Amanda Goodwin

Goodwin AT et al. Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation. Development, 2023, 150(9):dev201046. doi.org/10.1242/dev.201046

Goodwin AT et al. Evaluation of outpatient treatment for non-hospitalised patients with COVID-19: The experience of a regional centre in the UK. PLoS One, 2023, 18(3):e0281915. doi.org/10.1371/journal.pone.0281915

Cash E, Goodwin AT, Tatler AL. Adenosine receptor signalling as a driver of pulmonary fibrosis. Pharmacol Ther., 2023, 249:108504. doi.org/10.1016/j.pharmthera.2023.108504

Jha A, Ward T, Walker A, Goodwin AT, Chalmers JD. Review of the British Thoracic Society Winter Meeting 2021, 24-26 November 2021. Thorax, 2022, 77(10):1030-1035. doi.org/10.1136/thorax-2022-219150

Goodwin AT,Tatler AL, Noble P. Plasma cells – a feasible therapeutic target in pulmonary fibrosis? Eur Respir J., 2022, 60(5):2201748. doi.org/10.1183/13993003.01748-2022

Anna Grabowska

Mehradnia F, Moloney C, Cavanagh RJ, Ibrahim A, Pearce AK, Ritchie A, Clarke P, Rahman R,Grabowska AM, Alexander C. Polymer Architecture Alters Tissue Distribution and Enhances Cytotoxicity Profiles in Orthotopic Models of Triple Negative Breast Cancers. Biomater Sci., 2023, 11(19):6545-6560. doi.org/10.1039/d3bm00609c

Alblihy A, Ali R, Algethami M, Ritchie AA, Shoqafi A, Alqahtani S, Mesquita KA, Toss MS, Ordóñez-Morán P, Jeyapalan J, Dekker L, Salerno M, Hartsuiker E, Grabowska AM, Rakha EA, Mongan NP, Madhusudan S. Selective killing of BRCA2 deficient ovarian cancer cells by MRE11 blockade. Int. J. of Mol. Sci., 2023, 30:10966. doi.org/10.1038/s41698-022-00298-0

Balasubramanian B, Yacqub-Usman K, Venkatraman S, Myint KZ, Juengsamarn J, Sarkhampee P, Lertsawatvicha N, Sripa J, Kuakpaetoon T, Suriyonplengsaeng C, Wongprasert K, Grabowska AM, Bates DO, Janvilsri T, Tohtong R. Targeting FGFRs using PD173074 as a novel therapeutic strategy in cholangiocarcinoma. Cancers, 2023, 15:2528. doi.org/10.3390/cancers15092528

Jones, S, Ashworth JC, Meakin M, Collier P, Probert C, Ritchie AA, Merry CLR,Grabowska AM. Application of a 3D hydrogel-based model to replace use of animals for passaging patient-derived xenografts. In vitro models, 2023, 2:99–111. doi.org/10.1007/s44164-023-00048-x

Linke F, Johnson JEC, Kern S, Bennett CD, Lourdusamy A, Lea D, Clifford SC, Merry CLR, Stolnik S, Alexander MR, Peet AC, Scurr DJ, Griffiths RL, Grabowska AM, Kerr ID, Coyle B. Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. Acta Neuropathol Commun., 2023, 11(1):6. doi.org/10.1186/s40478-022-01496-4

Diringer MC, Coliat P, Mathieu C, Laurent N, Mura C, Banerjee M, Grabowska AM, Ritchie A, Clarke P, Bernard A, Vit C, Burckel H, Noel G, Harvey P, Pivot X, Detappe A. Clinically translatable transcrocetin delivery platform for correction of tumor hypoxia and enhancement of radiation therapy effects. Small, 2022, 19: 2205961. doi.org/10.1002/smll.202205961

Alblihy A, Ali R, Algethami M, Ritchie AA, Allegrucci C, Ordonez Moran P, Mesquita KA, Shoqafi A, Luke J, Toss MS, Alabdullah ML, Jeyapalan JN,Grabowska AM, Rakha EA, Mongan NP, Madhusudan S. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. NPJ Precis Oncol., 2022, 6(1):51. doi.org/10.1038/s41698-022-00298-0

Supradit K, Boonsri B, Duangdara J, Thitiphatphuvanon T, Suriyonplengsaeng C, Kangsamaksin T, Janvilisri T, Tohtong R, Yacqub-Usman K, Grabowska AM, Bates DO, Wongprasert K. Inhibition of serine/arginine-rich protein kinase-1 (SRPK1) prevents cholangiocarcinoma cells induced angiogenesis. Toxicol in Vitro, 2022, 82:105385. doi.org/10.1016/j.tiv.2022.105385

Sueca-Comes M, Rusu E, Grabowska AM, Bates D. Looking under the lamp-post - the search for new cancer targets in the human kinome. Pharmacological Reviews, 2022, 74:1136. doi.org/10.1124/pharmrev.121.000410

Travanut, A., Monteiro PF, Smith S, Howdle SM, Grabowska AM, Kellam B, Meier MAR, Alexander C. Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles. J Mater Chem B., 2022, 10(20):3895-3905. doi.org/10.1039/d2tb00045h

Carroll C, Bolland H, Vancauwenberghe E, Collier P, Ritchie AA, Clarke PA, Grabowska AM, Harris AL, McIntyre A. Targeting Hypoxia Regulated Sodium Driven Bicarbonate Transporters Reduces Triple Negative Breast Cancer Metastasis. Neoplasia, 2022, 25:41. doi.org/10.1016/j.neo.2022.01.003

Sharpe BS, Hayden A, Manousopoulou A, Cowie A, Walker RC, Harrington J, Izadi F, Breininger SP, Gibson J, Pickering O, Jaynes E, Kyle E, Saunders JH, Parsons SL, Ritchie AA, Clarke PA, Collier P, Mongan NM, Bates DO, Yacqub-Usman K, Garbis SD, Walters Z, Rose-Zerilli M, Grabowska AM, Underwood TJ. Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts. Cell Rep Med., 2022, 3(6):100541. doi.org/10.1016/j.xcrm.2022.100541

Andrew Green

Nguyen HL, Geukens T, Maetens M, Aparicio S, Bassez A, Borg A, Brock J, Broeks A, Caldas C, Cardoso F, De Schepper M, Delorenzi M, Drukker CA, Glas AM, Green AR, Isnaldi E, Eyfjörð J, Khout H, Knappskog S, Krishnamurthy S, Lakhani SR, Langerod A, Martens JWM, McCart Reed AE, Murphy L, Naulaerts S, Nik-Zainal S, Nevelsteen I, Neven P, Piccart M, Poncet C, Punie K, Purdie C, Rakha EA, Richardson A, Rutgers E, Vincent-Salomon A, Simpson PT, Schmidt MK, Sotiriou C, Span PN, Tan KTB, Thompson A, Tommasi S, Van Baelen K, Van de Vijver M, Van Laere S, Van't Veer L, Viale G, Viari A, Vos H, Witteveen AT, Wildiers H, Floris G, Garg AD, Smeets A, Lambrechts D, Biganzoli E, Richard F, Desmedt C. Obesity-associated changes in molecular biology of primary breast cancer. Nat Commun., 2023, 14(1):4418. doi.org/10.1038/s41467-023-39996-z

Makhlouf S, Althobiti M, Toss M, Muftah AA, Mongan NP, Lee AHS, Green AR, Rakha EA. The Clinical and Biological Significance of Estrogen Receptor-Low Positive Breast Cancer. Mod Pathol., 2023, 36(10):100284. doi.org/10.1016/j.modpat.2023.100284

Lashen AG, Toss MS, Wootton L, Green AR, Mongan NP, Madhusudan S, Rakha E. Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer. Histopathology, 2023, 83(3):414-425. doi.org/10.1111/his.14960

Kalvala J, Parks RM, Abdi J, Green AR, Cheung KL. Assessment of the Androgen Receptor in Older Women with Primary Breast Cancer: Association with a Panel of Biomarkers and Breast Cancer Specific Survival. Adv Ther., 2023, 40(6):2820-2835. doi.org/10.1007/s12325-023-02504-2

Ibrahim A, Miligy IM, Toss MS, Green AR, Rakha EA. High Inner Centromere Protein (INCENP) expression correlates with aggressive features and predicts poor prognosis in patients with invasive breast cancer. Pathobiology, 2023, Apr 7. doi.org/10.1159/000529628

Algethami M, Toss MS, Woodcock CL, Jaipal C, Brownlie J, Shoqafi A, Alblihy A, Mesquita KA, Green AR, Mongan NP, Jeyapalan JN, Rakha EA, Madhusudan S. Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers. NPJ Breast Cancer, 2023, 9(1):18. doi.org/10.1038/s41523-023-00524-3

Storr SJ, Hoskin V, Aiyappa-Maudsley R, Ghaffari A, Varma S, Green A, Rakha E, Ellis IO, Greer PA, Martin SG. A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease. Cancer Med., 2023, 12(9):10908-10916. doi.org/10.1002/cam4.5802

Ciscar M, Trinidad EM, Perez-Chacon G, Alsaleem M, Jimenez M, Jimenez-Santos MJ, Perez-Montoyo H, Sanz-Moreno A, Vethencourt A, Toss M, Petit A, Soler-Monso MT, Lopez V, Gomez-Miragaya J, Gomez-Aleza C, Dobrolecki LE, Lewis MT, Bruna A, Mouron S, Quintela-Fandino M, Al-Shahrour F, Martinez-Aranda A, Sierra A, Green AR, Rakha E, Gonzalez-Suarez E. RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer. EMBO Mol Med., 2023, 15(4):e16715. doi.org/10.15252/emmm.202216715

Lashen AG, Toss MS, Ghannam SF, Makhlouf S, Green A, Mongan NP, Rakha E. Expression, assessment and significance of Ki67 expression in breast cancer: an update J Clin Pathol., 2023, 76(6):357-364. doi.org/10.1136/jcp-2022-208731

Ibrahim A, Toss MS, Atallah NM, Al Saleem M, Green AR, Rakha EA. Combined proliferation and apoptosis index provides better risk stratification in breast cancer. Histopathology, 2023, 82(7):1029-1047. doi.org/10.1111/his.14887

Lashen AG, Toss MS, Mongan NP, Green AR, Rakha EA. The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up. Cancer, 2023, 129(8):1183-1194. doi.org/10.1002/cncr.34655

Kariri YA, Joseph C, Alsaleem MA, Elsharawy KA, Alsaeed S, Toss MS, Mongan NP,Green AR, Rakha EA. Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer. Cancers (Basel), 2022, 14(22):5643. doi.org/10.3390/cancers14225643

Aljohani AI, Toss MS, Green AR, Rakha EA. The clinical significance of cyclin B1 (CCNB1) in invasive breast cancer with emphasis on its contribution to lymphovascular invasion development. Breast Cancer Res Treat., 2023, 198(3):423-435. doi.org/10.1007/s10549-022-06801-2

Xu Q, Kaur J, Wylie D, Mittal K, Li H, Kolachina R, Aleskandarany M, Toss MS, Green AR, Yang J, Yankeelov TE, Bhattarai S, Janssen EAM, Kong J, Rakha EA, Kowalski J, Aneja R. A Case Series Exploration of Multi-Regional Expression Heterogeneity in Triple-Negative Breast Cancer Patients. Int J Mol Sci., 2022, 23(21):13322. doi.org/10.3390/ijms232113322

Atallah NM, Toss MS, Green AR, Mongan NP, Ball G, Rakha EA. Refining the definition of HER2-low class in invasive breast cancer. Histopathology, 2022, 81(6):770-785. doi.org/10.1111/his.14780

Lashen A, Toss MS, Green AR, Mongan NP, Rakha E. Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods. Histopathology, 2022, 81(6):786-798. doi.org/10.1111/his.14781

Aiyappa-Maudsley R, Storr SJ, Rakha EA,Green AR, Ellis IO, Martin SG. CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer. J Pathol Clin Res., 2022, 8(6):550-566. doi.org/10.1002/cjp2.291

Miligy IM, Toss MS, Gorringe KL, Ellis IO, Green AR, Rakha EA. Aurora Kinase A Is an Independent Predictor of Invasive Recurrence in Breast Ductal Carcinoma in situ. Pathobiology, 2022, 89(6):382-392. doi.org/10.1159/000522244

Saunus JM, De Luca XM, Northwood K, Raghavendra A, Hasson A, McCart Reed AE, Lim M, Lal S, Vargas AC, Kutasovic JR, Dalley AJ, Miranda M, Kalaw E, Kalita-de Croft P, Gresshoff I, Al-Ejeh F, Gee JMW, Ormandy C, Khanna KK, Beesley J, Chenevix-Trench G, Green AR, Rakha EA, Ellis IO, Nicolau DV Jr, Simpson PT, Lakhani SR. Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. NPJ Breast Cancer, 2022, 8(1):57. doi: doi.org/10.1038/s41523-022-00425-x

Lashen A, Toss MS, Alsaleem M, Green AR, Mongan NP, Rakha EA.The characteristics and clinical significance of atypical mitosis in breast cancer. E. Mod Pathol., 2022, 35(10):1341-1348. doi.org/10.1038/s41379-022-01080-0

Danenberg E, Bardwell H, Zanotelli VRT, Provenzano E, Chin SF, Rueda OM, Green A, Rakha E, Aparicio S, Ellis IO, Bodenmiller B, Caldas C, Ali HR. Breast tumor microenvironment structures are associated with genomic features and clinical outcome. Nat Genet., 2022, 54(5):660-669. doi.org/10.1038/s41588-022-01041-y

Hagenaars SC, Vangangelt KMH, Van Pelt GW, Karancsi Z, Tollenaar RAEM, Green AR, Rakha EA, Kulka J, Mesker WE. Standardization of the tumor-stroma ratio scoring method for breast cancer research. Breast Cancer Res Treat., 2022, 193(3):545-553. doi.org/10.1007/s10549-022-06587-3

Aljohani AI, Toss MS, El-Sharawy KA, Mirza S, Ball GR, Green AR, Rakha EA.Upregulation of Cyclin B2 (CCNB2) in breast cancer contributes to the development of lymphovascular invasion. Am J Cancer Res., 2022, 12(2):469-489. https://pubmed.ncbi.nlm.nih.gov/35261781/

Kariri Y, Toss MS, Alsaleem M, Elsharawy KA, Joseph C, Mongan NP,Green AR, Rakha EA. Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer. Breast Cancer Res Treat., 2022, 192(3):529-539. doi.org/10.1007/s10549-022-06531-5

Shiino S, Ball G, Syed BM, Kurozumi S, Green AR, Tsuda H, Takayama S, Suto A, Rakha EA. Prognostic significance of receptor expression discordance between primary and recurrent breast cancers: a meta-analysis. Breast Cancer Res Treat., 2022, 191(1):1-14. doi.org/10.1007/s10549-021-06390-6

Kalvala J, Parks RM, Green AR, Cheung KL. Concordance between core needle biopsy and surgical excision specimens for Ki-67 in breast cancer - a systematic review of the literature. Histopathology, 2022, 80(3):468-484. doi.org/10.1111/his.14555

Alsaeed SA, Toss M, Alsaleem M, Aleskandarany M, Joseph C, Kurozumi S, Ball G, Mongan N, Green A, Rakha E. Prognostic significance of heat shock protein 90AA1 (HSP90α) in invasive breast cancer. J Clin Pathol., 2022, 75(4):263-269. doi.org/10.1136/jclinpath-2020-207106

Ruth Griffin

Wood L, Omorotionmwan BB, Blanchard AM, Dowle A, Bishop AL, Griffin R. Characterisation of the butyrate production pathway in probiotic MIYAIRI588 by a combined whole genome-proteome approach. bioRxiv, 2023. doi.org/10.1101/2023.08.20.554021

Hughes J, Aston C, Kelly ML, Griffin R. Towards Development of a Non-Toxigenic Clostridioides difficile Oral Spore Vaccine against Toxigenic C. difficile. Pharmaceutics, 2022, 14(5):1086. doi.org/10.3390/pharmaceutics14051086

Richard Grundy

Thomas S, Embry L, Walsh K, Bull K, Grundy R, Kennedy C, Lemiere J, Hernáiz Driever P, Limond J, Chevignard M, Hardy K. Transatlantic progress in measurement of cognitive outcomes in paediatric oncology trials. Pediatr Blood Cancer, 2023, 70(5):e30171. doi.org/10.1002/pbc.30171

Griesinger AM, Riemondy K, Eswaran N, Donson AM, Willard N, Prince EW, Paine SML, Bowes G, Rheaume J, Chapman RJ, Ramage J, Jackson A, Grundy RG, Foreman NK, Ritzmann TA. Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma. iScience, 2023, 26(9):107585. doi.org/10.1016/j.isci.2023.107585

Milne P, Bomken S, Slater O, Kumar A, Nelson A, Roy S, Velazquez J, Mankad K, Nicholson J, Yeomanson D, Grundy R, Kamal A, Penn A, Pears J, Millen G, Morland B, Hayden J, Lam J, Madkhali M, MacDonald J, Singh P, Pagan S, Rodriguez-Galindo C, Minkov M, Donadieu J, Picarsic J, Allen C, Bigley V, Collin M. Lineage switching of the cellular distribution of BRAFV600E in multisystem Langerhans cell histiocytosis. Blood Adv., 2023, 7(10):2171-2176. doi.org/10.1182/bloodadvances.2021006732

Briggs M, Das A, Firth H, Levine A, Sánchez-Ramírez S, Negm L, Ercan AB, Chung J, Bianchi V, Jalloh I, Phyu P, Thorp N, Grundy RG, Hawkins C, Trotman J, Tarpey P, Tabori U, Allinson K, Murray MJ; Genomics England Research Consortium. Recurrent posterior fossa group A (PFA) ependymoma in a young child with constitutional mismatch repair deficiency (CMMRD). Neuropathol Appl Neurobiol., 2023, 49(1):e12862. doi.org/10.1111/nan.12862

Sievers P, Sill M, Schrimpf D, Abdullaev Z, Donson AM, Lake JA, Friedel D, Scheie D, Tynninen O, Rauramaa T, Vepsäläinen KL, Samuel D, Chapman R, Grundy RG, Pajtler KW, Tauziède-Espariat A, Métais A, Varlet P, Snuderl M, Jacques TS, Aldape K, Reuss DE, Korshunov A, Wick W, Pfister SM, von Deimling A, Sahm F, Jones DTW. Pediatric-type high-grade neuroepithelial tumors with CIC gene fusion share a common DNA methylation signature. NPJ Precis Oncol., 2023, 7(1):30. doi.org/10.1038/s41698-023-00372-1

Powell SJ, Withey SB, Sun Y, Grist JT, Novak J, MacPherson L, Abernethy L, Pizer B, Grundy R, Morgan PS, Jaspan T, Bailey S, Mitra D, Auer DP, Avula S, Arvanitis TN, Peet A. Applying machine learning classifiers to automate quality assessment of paediatric dynamic susceptibility contrast (DSC-) MRI data. Br J Radiol., 2023, 96(1145):20201465. doi.org/10.1259/bjr.20201465

Donson AM, Bertrand KC, Riemondy KA, Gao D, Zhuang Y, Sanford B, Norris GA, Chapman RJ, Fu R, Willard N, Griesinger AM, Ribeiro de Sousa G, Amani V, Grimaldo E, Hankinson TC, Booker F, Sill M, Grundy RG, Pajtler KW, Ellison DW, Foreman NK, Ritzmann TA. Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: A multicenter study. Neuro Oncol., 2023, 25(10):1854-1867. doi.org/10.1093/neuonc/noad096

Jackson TJ, Napper R, Haeusler GM, Pizer B, Bate J, Grundy RG, Samarasinghe S, Angelini P, Ball-Gamble A, Phillips B, Morgan JE. Can I go home now? The safety and efficacy of a new UK paediatric febrile neutropenia protocol for risk-stratified early discharge on oral antibiotics. Arch Dis Child, 2023, 108(3):192-197. doi.org/10.1136/archdischild-2021-323254

Butler A, Meijer L, Liu JF, Chohan M, Jalloh I, Macarthur D, Parr M, Wilne S, Wilson S, Walker D, Grundy R, Dandapani M. Evaluating the efficacy and safety of single-agent etoposide intra-CSF chemotherapy in children and young people with relapsed/refractory central nervous system tumours. Childs Nerv Syst., 2023, 39(6):1537-1544. doi.org/10.1007/s00381-023-05872-w

Chapman RJ, Ghasemi DR, Andreiuolo F, Zschernack V, Espariat AT, Buttarelli FR, Giangaspero F, Grill J, Haberler C, Paine SML, Scott I, Jacques TS, Sill M, Pfister S, Kilday JP, Leblond P, Massimino M, Witt H, Modena P, Varlet P, Pietsch T, Grundy RG, Pajtler KW, Ritzmann TA. Optimizing biomarkers for accurate ependymoma diagnosis, prognostication, and stratification within International Clinical Trials: A BIOMECA study. Neuro Oncol., 2023, 25(10):1871-1882. doi.org/10.1093/neuonc/noad055

Brown S, Chowdhury T, Collin M, Grundy RG, Howell L, Ramanujachar R, Rees H, Vora A, Gray JC, Bate J. National advisory panels for childhood cancer in the United Kingdom: An evaluation of current practice and a best practice statement for the future. Pediatr Blood Cancer, 2023, 70(3):e30159. doi.org/10.1002/pbc.30159

Izquierdo E, Carvalho DM, Mackay A, Temelso S, Boult JKR, Pericoli G, Fernandez E, Das M, Molinari V, Grabovska Y, Rogers RF, Ajmone-Cat MA, Proszek PZ, Stubbs M, Depani S, O'Hare P, Yu L, Roumelioti G, Choudhary JS, Clarke M, Fairchild AR, Jacques TS, Grundy RG, Howell L, Picton S, Adamski J, Wilson S, Gray JC, Zebian B, Marshall LV, Carceller F, Grill J, Vinci M, Robinson SP, Hubank M, Hargrave D, Jones C. DIPG Harbors Alterations Targetable by MEK Inhibitors, with Acquired Resistance Mechanisms Overcome by Combinatorial Inhibition. Cancer Discov., 2022, 12(3):712-729. doi.org/10.1158/2159-8290.cd-20-0930

Branter J, Estevez-Cebrero M, Diksin M, Griffin M, Castellanos-Uribe M, May S, Rahman R, Grundy R, Basu S, Smith S. Genome-Wide Expression and Anti-Proliferative Effects of Electric Field Therapy on Pediatric and Adult Brain Tumors. Int J Mol Sci., 2022, 23(4):1982. doi.org/10.3390/ijms23041982

Bishop E, Dimitrova M, Froggatt A, Estevez-Cebrero M, Storer LCD, Mussai F, Paine S, Grundy RG,Dandapani M. Characterisation of Expression the Arginine Pathway Enzymes in Childhood Brain Tumours to Determine Susceptibility to Therapeutic Arginine Depletion. Biomed Res Int., 2022, 2022:9008685. doi.org/10.1155/2022/9008685

Nohtani M, Vrzalikova K, Ibrahim M, Powell JE, Fennell É, Morgan S, Grundy R, McCarthy K, Dewberry S, Bouchal J, Bouchalova K, Kearns P, Murray PG. Impact of Tumour Epstein-Barr Virus Status on Clinical Outcome in Patients with Classical Hodgkin Lymphoma (cHL): A Review of the Literature and Analysis of a Clinical Trial Cohort of Children with cHL. Cancers (Basel), 2022, 14(17):4297. doi.org/10.3390/cancers14174297

Leblond P, Massimino M, English M, Ritzmann TA, Gandola L, Calaminus G, Thomas S, Pérol D, Gautier J, Grundy RG, Frappaz D. Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol. Front Neurol., 2022, 13:887544. doi.org/10.3389/fneur.2022.887544

Withey SB, MacPherson L, Oates A, Powell S, Novak J, Abernethy L, Pizer B, Grundy R, Morgan PS, Bailey S, Mitra D, Arvanitis TN, Auer DP, Avula S, Peet AC. Dynamic susceptibility-contrast magnetic resonance imaging with contrast agent leakage correction aids in predicting grade in pediatric brain tumours: a multicenter study. Pediatr Radiol., 2022, 52(6):1134-1149. doi.org/10.1007/s00247-021-05266-7

 Apps JR, Maycock S, Ellison DW, Jaspan T, Ritzmann TA, Macarthur D, Mallucci C, Wheatley K, Veal GJ, Grundy RG, Picton S. Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04). Neurooncol Adv., 2022, 4(1):vdac053. doi.org/10.1093/noajnl/vdac053

Ritzmann TA, Chapman RJ, Kilday JP, Thorp N, Modena P, Dineen RA, Macarthur D, Mallucci C, Jaspan T, Pajtler KW, Giagnacovo M, Jacques TS, Paine SML, Ellison DW, Bouffet E, Grundy RG. SIOP Ependymoma I: Final results, long-term follow-up, and molecular analysis of the trial cohort-A BIOMECA Consortium Study. Neuro Oncol., 2022, 24(6):936-948. doi.org/10.1093/neuonc/noac012

Millen GC, Arnold R, Cazier JB, Curley H, Feltbower R, Gamble A, Glaser A, Grundy RG, Kirton L, Lee LYW, McCabe MG, Palles C, Phillips B, Stiller CA, Varnai C, Kearns P. COVID-19 in children with haematological malignancies. Arch Dis Child., 2022, 107(2):186-188. doi.org/10.1136/archdischild-2021-322062

Pratt D, Lucas CG, Selvam PP, Abdullaev Z, Ketchum C, Quezado M, Armstrong TS, Gilbert MR, Papanicolau-Sengos A, Raffeld M, Choo-Wosoba H, Chan P, Whipple N, Nasrallah M, Santi M, Ramaswamy V, Giannini C, Ritzmann TA, Grundy RG, Burford A, Jones C, Hawkins C, Venneti S, Solomon DA, Aldape K. Recurrent ACVR1 mutations in posterior fossa ependymoma. Acta Neuropathol., 2022, 144(2):373-376. doi.org/10.1007/s00401-022-02435-2

Lindsay HB, Massimino M, Avula S, Stivaros S, Grundy R, Metrock K, Bhatia A, Fernández-Teijeiro A, Chiapparini L, Bennett J, Wright K, Hoffman LM, Smith A, Pajtler KW, Poussaint TY, Warren KE, Foreman NK, Mirsky DM. Response assessment in paediatric intracranial ependymoma: recommendations from the Response Assessment in Pediatric Neuro-Oncology (RAPNO) working group. Lancet Oncol., 2022, 23(8):e393-e401. doi.org/10.1016/s1470-2045(22)00222-4

Mohammed OJ, Cebrero ME, Ahmad O, Peet A, Grundy RG, Lourdusamy A. The Molecular Landscape of Medulloblastoma in Teenagers and Young Adults. Cancers (Basel), 2022, 14(1):251. doi.org/10.3390/cancers14010251

Wood J, Abdelrazig S, Evseev S, Ortori C, Castellanos-Uribe M, May ST, Barrett DA, Diksin M, Chakraborty S, Kim DH, Grundy RG, Rahman R. Lipoprotein Deprivation Reveals a Cholesterol-Dependent Therapeutic Vulnerability in Diffuse Glioma Metabolism. Cancers (Basel), 2022, 14(16):3873. doi.org/10.3390/cancers14163873

Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA. Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma. J Magn Reson Imaging, 2022, 56(1):147-157. doi.org/10.1002/jmri.28007

Nick Hannan

Gajera KR, Fair KL, Moran GW, Hannan NRF, Huelsken J, Ordóñez-Morán P. In Vitro and in Vivo Assays for Testing Retinoids Effect on Intestinal Progenitors' Lineage Commitments. Methods Mol Biol., 2023, 2650:53-61. doi.org/10.1007/978-1-0716-3076-1_5

Cuevas-Ocaña S, Yang JY, Aushev M, Schlossmacher G, Bear CE, Hannan NRF, Perkins ND, Rossant J, Wong AP, Gray MA. A Cell-Based Optimised Approach for Rapid and Efficient Gene Editing of Human Pluripotent Stem Cells. Int J Mol Sci., 2023, 24(12):10266. doi.org/10.3390/ijms241210266

Grove JI, Lo PCK, Shrine N, Barwell J, Wain LV, Tobin MD, Salter AM, Borkar AN, Cuevas-Ocaña S, Bennett N, John C, Ntalla I, Jones GE, Neal CP, Thomas MG, Kuht H, Gupta P, Vemala VM, Grant A, Adewoye AB, Shenoy KT, Balakumaran LK, Hollox EJ, Hannan NRF, Aithal GP. Identification and characterisation of a rare MTTP variant underlying hereditary non-alcoholic fatty liver disease. JHEP Rep., 2023, 5(8):100764. doi.org/10.1016/j.jhepr.2023.100764

Kim Hardie

Hardie KR, Fenn, SJ. Antimicrobial Profile: Rifampicin: a broad-spectrum antibiotic. J Med Microbiol., 2022, 71(8). doi:10.1099/jmm.0.001566

Dubern J-F, Halliday N, Camara M, Winzer K, Barrett DA, Hardie KR,Williams P. Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa. Microbiology (Reading), 2023, 169(4):001316. doi:10.1099/mic.0.001316

Kasza K, Elsherbeny A, Moloney C, Hardie KR,Camara M, Alexander C, Gurnani P. Hybrid poly(ß-amino ester) triblock copolymers utilising a RAFT polymerisation grafting-from methodology. Macromol Chem Phys., 2023. doi.org/10.1002/macp.202300262

John Heap

Sellés Vidal L, Isalan M, Heap JT, Ledesma-Amaro R. A primer to directed evolution: current methodologies and future directions. RSC Chem Biol., 2023, 4(4):271-291. doi.org/10.1039/d2cb00231k

Passmore IJ, Faulds-Pain A, Abouelhadid S, Harrison MA, Hall CL, Hitchen P, Dell A, Heap JT, Wren BW. A combinatorial DNA assembly approach to biosynthesis of N-linked glycans in E. coli. Glycobiology, 2023, 33(2):138-149. doi.org/10.1093/glycob/cwac082

Moreira JPC, Heap JT, Alves JI, Domingues L. Developing a genetic engineering method for Acetobacterium wieringae to expand one-carbon valorization pathways. Biotechnol Biofuels Bioprod., 2023, 16(1):24. doi.org/10.1186/s13068-023-02259-6

Little GT, Sellés Vidal L, Steadman M, Leyden-Preece R, Taylor GM, Heap JT. Complete Genome Sequence of Paraclostridium bifermentans DSM 14991. Microbiol Resour Announc., 2022, 11(7):e0010322. doi.org/10.1128/mra.00103-22

Moreira J, Heap J, Alves J, Domingues L. Expanding the molecular toolkit for the new gas-converting Acetobacterium wieringae strain JM. BioIberoAmerica, 3rd IberoAmerican Congress on Biotechnology, Braga, Portugal. 2022, 299. https://hdl.handle.net/1822/76991

Stephan Heeb

Mellini M, Letizia M, Caruso L, Guiducci A, Meneghini C, Heeb S, Williams P, Cámara M, Visca P, Imperi F, Leoni L, Rampioni G. RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing. mBio., 2023, Oct 16:e0203923. doi.org/10.1128/mbio.02039-23

Giallonardi G, Letizia M, Mellini M, Frangipani E, Halliday N, Heeb S, Cámara M, Visca P, Imperi F, Leoni L, Williams P, Rampioni G. Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms. Front Cell Infect Microbiol., 2023, 13:1183681. doi.org/10.3389/fcimb.2023.1183681

Dubern JF, Romero M, Mai-Prochnow A, Messina M, Trampari E, Gijzel HN, Chan KG, Carabelli AM, Barraud N, Lazenby J, Chen Y, Robertson S, Malone JG, Williams P,Heeb S, Cámara M. ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa. NPJ Biofilms Microbiomes, 2022, 8(1):64. doi.org/10.1038/s41522-022-00325-9

Romero M, Mayer C, Heeb S, Wattanavaekin K, Cámara M, Otero A, Williams P. Mushroom-shaped structures formed in Acinetobacter baumannii biofilms grown in a roller bioreactor are associated with quorum sensing-dependent Csu-pilus assembly. Environ Microbiol., 2022, 24(9):4329-4339. doi.org/10.1111/1462-2920.15985

Mohammad Ilyas

Ham-Karim H, Negm O, Ahmad N, Ilyas M. Investigating genomic, proteomic, and post-transcriptional regulation profiles in colorectal cancer: a comparative study between primary tumors and associated metastases. Cancer Cell Int., 2023, 23(1):192. doi.org/10.1186/s12935-023-03020-7

Talhouni S, Fadhil W, Mongan NP, Field L, Hunter K, Makhsous S, Maciel-Guerra A, Kaur N, Nestarenkaite A, Laurinavicius A, Willcox BE, Dottorini T, Spendlove I, Jackson AM,Ilyas M,Ramage JM. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided "immune-hot" colorectal cancers. Front Immunol., 2023, 14:1057292. doi.org/10.3389/fimmu.2023.1057292

Williams CJM, Elliott F, Sapanara N, Aghaei F, Zhang L, Muranyi A, Yan D, Bai I, Zhao Z, Shires M, Wood HM, Richman SD, Hemmings G, Hale M, Bottomley D, Galvin L, Cartlidge C, Dance S, Bacon CM, Mansfield L, Young-Zvandasara K, Sudan A, Lambert K, Bibby I, Coupland SE, Montazeri A, Kipling N, Hughes K, Cross SS, Dewdney A, Pheasey L, Leng C, Gochera T, Mangham DC, Saunders M, Pritchard M, Stott H, Mukherjee A,Ilyas M, Silverman R, Hyland G, Sculthorpe D, Thornton K, Gould I, O'Callaghan A, Brown N, Turnbull S, Shaw L, Seymour MT, West NP, Seligmann JF, Singh S, Shanmugam K, Quirke P. Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer. Clin Cancer Res., 2023, 29(20):4153-4165. doi.org/10.1158/1078-0432.ccr-23-0859

Dalleywater W, Wheat F, Sculthorpe D, Hyland G, Ilyas M. In Vitro Culture and Histological Evaluation of 3D Organotypic Cultures. Methods Mol Biol., 2023, 2650:155-170. doi.org/10.1007/978-1-0716-3076-1_13

Cahyani I, Putro EW, Ridwanuloh AM, Wibowo S, Hariyatun H, Syahputra G, Akbariani G, Utomo AR, Ilyas M, Loose M, Kusharyoto W, Susanti S. Genome Profiling of SARS-CoV-2 in Indonesia, ASEAN and the Neighbouring East Asian Countries: Features, Challenges and Achievements. Viruses, 2022, 14(4):778. doi.org/10.3390/v14040778

Elsheikh S, Kouzoukakis I, Fielden C, Li W, Lashin SE, Khair N, Raposo TP, Fadhil W, Rudland P, Aleskandarany M, Patel P, El-Tanani M, Ilyas M. Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion. J Clin Pathol., 2022, 75(1):24-29. doi.org/10.1136/jclinpath-2020-206871

Ilyas M. Artificial Intelligence in cancer pathology-hope or hype? Lancet Digit Health, 2022, 4(11):e766-e767. doi.org/10.1016/s2589-7500(22)00193-5

Andrew Jackson

Griesinger A, Riemondy K, Eswaran N, Donson A, Willard N, Prince E, Paine S, Bowes G, Rheaume J, Chapman R, Ramage J, Jackson AM, Grundy R, Foreman N, Ritzmann T. Multi-Omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high risk pediatric ependymoma. iScience, 2023. 26(9):107585. doi.org/10.1016/j.isci.2023.107585

Talhouni S, Fadhil Q, Mongan N, Field L, Hunter K, Makhsous S, Maciel-Guerra A, Kaur N, Nestarenkaite A, Laurinavincius A, Willcox B, Dottorini T, Spendlove I, Jackson AM, Ilyas M, Ramage JM. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided “immune-hot” colorectal cancers. Front Immunol., 2023, 14:1057292. doi.org/10.3389/fimmu.2023.1057292

Gyan E, Owiredu W, Fondjo L, Jackson AM, Green A, Toss M, Akakpo P, Derkyi-Kwarteng L, Rahman G. 2022 The combination phenotype of B-cell specific Moloney murine leukaemia virus integration site 1 (BMI1) and CD44⁺/CD24^−/low associates with poor clinicopathological features in African patients with breast cancer. Gene Rep., 2022, 26:101475. doi.org/10.1016/j.genrep.2021.101475

Victoria James

Ogurcov S, Shulman I, Garanina E, Sabirov D, Baichurina I, Kuznetcov M, Masgutova G, Kostennikov A, Rizvanov A, James V, Mukhamedshina Y. Blood Serum Cytokines in Patients with Subacute Spinal Cord Injury: A Pilot Study to Search for Biomarkers of Injury Severity. Brain Sci., 2021, 11(3):322. doi.org/10.3390%2Fbrainsci11030322

Akhmetzyanova ER, Timofeeva AV, Sabirov DK, Kostennikov AA, Rogozhin AA, James V, Arkhipova SS, Rizvanov AA, Mukhamedshina YO. Increasing Severity of Spinal Cord Injury Results in Microglia/Macrophages With Annular-Shaped Morphology and No Change in Expression of CD40 and Tumor Growth Factor-β During the Chronic Post-injury Stage. Front Mol Neurosci., 2022, 4:802558. : doi.org/10.3389%2Ffnmol.2021.802558

Anderson JR, Jacobsen S, Walters M, Bundgaard L, Diendorfer A, Hackl M, Clarke EJ, James V, Peffers MJ. Small non-coding RNA landscape of extracellular vesicles from a post-traumatic model of equine osteoarthritis. Front Vet Sci., 2022, 9:901269. doi.org/10.3389/fvets.2022.901269

Bhome R, Emaduddin M, James V, House LM, Thirdborough SM, Mellone M, Tulkens J, Primrose JN, Thomas GJ, De Wever O, Mirnezami AH, Sayan AE. Epithelial to mesenchymal transition influences fibroblast phenotype in colorectal cancer by altering miR-200 levels in extracellular vesicles. J Extracell Vesicles, 2022, 11(5):e12226. doi.org/10.1002/jev2.12226

Clarke EJ, Johnson E, Caamaño Gutierrez E, Andersen C, Berg LC, Jenkins RE, Lindegaard C, Uvebrant K, Lundgren-Åkerlund E, Turlo A, James V, Jacobsen S, Peffers MJ. Temporal extracellular vesicle protein changes following intraarticular treatment with integrin α10β1-selected mesenchymal stem cells in equine osteoarthritis. Front Vet Sci., 2022, 9:1057667. doi.org/10.3389/fvets.2022.1057667

Clarke EJ, Lima C, Anderson JR, Castanheira C, Beckett A, James V, Hyett J, Goodacre R, Peffers MJ. Optical photothermal infrared spectroscopy can differentiate equine osteoarthritic plasma extracellular vesicles from healthy controls. Anal Methods., 2022, 14(37):3661-3670. doi.org/10.1039/d2ay00779g

Gomez N, James V, Onion D, Fairclough LC. Extracellular vesicles and chronic obstructive pulmonary disease (COPD): a systematic review. Respir Res., 2022, 23(1):82 doi.org/10.1186/s12931-022-01984-0

Kabdesh IM, Mukhamedshina YO, Arkhipova SS, Sabirov DK, Kuznecov MS, Vyshtakalyuk AB, Rizvanov AA, James V, Chelyshev YA. Cellular and Molecular Gradients in the Ventral Horns With Increasing Distance From the Injury Site After Spinal Cord Contusion. Front Cell Neurosci., 2022, 16:817752. doi.org/10.3389/fncel.2022.817752

Wijesinghe SN, Anderson J, Brown TJ, Nanus DE, Housmans B, Green JA, Hackl M, Choi KK, Arkill KP, Welting T, James V, Jones SW, Peffers MJ. The role of extracellular vesicle miRNAs and tRNAs in synovial fibroblast senescence. Front Mol Biosci., 2022, 9:971621 doi.org/10.3389/fmolb.2022.971621

Anderson J, Riasat K, James V, Peffers M. Regenerative Potential Of Extracellular Vesicles From Multiple Sources. Osteoarthritis and Cartilage, 2023, 31, S234. doi.org/10.1016/j.joca.2023.01.228

Anderson JR, Johnson E, Jenkins R, Jacobsen S, Green D, Walters M, Bundgaard L, Hausmans BAC, van den Akker G, Welting TJM, Chabronova A, Kharaz YA, Clarke EJ, James V, Peffers MJ. Multi-Omic Temporal Landscape of Plasma and Synovial Fluid-Derived Extracellular Vesicles Using an Experimental Model of Equine Osteoarthritis. Int J Mol Sci., 2023, 24(19):14888. doi.org/10.3390/ijms241914888

Castanheira C, Anderson J, Clarke E, Taylor S, Hackl M, Clegg P, James V, Peffers M. (2023) Extracellular Vesicle MicroRNA Crosstalk Between Equine Chondrocytes And Synoviocytes-An In Vitro Approach. Osteoarthr Cartilage, 2023, 31, S338. doi.org/10.1016/j.joca.2023.01.375

Gomez NE, James V,Arkill KP, Nizamudeen ZA, Onion D, Fairclough LC. PBMC-derived extracellular vesicles in a smoking-related inflammatory disease model. Eur J Immunol., 2023, 53(6):e2250143. doi.org/10.1002/eji.202250143

Jeyapalan JN,James V, Gardner DS, Lothion-Roy JH, Mongan NP, Rutland CS. Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anat Histol Embryol., 2023, 52(1):93-100. doi.org/10.1111/ahe.12842

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C,James VH,Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E, Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Clinical and molecular significance of the RNA m⁶A methyltransferase complex in prostate cancer. Front Genet., 2023, 13:1096071. doi.org/10.3389/fgene.2022.1096071

Reviews

Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S, Allegrucci C, James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, Mongan NP, Jeyapalan JN. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front Endocrinol (Lausanne), 2022, 13:1006101. doi.org/10.3389/fendo.2022.1006101

Ryman-Tubb T, Lothion-Roy JH, Metzler VM, Harris AE, Robinson BD, Rizvanov AA, Jeyapalan JN,James VH, England G, Rutland CS, Persson JL, Kenner L, Rubin MA, Mongan NP, de Brot S. Comparative pathology of dog and human prostate cancer. Vet Med Sci., 2022, 8(1):110-120. doi.org/10.1002/vms3.642

Gomzikova M, James V, Rizvanov A. Extracellular Vesicles Derived from Mesenchymal Stem Cells: Biological Activity and Approaches of Large-Scale Production. In: Handbook of Stem Cell Therapy. Springer Singapore, 2022, 1-27.

Wesson F, Brown TJ, James V. Extracellular vesicles, tumor growth, and the metastatic process. In: Bone Sarcomas and Bone Metastases-From Bench to Bedside. Academic Press, 2022, 275-284.

Sheela Jayaraman

Jain A, Gosling J, Liu S, Wang H, Stone EM, Chakraborty S, Jayaraman PS, Smith S, Amabilino DB, Fromhold M, Long YT, Pérez-García L, Turyanska L, Rahman R, Rawson FJ. Wireless electrical-molecular quantum signalling for cancer cell apoptosis. Nat Nanotechnol., 2023. doi.org/10.1038/s41565-023-01496-y

Reolizo LM, Williams H, Wadey K, Frankow A, Li Z, Gaston K,Jayaraman PS, Johnson JL, George SJ. Inhibition of Intimal Thickening By PRH (Proline-Rich Homeodomain) in Mice. Arterioscler Thromb Vasc Biol., 2023, 43(3):456-473. doi: doi.org/10.1161/atvbaha.122.318367

Kitchen P, Gaston K, Jayaraman PS. Transcription Factor Chromatin Immunoprecipitation in Endothelial Cells. Methods Mol Biol., 2022; 2441:257-275. doi.org/10.1007/978-1-0716-2059-5_20

Jennie Jeyapalan

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C, James VH, Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E, Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Clinical and molecular significance of the RNA m⁶A methyltransferase complex in prostate cancer. Front Genet., 2023, 13:1096071. doi.org/10.3389/fgene.2022.1096071

Jeyapalan JN,James V, Gardner DS, Lothion-Roy JH, Mongan NP, Rutland CS. Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anat Histol Embryol., 2023, 52(1):93-100. doi.org/10.1111/ahe.12842

lblihy A, Ali R, Algethami M, Shoqafi A, Toss MS, Brownlie J, Tatum NJ, Hickson I, Moran PO, Grabowska A,Jeyapalan JN,Mongan NP, Rakha EA, Madhusudan S. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. NPJ Precis Oncol., 2022, 6(1):51. doi.org/10.1038/s41698-022-00298-0

Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S, Allegrucci C, James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, Mongan NP, Jeyapalan JN. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front Endocrinol (Lausanne), 2022, 13:1006101. doi.org/10.3389/fendo

Simpson S, Rizvanov AA, Jeyapalan JN, de Brot S, Rutland CS. Canine osteosarcoma in comparative oncology: Molecular mechanisms through to treatment discovery. Front Vet Sci., 2022, 9:965391. doi.org/10.3389/fvets.2022.965391

Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Metzler VM, Persson JL, Robinson BD, Khani F, Alsaleem M, Ntekim A, Madhusudan S, Davis MB, Laursen KB, Gudas LJ, Rutland CS, Toss MS, Archer N, Bodi Z, Rakha EA, Fray RG, Jeyapalan JN,MonganNP. The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers (Basel), 2022, 14(20). doi.org/10.3390/cancers14205148

Simon Johnson

Saunders P, Wu Z, Fahy WA, Stewart ID, Saini G, Smith DJF, Braybrooke R, Stock C, Renzoni EA, Johnson SR, Jenkins RG, Belvisi MG, Smith JA, Maher TM, Molyneaux PL. The Burden and Impact of Cough in Patients with Idiopathic Pulmonary Fibrosis: An Analysis of the Prospective Observational PROFILE Study. Ann Am Thorac Soc., 2023, 20(9):1267-1273. 

 doi.org/10.1513/annalsats.202302-174oc

Portelli MA, Bhaker S, Pang V, Bates DO,Johnson SR, Mazar AP, Shaw D, Brightling C, Sayers I. Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity. Clin Transl Allergy, 2023, 13(10):e12293. doi.org/10.1002%2Fclt2.12293

Tatler AL, Philp CJ, Hill MR, Cox S, Bullock AM, Habgood A, John A, Middlewick R, Stephenson KE, Goodwin AT, Billington CK, O'Dea RD, Johnson SR,* Brook BS*. Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis. Am J Physiol Lung Cell Mol Physiol., 2023, 324(3):L271-L284. *Joint senior authors. doi.org/10.1152/ajplung.00034.2022 

Palipana AK, Gecili E, Song S, Johnson SR, Szczesniak RD, Gupta N. Predicting Individualized Lung Disease Progression in Treatment-Naive Patients With Lymphangioleiomyomatosis. Chest, 2023, 163(6):1458-1470. doi.org/10.1016/j.chest.2022.12.027

Stewart I, Jacob J, George PM, Molyneaux PL, Porter JC, Adams W, Allen RJ, Aul R, Baillie JK, Barratt SL, Beirne P, Bianchi SM, Blaikley JF, Brooke J, Chalmers J, Chambers RC, Chaudhuri N, Coleman C, Collier G, Denneny EK, Docherty A, Elneima O, Evans R, Fabbri L, Gibbons MA, Gleeson FV, Greening N, Gooptu B, Guillen Guio B, Hall IP, Hanley NA, Harris V, Harrison E, Horsley A, Houchen-Wolloff L, Heightman M, Hillman TE, Jarrold I, Johnson SR, Jones MG, Khan F, Lawson R, Leavy O, Lone N, Marks M, McAuley H, Mehta P, Mitchell JA, Parekh D, Parmar A, Pearl J, Piper Hanley K, Platé M, Poinasamy K, Quint JK, Raman B, Richardson M, Rivera-Ortega P, Saunders L, Saunders R, Semple M, Sereno M, Shikotra A, Simpson AJ, Singapuri A, Smith DJF, Spears M, Spencer LG, Stanel SC, Thickett DR, Thompson AAR, Thorpe M, Thwaites R, Walsh SL, Walker S, Weatherley ND, Weeks ME, Wild JM, Wootton DG, Wright L, Brightling CE, Ho LP, Wain LV, Jenkins RG. On behalf of the PHOSP-COVID Study Collaborative Group* Estimated prevalence and risk factors for interstitial lung disease following COVID-19 hospitalisation: an interim analysis of the UKILD Long-COVID study. Am J Respir Crit Care Med., 2023, 207(6):693-703. doi.org/10.1164/rccm.202203-0564oc

Chioccioli M, Roy S, Newell R, Pestano L, Dickinson B, Rigby K, Herazo-Maya J, Jenkins G, Ian S, Saini G, Johnson SR, Braybrooke R, Yu G, Sauler M, Ahangari F, Ding S, DeIuliis J, Aurelien N, Montgomery RL, Kaminski N. A lung targeted miR-29 mimic as a therapy for pulmonary fibrosis. EBioMedicine, 2022, 85:104304. doi.org/10.1016/j.ebiom.2022.104304

Johnson J, Stewart I, Johnson SR. Disease monitoring using lung function trajectory in lymphangioleiomyomatosis: assessment in two national cohorts. Thorax, 2023, 78(1):61-68. doi.org/10.1136/thoraxjnl-2021-217809

Warrior K, Leard LE, Nair AR, Gries CJ, Fisher AJ, Johnson SR, McCormack FX, Dilling DF. A survey of use of mTOR inhibitors in patients with lymphangioleiomyomatosis listed for lung transplant. Respir Med., 2022, 195:106779. doi.org/10.1016/j.rmed.2022.106779

Barrie Kellam

Anane-Adjei AB, Fletcher NL, Cavanagh RJ, Houston ZH, Crawford T, Pearce AK, Taresco V, Ritchie AA, Clarke P, Grabowska AM, Gellert PR, Ashford MB, Kellam B, Thurecht KJ, Alexander C. Synthesis, characterisation and evaluation of hyperbranched N-(2-hydroxypropyl) methacrylamides for transport and delivery in pancreatic cell lines in vitro and in vivo. Biomater Sci., 2022, 10(9):2328-2344. doi.org/10.1039/d1bm01548f

Travanut A, Monteiro PF, Smith S, Howdle SM, Grabowska AM,Kellam B, Meier MAR, Alexander C. Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles. J Mater Chem B., 2022, 10(20):3895-3905. doi.org/10.1039/d2tb00045h

Kok ZY, Stoddart LA, Mistry SJ, Mocking TAM, Vischer HF, Leurs R, Hill SJ, Mistry SN,Kellam B. Optimization of Peptide Linker-Based Fluorescent Ligands for the Histamine H₁ Receptor. J Med Chem., 2022, 65(12):8258-8288. doi.org/10.1021/acs.jmedchem.2c00125

Damaskinaki FN, Jooss NJ, Martin EM, Clark JC, Thomas MR, Poulter NS, Emsley J,Kellam B, Watson SP, Slater A. Characterizing the binding of glycoprotein VI with nanobody 35 reveals a novel monomeric structure of glycoprotein VI where the conformation of D1+D2 is independent of dimerization. J Thromb Haemost., 2023, 21(2):317-328. doi.org/10.1016/j.jtha.2022.11.002

Dekkers S, Caspar B, Goulding J, Kindon ND, Kilpatrick LE, Stoddart LA, Briddon SJ, Kellam B, Hill SJ, Stocks MJ. Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor. J Med Chem., 2023, 66(7):5208-5222. doi.org/10.1021/acs.jmedchem.3c00151

Sophie Kellaway

Edginton-White B, Maytum A, Kellaway SG, Goode DK, Keane P, Pagnuco I, Assi SA, Ames L, Clarke M, Cockerill PN, Göttgens B, Cazier JB, Bonifer C. A genome-wide relay of signalling-responsive enhancers drives hematopoietic specification. Nat Commun., 2023, 14(1):267. doi.org/10.1038/s41467-023-35910-9

Adamo A, Chin P, Keane P, Assi SA, Potluri S, Kellaway SG, Coleman D, Ames L, Ptasinska A, Delwel HR, Cockerill PN, Bonifer C. Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia. Leukemia, 2023, 37(1):102-112. doi.org/10.1038/s41375-022-01744-5

Tirtakusuma R, Szoltysek K, Milne P, Grinev VV, Ptasinska A, Chin PS, Meyer C, Nakjang S, Hehir-Kwa JY, Williamson D, Cauchy P, Keane P, Assi SA, Ashtiani M, Kellaway SG, Imperato MR, Vogiatzi F, Schweighart EK, Lin S, Wunderlich M, Stutterheim J, Komkov A, Zerkalenkova E, Evans P, McNeill H, Elder A, Martinez-Soria N, Fordham SE, Shi Y, Russell LJ, Pal D, Smith A, Kingsbury Z, Becq J, Eckert C, Haas OA, Carey P, Bailey S, Skinner R, Miakova N, Collin M, Bigley V, Haniffa M, Marschalek R, Harrison CJ, Cargo CA, Schewe D, Olshanskaya Y, Thirman MJ, Cockerill PN, Mulloy JC, Blair HJ, Vormoor J, Allan JM, Bonifer C, Heidenreich O, Bomken S. Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia. Blood, 2022, 140(17):1875-1890. doi.org/10.1182/blood.2021015036

Kellaway SG, Coleman DJL, Cockerill PN, Raghavan M, Bonifer C. Molecular Basis of Hematological Disease Caused by Inherited or Acquired RUNX1 Mutations. Exp Hematol., 2022, 111:1-12. doi.org/10.1016/j.exphem.2022.03.009

Schnoeder TM, Schwarzer A, Jayavelu AK, Hsu CJ, Kirkpatrick J, Döhner K, Perner F, Eifert T, Huber N, Arreba-Tutusaus P, Dolnik A, Assi SA, Nafria M, Jiang L, Dai YT, Chen Z, Chen SJ, Kellaway SG, Ptasinska A, Ng ES, Stanley EG, Elefanty AG, Buschbeck M, Bierhoff H, Brodt S, Matziolis G, Fischer KD, Hochhaus A, Chen CW, Heidenreich O, Mann M, Lane SW, Bullinger L, Ori A, von Eyss B, Bonifer C, Heidel FH. PLCG1 is required for AML1-ETO leukemia stem cell self-renewal. Blood, 2022, 139(7):1080-1097. doi.org/10.1182/blood.2021012778

Laura Kilpatrick

Ogrodzinski L, Platt S, Goulding J, Alexander C, Farr TD, Woolard J, Hill SJ, Kilpatrick LE. Probing expression of E-selectin using CRISPR-Cas9-mediated tagging with HiBiT in human endothelial cells. iScience, 2023, 26(7):107232. doi.org/10.1016/j.isci.2023.107232

Van Daele M, Kilpatrick LE, Woolard J, Hill SJ. Characterisation of tyrosine kinase inhibitor-receptor interactions at VEGFR2 using sunitinib-red and nanoBRET. Biochem Pharmacol., 2023, 3:115672. doi.org/10.1016/j.bcp.2023.115672.

Hill SJ, Kilpatrick LE. Kinetic analysis of fluorescent ligand binding to cell surface receptors: Insights into conformational changes and allosterism in living cells. Br J Pharmacol., 2023. doi.org/10.1111/bph.16185. Epub ahead of print. 

Lay CS, Isidro-Llobet A, Kilpatrick LE, Craggs PD, Hill SJ. Characterisation of IL-23 receptor antagonists and disease relevant mutants using fluorescent probes. Nat Commun., 2023, 14(1):2882. doi.org/10.1038/s41467-023-38541-2

van den Bor J, Bergkamp ND, Anbuhl SM, Dekker F, Comez D, Perez Almeria CV, Bosma R, White CW, Kilpatrick LE, Hill SJ, Siderius M, Smit MJ, Heukers R. NanoB² to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET. Cell Rep Methods, 2023, 3(3):100422. doi.org/10.1016/j.crmeth.2023.100422

Dekkers S, Caspar B, Goulding J, Kindon ND, Kilpatrick LE, Stoddart LA, Briddon SJ, Kellam B, Hill SJ, Stocks MJ. Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor. J Med Chem., 2023, 66(7):5208-5222. doi.org/10.1021/acs.jmedchem.3c00151

Lay CS, Kilpatrick LE, Craggs PD, Hill SJ. Use of NanoBiT and NanoBRET to characterise interleukin-23 receptor dimer formation in living cells. Br J Pharmacol., 2023, 180(11):1444-1459. doi.org/10.1111/bph.16018

Comez D, Glenn J, Anbuhl SM, Heukers R, Smit MJ, Hill SJ, Kilpatrick LE.Fluorescently tagged nanobodies and NanoBRET to study ligand-binding and agonist-induced conformational changes of full-length EGFR expressed in living cells. Front Immunol., 2022,13:1006718. doi.org/10.3389/fimmu.2022.1006718

Katalin Kovacs

Myers B, Catrambone F, Allen S, Hill PJ, Kovács K, Rawson FJ. Engineering nanowires in bacteria to elucidate electron transport structural–functional relationships. Sci Rep., 2023, 13, 8843. doi.org/10.1038/s41598-023-35553-2

Salinas A, McGregor C, Irorere V, Arenas-López C, Bommareddy RR, Winzer K,Kovács, K. Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid. Metab Eng., 2022, 74, 178-190. doi.org/10.1016/j.ymben.2022.10.014

Turco F, Garavaglia M, Van Houdt R, Hill P, Rawson FJ, Kovács, K. Synthetic Biology Toolbox, Including a Single-Plasmid CRISPR-Cas9 System to Biologically Engineer the Electrogenic, Metal-Resistant Bacterium Cupriavidus metallidurans CH34. ACS Synth. Biol., 2022, 11, 11, 3617–3628. doi.org/10.1021/acssynbio.2c00130

Bennett M R, Moloney C, Catrambone F, Turco F, Myers B, Kovács K, Hill PJ, Alexander C, Rawson FJ, Gurnani P. Oxygen-Tolerant RAFT Polymerization Initiated by Living Bacteria. ACS Macro Lett, 2022, 11(8), 954-960. doi.org/10.1021/acsmacrolett.2c00372 

Myers B, Hill P, Rawson FJ, Kovács K. Enhancing Microbial Electron Transfer Through Synthetic Biology and Biohybrid Approaches: Part 1/2. Johnson Matthey Technology Review, 2022, 63(4), 443–454. doi.org/10.1595/205651322x16548607638938

Jawed K, Irorere VU, Bommareddy RR, Minton NP,Kovács K. Establishing Mixotrophic Growth of Cupriavidus necator H16 on CO2 and Volatile Fatty Acids. Fermentation, 2022, 8(3), Article 125. doi.org/10.3390/fermentation8030125

Charles Laughton

Casella BM, Farmer JP, Nesheva DN, Williams HEL, Charlton SJ, Holliday ND, Laughton CA, Mistry SN. Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2. J Med Chem., 2023, 66(18):12911-12930. doi.org/10.1021/acs.jmedchem.3c00849

Contreas L, Hook AL, Winkler DA, Figueredo G, Williams P,Laughton CA, Alexander MR, Williams PM. Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. ACS Appl Mater Interfaces, 2023, 15(11):14155–63. doi.org/10.1021/acsami.2c23182

Saleh MM, Abuarqoub DA, Hammad AM, Hossan MS, Ahmed N, Aslam N, Naser AY, Moody CJ, Laughton CA,Bradshaw TD. In Vitro Anticancer Properties of Novel Bis-Triazoles. Curr Issues Mol Biol., 2022, 45(1):175-196. doi.org/10.3390/cimb45010014

Farmer JP, Mistry SN,Laughton CA, Holliday ND. Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators. FASEB J., 2022, 36(11):e22576. doi.org/10.1096/fj.202201024r

Arockia Lourdusamy

Kalinichenko LS, Mühle C, Jia T, Anderheiden F, Datz M, Eberle AL, Eulenburg V, Granzow J, Hofer M, Hohenschild J, Huber SE, Kämpf S, Kogias G, Lacatusu L, Lugmair C, Taku SM, Meixner D, Sembritzki NK, Praetner M, Rhein C, Sauer C, Scholz J, Ulrich F, Valenta F, Weigand E, Werner M, Tay N, Mc Veigh CJ, Haase J, Wang AL, Abdel-Hafiz L, Huston JP, Smaga I, Frankowska M, Filip M, Lourdusamy A, Kirchner P, Ekici AB, Marx LM, Suresh NP, Frischknecht R, Fejtova A, Saied EM, Arenz C, Bozec A, Wank I, Kreitz S, Hess A, Bäuerle T, Ledesma MD, Mitroi DN, Miranda AM, Oliveira TG, Lenz B, Schumann G, Kornhuber J, Müller CP. Adult alcohol drinking and emotional tone are mediated by neutral sphingomyelinase during development in males. Cereb Cortex, 2023, 33(3):844-864. doi.org/10.1093/cercor/bhac106

Mohammed OJ, Cebrero ME, Ahmad O, Peet A, Grundy RG,Lourdusamy A. The Molecular Landscape of Medulloblastoma in Teenagers and Young Adults. Cancers (Basel), 2022, 14(1):251. doi.org/10.3390/cancers14010251

Dury RJ, Lourdusamy A, Macarthur DC, Peet AC, Auer DP, Grundy RG, Dineen RA. Meta-Analysis of Apparent Diffusion Coefficient in Pediatric Medulloblastoma, Ependymoma, and Pilocytic Astrocytoma. J Magn Reson Imaging, 2022, 56(1):147-157. doi.org/10.1002/jmri.28007

Srinivasan Madhusudan

Alblihy A, Ali R, Algethami M, Ritchie AA, Shoqafi A, Alqahtani S, Mesquita KA, Toss MS, Ordóñez-Morán P, Jeyapalan JN, Dekker L, Salerno M, Hartsuiker E, Grabowska AM, Rakha EA, Mongan NP,Madhusudan S. Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. Int J Mol Sci., 2023, 24(13):10966. doi.org/10.3390/ijms241310966

Lashen AG, Toss MS, Wootton L, Green AR, Mongan NP,Madhusudan S,Rakha E. Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer. Histopathology, 2023, 83(3):414-425. doi.org/10.1111/his.14960

Metzler VM, de Brot S, Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Nilsson EM, Ntekim A, Persson JL, Robinson BD, Khani F, Laursen KB, Gudas LJ, Toss MS, Madhusudan S,Rakha E, Heery DM, Rutland CS, Mongan NP, Jeyapalan JN. The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Front Cell Dev Biol., 2023, 11:1116424. doi.org/10.3389/fcell.2023.1116424

Brownlie J, Kulkarni S, Algethami M, Jeyapalan JN, Mongan NP, Rakha EA,Madhusudan S. Targeting DNA damage repair precision medicine strategies in cancer. Curr Opin Pharmacol., 2023, 70:102381. doi.org/10.1016/j.coph.2023.102381

Tang H, Kulkarni S, Peters C, Eddison J, Al-Ani M, Madhusudan S. The Current Status of DNA-Repair-Directed Precision Oncology Strategies in Epithelial Ovarian Cancers. Int J Mol Sci., 2023, 24(8):7293. doi.org/10.3390/ijms24087293

Algethami M, Toss MS, Woodcock CL, Jaipal C, Brownlie J, Shoqafi A, Alblihy A, Mesquita KA, Green AR, Mongan NP, Jeyapalan JN, Rakha EA,Madhusudan S. Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers. NPJ Breast Cancer, 2023, 9(1):18. doi.org/10.1038/s41523-023-00524-3

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C, James VH,Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E, Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Clinical and molecular significance of the RNA m⁶A methyltransferase complex in prostate cancer. Front Genet., 2023, 13:1096071. doi.org/10.3389/fgene.2022.1096071

Lashen A, Toss MS, Fadhil W, Oni G, Madhusudan S, Rakha E. Evaluation oncotype DX^® 21-gene recurrence score and clinicopathological parameters: a single institutional experience. Histopathology, 2023, 82(5):755-766. doi.org/10.1111/his.14863

Algethami M, Kulkarni S, Sadiq MT, Tang HKC, Brownlie J, Jeyapalan JN, Mongan NP, Rakha EA,Madhusudan S. Towards Personalized Management of Ovarian Cancer. Cancer Manag Res., 2022, 14:3469-3483. doi.org/10.2147/cmar.s366681

Hurvitz SA, Hegg R, Chung WP, Im SA, Jacot W, Ganju V, Chiu JWY, Xu B, Hamilton E, Madhusudan S, Iwata H, Altintas S, Henning JW, Curigliano G, Perez-Garcia JM, Kim SB, Petry V, Huang CS, Li W, Frenel JS, Antolin S, Yeo W, Bianchini G, Loi S, Tsurutani J, Egorov A, Liu Y, Cathcart J, Ashfaque S, Cortés J. Trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer: updated results from DESTINY-Breast03, a randomised, open-label, phase 3 trial. Lancet, 2023, 401(10371):105-117.

doi.org/10.1016/s0140-6736(22)02420-5

Kulkarni S, Brownlie J, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S. Evolving DNA repair synthetic lethality targets in cancer. Biosci Rep., 2022, 42(12):BSR20221713. doi.org/10.1042/bsr20221713

Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Metzler VM, Persson JL, Robinson BD, Khani F, Alsaleem M, Ntekim A, Madhusudan S, Davis MB, Laursen KB, Gudas LJ, Rutland CS, Toss MS, Archer N, Bodi Z, Rakha EA, Fray RG, Jeyapalan JN, Mongan NP. The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers (Basel), 2022, 14(20):5148. doi.org/10.3390/cancers14205148

Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S,Allegrucci C,James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, Mongan NP, Jeyapalan JN. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front Endocrinol (Lausanne), 2022, 13:1006101. doi.org/10.3389/fendo.2022.1006101

Bahl A, Wilson W, Ball J, Renninson E, Dubey S, Bravo A, Foulstone E, Spensley S, Bowen R, Mansi J, Waters S, Riddle P, Wheatley D, Stephens P, Bezecny P, Madhusudan S, Verrill M, Braybrooke J, Comins C, Mohan V, Gee A, Kirk H, Markham A, Evans H, Watson E, Callaway M, Pearson S, Hackshaw A, Churn M. Concept: A randomised multicentre trial of first line chemotherapy comparing three weekly cabazitaxel versus weekly paclitaxel in HER2 negative metastatic breast cancer. Breast, 2022, 66:69-76. doi.org/10.1016/j.breast.2022.09.005

Alblihy A, Ali R, Algethami M, Shoqafi A, Toss MS, Brownlie J, Tatum NJ, Hickson I, Moran PO,Grabowska A, Jeyapalan JN, Mongan NP, Rakha EA,Madhusudan S. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. NPJ Precis Oncol., 2022, 6(1):51. doi.org/10.1038/s41698-022-00298-0

Ali R, Aouida M, Alhaj Sulaiman A, Madhusudan S, Ramotar D. Can Cisplatin Therapy Be Improved? Pathways That Can Be Targeted. Int J Mol Sci., 2022, 23(13):7241. doi.org/10.3390/ijms23137241

Mahmoodi A, Shoqafi A, Sun P, Giannakeas V, Cybulski C, Nofech-Mozes S, Masson JY, Sharma S, Samani AA, Madhusudan S, Narod SA, Akbari MR. High Expression of RECQL Protein in ER-Positive Breast Tumours Is Associated With a Better Survival. Front Oncol., 2022, 12:877617. doi.org/10.3389/fonc.2022.877617

Anna Malecka

Delcassian D, Malecka AA, Opoku D, Cabeza VP, Merry C, Jackson AM. Primary human macrophages are polarized towards pro-inflammatory phenotypes in alginate hydrogels. bioRxiv, 2019, 824391. doi.org/10.1101/824391

Jeyaraman J, Malecka A, Billimoria P, Shukla A, Marandi B, Patel PM, Jackson AM, Sri S. Immuno-silent polymer capsules encapsulating nanoparticles for bioimaging applications. J. Mater. Chem. B, 2017, 5:5251-5258. doi.org/10.1039/C7TB01044C

Stewart Martin

Vasan R, Yadav J, Aiyappa-Maudsley R, Deen S, Storr SJ,Martin SG. High BMP7 expression is associated with poor prognosis in ovarian cancer. J Cell Mol Med., 2023, Sep 8. doi.org/10.1111/jcmm.17951

McCabe A, Martin S, Shah J, Morgan PS, Panek R. T₁ based oxygen-enhanced MRI in tumours; a scoping review of current research. Br J Radiol., 2023, 96(1146):20220624. doi.org/10.1259/bjr.20220624

Köbel M, Kang EY, Weir A, Rambau PF, Lee CH, Nelson GS, Ghatage P, Meagher NS, Riggan MJ, Alsop J, Anglesio MS, Beckmann MW, Bisinotto C, Boisen M, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, Deen S, El-Bahrawy MA, Elishaev E, Erber R, Fereday S; AOCS Group; Fischer A, Gayther SA, Barquin-Garcia A, Gentry-Maharaj A, Gilks CB, Gronwald H, Grube M, Harnett PR, Harris HR, Hartkopf AD, Hartmann A, Hein A, Hendley J, Hernandez BY, Huang Y, Jakubowska A, Jimenez-Linan M, Jones ME, Kennedy CJ, Kluz T, Koziak JM, Lesnock J, Lester J, Lubiński J, Longacre TA, Lycke M, Mateoiu C, McCauley BM, McGuire V, Ney B, Olawaiye A, Orsulic S, Osorio A, Paz-Ares L, Ramón Y Cajal T, Rothstein JH, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Steed H, Storr SJ, Talhouk A, Traficante N, Wang C, Whittemore AS, Widschwendter M, Wilkens LR, Winham SJ, Benitez J, Berchuck A, Bowtell DD, Candido Dos Reis FJ, Campbell I, Cook LS, DeFazio A, Doherty JA, Fasching PA, Fortner RT, García MJ, Goodman MT, Goode EL, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Kommoss S, Le ND, Martin SG, Menon U, Modugno F, Pharoah PD, Schildkraut JM, Sieh W, Staebler A, Sundfeldt K, Swerdlow AJ, Ramus SJ, Brenton JD. p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study. J Pathol Clin Res., 2023, 9(3):208-222. doi.org/10.1002/cjp2.311

Storr SJ, Hoskin V, Aiyappa-Maudsley R, Ghaffari A, Varma S, Green A, Rakha E, Ellis IO, Greer PA, Martin SG. A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease. Cancer Med., 2023, 12(9):10908-10916. doi.org/10.1002/cam4.5802

Aiyappa-Maudsley R, Storr SJ, Rakha EA, Green AR, Ellis IO, Martin SG. CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer. J Pathol Clin Res., 2022, 8(6):550-566. doi.org/10.1002/cjp2.291

Aiyappa-Maudsley R, Elsalem L, Ibrahim AIM, Pors K, Martin SG. In vitro radiosensitization of breast cancer with hypoxia-activated prodrugs. J Cell Mol Med., 2022, 26(16):4577-4590. doi.org/10.1111/jcmm.17486

Yao A, Storr SJ, Inman M, Barwell L, Moody CJ, Martin SG. Cytotoxic and Radiosensitising Effects of a Novel Thioredoxin Reductase Inhibitor in Brain Cancers. Mol Neurobiol., 2022, 59(6):3546-3563. doi.org/10.1007/s12035-022-02808-4

Martin SG,Rakha E, Storr SJ. Quantifying Lymphatic Vessel Density in Human Tissue Samples. Methods Mol Biol., 2022, 2022:2441:183-189. doi.org/10.1007/978-1-0716-2059-5_14

Alvaro Mata

X Renhao, Deng X, Xu X, Tian Y, Hasan A, Mata A, Zhang L, Liu L. Elastin-like recombinamer-mediated hierarchical mineralization coatings on Zr-16Nb-xTi (x=4,16wt%) alloy surfaces improve biocompatibility. Biomater Adv., 2023, 151:213471.10.1016/j.bioadv.2023.213471

Martínez-Espuga M, Mata A, Ordóñez-Morán P. Intestinal cell differentiation and phenotype in 2D and 3D cell culture models. Methods Mol Biol., 2023, 2650:235-243, 10.1007/978-1-0716-3076-1_18

Ligorio C, Mata A. Bioengineering synthetic extracellular matrices through function-encoding peptides. Nat Rev Bioeng., 2023, 1-19.10.1038/s44222-023-00055-3

Curvello R, Kast V, Ordóñez-Morán P. et al. Biomaterial-based platforms for tumour tissue engineering. 2023. Nat Rev Mater., 8, 314–330. doi.org/10.1038/s41578-023-00535-3

Majkowska A, Inostroza-Brito KE, Gonzalez M, Redondo-Gomez C, Rice A, Rodriguez-Cabello JC, Del Rio Hernandez A, Mata A. Biomacromolecules, 2023, 24(10):4419-4429. 10.1021/acs.biomac.2c01095

Wu Y, Yang J, van Teijlingen A, Berardo A, Corridori I, Feng J, Xu J, Titirici MM, Rodriguez-Cabello JC, Pugno NM, Sun J, Wang W, Mata A. Disinfector-assisted low temperature reduced graphene oxide-protein surgical dressing for the postoperative photothermal treatment of melanoma. Adv Funct Mater., 2022, 32 (38):2205802. doi.org/10.1021/acs.biomac.2c01095

Hasan A, Bagnol R, Owen R, Latif A, Rostam HM, Elsharkawy S, Rose FRAJ, Rodríguez-Cabello JC, Ghaemmaghami AM, Eglin D, Mata A. Mineralizing coating on 3D printed scaffolds for the promotion of osseointegration.Front Bioeng Biotechnol., 2022, 10:836386. 

doi.org/10.3389/fbioe.2022.836386

Bu W, Wu Y, Ghaemmaghami AM, Sun H, Mata A. Rational design of hydrogels for immunomodulation. Regen Biomater., 2022, 9:rbac009.doi.org/10.1093/rb/rbac009

Azevedo HS and Mata A. Embracing complexity in biomaterials design. Biomater Biosyst., 2022, 6:100039. doi.org/10.1016/j.bbiosy.2022.100039

Hill J, Wildman R, Mata A. Exploiting the fundamental of biological organization for the advancement of biofabrication. Curr Opin Biotechnol., 2022, 74:42-54. doi.org/10.1016/j.copbio.2021.10.016

Ghosh M, Majkowska A, Misra R, Bera S, Rodriguez-Cabello JC, Mata A, Adler-Abramovich L. Disordered protein stabilization by co-assembly of short peptides enables formation of robust membranes. ACS Appl Mater Interfaces, 2022, 14(1):464-473. doi.org/10.1021/acsami.1c22136

Redondo-Gomez C, Padilla-Lopategui S, Mata A, Azevedo HS. Peptide amphiphile hydrogels based on homoternary cucurbit[8]uril host-guest complexes. Bioconjug Chem., 2022, 33(1):111-120.doi.org/10.1021/acs.bioconjchem.1c00441

Alan McIntyre

Pérez-Cota F, Martínez-Arellano G, La Cavera S 3rd, Hardiman W, Thornton L, Fuentes-Domínguez R, Smith RJ, McIntyre A, Clark M. Classification of cancer cells at the sub-cellular level by phonon microscopy using deep learning. Sci Rep., 2023, 13(1):16228. doi.org/10.1038/s41598-023-42793-9

Pinel GD, Horder JL, King JR, McIntyre A,Mongan NP, López GG, Benest AV. Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching. In Angiogenesis: Methods and Protocols (pp. 369-426). New York, NY: Springer US. 2022. ISBN 1064-3745

Carroll CP, Bolland H, Vancauwenberghe E, Collier P, Ritchie AA, Clarke PA, Grabowska AM, Harris AL, McIntyre A. Targeting hypoxia regulated sodium driven bicarbonate transporters reduces triple negative breast cancer metastasis. Neoplasia, 2022. 25:41-52. doi.org/10.1016/j.neo.2022.01.003

Cathy Merry

Mendonca T, Lis-Slimak K, Matheson AB, Smith MG, Anane-Adjei AB, Ashworth JC, Cavanagh R, Paterson L, Dalgarno PA, Alexander C, Tassieri M, Merry CLR, Wright AJ. OptoRheo: Simultaneous in situ micro-mechanical sensing and imaging of live 3D biological systems. Commun Biol., 2023, 6(1):463. doi.org/10.1038/s42003-023-04780-8

James JR, Curd J, Ashworth JC, Abuhantash M, Grundy M, Seedhouse CH,Arkill KP, Wright AJ, Merry CLR,Thompson A. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. Int J Mol Sci., 2023, 24(4):4235. doi.org/10.3390/ijms24044235

Linke F, Johnson JEC, Kern S, Bennett CD, Lourdusamy A, Lea D, Clifford SC, Merry CLR, Stolnik S, Alexander MR, Peet AC, Scurr DJ, Griffiths RL, Grabowska AM, Kerr ID, Coyle B. Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging. Acta Neuropathol Commun., 2023, 11(1):6. doi: doi.org/10.1186/s40478-022-01496-4

Merry CLR, Lindahl U, Couchman J, Esko JD. Proteoglycans and Sulfated Glycosaminoglycans. In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Mohnen D, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 4th ed. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2022. Chapter 17. PMID: 35536939.

Nigel Minton

Seys FM, Humphreys CM, Tomi-Andrino C, Li Q, Millat T, Yang S, Minton NP. Base editing enables duplex point mutagenesis in Clostridium autoethanogenum at the price of numerous off-target mutations. Front Bioeng Biotechnol., 2023, 11:1211197. doi.org/10.3389/fbioe.2023.1211197

Poulalier-Delavelle M, Baker JP, Millard J, Winzer K,Minton NP. Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum. Front Bioeng Biotechnol., 2023, 11:1213236. doi.org/10.3389/fbioe.2023.1213236

Omorotionmwan BB, Wang H, Baker JP, Gizynski K, Yoo M, Akaluka C, Zhang Y,Minton NP. Front Chromosomal engineering of inducible isopropanol- butanol-ethanol production in Clostridium acetobutylicum. Bioeng Biotechnol., 2023, 11:1218099. doi.org/10.3389/fbioe.2023.1218099

Millard J, Agius A, Zhang Y, Soucaille P,Minton NP. Exploitation of a Type 1 Toxin-Antitoxin System as an Inducible Counter-Selective Marker for Genome Editing in the Acetogen Eubacterium limosum. Microorganisms, 2023, 11(5):1256. doi.org/10.3390/microorganisms11051256

Sheng L, Madika A, Lau MSH, Zhang Y,Minton NP. Metabolic engineering for the production of acetoin and 2,3-butanediol at elevated temperature in Parageobacillus thermoglucosidasius NCIMB 11955. Front Bioeng Biotechnol., 2023, 11: 1191079. doi.org/10.3389/fbioe.2023.1191079

Rawson AM, Dempster AW, Humphreys CM, Minton NP. Pathogenicity and virulence of Clostridium botulinum. Virulence, 2023, 14(1):2205251. doi.org/10.1080/21505594.2023.2205251

Simpson M, Bilverstone T, Leslie J, Donlan A, Uddin MJ, Petri WA, Marin N, Kuehne S, Minton NP, Petri WA Jr. Clostridioides difficile Binary Toxin Binding Component Increases Virulence in a Hamster Model. Open Forum Infect Dis., 2023, 10(3):ofad040. doi.org/10.1093/ofid/ofad040

Rumah BL, Claxton Stevens BH, Yeboah JE, Stead CE, Harding EL, Minton NP, Zhang Y. In Vivo Genome Editing in Type I and II Methanotrophs Using a CRISPR/Cas9 System. ACS Synth Biol., 2023, 12(2):544-554. doi.org/10.1021/acssynbio.2c00554

Salinas A, McGregor C, Irorere V, Arenas-López C, Bommareddy RR, Winzer K,Minton NP,Kovács K. Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid. Metab Eng., 2022, 74:178-190. doi.org/10.1016/j.ymben.2022.10.014

Madika A, Spencer J, Lau MSH, Sheng L, Zhang Y,Minton NP. pMTL60000: A modular plasmid vector series for Parageobacillus thermoglucosidasius strain engineering. J Microbiol Methods, 2022, 202:106600. doi.org/10.1016/j.mimet.2022.106600

Pregnon G, Minton NP, Soucaille P. Genome Sequence of Eubacterium limosum B2 and Evolution for Growth on a Mineral Medium with Methanol and CO₂ as Sole Carbon Sources. Microorganisms, 2022, 10(9):1790. doi.org/10.3390/microorganisms10091790

Cengic I, Cañadas IC, Minton NP, Hudson EP. ACS Synth Biol. Inducible CRISPR/Cas9 Allows for Multiplexed and Rapidly Segregated Single-Target Genome Editing in Synechocystis Sp. PCC 6803. ACS Synth Biol., 2022, 11(9):3100-3113. doi.org/10.1021/acssynbio.2c00375

Baker JP, Sáez-Sáez J, Jensen SI, Nielsen AT, Minton NP. A clean in-frame knockout system for gene deletion in Acetobacterium woodii. J Biotechnol., 2022, 353:9-18. doi.org/10.1016/j.jbiotec.2022.05.013

Pearcy N, Garavaglia M, Millat T, Gilbert JP, Song Y, Hartman H, Woods C, Tomi-Andrino C, Reddy Bommareddy R, Cho BK, Fell DA, Poolman M, King JR, Winzer K, Twycross J, Minton NP. A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications. PLoS Comput Biol., 2022, 18(5):e1010106. doi.org/10.1371/journal.pcbi.1010106

Bourgade B, Humphreys CM, Millard J, Minton NP, Islam MA. Design, Analysis, and Implementation of a Novel Biochemical Pathway for Ethylene Glycol Production in Clostridium autoethanogenum. ACS Synth Biol., 2022, 11(5):1790-1800. doi.org/10.1021/acssynbio.1c00624

Woods C, Humphreys CM, Tomi-Andrino C, Henstra AM, Köpke M, Simpson SD, Winzer K, Minton NP. Required Gene Set for Autotrophic Growth of Clostridium autoethanogenum. Appl Environ Microbiol., 2022, 88(7):e0247921. doi.org/10.1128/aem.02479-21

Hanko EKR, Sherlock G, Minton NP, Malys N. Biosensor-informed engineering of Cupriavidus necator H16 for autotrophic D-mannitol production. Metab Eng., 2022, 72:24-34. doi.org/10.1016/j.ymben.2022.02.003

Nowakowska MB, Selby K, Przykopanski A, Krüger M, Krez N, Dorner BG, Dorner MB, Jin R, Minton NP, Rummel A, Lindström M. Construction and validation of safe Clostridium botulinum Group II surrogate strain producing inactive botulinum neurotoxin type E toxoid. Sci Rep., 2022, 12(1):1790. doi.org/10.1038/s41598-022-05008-1

Whittle MJ, Bilverstone TW, van Esveld RJ, Lücke AC, Lister MM, Kuehne SA, Minton NP. A Novel Bacteriophage with Broad Host Range against Clostridioides difficile Ribotype 078 Supports SlpA as the Likely Phage Receptor. Microbiol Spectr., 2022, 10(1):e0229521. doi.org/10.1128/spectrum.02295-21

Mook A, Beck MH, Baker JP, Minton NP, Dürre P, Bengelsdorf FR. Autotrophic lactate production from H₂ + CO₂ using recombinant and fluorescent FAST-tagged Acetobacterium woodii strains. Appl Microbiol Biotechnol., 2022, 106(4):1447-1458. doi.org/10.1007/s00253-022-11770-z

Piatek P, Humphreys C, Raut MP, Wright PC, Simpson S, Köpke M, Minton NP,Winzer K. Agr Quorum Sensing influences the Wood-Ljungdahl pathway in Clostridium autoethanogenum. Sci Rep., 2022, 12(1):411. doi.org/10.1038/s41598-021-03999-x

Shailesh Mistry

Casella BM, Farmer JP, Nesheva DN, Williams HE, Charlton SJ, Holliday ND, Laughton CA, Mistry SN. Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2. J. Med. Chem., 2023, 66(18) 12911-12930. doi.org/10.1021/acs.jmedchem.3c00849

Hill R, Sanchez J, Lemel L, Antonijevic M, Hosking Y, Mistry SN, Kruegel AC, Javitch JA, Lane JR, Canals M. Assessment of the potential of novel and classical opioids to induce respiratory depression in mice. Br. J. Pharmacol., 2023, 1-15. doi.org/10.1111/bph.16199

Dwomoh L, Rossi M, Scarpa M, Khajehali E, Molloy C, Herzyk P, Mistry SN, Bottrill AR, Sexton PM, Christopoulos A, Conn PJ, Lindsley CW, Bradley SJ, Tobin AB. M₁ muscarinic receptor activation reduces the molecular pathology and slows the progression of prion-mediated neurodegenerative disease. Sci. Signal., 2022, 15(760) eabm3720. doi.org/10.1126/scisignal.abm3720

Farmer JP, Mistry SN, Laughton CA, Holliday ND. Development of fluorescent peptide G protein-coupled receptor activation biosensors for NanoBRET characterization of intracellular allosteric modulators. FASEB J., 2022, 36:e22576. doi.org/10.1096/fj.202201024R

Kok ZY, Stoddart LA, Mistry SJ, Mocking TAM, Vischer HF, Leurs R, Hill SJ, Mistry SN, Kellam B. Optimisation of peptide liker-based fluorescent ligands for the Histamine H₁ receptor. J. Med. Chem., 2022, 65(12) 8258-8288. doi.org/10.1021/acs.jmedchem.2c00125

Nigel Mongan

Talhouni S, Fadhil W, Mongan NP, Field L, Hunter K, Makhsous S, Maciel-Guerra A, Kaur N, Nestarenkaite A, Laurinavicius A, Willcox BE, Dottorini T, Spendlove I, Jackson AM, Ilyas M, Ramage JM. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided "immune-hot" colorectal cancers. Front Immunol., 2023, 14:1057292. doi.org/10.3389/fimmu.2023.1057292

Metzler VM, de Brot S, Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Nilsson EM, Ntekim A, Persson JL, Robinson BD, Khani F, Laursen KB, Gudas LJ, Toss MS, Madhusudan S, Rakha E, Heery DM, Rutland CS, Mongan NP, Jeyapalan JN. The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Front Cell Dev Biol., 2023, 11:1116424. doi.org/10.3389/fcell.2023.1116424

Manabile MA, Hull R, Khanyile R, Molefi T, Damane BP, Mongan NP,Bates DO, Dlamini Z. Alternative Splicing Events and Their Clinical Significance in Colorectal Cancer: Targeted Therapeutic Opportunities. Cancers (Basel), 2023, 15(15). doi.org/10.3390/cancers15153999

Makhlouf S, Althobiti M, Toss M, Muftah AA, MonganNP, Lee AHS, Green AR, Rakha EA. The Clinical and Biological Significance of Estrogen Receptor-Low Positive Breast Cancer. Modern Pathol., 2023, 36(10):100284. doi.org/10.1016/j.modpat.2023.100284

Lashen AG, Toss MS, Wootton L, Green AR,MonganNP, Madhusudan S, Rakha E. Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer. Histopathology, 2023, 83(3):414-25. doi.org/10.1111/his.14960

Lashen AG, Toss MS, MonganNP, Green AR, Rakha EA. The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up. Cancer, 2023, 129(8):1183-94. doi.org/10.1002/cncr.34655

Lashen AG, Toss MS, Ghannam SF, Makhlouf S, Green A, Mongan NP, Rakha E. Expression, assessment and significance of Ki67 expression in breast cancer: an update. Journal Clin Pathol., 2023, 76(6):357-64. doi.org/10.1136/jcp-2022-208731

Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, MonganNP, Nanus DM, Heller DA, Gudas LJ. NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma. Cancer Biol Ther., 2023, 24(1):2170669. doi.org/10.1080/15384047.2023.2170669

Jeyapalan JN, James V, Gardner DS, Lothion-Roy JH, Mongan NP, Rutland CS. Impact of COVID-19 on student attainment and pedagogical needs when undertaking independent scientific research. Anat Histol Embryol., 2023, 52(1):93-100. doi.org/10.1111/ahe.12842

Ghannam SF, Rutland CS, Allegrucci C, MonganNP, Rakha E. Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? Histopathology, 2023, 83(3):376-93. doi.org/10.1111/his.14939

Ghannam SF, Rutland CS, Allegrucci C, Mongan NP, Rakha E. Defining invasion in breast cancer: the role of basement membrane. J Clin Pathol., 2023, 76(1):11-18. doi.org/10.1136/jcp-2022-208584

Brownlie J, Kulkarni S, Algethami M, Jeyapalan JN, MonganNP, Rakha EA, Madhusudan S. Targeting DNA damage repair precision medicine strategies in cancer. Curr Opin Pharmacol., 2023, 70:102381. doi.org/10.1016/j.coph.2023.102381

Baron F, Zhang M, Archer N, Bellows E, Knight HM, Welham S, Rutland CS, MonganNP, Hayes CJ, Fray RG, Bodi Z. The importance of m(6)A topology in chicken embryo mRNA: a precise mapping of m(6)A at the conserved chicken beta-actin zipcode. RNA, 2023, 29(6):777-89. doi.org/10.1261/rna.079615.123

Atallah NM, Wahab N, Toss MS, Makhlouf S, Ibrahim AY, Lashen AG, Ghannam S, MonganNP, Jahanifar M, Graham S, Bilal M, Bhalerao A, Ahmed Raza SE, Snead D, Minhas F, Rajpoot N, Rakha E. Deciphering the Morphology of Tumor-Stromal Features in Invasive Breast Cancer Using Artificial Intelligence. Mod Pathol., 2023, 36(10):100254. doi.org/10.1016/j.modpat.2023.100254

Atallah NM, Alsaleem M, Toss MS, MonganNP, Rakha E. Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level. Br J Cancer., 2023, Sep 22. doi.org/10.1038/s41416-023-02426-4

Algethami M, Toss MS, Woodcock CL, Jaipal C, Brownlie J, Shoqafi A, Alblihy A, Mesquita KA, Green AR, MonganNP, Jeyapalan JN, Rakha EA, Madhusudan S. Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers. NPJ Breast Cancer, 2023, 9(1):18. doi.org/10.1038/s41523-023-00524-3

Alblihy A, Ali R, Algethami M, Ritchie AA, Shoqafi A, Alqahtani S, Mesquita KA, Toss MS, Ordonez-Moran P, Jeyapalan JN, Dekker L, Salerno M, Hartsuiker E, Grabowska AM, Rakha EA, Mongan NP, Madhusudan S. Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. Int J Mol Sci., 2023, 24(13). doi.org/10.3390/ijms241310966

Zhang M, Bodi Z, Mackinnon K, Zhong S, Archer N, MonganNP, Simpson GG, Fray RG. Two zinc finger proteins with functions in m(6)A writing interact with HAKAI. Nat Commun. 2022, 13(1):1127. doi.org/10.1038/s41467-022-28753-3

Wang T, Sarwar M, Whitchurch JB, Collins HM, Green T, Semenas J, Ali A, Roberts CJ, Morris RD, Hubert M, Chen S, El-Schich Z, Wingren AG, Grundstrom T, Lundmark R, MonganNP, Gunhaga L, Heery DM, Persson JL. PIP5K1alpha is Required for Promoting Tumor Progression in Castration-Resistant Prostate Cancer. Front Cell Dev Biol., 2022, 10:798590. doi.org/10.3389/fcell.2022.798590

Sharpe BP, Hayden A, Manousopoulou A, Cowie A, Walker RC, Harrington J, Izadi F, Breininger SP, Gibson J, Pickering O, Jaynes E, Kyle E, Saunders JH, Parsons SL, Ritchie AA, Clarke PA, Collier P, MonganNP, Bates DO, Yacqub-Usman K, Garbis SD, Walters Z, Rose-Zerilli M, Grabowska AM, Underwood TJ. Phosphodiesterase type 5 inhibitors enhance chemotherapy in preclinical models of esophageal adenocarcinoma by targeting cancer-associated fibroblasts. Cell Rep Med., 2022, 3(6):100541. doi.org/10.1016/j.xcrm.2022.100541

Ryman-Tubb T, Lothion-Roy JH, Metzler VM, Harris AE, Robinson BD, Rizvanov AA, Jeyapalan JN, James VH, England G, Rutland CS, Persson JL, Kenner L, Rubin MA, MonganNP, de Brot S. Comparative pathology of dog and human prostate cancer. Vet Med Sci., 2022, 8(1):110-20. doi.org/10.1002/vms3.642

Pinel GD, Horder JL, King JR, McIntyre A,Mongan NP, Lopez GG, Benest AV. Endothelial Cell RNA-Seq Data: Differential Expression and Functional Enrichment Analyses to Study Phenotypic Switching. Methods Mol Biol., 2022, 2441:369-426. doi.org/10.1007/978-1-0716-2059-5_29

Martini R, Delpe P, Chu TR, Arora K, Lord B, Verma A, Bedi D, Karanam B, Elhussin I, Chen Y, Gebregzabher E, Oppong JK, Adjei EK, Jibril Suleiman A, Awuah B, Muleta MB, Abebe E, Kyei I, Aitpillah FS, Adinku MO, Ankomah K, Osei-Bonsu EB, Chitale DA, Bensenhaver JM, Nathanson DS, Jackson L, Petersen LF, Proctor E, Stonaker B, Gyan KK, Gibbs LD, Monojlovic Z, Kittles RA, White J, Yates CC, Manne U, Gardner K, Mongan N, Cheng E, Ginter P, Hoda S, Elemento O, Robine N, Sboner A, Carpten JD, Newman L, Davis MB. African Ancestry-Associated Gene Expression Profiles in Triple-Negative Breast Cancer Underlie Altered Tumor Biology and Clinical Outcome in Women of African Descent. Cancer Discov., 2022, 12(11):2530-51. doi.org/10.1158/2159-8290.cd-22-0138

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C, James VH, Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E, Jeyapalan JN, Rutland CS, MonganNP, Woodcock CL. Clinical and molecular significance of the RNA m(6)A methyltransferase complex in prostate cancer. Front Genet., 2022, 13:1096071. doi.org/10.3389/fgene.2022.1096071

Lashen A, Toss MS, Green AR,Mongan NP, Rakha E. Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods. Histopathology, 2022, 81(6):786-98. doi.org/10.1111/his.14781

Lashen A, Toss MS, Alsaleem M, Green AR, Mongan NP, Rakha E. The characteristics and clinical significance of atypical mitosis in breast cancer. Mod Pathol., 2022, 35(10):1341-8. doi.org/10.1038/s41379-022-01080-0

Larsson PF, Karlsson R, Sarwar M, Miftakhova R, Wang T, Syed Khaja AS, Semenas J, Chen S, Hedblom A, Ali A, Ekstrom-Holka K, Simoulis A, Kumar A, Wingren AG, Robinson B, Nyunt Wai S, MonganNP, Heery DM, Ohlund D, Grundstrom T, Odum N, Persson JL. FcgammaRIIIa receptor interacts with androgen receptor and PIP5K1alpha to promote growth and metastasis of prostate cancer. Mol Oncol., 2022, 16(13):2496-2517. doi.org/10.1002/1878-0261.13166

Kurozumi S, Kaira K, Matsumoto H, Kurosumi M, Yokobori T, Kanai Y, Sekine C, Honda C, Katayama A, Furuya M, Shiino S, Makiguchi T, Mongan NP,Rakha EA, Oyama T, Fujii T, Shirabe K, Horiguchi J. Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer. Sci Rep., 2022, 12(1):2742. doi.org/10.1038/s41598-022-06615-8

Kulkarni S, Brownlie J, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S. Evolving DNA repair synthetic lethality targets in cancer. Biosci Rep., 2022, 42(12). doi.org/10.1042/bsr20221713

Kariri YA, Joseph C, Alsaleem MA, Elsharawy KA, Alsaeed S, Toss MS, Mongan NP,Green AR,Rakha EA. Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer. Cancers (Basel), 2022, 14(22). doi.org/10.3390/cancers14225643

Kariri Y, Toss MS, Alsaleem M, Elsharawy KA, Joseph C, MonganNP, Green AR, Rakha EA. Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer. Breast Cancer Res Treat., 2022, 192(3):529-39. doi.org/10.1007/s10549-022-06531-5

Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S, Allegrucci C, James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, MonganNP, Jeyapalan JN. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front Endocrinol (Lausanne), 2022, 13:1006101. doi.org/10.3389/fendo.2022.1006101

Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Metzler VM, Persson JL, Robinson BD, Khani F, Alsaleem M, Ntekim A, Madhusudan S, Davis MB, Laursen KB, Gudas LJ, Rutland CS, Toss MS, Archer N, Bodi Z, Rakha EA, Fray RG, Jeyapalan JN, Mongan NP. The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers (Basel), 2022, 14(20). doi.org/10.3390/cancers14205148

de Brot S, Lothion-Roy J, Grau-Roma L, White E, Guscetti F, Rubin MA, MonganNP. Histological and immunohistochemical investigation of canine prostate carcinoma with identification of common intraductal carcinoma component. Vet Comp Oncol., 2022, 20(1):38-49. doi.org/10.1111/vco.12704

Benjamin DN, O'Donovan TR, Laursen KB, Orfali N, Cahill MR, MonganNP, Gudas LJ, McKenna SL. All-Trans-Retinoic Acid Combined With Valproic Acid Can Promote Differentiation in Myeloid Leukemia Cells by an Autophagy Dependent Mechanism. Front Oncol., 2022, 12:848517. doi.org/10.3389/fonc.2022.848517

Atallah NM, Toss MS, Green AR,MonganNP, Ball G, Rakha EA. Refining the definition of HER2-low class in invasive breast cancer. Histopathology, 2022, 81(6):770-85. doi.org/10.1111/his.14780

Alsaeed SA, Toss M, Alsaleem M, Aleskandarany M, Joseph C, Kurozumi S, Ball G, MonganN,Green A, Rakha E. Prognostic significance of heat shock protein 90AA1 (HSP90alpha) in invasive breast cancer. J Clin Pathol., 2022, 75(4):263-269. doi.org/10.1136/jclinpath-2020-207106

Algethami M, Kulkarni S, Sadiq MT, Tang HKC, Brownlie J, Jeyapalan JN,Mongan NP, Rakha EA,Madhusudan S. Towards Personalized Management of Ovarian Cancer. Cancer Manag Res., 2022, 14:3469-83. doi.org/10.2147/cmar.s366681

Alblihy A, Ali R, Algethami M, Shoqafi A, Toss MS, Brownlie J, Tatum NJ, Hickson I, Moran PO,Grabowska A, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. NPJ Precis Oncol., 2022, 6(1):51. doi.org/10.1038/s41698-022-00298-0

Abhik Mukherjee

Corden C, Boitor R, Dusanjh PK, Harwood A, Mukherjee A, Gomez D, Notingher I. Autofluorescence-Raman Spectroscopy for Ex Vivo Mapping Colorectal Liver Metastases and Liver Tissue. J Surg Res., 2023, 288:10-20. doi.org/10.1016/j.jss.2023.02.014

Williams CJM, Elliott F, Sapanara N, Aghaei F, Zhang L, Muranyi A, Yan D, Bai I, Zhao Z, Shires M, Wood HM, Richman SD, Hemmings G, Hale M, Bottomley D, Galvin L, Cartlidge C, Dance S, Bacon CM, Mansfield L, Young-Zvandasara K, Sudan A, Lambert K, Bibby I, Coupland SE, Montazeri A, Kipling N, Hughes K, Cross SS, Dewdney A, Pheasey L, Leng C, Gochera T, Mangham DC, Saunders M, Pritchard M, Stott H, Mukherjee A,Ilyas M, Silverman R, Hyland G, Sculthorpe D, Thornton K, Gould I, O'Callaghan A, Brown N, Turnbull S, Shaw L, Seymour MT, West NP, Seligmann JF, Singh S, Shanmugam K, Quirke P. Associations between AI-Assisted Tumor Amphiregulin and Epiregulin IHC and Outcomes from Anti-EGFR Therapy in the Routine Management of Metastatic Colorectal Cancer. Clin Cancer Res., 2023, 29(20):4153-4165. doi.org/10.1158/1078-0432.ccr-23-0859

Babaei-Jadidi R, Kashfi H, Alelwani W, Karimi Bakhtiari A, Kattan SW, Mansouri OA, Mukherjee A, Lobo DN, Nateri AS. Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids. Oncogenesis, 2022, 11(1):4. doi.org/10.1038/s41389-021-00376-1

Paloma Ordonez Moran

Gajera KR, Fair KL, Moran GW, Hannan NRF, Huelsken J, Ordóñez-Morán P. In Vitro and in Vivo Assays for Testing Retinoids Effect on Intestinal Progenitors' Lineage Commitments. Methods Mol Biol., 2023, 2650:53-61. doi.org/10.1007/978-1-0716-3076-1_5

Alblihy A, Ali R, Algethami M, Ritchie AA, Shoqafi A, Alqahtani S, Mesquita KA, Toss MS, Ordóñez-Morán P, Jeyapalan JN, Dekker L, Salerno M, Hartsuiker E, Grabowska AM, Rakha EA, Mongan NP, Madhusudan S. Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. Int J Mol Sci., 2023, 24(13):10966. doi.org/10.3390/ijms241310966

Martínez-Espuga M, Mata A, Ordóñez-Morán P. Intestinal Cell Differentiation and Phenotype in 2D and 3D Cell Culture Models. Methods Mol Biol., 2023, 2650:235-243. doi.org/10.1007/978-1-0716-3076-1_18

Marva G, Ünsal S, Benest AV, Bates DO, Ordóñez-Morán P. Novel Approach to Measure Transepithelial Electrical Resistance in Intestinal Cells. Methods Mol Biol., 2023, 2650:35-42. doi.org/10.1007/978-1-0716-3076-1_3

Bonilla-Díaz A, Ordóñez-Morán P. Differentiated Epithelial Cells of the Gut. Methods Mol Biol., 2023, 2650:3-16. doi.org/10.1007/978-1-0716-3076-1_1

Mahmoud R, Ordóñez-Morán P,Allegrucci C. Challenges for Triple Negative Breast Cancer Treatment: Defeating Heterogeneity and Cancer Stemness. Cancers (Basel), 2022, 14(17):4280. doi.org/10.3390/cancers14174280

Alblihy A, Ali R, Algethami M, Shoqafi A, Toss MS, Brownlie J, Tatum NJ, Hickson I, Moran PO, Grabowska A, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. NPJ Precis Oncol., 2022, 6(1):51. doi.org/10.1038/s41698-022-00298-0

Ellis O’Neill

O'Neill EC. Glycosylated proteins in the protozoan alga Euglena gracilis: a proteomic approach. FEMS Microbiol Lett., 2023, 370:fnac120. doi.org/10.1093/femsle/fnac120

Aldholmi M, Ahmad R, Carretero-Molina D, Pérez-Victoria I, Martín J, Reyes F, Genilloud O, Gourbeyre L, Gefflaut T, Carlsson H, Maklakov A, O'Neill E, Field RA, Wilkinson B, O'Connell M, Ganesan A. Euglenatides, Potent Antiproliferative Cyclic Peptides Isolated from the Freshwater Photosynthetic Microalga Euglena gracilis. Angew Chem Int Ed Engl., 2022, 61(23):e202203175. doi.org/10.1002/anie.202203175

Ebenezer TE, Low RS, O'Neill EC, Huang I, DeSimone A, Farrow SC, Field RA, Ginger ML, Guerrero SA, Hammond M, Hampl V, Horst G, Ishikawa T, Karnkowska A, Linton EW, Myler P, Nakazawa M, Cardol P, Sánchez-Thomas R, Saville BJ, Shah MR, Simpson AGB, Sur A, Suzuki K, Tyler KM, Zimba PV, Hall N, Field MC. Euglena International Network (EIN): Driving euglenoid biotechnology for the benefit of a challenged world. Biol Open., 2022, 11(11):bio059561. doi.org/10.1242/bio.059561

Poulam Patel

Brown JE, Royle KL, Gregory W, Ralph C, Maraveyas A, Din O, Eisen T, Nathan P, Powles T, Griffiths R, Jones R, Vasudev N, Wheater M, Hamid A, Waddell T, McMenemin R, Patel P, Larkin J, Faust G, Martin A, Swain J, Bestall J, McCabe C, Meads D, Goh V, Min Wah T, Brown J, Hewison J, Selby P, Collinson F; STAR Investigators. Temporary treatment cessation versus continuation of first-line tyrosine kinase inhibitor in patients with advanced clear cell renal cell carcinoma (STAR): an open-label, non-inferiority, randomised, controlled, phase 2/3 trial. Lancet Oncol., 2023, 24(3):213-227. doi.org/10.1016/s1470-2045(22)00793-8

Vasudev NS, Scelo G, Glennon KI, Wilson M, Letourneau L, Eveleigh R, Nourbehesht N, Arseneault M, Paccard A, Egevad L, Viksna J, Celms E, Jackson SM, Abedi-Ardekani B, Warren AY, Selby PJ, Trainor S, Kimuli M, Cartledge J, Soomro N, Adeyoju A, Patel PM, Wozniak MB, Holcatova I, Brisuda A, Janout V, Chanudet E, Zaridze D, Moukeria A, Shangina O, Foretova L, Navratilova M, Mates D, Jinga V, Bogdanovic L, Kovacevic B, Cambon-Thomsen A, Bourque G, Brazma A, Tost J, Brennan P, Lathrop M, Riazalhosseini Y, Banks RE. Application of Genomic Sequencing to Refine Patient Stratification for Adjuvant Therapy in Renal Cell Carcinoma. Clin Cancer Res., 2023, 29(7):1220-1231. doi.org/10.1158/1078-0432.ccr-22-1936

Atallah E, Welsh SJ, O'Carrigan B, Oshaughnessy A, Dolapo I, Kerr AS, Kucharczak J, Lee CYC, Crooks C, Hicks A, Chimakurthi CR, Rao A, Franks H,Patel PM, Aithal GP. Incidence, risk factors and outcomes of checkpoint inhibitor-induced liver injury: A 10-year real-world retrospective cohort study. JHEP Rep., 2023, 5(10):100851. doi.org/10.1016/j.jhepr.2023.100851

Suárez C, Larkin JMG, Patel P, Valderrama BP, Rodriguez-Vida A, Glen H, Thistlethwaite F, Ralph C, Srinivasan G, Mendez-Vidal MJ, Hartmaier R, Markovets A, Prendergast A, Szabados B, Mousa K, Powles T. Phase II Study Investigating the Safety and Efficacy of Savolitinib and Durvalumab in Metastatic Papillary Renal Cancer (CALYPSO). J Clin Oncol., 2023, 41(14):2493-2502. doi.org/10.1200/jco.22.01414

Elsheikh S, Kouzoukakis I, Fielden C, Li W, Lashin SE, Khair N, Raposo TP, Fadhil W, Rudland P, Aleskandarany M, Patel P, El-Tanani M, Ilyas M. Ran GTPase is an independent prognostic marker in malignant melanoma which promotes tumour cell migration and invasion. J Clin Pathol., 2022, 75(1):24-29. doi.org/10.1136/jclinpath-2020-206871

Ruman Rahman

Moloney C, Mehradina F, Cavanagh RJ, Ibrahim A, Pearce AK, Ritchie A, Clarke P, Rahman R, Grabowska AM, Alexander C. Chain-extension in hyperbranched polymers alters tissue distribution and cytotoxicity profiles in orthotopic models of triple negative breast cancers. Biomater Sci., 2023, 11(19):6545-6560. doi.org/10.1039/d3bm00609c

Jain A, Gosling J, Liu S, Wang H, Stone EM, Chakraborty S, Jayaraman PS, Smith S, Amabilino DB, Fromhold M, Long YT, Pérez-García L, Turyanska L, Rahman R, Rawson FJ. Wireless electrical-molecular quantum signalling for cancer cell apoptosis. Nat Nanotechnol., 2023, Sep 14. doi.org/10.1038/s41565-023-01496-y

Andrieux G⁺, Das T⁺, Griffin M, Boerries M, Heiland DH, Smith SJ, Rahman R*, Chakraborty S*. Spatial transcriptomics reveals unique defining molecular features of fluorescence-sorted 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survival. Genome Med., 2023, 15:48. doi.org/10.1186/s13073-023-01207-1 

+ Contributed equally. * Contributed equally. 

Adekeye A, Needham D, Rahman R. Low density lipoprotein pathway is a ubiquitous metabolic vulnerability in high grade glioma amenable for nanotherapeutic delivery. Pharmaceutics, 2023, 15: 599. doi.org/10.3390/pharmaceutics15020599

He W, Edney MK, Paine S, Griffiths RL, Scurr DJ, Rahman R, Kim D-H. Untargeted metabolomic characterisation of glioblastoma intra-tumour heterogeneity using orbitrap-secondary ion mass spectrometry. Anal Chem, 2023, 95(14): 5994-6001. doi.org/10.1021/acs.analchem.2c05807

Martins C, Araujo M, Malfatani A, Pacheco C, Smith SJ,Rahman R, Aylott JW, Preat V*, Sarmento B*. Stimuli-responsive multifunctional nanomedicine for enhanced glioblastoma chemotherapy augments multistage blood-to-brain trafficking and tumor targeting. Small, 2023, 19(22):e2300029. doi.org/10.1002/smll.202300029

 Muresan P*, McCrorie P*, Smith F, Vasey C, Taresco V, Scurr D, Kern S, Smith S, Gershkovich P,Rahman R, Marlow M. Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site. Eur J Pharm Biopharm., 2023, 182:53-61. doi.org/10.1016/j.ejpb.2022.11.016

Jain A, Jobson I, Griffin M, Rahman R, Smith S, Rawson F. Electric field responsive nanotransducers for glioblastoma. Bioelectron Med., 2022, 8:17. 

doi.org/10.1186/s42234-022-00099-7

Wood J, Abdelrazig S, Evseev S, Ortori C, Castellanos-Uribe M, May ST, Barrett DA, Chakraborty S, Kim D-H, Grundy RG,Rahman R. Lipoprotein deprivation reveals a cholesterol-dependent therapeutic vulnerability in adult and paediatric diffuse glioma metabolism. Cancers (Basel), 2022, 14: 3873. doi.org/10.3390/cancers14163873

 Rahman R, Janowski M, Killick-Cole CL, Singleton W, Walczak P, Khatua S, Faltings L, Symons M, Schneider JR, Kwan K, Boockvar JA, Gill SS, Oliveira JM, Beccaria K, Carpentier A, Canney M, Pearl M, Veal G, Meijer L, Walker D. On behalf of Children’s Brain Tumour Drug Delivery Consortium. Childhood brain tumours: A review of strategies to translate CNS drug delivery to clinical trials. Cancers (Basel), 2023, 15: 857. doi.org/10.3390/cancers15030857

Muresan P, Woodhams S, Smith F, Taresco V, Shah J, Wong M, Chapman V, Smith S, Hathway G, Rahman R, Gershkovich P, Marlow M. Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution after intrathecal delivery. Nanomedicine, 2023, 49:102664. doi.org/10.1016/j.nano.2023.102664

 McCrorie P, Rowlinson J, Scurr D, Marlow M, Rahman R. Detection of label-free drugs within brain tissue using Orbitrap secondary ion mass spectrometry as a complement to neuro-oncological drug delivery. Pharmaceutics, 2022, 14: 571. doi.org/10.3390/pharmaceutics14030571

Williams G, Chambers D, Rahman R, Molina-Holgado F. Transcription profile and pathway analysis for CB2 antagonist treatment in the core and boundary of human glioblastoma cells. Molecules, 2022, 27(7):2048. doi.org/10.3390/molecules27072049

 Tomi-Andrino C, Pandele A, Winzer K, King J, Rahman R, Kim D-H. Metabolic modelling-based drug repurposing in Glioblastoma. Sci Rep., 2022, 12:11189. doi.org/10.1038/s41598-022-14721-w

Branter J, Cebrero ME, Diksin M, Griffin M, Castellanos-Uribe M, May S, Rahman R, Grundy RG, Basu S, Smith S. Genome wide expression and anti-proliferative effects of electric field therapy on paediatric and adult brain tumours. Int J Mol Sci, 2022, 23(4): 1982. doi.org/10.3390/ijms23041982

Alazzo A, Gumus N, Gurnani P, Stolnik S, Rahman R, Spriggs K, Alexander C. Investigating histidinylated highly branched poly(lysine) for siRNA delivery. J Mater Chem B., 2022, 10(2): 236-246. doi.org/10.1039/d1tb01793d

Emad Rakha

Atallah NM, Alsaleem M, Toss MS, Mongan NP,Rakha E. Differential response of HER2-positive breast cancer to anti-HER2 therapy based on HER2 protein expression level. Br J Cancer, 2023, Sep 22. doi.org/10.1038/s41416-023-02426-4

 Lee AHS, Hodi Z, Abbas A, Wencyk P, Ellis IO, Rakha E. Should a borderline negative HER2 result in a core biopsy of invasive carcinoma of the breast have HER2 assessment repeated in the excision specimen? J Clin Pathol., 2023, Aug 30:jcp-2023-209091. doi.org/10.1136/jcp-2023-209091

Nguyen HL, Geukens T, Maetens M, Aparicio S, Bassez A, Borg A, Brock J, Broeks A, Caldas C, Cardoso F, De Schepper M, Delorenzi M, Drukker CA, Glas AM, Green AR, Isnaldi E, Eyfjörð J, Khout H, Knappskog S, Krishnamurthy S, Lakhani SR, Langerod A, Martens JWM, McCart Reed AE, Murphy L, Naulaerts S, Nik-Zainal S, Nevelsteen I, Neven P, Piccart M, Poncet C, Punie K, Purdie C, Rakha EA, Richardson A, Rutgers E, Vincent-Salomon A, Simpson PT, Schmidt MK, Sotiriou C, Span PN, Tan KTB, Thompson A, Tommasi S, Van Baelen K, Van de Vijver M, Van Laere S, Van't Veer L, Viale G, Viari A, Vos H, Witteveen AT, Wildiers H, Floris G, Garg AD, Smeets A, Lambrechts D, Biganzoli E, Richard F, Desmedt C. Obesity-associated changes in molecular biology of primary breast cancer. Nat Commun., 2023, 14(1):4418. doi.org/10.1038/s41467-023-39996-z

Makhlouf S, Althobiti M, Toss M, Muftah AA, Mongan NP, Lee AHS, Green AR, Rakha EA. The Clinical and Biological Significance of Estrogen Receptor-Low Positive Breast Cancer. Mod Pathol., 2023, 36(10):100284. doi.org/10.1016/j.modpat.2023.100284

Alblihy A, Ali R, Algethami M, Ritchie AA, Shoqafi A, Alqahtani S, Mesquita KA, Toss MS, Ordóñez-Morán P, Jeyapalan JN,Dekker L, Salerno M, Hartsuiker E, Grabowska AM,Rakha EA,Mongan NP, Madhusudan S. Selective Killing of BRCA2-Deficient Ovarian Cancer Cells via MRE11 Blockade. Int J Mol Sci., 2023, 24(13):10966. doi.org/10.3390/ijms241310966

Zaakouk M, Quinn C, Provenzano E, Boyd C, Callagy G, Elsheikh S, Flint J, Millican-Slater R, Gunavardhan A, Mir Y, Makhija P, Di Palma S, Pritchard S, Tanchel B, Rakha E, Atallah NM, Lee AHS, Pinder S, Shaaban AM. Concordance of HER2-low scoring in breast carcinoma among expert pathologists in the United Kingdom and the republic of Ireland -on behalf of the UK national coordinating committee for breast pathology. Breast, 2023, 70:82-91. doi.org/10.1016/j.breast.2023.06.005

Atallah NM, Wahab N, Toss MS, Makhlouf S, Ibrahim AY, Lashen AG, Ghannam S, Mongan NP, Jahanifar M, Graham S, Bilal M, Bhalerao A, Ahmed Raza SE, Snead D, Minhas F, Rajpoot N, Rakha E. Deciphering the Morphology of Tumor-Stromal Features in Invasive Breast Cancer Using Artificial Intelligence. Mod Pathol., 2023, 36(10):100254. doi.org/10.1016/j.modpat.2023.100254

Alsolami A, ALGhasab NS, Alharbi MSM, Bashir AI, Saleem M, Syed Khaja AS, Aldakheel DF, Rakha E, Alshammari JA, Taha TE, Melibari Z, Alharbi YH, Almutlag AA, Said KB; Ha’il COM Research Unit Group. Community-Acquired Methicillin-Resistant Staphylococcus aureus in Hospitals: Age-Specificity and Potential Zoonotic-Zooanthroponotic Transmission Dynamics. Diagnostics (Basel), 2023, 16;13(12):2089. doi.org/10.3390/diagnostics13122089

Lee AHS, Toss MS, James JJ, Hodi Z, Ellis IO, Rakha EA. Preoperative diagnosis of ductal carcinoma in situ of the breast over a 24-year period. Histopathology, 2023, 83(3):435-442. doi.org/10.1111/his.14994

Rakha EA, Adebayo LA, Abbas A, Hodi Z, Lee AHS, Ellis IO. Second opinion (external specialist referral) practice of breast pathology: the Nottingham experience. Histopathology, 2023, 83(3):394-405. doi.org/10.1111/his.14993

Ambrosini-Spaltro A, Di Donato F, Saragoni L, Cserni G, Rakha E, Foschini MP. Prognostic Markers of Microinvasive Breast Carcinoma: A Systematic Review and Meta-Analysis. Cancers (Basel), 2023, 15(11):3007. doi.org/10.3390/cancers15113007

Ghannam SF, Rutland CS, Allegrucci C, Mongan NP,Rakha E. Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? Histopathology, 2023,83(3):376-393. doi.org/10.1111/his.14939

Lashen AG, Toss MS, Wootton L, Green AR, Mongan NP, Madhusudan S,Rakha E. Characteristics and prognostic significance of polo-like kinase-1 (PLK1) expression in breast cancer. Histopathology, 2023, 83(3):414-425. doi.org/10.1111/his.14960

Metzler VM, de Brot S, Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Nilsson EM, Ntekim A, Persson JL, Robinson BD, Khani F, Laursen KB, Gudas LJ, Toss MS, Madhusudan S, Rakha E, Heery DM, Rutland CS, Mongan NP, Jeyapalan JN. The KDM5B and KDM1A lysine demethylases cooperate in regulating androgen receptor expression and signalling in prostate cancer. Front Cell Dev Biol., 2023, 11:1116424. doi.org/10.3389/fcell.2023.1116424

Brownlie J, Kulkarni S, Algethami M, Jeyapalan JN, Mongan NP,Rakha EA,Madhusudan S. Targeting DNA damage repair precision medicine strategies in cancer. Curr Opin Pharmacol., 2023, 70:102381. doi.org/10.1016/j.coph.2023.102381

Lashen AG, Toss MS, Rakha EA. Reply to "Increased survival of women with luminal breast cancer and progesterone receptor immunohistochemical expression of greater than 10%". Cancer, 2023, 129(13):2105. doi.org/10.1002/cncr.34826

Ibrahim A, Miligy IM, Toss MS, Green AR, Rakha EA. High Inner Centromere Protein (INCENP) expression correlates with aggressive features and predicts poor prognosis in patients with invasive breast cancer. Pathobiology, 2023, Apr 7. doi.org/10.1159/000529628

Algethami M, Toss MS, Woodcock CL, Jaipal C, Brownlie J, Shoqafi A, Alblihy A, Mesquita KA, Green AR, Mongan NP, Jeyapalan JN, Rakha EA, Madhusudan S. Unravelling the clinicopathological and functional significance of replication protein A (RPA) heterotrimeric complex in breast cancers. NPJ Breast Cancer, 2023, 9(1):18. doi.org/10.1038/s41523-023-00524-3

Storr SJ, Hoskin V, Aiyappa-Maudsley R, Ghaffari A, Varma S, Green A, Rakha E, Ellis IO, Greer PA, Martin SG. A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease. Cancer Med., 2023, 12(9):10908-10916. doi.org/10.1002/cam4.5802

Said KB, AlGhasab NS, Alharbi MSM, Alsolami A, Bashir AI, Saleem M, Syed Khaja AS, Aldakheel DF, Rakha E, Alshamri JA, Al-Hazimi A, Alrodhaiman AJ, Taha TE, Alanazi HH, Ha'il Com Research Unit Group. A Sequalae of Lineage Divergence in Staphylococcus aureus from Community-Acquired Patterns in Youth to Hospital-Associated Profiles in Seniors Implied Age-Specific Host-Selection from a Common Ancestor. Diagnostics (Basel), 2023, 13(5):819. doi.org/10.3390/diagnostics13050819

Ciscar M, Trinidad EM, Perez-Chacon G, Alsaleem M, Jimenez M, Jimenez-Santos MJ, Perez-Montoyo H, Sanz-Moreno A, Vethencourt A, Toss M, Petit A, Soler-Monso MT, Lopez V, Gomez-Miragaya J, Gomez-Aleza C, Dobrolecki LE, Lewis MT, Bruna A, Mouron S, Quintela-Fandino M, Al-Shahrour F, Martinez-Aranda A, Sierra A, Green AR, Rakha E, Gonzalez-Suarez E. RANK is a poor prognosis marker and a therapeutic target in ER-negative postmenopausal breast cancer. EMBO Mol Med., 2023, 15(4):e16715. doi.org/10.15252/emmm.202216715

Lashen AG, Toss MS, Ghannam SF, Makhlouf S, Green A, Mongan NP,Rakha E. Expression, assessment and significance of Ki67 expression in breast cancer: an update J Clin Pathol., 2023, 76(6):357-364. doi.org/10.1136/jcp-2022-208731

Ibrahim A, Toss MS, Atallah NM, Al Saleem M, Green AR, Rakha EA. Combined proliferation and apoptosis index provides better risk stratification in breast cancer. Histopathology, 2023, 82(7):1029-1047. doi.org/10.1111/his.14887

Saleem M, Syed Khaja AS, Hossain A, Alenazi F, Said KB, Moursi SA, Almalaq HA, Mohamed H, Rakha E, Alharbi MS, Babiker SAA, Usman K. Pathogen Burden Among ICU Patients in a Tertiary Care Hospital in Hail Saudi Arabia with Particular Reference to β-Lactamases Profile. Infect Drug Resist., 2023, 16:769-778. doi.org/10.2147/idr.s394777

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C, James VH, Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E,Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Front Genet., 2023,13:1096071. doi.org/10.3389/fgene.2022.1096071

Lashen AG, Toss MS, Mongan NP, Green AR,Rakha EA. The clinical value of progesterone receptor expression in luminal breast cancer: A study of a large cohort with long-term follow-up. Cancer, 2023, 129(8):1183-1194. doi.org/10.1002/cncr.34655

Lashen A, Toss MS, Fadhil W, Oni G, Madhusudan S,Rakha E. Evaluation oncotype DX^® 21-gene recurrence score and clinicopathological parameters: a single institutional experience. Histopathology, 2023, 82(5):755-766. doi.org/10.1111/his.14863

Luan H, Bielecki TA, Mohapatra BC, Islam N, Mushtaq I, Bhat AM, Mirza S, Chakraborty S, Raza M, Storck MD, Toss MS, Meza JL, Thoreson WB, Coulter DW, Rakha EA, Band V, Band H. EHD2 overexpression promotes tumorigenesis and metastasis in triple-negative breast cancer by regulating store-operated calcium entry. Elife, 2023, 12:e81288. doi.org/10.7554/elife.81288

Rakha EA, Tan PH, Quinn C, Provenzano E, Shaaban AM, Deb R, Callagy G, Starczynski J, Lee AHS, Ellis IO 1, Pinder SE. UK recommendations for HER2 assessment in breast cancer: an update. J Clin Pathol., 2023, 76(4):217-227. doi.org/10.1136/jcp-2022-208632

Quinn C, Maguire A, Rakha E. Pitfalls in breast pathology. Histopathology, 2023, 82(1):140-161. doi.org/10.1111/his.14799

Tse GM, Tan PH, Rakha EA. Annual Review Issue: Breast Pathology. Histopathology, 2023, 82(1):2-4. doi.org/10.1111/his.14835

Ellis IO, Rakha EA, Tse GM, Tan PH. An international unified approach to reporting and grading invasive breast cancer. An overview of the International Collaboration on Cancer Reporting (ICCR) initiative. Histopathology, 2023, 82(1):189-197. doi.org/10.1111/his.14802

Rakha EA, Tse GM, Quinn CM. An update on the pathological classification of breast cancer. Histopathology, 2023, 82(1):5-16. doi.org/10.1111/his.14786

Shiino S, Quinn C, Ball G, Syed BM, Kurozumi S, Tsuda H, Rakha EA. Prognostic significance of microinvasion with ductal carcinoma in situ of the breast: a meta-analysis. Breast Cancer Res Treat., 2023, 197(2):245-254. doi.org/10.1007/s10549-022-06800-3

Aljohani AI, Toss MS, Green AR, Rakha EA. The clinical significance of cyclin B1 (CCNB1) in invasive breast cancer with emphasis on its contribution to lymphovascular invasion development. Breast Cancer Res Treat., 2023, 198(3):423-435. doi.org/10.1007/s10549-022-06801-2

Ibrahim A, Toss MS, Makhlouf S, Miligy IM, Minhas F, Rakha EA. Improving mitotic cell counting accuracy and efficiency using phosphohistone-H3 (PHH3) antibody counterstained with haematoxylin and eosin as part of breast cancer grading. Histopathology, 2023, 82(3):393-406. doi.org/10.1111/his.14837

Ghannam SF, Rutland CS, Allegrucci C, Mongan NP,Rakha E. Defining invasion in breast cancer: the role of basement membrane. J Clin Pathol., 2023,76(1):11-18. doi.org/10.1136/jcp-2022-208584

Ghannam SF, Rutland CS, Allegrucci C, Mongan NP, Rakha E. Encapsulated papillary carcinoma of the breast: does it have a native basement membrane? Histopathology, 2023, 83(3):376-393. doi.org/10.1111/his.14939

Rakha EA, Brogi E, Castellano I, Quinn C. Spindle cell lesions of the breast: a diagnostic approach. Virchows Arch., 2022, 480(1):127-145. doi.org/10.1007/s00428-021-03162-x

Katayama A, Toss MS, Parkin M, Ellis IO, Quinn C, Rakha EA. Atypia in breast pathology: what pathologists need to know. Pathology, 2022, 54(1):20-31. doi.org/10.1016/j.pathol.2021.09.008

Atallah NM, Toss MS, Green AR, Mongan NP, Ball G, Rakha EA. Refining the definition of HER2-low class in invasive breast cancer. Histopathology, 2022, 81(6):770-785. doi.org/10.1111/his.14780

Harris AE, Metzler VM, Lothion-Roy J, Varun D, Woodcock CL, Haigh DB, Endeley C, Haque M, Toss MS, Alsaleem M, Persson JL, Gudas LJ, Rakha E, Robinson BD, Khani F, Martin LM, Moyer JE, Brownlie J, Madhusudan S,Allegrucci C,James VH, Rutland CS, Fray RG, Ntekim A, de Brot S, Mongan NP, Jeyapalan JN. Exploring anti-androgen therapies in hormone dependent prostate cancer and new therapeutic routes for castration resistant prostate cancer. Front Endocrinol (Lausanne), 2022, 13:1006101. doi.org/10.3389/fendo.2022.1006101

Algethami M, Kulkarni S, Sadiq MT, Tang HKC, Brownlie J, Jeyapalan JN,Mongan NP, Rakha EA,Madhusudan S. Towards Personalized Management of Ovarian Cancer. Cancer Manag Res., 2022, 14:3469-83. doi.org/10.2147/cmar.s366681

Rakha EA, Tan PH. Immunohistochemistry in Breast Cancer: Practice Points and Pitfalls. Pathobiology, 2022, 9(5):261-262. doi.org/10.1159/000525093

Rakha EA, Vougas K, Tan PH. Digital Technology in Diagnostic Breast Pathology and Immunohistochemistry. Pathobiology, 2022, 89(5):334-342. doi.org/10.1159/000521149

Rakha EA, Chmielik E, Schmitt FC, Tan PH, Quinn CM, Gallagy G. Assessment of Predictive Biomarkers in Breast Cancer: Challenges and Updates. Pathobiology, 2022, 89(5):263-277. doi.org/10.1159/000525092

Hagenaars SC, Vangangelt KMH, Van Pelt GW, Karancsi Z, Tollenaar RAEM, Green AR, Rakha EA, Kulka J, Mesker WE. Standardization of the tumor-stroma ratio scoring method for breast cancer research. Breast Cancer Res Treat., 2022, 193(3):545-553. doi.org/10.1007/s10549-022-06587-3

Rakha E, Tan PH. Head to head: do neuroendocrine tumours in the breast truly exist? Histopathology, 2022, 81(1):2-14. doi.org/10.1111/his.14627

Rakha E, Toss M, Quinn C. Specific cell differentiation in breast cancer: a basis for histological classification. J Clin Pathol., 2022, 75(2):76-84. doi.org/10.1136/jclinpath-2021-207487

Barkur S, Notingher I, Rakha E. Intra-operative assessment of sentinel lymph nodes for breast cancer surgery: An update. Surg Oncol., 2022, 40:101678. doi.org/10.1016/j.suronc.2021.101678

Ghannam SF, Rutland CS, Allegrucci C, Mongan NP, Rakha E. Defining invasion in breast cancer: the role of basement membrane. J Clin Pathol., 2023, 76(1):11-18. doi.org/10.1136/jcp-2022-208584

Shiino S, Ball G, Syed BM, Kurozumi S, Green AR, Tsuda H, Takayama S, Suto A, Rakha EA. Prognostic significance of receptor expression discordance between primary and recurrent breast cancers: a meta-analysis. Breast Cancer Res Treat., 2022, 191(1):1-14. doi.org/10.1007/s10549-021-06390-6

Ibrahim A, Lashen A, Toss M, Mihai R, Rakha E. Assessment of mitotic activity in breast cancer: revisited in the digital pathology era. J Clin Pathol., 2022, 75(6):365-372. doi.org/10.1136/jclinpath-2021-207742

Martin SG,Rakha E, Storr SJ. Quantifying Lymphatic Vessel Density in Human Tissue Samples. Methods Mol Biol., 2022, 2022:2441:183-189. doi.org/10.1007/978-1-0716-2059-5_14

Kulkarni S, Brownlie J, Jeyapalan JN, Mongan NP, Rakha EA, Madhusudan S. Evolving DNA repair synthetic lethality targets in cancer. Biosci Rep., 2022, 42(12). doi.org/10.1042/bsr20221713

Fox SB, Webster F, Chen CJ, Chua B, Collins L, Foschini MP, Bruce Mann G, Millar E, Pinder SE, Rakha E, Shaaban A, Tan BY, Tse G, Watson P, Tan PH. Dataset for pathology reporting of ductal carcinoma in situ, variants of lobular carcinoma in situ and low-grade lesions: recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathology, 2022, 81(4):467-476. doi.org/10.1111/his.14725

Haigh DB, Woodcock CL, Lothion-Roy J, Harris AE, Metzler VM, Persson JL, Robinson BD, Khani F, Alsaleem M, Ntekim A, Madhusudan S, Davis MB, Laursen KB, Gudas LJ, Rutland CS, Toss MS, Archer N, Bodi Z, Rakha EA, Fray RG, Jeyapalan JN, Mongan NP. The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer. Cancers (Basel), 2022, 14(20). doi.org/10.3390/cancers14205148

Lashen A, Toss MS, Alsaleem M, Green AR, Mongan NP, Rakha EA.The characteristics and clinical significance of atypical mitosis in breast cancer. E. Mod Pathol., 2022, 35(10):1341-1348. doi.org/10.1038/s41379-022-01080-0

Haghighat M, Browning L, Sirinukunwattana K, Malacrino S, Khalid Alham N, Colling R, Cui Y, Rakha E, Hamdy FC, Verrill C, Rittscher J. Automated quality assessment of large digitised histology cohorts by artificial intelligence. Sci Rep., 2022, 12(1):5002. doi.org/10.1038/s41598-022-08351-5

Lu W, Miligy IM, Minhas F, Park YS, Snead DRJ, Rakha EA, Verrill C, Rajpoot N. Lessons from a breast cell annotation competition series for school pupils. Sci Rep., 2022, 12(1):7792. doi.org/10.1038/s41598-022-11782-9

Mirza S, Kalluchi A, Raza M, Saleem I, Mohapatra B, Pal D, Ouellette MM, Qiu F, Yu L, Lobanov A, Zheng ZM, Zhang Y, Alsaleem MA, Rakha EA, Band H, Rowley MJ, Band V. Ecdysoneless Protein Regulates Viral and Cellular mRNA Splicing to Promote Cervical Oncogenesis. Mol Cancer Res., 2022, 20(2):305-318. doi.org/10.1158/1541-7786.mcr-21-0567

Mohapatra BC, Mirza S, Bele A, Gurumurthy CB, Raza M, Saleem I, Storck MD, Sarkar A, Kollala SS, Shukla SK, Southekal S, Wagner KU, Qiu F, Lele SM, Alsaleem MA, Rakha EA, Guda C, Singh PK, Cardiff RD, Band H, Band V. Ecdysoneless Overexpression Drives Mammary Tumorigenesis through Upregulation of C-MYC and Glucose Metabolism. Mol Cancer Res., 2022, 20(9):1391-1404. doi.org/10.1158/1541-7786.mcr-22-0122

Wahab N, Miligy IM, Dodd K, Sahota H, Toss M, Lu W, Jahanifar M, Bilal M, Graham S, Park Y, Hadjigeorghiou G, Bhalerao A, Lashen AG, Ibrahim AY, Katayama A, Ebili HO, Parkin M, Sorell T, Raza SEA, Hero E, Eldaly H, Tsang YW, Gopalakrishnan K, Snead D, Rakha E, Rajpoot N, Minhas F. Semantic annotation for computational pathology: multidisciplinary experience and best practice recommendations. J Pathol Clin Res., 2022, 8(2):116-128. doi.org/10.1002/cjp2.256

Aiyappa-Maudsley R, Storr SJ, Rakha EA, Green AR, Ellis IO, Martin SG. CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer. J Pathol Clin Res., 2022, 8(6):550-566. doi.org/10.1002/cjp2.291

Katayama A, Toss MS, Parkin M, Sano T, Oyama T, Quinn CM, Ellis IO, Rakha EA. Nuclear morphology in breast lesions: refining its assessment to improve diagnostic concordance. Histopathology, 2022, 80(3):515-528. doi.org/10.1111/his.14577

Alsaeed SA, Toss M, Alsaleem M, Aleskandarany M, Joseph C, Kurozumi S, Ball G, MonganN,Green A, Rakha E. Prognostic significance of heat shock protein 90AA1 (HSP90alpha) in invasive breast cancer. J Clin Pathol., 2022, 75(4):263-269. doi.org/10.1136/jclinpath-2020-207106

Constantinidou A, Marcou Y, Toss MS, Simmons T, Bernhisel R, Hughes E, Probst B, Meek S, Kakouri E, Georgiou G, Zouvani I, Savvidou G, Kuhl V, Doedt J, Wagner S, Gutin A, Slavin TP, Lanchbury JS, Kronenwett R, Ellis IO, Rakha EA. Clinical Validation of EndoPredict in Pre-Menopausal Women with ER-Positive, HER2-Negative Primary Breast Cancer. Clin Cancer Res., 2022, 28(20):4435-4443. doi.org/10.1158/1078-0432.ccr-22-0619

Lu W, Toss M, Dawood M, Rakha E, Rajpoot N, Minhas F. SlideGraph+: Whole slide image level graphs to predict HER2 status in breast cancer. Med Image Anal., 2022, 80:102486. doi.org/10.1016/j.media.2022.102486

Jaroensri R, Wulczyn E, Hegde N, Brown T, Flament-Auvigne I, Tan F, Cai Y, Nagpal K, Rakha EA, Dabbs DJ, Olson N, Wren JH, Thompson EE, Seetao E, Robinson C, Miao M, Beckers F, Corrado GS, Peng LH, Mermel CH, Liu Y, Steiner DF, Chen PC. Deep learning models for histologic grading of breast cancer and association with disease prognosis. NPJ Breast Cancer, 2022, 8(1):113. doi.org/10.1038/s41523-022-00478-y

Xu Q, Kaur J, Wylie D, Mittal K, Li H, Kolachina R, Aleskandarany M, Toss MS, Green AR, Yang J, Yankeelov TE, Bhattarai S, Janssen EAM, Kong J, Rakha EA, Kowalski J, Aneja R. A Case Series Exploration of Multi-Regional Expression Heterogeneity in Triple-Negative Breast Cancer Patients. Int J Mol Sci., 2022, 23(21):13322. doi.org/10.3390/ijms232113322

Kariri Y, Toss MS, Alsaleem M, Elsharawy KA, Joseph C, Mongan NP,Green AR, Rakha EA. Ubiquitin-conjugating enzyme 2C (UBE2C) is a poor prognostic biomarker in invasive breast cancer. Breast Cancer Res Treat., 2022, 192(3):529-539. doi.org/10.1007/s10549-022-06531-5

Saunus JM, De Luca XM, Northwood K, Raghavendra A, Hasson A, McCart Reed AE, Lim M, Lal S, Vargas AC, Kutasovic JR, Dalley AJ, Miranda M, Kalaw E, Kalita-de Croft P, Gresshoff I, Al-Ejeh F, Gee JMW, Ormandy C, Khanna KK, Beesley J, Chenevix-Trench G, Green AR, Rakha EA, Ellis IO, Nicolau DV Jr, Simpson PT, Lakhani SR. Epigenome erosion and SOX10 drive neural crest phenotypic mimicry in triple-negative breast cancer. NPJ Breast Cancer, 2022, 8(1):57. doi.org/10.1038/s41523-022-00425-x

Atallah NM, Toss MS, Verrill C, Salto-Tellez M, Snead D, Rakha EA. Potential quality pitfalls of digitalized whole slide image of breast pathology in routine practice. Mod Pathol., 2022, 35(7):903-910. doi.org/10.1038/s41379-021-01000-8

Ibrahim A, Lashen AG, Katayama A, Mihai R, Ball G, Toss MS, Rakha EA. Defining the area of mitoses counting in invasive breast cancer using whole slide image. Mod Pathol., 2022, 35(6):739-748. doi.org/10.1038/s41379-021-00981-w

Mittal K, Kaur J, Sharma S, Sharma N, Wei G, Choudhary I, Imhansi-Jacob P, Maganti N, Pawar S, Rida P, Toss MS, Aleskandarany M, Janssen EA, Søiland H, Gupta MV, Reid MD, Rakha EA, Aneja R. Hypoxia Drives Centrosome Amplification in Cancer Cells via HIF1α-dependent Induction of Polo-Like Kinase 4. Mol Cancer Res., 2022, 20(4):596-606. doi.org/10.1158/1541-7786.mcr-20-0798

Lashen A, Toss MS, Green AR,Mongan NP, Rakha E. Ki67 assessment in invasive luminal breast cancer: a comparative study between different scoring methods. Histopathology, 2022, 81(6):786-98. doi.org/10.1111/his.14781

Lothion-Roy J, Haigh DB, Harris AE, Metzler VM, Alsaleem M, Toss MS, Kariri Y, Ntekim A, Robinson BD, Khani F, Gudas LJ, Allegrucci C, James VH, Madhusudan S, Mather M, Emes RD, Archer N, Fray RG, Rakha E,Jeyapalan JN, Rutland CS, Mongan NP, Woodcock CL. Clinical and molecular significance of the RNA m6A methyltransferase complex in prostate cancer. Front Genet., 2023,13:1096071. doi.org/10.3389/fgene.2022.1096071

Aljohani AI, Toss MS, El-Sharawy KA, Mirza S, Ball GR, Green AR, Rakha EA.Upregulation of Cyclin B2 (CCNB2) in breast cancer contributes to the development of lymphovascular invasion. Am J Cancer Res., 2022, 12(2):469-489. https://pubmed.ncbi.nlm.nih.gov/35261781/

Miligy IM, Toss MS, Gorringe KL, Ellis IO, Green AR, Rakha EA. Aurora Kinase A Is an Independent Predictor of Invasive Recurrence in Breast Ductal Carcinoma in situ. Pathobiology, 2022, 89(6):382-392. doi.org/10.1159/000522244

lblihy A, Ali R, Algethami M, Shoqafi A, Toss MS, Brownlie J, Tatum NJ, Hickson I, Moran PO, Grabowska A,Jeyapalan JN,Mongan NP, Rakha EA, Madhusudan S. Targeting Mre11 overcomes platinum resistance and induces synthetic lethality in XRCC1 deficient epithelial ovarian cancers. NPJ Precis Oncol., 2022, 6(1):51. doi.org/10.1038/s41698-022-00298-0

De Schepper M, Vincent-Salomon A, Christgen M, Van Baelen K, Richard F, Tsuda H, Kurozumi S, Brito MJ, Cserni G, Schnitt S, Larsimont D, Kulka J, Fernandez PL, Rodríguez-Martínez P, Olivar AA, Melendez C, Van Bockstal M, Kovacs A, Varga Z, Wesseling J, Bhargava R, Boström P, Franchet C, Zambuko B, Matute G, Mueller S, Berghian A, Rakha E, van Diest PJ, Oesterreich S, Derksen PWB, Floris G, Desmedt C. Results of a worldwide survey on the currently used histopathological diagnostic criteria for invasive lobular breast cancer. Mod Pathol., 2022, 35(12):1812-1820. doi.org/10.1038/s41379-022-01135-2

Kurozumi S, Kaira K, Matsumoto H, Kurosumi M, Yokobori T, Kanai Y, Sekine C, Honda C, Katayama A, Furuya M, Shiino S, Makiguchi T, Mongan NP,Rakha EA, Oyama T, Fujii T, Shirabe K, Horiguchi J. Association of L-type amino acid transporter 1 (LAT1) with the immune system and prognosis in invasive breast cancer. Sci Rep., 2022, 12(1):2742. doi.org/10.1038/s41598-022-06615-8

Bundred N, Porta N, Brunt AM, Cramer A, Hanby A, Shaaban AM, Rakha EA, Armstrong A, Cutress RI, Dodwell D, Emson MA, Evans A, Hartup SM, Horgan K, Miller SE, McIntosh SA, Morden JP, Naik J, Narayanan S, Ooi J, Skene AI, Cameron DA, Bliss JM. Combined Perioperative Lapatinib and Trastuzumab in Early HER2-Positive Breast Cancer Identifies Early Responders: Randomized UK EPHOS-B Trial Long-Term Results. Clin Cancer Res., 2022, 28(7):1323-1334.

doi.org/10.1158/1078-0432.ccr-21-3177

Kariri YA, Joseph C, Alsaleem MA, Elsharawy KA, Alsaeed S, Toss MS, Mongan NP,Green AR,Rakha EA. Mechanistic and Clinical Evidence Supports a Key Role for Cell Division Cycle Associated 5 (CDCA5) as an Independent Predictor of Outcome in Invasive Breast Cancer. Cancers (Basel), 2022, 14(22). doi.org/10.3390/cancers14225643

Katayama A, Starczynski J, Toss MS, Shaaban AM, Provenzano E, Quinn CM, Callagy G, Purdie CA, Millican-Slater R, Purnell D, Chagla L, Oyama T, Pinder SE, Chan S, Ellis I, Lee AHS, Rakha EA. The frequency and clinical significance of centromere enumeration probe 17 alterations in human epidermal growth factor receptor 2 immunohistochemistry-equivocal invasive breast cancer. Histopathology, 2022, 81(4):511-519. doi.org/10.1111/his.14728

Aljohani AI, Toss MS, Green AR, Rakha EA. The clinical significance of cyclin B1 (CCNB1) in invasive breast cancer with emphasis on its contribution to lymphovascular invasion development. Breast Cancer Res Treat., 2023, 198(3):423-435. doi.org/10.1007/s10549-022-06801-2

Judith Ramage

Talhouni S, Fadhil W, Mongan NP, Field L, Hunter K, Makhsous S, Maciel-Guerra A, Kaur N, Nestarenkaite A, Laurinavicius A, Willcox BE, Dottorini T, Spendlove I, Jackson AM, Ilyas M,Ramage JM. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided "immune-hot" colorectal cancers. Front Immunol., 2023, 14:1057292. doi.org/10.3389/fimmu.2023.1057292

Griesinger AM, Riemondy K, Eswaran N, Donson AM, Willard N, Prince EW, Paine SML, Bowes G, Rheaume J, Chapman RJ, Ramage J,Jackson A, Grundy RG, Foreman NK, Ritzmann TA. Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma. iScience, 2023, 26(9):107585. doi.org/10.1016/j.isci.2023.107585

Frankie Rawson

Sharma B, Jain A, Rawson FJ, Chaudhary GR, Pérez-García L, Kaur G. Biocompatible metallosurfactant-based nanocolloid-loaded Rose Bengal with excellent singlet oxygen-induced phototoxicity efficiency against cancer cells. J Mater Chem B., 2023, 11(22):4899-4913. doi.org/10.1039/d2tb02730e

Potts JC, Jain A, Amabilino DB, Rawson FJ, Pérez-García L. Molecular Surface Quantification of Multifunctionalized Gold Nanoparticles Using UV-Visible Absorption Spectroscopy Deconvolution. Anal Chem., 2023, 95(35):12998-13002. doi.org/10.1021/acs.analchem.3c01649

Peteni S, Ozoemena OC, Khawula T, Haruna AB, Rawson FJ, Shai LJ, Ola O, Ozoemena KI. Electrochemical Immunosensor for Ultra-Low Detection of Human Papillomavirus Biomarker for Cervical Cancer. ACS Sens., 2023, 8(7):2761-2770. doi.org/10.1021/acssensors.3c00677

Barbosa F, Garrudo FFF, Alberte PS, Resina L, Carvalho MS, Jain A, Marques AC, Estrany F, Rawson FJ, Aléman C, Ferreira FC, Silva JC. Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering. Sci Technol Adv Mater., 2023, 24(1):2242242. doi.org/10.1080/14686996.2023.2242242

Myers B, Catrambone F, Allen S, Hill PJ, Kovacs K, Rawson FJ. Engineering nanowires in bacteria to elucidate electron transport structural-functional relationships. Sci Rep., 2023, 13(1):8843. doi.org/10.1038/s41598-023-35553-2

Jain A, Gosling J, Liu S, Wang H, Stone EM, Chakraborty S, Jayaraman PS, Smith S, Amabilino DB, Fromhold M, Long YT, Pérez-García L, Turyanska L, Rahman R,Rawson FJ. Wireless electrical-molecular quantum signalling for cancer cell apoptosis. Nat Nanotechnol., 2023, Sep 14. doi.org/10.1038/s41565-023-01496-y

Jain A, Jobson I, Griffin M, Rahman R, Smith S,Rawson FJ. Electric field responsive nanotransducers for glioblastoma. Bioelectron Med., 2022, 8(1):17. doi.org/10.1186/s42234-022-00099-7

Sanjuan-Alberte P, Whitehead C, Jones JN, Silva JC, Carter N, Kellaway S, Hague RJM, Cabral JMS, Ferreira FC, White LJ, Rawson FJ. Printing biohybrid materials for bioelectronic cardio-3D-cellular constructs. iScience, 2022, 25(7):104552. doi.org/10.1016/j.isci.2022.104552

Bennett MR, Moloney C, Catrambone F, Turco F, Myers B, Kovacs K, Hill PJ, Alexander C, Rawson FJ, Gurnani P. Oxygen-Tolerant RAFT Polymerization Initiated by Living Bacteria. ACS Macro Lett., 2022, 11(8):954-960. doi.org/10.1021/acsmacrolett.2c00372

Sharma B, Jain A, Pérez-García L, Watts JA, Rawson FJ, Chaudhary GR, Kaur G. Metallocatanionic vesicle-mediated enhanced singlet oxygen generation and photodynamic therapy of cancer cells. J Mater Chem B., 2022, 10(13):2160-2170. doi.org/10.1039/d2tb00011c

Turco F, Garavaglia M, Van Houdt R, Hill P, Rawson FJ,Kovacs K. Synthetic Biology Toolbox, Including a Single-Plasmid CRISPR-Cas9 System to Biologically Engineer the Electrogenic, Metal-Resistant Bacterium Cupriavidus metallidurans CH34. ACS Synth Biol., 2022, 11(11):3617-3628. doi.org/10.1021/acssynbio.2c00130

Smith F, Sabri AH, Heppel M, Fonseca I, Chowdhury F, Cheung K, Willmor S, Rawson F, Marlow M. The clinical and translational prospects of microneedle devices, with a focus on insulin therapy for diabetes mellitus as a case study. Int J Pharm., 2022, 628:122234. doi.org/10.1016/j.ijpharm.2022.122234

Timothy Ritzmann

Griesinger A.M, Riemondy K, Eswaran N, Donson A.M, Willard N, Prince EW, Paine SML, Bowes G, Rheaume J, Chapman RJ, Ramage J, Jackson A, Grundy RG, Foreman NK, Ritzmann TA. Multi-Omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high risk pediatric ependymoma. iScience, 2023, 26(9):107585. https://doi.org/10.1016/j.isci.2023.107585

Donson AM, Bertrand KC, Riemondy KA, Gao D, Zhuang Y, Sanford B, Norris GA, Chapman RJ, Fu R, Willard N, Griesinger AM, Ribeiro de Sousa G, Amani V, Grimaldo E, Hankinson TC, Booker F, Sill M, Grundy RG, Pajtler KW, Ellison DW, Foreman NK, Ritzmann TA. Significant increase of high-risk chromosome 1q gain and 6q loss at recurrence in posterior fossa group A ependymoma: A multicentre study. Neuro Oncol., 2023, noad096. doi.org/10.1093/neuonc/noad096

Chapman RJ, Ghasemi DR, Andreiuolo F, Zschernack V, Tauziede-Espariat A, Buttarelli F, Giangaspero F, Grill J, Haberler C, Paine S, Scott I, Jacques TS, Sill M, Pfister S, Kilday JP, Leblond P, Massimino M, Witt H, Modena P, Varlet P, Pietsch T, Grundy RG, Pajtler KW, Ritzmann TA. Optimising biomarkers for accurate ependymoma diagnosis, prognostication and stratification within International Clinical Trials: A BIOMECA study. Neuro Oncol., 2023, noad055. doi.org/10.1093/neuonc/noad055

Fu R, Norris GA, Willard N, Griesinger AM, Riemondy KA, Amani V, Grimaldo E, Harris F, Hankinson TC, Mitra S, Ritzmann TA, Grundy RG, Foreman NK, Donson AM. Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma. Neuro Oncol., 2023, 25(4): 786-798. doi.org/10.1093/neuonc/noac219

Leblond P, Massimino M, English M, Ritzmann TA, Gandola L, Calaminus G, Thomas S, Pérol D, Gautier J, Grundy RG and Frappaz D. Toward Improved Diagnosis Accuracy and Treatment of Children, Adolescents, and Young Adults With Ependymoma: The International SIOP Ependymoma II Protocol. Front. Neurol., 2022, 13:887544. doi.org/10.3389/fneur.2022.887544

Pratt D, Lucas CG, Selvam PP, Abdullaev Z, Ketchum C, Quezado M, Armstrong TS, Gilbert MR, Papanicolau-Sengos A, Raffeld M, Choo-Wosoba H, Chan P, Whipple N, Nasrallah M, Santi M, Ramaswamy V, Giannini C, Ritzmann TA, Grundy RG, Burford A, Jones C, Hawkins C, Venneti S, Solomon D, Aldape K. Recurrent ACVR1 mutations in posterior fossa ependymoma. Acta Neuropathol., 2022, 144(2), 373–376. doi.org/10.1007/s00401-022-02435-2

Apps JR, Maycock, S, Ellison DW, Jaspan T, Ritzmann TA, Macarthur D, Mallucci C, Wheatley K, Veal GJ, Grundy RG, Picton S. Phase II study of intravenous etoposide in patients with relapsed ependymoma (CNS 2001 04). Neurooncon Adv., 2022. 4(1), vdac053. doi.org/10.1093/noajnl/vdac053

Ritzmann TA, Chapman RJ, Kilday JP, Thorp N, Modena P, Dineen RA, Macarthur D, Mallucci C, Jaspan T, Pajtler KW, Giagnacovo M, Jacques TS, Paine SML, Ellison DW, Bouffet E, Grundy RG., on behalf of the BIOMECA Consortium. SIOP Ependymoma I: Final results, long-term follow-up, and molecular analysis of the trial cohort — A BIOMECA Consortium Study Neuro Oncol., 2022, 4(6):936-948. doi.org/10.1093/neuonc/noac012

Karen Robinson

Wilkinson D, Alsharaf L, Thompson S, Paulin A, Takor R, Zaitoun A, Robinson K, Thomas J, McVicker G, Winter J. Characterization of a Helicobacter pylori strain with high biofilm-forming ability. J Med Microbiol., 2023, Jun;72(6). doi.org/10.1099/jmm.0.001710

Nabavi-Rad A, Jamshidizadeh S, Azizi M, Yadegar A, Robinson K, Monaghan TM, Zali MR. The synergistic effect of Levilactobacillus brevis IBRC-M10790 and vitamin D3 on Helicobacter pylori-induced inflammation. Front Cell Infect Microbiol., 2023, 13:1171469. doi.org/10.3389/fcimb.2023.1171469

Wilkinson DJ, Dickins B, Robinson K, Winter JA. Genomic diversity of Helicobacter pylori populations from different regions of the human stomach. Gut Microbes, 2022, 14(1):2152306. doi.org/10.1080/19490976.2022.2152306

Kaneko K, Zaitoun AM, Letley DP, Rhead JL, Torres J, Spendlove I, Atherton JC, Robinson K. The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa. J Pathol., 2022, 258(2):199-209. doi.org/10.1002/path.5990

Felicity Rose

Tint NL, Cheng KKW, Dhillon AS, Keane PA, Alexander P, Kennedy D, Chau DYS, Rose FRAJ, Allan BDS. An in vitro assessment of the thermoreversible PLGA-PEG-PLGA copolymer: Implications for Descemet's membrane endothelial keratoplasty. Clin Exp Ophthalmol., 2023, 51(1):58-66. doi.org/10.1111/ceo.14167

Hasan A, Bagnol R, Owen R, Latif A, Rostam HM, Elsharkawy S, Rose FRAJ, Rodríguez-Cabello JC, Ghaemmaghami AM, Eglin D, Mata A. Mineralizing Coating on 3D Printed Scaffolds for the Promotion of Osseointegration. Front Bioeng Biotechnol., 2022, 10:836386. doi.org/10.3389/fbioe.2022.836386

He Y, Luckett J, Begines B, Dubern JF, Hook AL, Prina E, Rose FRAJ, Tuck CJ, Hague RJM, Irvine DJ, Williams P, Alexander MR, Wildman RD. Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices. Biomaterials, 2022, 281:121350. doi.org/10.1016/j.biomaterials.2021.121350

Ramis J, Middlewick R, Pappalardo F, Cairns JT, Stewart ID, John AE, Naveed SU, Krishnan R, Miller S, Shaw DE, Brightling CE, Buttery L,Rose F, Jenkins G, Johnson SR, Tatler AL. Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling. Eur Respir J., 2022, 60(1):2004361. doi.org/10.1183/13993003.04361-2020

Ian Sayers

Shrine N, Izquierdo AG, Chen J, Packer R, Hall RJ, Guyatt AL, Batini C, Thompson RJ, Pavuluri C, Malik V, Hobbs BD, Moll M, Kim W, Tal-Singer R, Bakke P, Fawcett KA, John C, Coley K, Piga NN, Pozarickij A, Lin K, Millwood IY, Chen Z, Li L; China Kadoorie Biobank Collaborative Group; Wijnant SRA, Lahousse L, Brusselle G, Uitterlinden AG, Manichaikul A, Oelsner EC, Rich SS, Barr RG, Kerr SM, Vitart V, Brown MR, Wielscher M, Imboden M, Jeong A, Bartz TM, Gharib SA, Flexeder C, Karrasch S, Gieger C, Peters A, Stubbe B, Hu X, Ortega VE, Meyers DA, Bleecker ER, Gabriel SB, Gupta N, Smith AV, Luan J, Zhao JH, Hansen AF, Langhammer A, Willer C, Bhatta L, Porteous D, Smith BH, Campbell A, Sofer T, Lee J, Daviglus ML, Yu B, Lim E, Xu H, O'Connor GT, Thareja G, Albagha OME; Qatar Genome Program Research (QGPR) Consortium; Suhre K, Granell R, Faquih TO, Hiemstra PS, Slats AM, Mullin BH, Hui J, James A, Beilby J, Patasova K, Hysi P, Koskela JT, Wyss AB, Jin J, Sikdar S, Lee M, May-Wilson S, Pirastu N, Kentistou KA, Joshi PK, Timmers PRHJ, Williams AT, Free RC, Wang X, Morrison JL, Gilliland FD, Chen Z, Wang CA, Foong RE, Harris SE, Taylor A, Redmond P, Cook JP, Mahajan A, Lind L, Palviainen T, Lehtimäki T, Raitakari OT, Kaprio J, Rantanen T, Pietiläinen KH, Cox SR, Pennell CE, Hall GL, Gauderman WJ, Brightling C, Wilson JF, Vasankari T, Laitinen T, Salomaa V, Mook-Kanamori DO, Timpson NJ, Zeggini E, Dupuis J, Hayward C, Brumpton B, Langenberg C, Weiss S, Homuth G, Schmidt CO, Probst-Hensch N, Jarvelin MR, Morrison AC, Polasek O, Rudan I, Lee JH, Sayers I, Rawlins EL, Dudbridge F, Silverman EK, Strachan DP, Walters RG, Morris AP, London SJ, Cho MH, Wain LV, Hall IP, Tobin MD. Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk. Nat Genet., 2023, 55(3):410-422. doi.org/10.1038/s41588-023-01314-0

Guyatt A, John C, Williams AT, Shrine N, Reeve NF; SpiroMeta consortium; Sayers I, Hall I, Wain LV, Sheehan N, Dudbridge F, Tobin MD. Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease. Thorax, 2023, 78(5):496-503. doi.org/10.1136/thoraxjnl-2021-217993

Rajasekar P, Hall RJ, Binaya KC, Mahapatra PS, Puppala SP, Thakker D, MacIsaac JL, Lin D, Kobor M, Bolton CE, Sayers I, Hall IP, Clifford RL. Nepalese indoor cookstove smoke extracts alter human airway epithelial gene expression, DNA methylation and hydroxymethylation. Environ Pollut., 2023, 337:122561. doi.org/10.1016/j.envpol.2023.122561

Packer RJ, Shrine N, Hall R, Melbourne CA, Thompson R, Williams AT, Paynton ML, Guyatt AL, Allen RJ, Lee PH, John C, Campbell A, Hayward C, de Vries M, Vonk JM, Davitte J, Hessel E, Michalovich D, Betts JC, Sayers I, Yeo A, Hall IP, Tobin MD, Wain LV. Genome-wide association study of chronic sputum production implicates loci involved in mucus production and infection. Eur Respir J., 2023, 61(6):2201667. doi.org/10.1183/13993003.01667-2022

John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH, Koskela JT, Luan J, Li X, Terzikhan N, Xu H, Bartz TM, Petersen H, Leng S, Belinsky SA, Cepelis A, Hernández Cordero AI, Obeidat M, Thorleifsson G, Meyers DA, Bleecker ER, Sakoda LC, Iribarren C, Tesfaigzi Y, Gharib SA, Dupuis J, Brusselle G, Lahousse L, Ortega VE, Jonsdottir I, Sin DD, Bossé Y, van den Berge M, Nickle D, Quint JK, Sayers I, Hall IP, Langenberg C, Ripatti S, Laitinen T, Wu AC, Lasky-Su J, Bakke P, Gulsvik A, Hersh CP, Hayward C, Langhammer A, Brumpton B, Stefansson K, Cho MH, Wain LV, Tobin MD. Genetic Associations and Architecture of Asthma-COPD Overlap. Chest, 2022, 161(5):1155-1166. doi.org/10.1016/j.chest.2021.12.674

Bhaker S, Portelli MA, Rakkar K, Shaw D, Johnson S, Brightling C, Sayers I. Human bronchial epithelial cells from patients with asthma have an altered gene expression profile. ERJ Open Res., 2022, 8(1):00625-2021. doi.org/10.1183/23120541.00625-2021

Fawcett KA, Demidov G, Shrine N, Paynton ML, Ossowski S, Sayers I, Wain LV, Hollox EJ. Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank. BMC Med Genomics, 2022, 15(1):119. doi.org/10.1186/s12920-022-01268-y

Claire Seedhouse

James JR, Ashworth JC, Abuhantash M, Grundy M, Seedhouse CH, Curd J, Arkill KP, Wright AJ, Merry CLR, Thompson A. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. Int. J. Mol. Sci., 2023, 24(4), 4235. doi.org/10.3390/ijms24044235

Jenkins HH, Lopez AAT, Tarantini FS, Tomlin H, Scales D, Lee IN, Wu S, Hyde R, Lis-Slimak K, Byaruhanga T, Thompson JL, Pijuan-Galito S, Doolan L, Kaneko K, Gwynne P, Reffin C, Park E, Dey J, Hill J, Arendt-Tranholm A, Stroud A, Petrie M, Denning C,Benest AV*,Seedhouse C*. Performance evaluation of a non-invasive one-step multiplex RT-qPCR assay for detection of SARS-CoV-2 direct from saliva. Sci Rep., 2022, 12(1):11553. *equal contribution.

doi: 10.1038/s41598-022-15616-6

Nicholson R, Menezes AC, Azevedo A, Leckenby A, Davies S, Seedhouse C, Gilkes A, Knapper S, Tonks A, Darley RL. Protein Kinase C Epsilon Overexpression Is Associated With Poor Patient Outcomes in AML and Promotes Daunorubicin Resistance Through p-Glycoprotein-Mediated Drug Efflux. Front Oncol., 2022, 12:840046. doi.org/10.3389/fonc.2022.840046

Tarantini FS, Wu S, Jenkins H, Lopez AT, Tomlin H, Hyde R, Lis-Slimak K, Thompson JL, Pijuan-Galitó S, Scales D, Kaneko K, Dey J, Park E, Hill J, Lee I, Doolan L, Arendt-Tranholm A, Denning C,Seedhouse C, Benest AV. Direct RT-qPCR assay for the detection of SARS-CoV-2 in saliva samples. Methods Protoc., 2022,5(2):25. doi.org/10.3390/mps5020025

Abdolrahman Shams-Nateri

Babaei-Jadidi R, Kashfi H, Alelwani W, Karimi Bakhtiari A, Kattan SW, Mansouri OA, Mukherjee A, Lobo DN, Nateri AS. Anti-miR-135/SPOCK1 axis antagonizes the influence of metabolism on drug response in intestinal/colon tumour organoids. Oncogenesis, 2022, 11(1):4. doi.org/10.1038/s41389-021-00376-1

Adolf IC, Almars A, Dharsee N, Mselle T, Akan G, Nguma IJ, Nateri AS, Atalar F. HLA-G and single nucleotide polymorphism (SNP) associations with cancer in African populations: Implications in personal medicine. Genes Dis., 2022 Jun 30;9(5):1220-1233. doi.org/10.1016/j.gendis.2021.06.004

Stuart Smith

Jain A, Gosling J, Liu S, Wang H, Stone EM, Chakraborty S, Jayaraman PS,Smith S, Amabilino DB, Fromhold M, Long YT, Pérez-García L, Turyanska L, Rahman R, Rawson FJ. Wireless electrical-molecular quantum signalling for cancer cell apoptosis. Nat Nanotechnol., 2023. doi.org/10.1038/s41565-023-01496-y

Andrieux G⁺, Das T⁺, Griffin M, Boerries M, Heiland DH, Smith SJ, Rahman R*, Chakraborty S*. Spatial transcriptomics reveals unique defining molecular features of fluorescence-sorted 5-aminolevulinic acid+ infiltrative tumor cells associated with glioblastoma recurrence and poor survival. Genome Med., 2023, 15:48. ⁺ Contributed equally. * Contributed equally. doi.org/10.1186/s13073-023-01207-1

Deacon S, Walker L, Radhi M, Smith S. The Regulation of m6A Modification in Glioblastoma: Functional Mechanisms and Therapeutic Approaches. Cancers (Basel), 2023, 15(13):3307. doi.org/10.3390/cancers15133307

Martins C, Araujo M, Malfatani A, Pacheco C, Smith SJ,Rahman R, Aylott JW, Preat V*, Sarmento B*. Stimuli-responsive multifunctional nanomedicine for enhanced glioblastoma chemotherapy augments multistage blood-to-brain trafficking and tumor targeting. Small, 2023, 19(22):e2300029. doi.org/10.1002/smll.202300029

Kumaria A, Kirkman MA, Scott RA, Dow GR, Leggate AJ, Macarthur DC, Ingale HA, Smith SJ, Basu S. A Reappraisal of the Pathophysiology of Cushing Ulcer: A Narrative Review. J Neurosurg Anesthesiol., 2023, May 11. doi.org/10.1097/ana.0000000000000918

Muresan P, Woodhams S, Smith F, Taresco V, Shah J, Wong M, Chapman V, Smith S, Hathway G, Rahman R, Gershkovich P, Marlow M. Evaluation of cannabidiol nanoparticles and nanoemulsion biodistribution in the central nervous system after intrathecal administration for the treatment of pain. Nanomedicine, 2023, 49:102664. doi.org/10.1016/j.nano.2023.102664

Jain A, Jobson I, Griffin M, Rahman R, Smith S,Rawson F. Electric field responsive nanotransducers for glioblastoma. Bioelectron Med., 2022, 8:17. 

doi.org/10.1186/s42234-022-00099-7

Muresan P*, McCrorie P*, Smith F, Vasey C, Taresco V, Scurr D, Kern S, Smith S,Gershkovich P,Rahman R, Marlow M. Development of nanoparticle loaded microneedles for drug delivery to a brain tumour resection site. Eur J Pharm Biopharm., 2023, 182:53-61. doi.org/10.1016/j.ejpb.2022.11.016

Branter J, Cebrero ME, Diksin M, Griffin M, Castellanos-Uribe M, May S, Rahman R, Grundy RG, Basu S, Smith S. Genome wide expression and anti-proliferative effects of electric field therapy on paediatric and adult brain tumours. Int J Mol Sci, 2022, 23(4): 1982. doi.org/10.3390/ijms23041982

Philippe Soucaille

Millard J, Agius A, Zhang Y,Soucaille P,Minton NP. Exploitation of a Type 1 Toxin-Antitoxin System as an Inducible Counter-Selective Marker for Genome Editing in the Acetogen Eubacterium limosum. Microorganisms, 2023, 11(5):1256. doi.org/10.3390/microorganisms11051256

Pregnon G, Minton NP,Soucaille P. Genome Sequence of Eubacterium limosum B2 and Evolution for Growth on a Mineral Medium with Methanol and CO₂ as Sole Carbon Sources. Microorganisms, 2022, 10(9):1790. doi.org/10.3390/microorganisms10091790

Panos Soultanas

Soultanas P, Janniere L. The metabolic control of DNA replication: mechanism and function. Open Biol., 2023, 13(8):230220. doi.org/10.1098/rsob.230220

Holland A, Pitoulias M, Soultanas P, Janniere L. The Replicative DnaE Polymerase of Bacillus subtilis Recruits the Glycolytic Pyruvate Kinase (PykA) When Bound to Primed DNA Templates. Life (Basel), 2023, 13(4):965. doi.org/10.3390/life13040965

Winterhalter C, Pelliciari S, Stevens D, Fenyk S, Marchand E, Cronin NB, Soultanas P, Costa TRD, Ilangovan A, Murray H. The DNA replication initiation protein DnaD recognises a specific strand of the Bacillus subtilis chromosome origin. Nucleic Acids Res., 2023, 51(9):4322-4340. doi.org/10.1093/nar/gkad277

Okoye JC, Holland A, Pitoulias M, Paschalis V, Piddubnyi A, Dufailu OA, Borén T, Oldfield NJ, Mahdavi J, Soultanas P. Ferric quinate (QPLEX) inhibits the interaction of major outer membrane protein (MOMP) with the Lewis b (Le^b) antigen and limits Campylobacter colonization in broilers. Front Microbiol., 2023, 14:1146418. doi.org/10.3389/fmicb.2023.1146418

He L, Lever R, Cubbon A, Tehseen M, Jenkins T, Nottingham AO, Horton A, Betts H, Fisher M, Hamdan SM, Soultanas P, Bolt EL. Interaction of human HelQ with DNA polymerase delta halts DNA synthesis and stimulates DNA single-strand annealing. Nucleic Acids Res., 2023, 51(4):1740-1749. doi.org/10.1093/nar/gkad032

Winterhalter C, Stevens D, Fenyk S, Pelliciari S, Marchand E, Soultanas P, Ilangovan A, Murray H. SirA inhibits the essential DnaA:DnaD interaction to block helicase recruitment during Bacillus subtilis sporulation. Nucleic Acids Res., 2023, 51(9):4302-4321. doi.org/10.1093/nar/gkac1060

Okoye JC, Bellamy-Carter J, Oldham NJ, Oldfield NJ, Mahdavi J, Soultanas P. Ferric quinate (QPLEX) interacts with the major outer membrane protein (MOMP) of Campylobacter jejuni and enters through the porin channel into the periplasmic space. Comput Struct Biotechnol J., 2022 Sep 24;20:5355-5363. doi.org/10.1016/j.csbj.2022.09.032

Horemans S, Pitoulias M, Holland A, Pateau E, Lechaplais C, Ekaterina D, Perret A, Soultanas P, Janniere L. Pyruvate kinase, a metabolic sensor powering glycolysis, drives the metabolic control of DNA replication. BMC Biol., 2022, 20(1):87. doi.org/10.1186/s12915-022-01278-3

Patent

Inventors: Mahdavi J, Ala’Aldeen D, Soultanas P.

Biofilm inhibiting compositions enhancing weight gain in livestock.

Applicant: Akeso Biomedical, Inc., Cambridge, MASS, USA.

US Patent No. US 11,311,511 B2. April 2022.

Ian Spendlove

Talhouni S, Fadhil W, Mongan NP, Field L, Hunter K, Makhsous S, Maciel-Guerra A, Kaur N, Nestarenkaite A, Laurinavicius A, Willcox BE, Dottorini T, Spendlove I,Jackson AM, Ilyas M, Ramage JM. Activated tissue resident memory T-cells (CD8+CD103+CD39+) uniquely predict survival in left sided "immune-hot" colorectal cancers. Front Immunol., 2023, 14:1057292. doi.org/10.3389/fimmu.2023.1057292

Kaneko K, Zaitoun AM, Letley DP, Rhead JL, Torres J, Spendlove I, Atherton JC, Robinson K. The active form of Helicobacter pylori vacuolating cytotoxin induces decay-accelerating factor CD55 in association with intestinal metaplasia in the human gastric mucosa. J Pathol., 2022, 258(2):199-209. doi.org/10.1002/path.5990

Michael Stocks

Chu Y, Wong A, Chen H, Ji L, Qin C, Feng W, Stocks MJ,Gershkovich P. Development of lipophilic ester prodrugs of dolutegravir for intestinal lymphatic transport. Eur J Pharm Biopharm., 2023, 191:90-102. doi.org/10.1016/j.ejpb.2023.08.015

Dekkers S, Caspar B, Goulding J, Kindon ND, Kilpatrick LE, Stoddart LA, Briddon SJ, Kellam B, Hill SJ, Stocks MJ. Small-Molecule Fluorescent Ligands for the CXCR4 Chemokine Receptor. J Med Chem., 2023, 66(7):5208-5222. doi.org/10.1021/acs.jmedchem.3c00151

Soukarieh F, Gurnani P, Romero M, Halliday N, Stocks M, Alexander C, Cámara M. Design of quorum sensing inhibitor-polymer conjugates to penetrate Pseudomonas aeruginosa biofilms. ACS Macro Letters, 2023, 12(3):314-319. DOI: doi.org/10.1021/acsmacrolett.2c00699

Davie RL, Edwards HJ, Evans DM, Hodgson ST, Stocks MJ, Smith AJ, Rushbrooke LJ, Pethen SJ, Roe MB, Clark DE, McEwan PA, Hampton SL. Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema. J Med Chem., 2022, 65(20):13629-13644. doi.org/10.1021/acs.jmedchem.2c00921

Feng W, Qin C, Abdelrazig S, Bai Z, Raji M, Darwish R, Chu Y, Ji L, Gray DA, Stocks MJ, Constantinescu CS, Barrett DA, Fischer PM, Gershkovich P. Vegetable oils composition affects the intestinal lymphatic transport and systemic bioavailability of co-administered lipophilic drug cannabidiol. Int J Pharm., 2022, 624:121947. doi.org/10.1016/j.ijpharm.2022.121947

Ayre J, Redmond JM, Vitulli G, Tomlinson L, Weaver R, Comeo E, Bosquillon C, Stocks MJ. Design, Synthesis, and Evaluation of Lung-Retentive Prodrugs for Extending the Lung Tissue Retention of Inhaled Drugs. J Med Chem., 2022, 65(14):9802-9818. doi.org/10.1021/acs.jmedchem.2c00416

Jewell A, Brookes A, Feng W, Ashford M, Gellert P, Butler J, Fischer PM, Scurr DJ, Stocks MJ, Gershkovich P. Distribution of a highly lipophilic drug cannabidiol into different lymph nodes following oral administration in lipidic vehicle. Eur J Pharm Biopharm., 2022, 174:29-34. doi: doi.org/10.1016/j.ejpb.2022.03.014

Brookes A, Ji L, Bradshaw TD,Stocks M, Gray D, Butler J, Gershkovich P. Is Oral Lipid-Based Delivery Systems for Drug Targeting to the Brain Feasible? European J Pharmaceutics and Biopharmaceutics, 2022, 172 112-122). doi.org/10.1016/j.ejpb.2022.02.004

Sarah Storr

Alanazi SM, Feroz W, Mishra R, Kilroy MK, Patel H, Yuan L, Storr SJ, Garrett JT. HER2 inhibition increases non-muscle myosin IIA to promote tumorigenesis in HER2+ breast cancers. PLoS One, 2023, 18(5):e0285251. doi.org/10.1371/journal.pone.0285251

Greener MR, Storr SJ. Conflicting theories on addiction aetiology and the strengths and limitations of substance use disorder disease modelling. Front Mol Neurosci., 2023, 16:1166852. doi.org/10.3389/fnmol.2023.1166852

Köbel M, Kang EY, Weir A, Rambau PF, Lee CH, Nelson GS, Ghatage P, Meagher NS, Riggan MJ, Alsop J, Anglesio MS, Beckmann MW, Bisinotto C, Boisen M, Boros J, Brand AH, Brooks-Wilson A, Carney ME, Coulson P, Courtney-Brooks M, Cushing-Haugen KL, Cybulski C, Deen S, El-Bahrawy MA, Elishaev E, Erber R, Fereday S; AOCS Group; Fischer A, Gayther SA, Barquin-Garcia A, Gentry-Maharaj A, Gilks CB, Gronwald H, Grube M, Harnett PR, Harris HR, Hartkopf AD, Hartmann A, Hein A, Hendley J, Hernandez BY, Huang Y, Jakubowska A, Jimenez-Linan M, Jones ME, Kennedy CJ, Kluz T, Koziak JM, Lesnock J, Lester J, Lubiński J, Longacre TA, Lycke M, Mateoiu C, McCauley BM, McGuire V, Ney B, Olawaiye A, Orsulic S, Osorio A, Paz-Ares L, Ramón Y Cajal T, Rothstein JH, Ruebner M, Schoemaker MJ, Shah M, Sharma R, Sherman ME, Shvetsov YB, Singh N, Steed H, Storr SJ, Talhouk A, Traficante N, Wang C, Whittemore AS, Widschwendter M, Wilkens LR, Winham SJ, Benitez J, Berchuck A, Bowtell DD, Candido Dos Reis FJ, Campbell I, Cook LS, DeFazio A, Doherty JA, Fasching PA, Fortner RT, García MJ, Goodman MT, Goode EL, Gronwald J, Huntsman DG, Karlan BY, Kelemen LE, Kommoss S, Le ND, Martin SG, Menon U, Modugno F, Pharoah PD, Schildkraut JM, Sieh W, Staebler A, Sundfeldt K, Swerdlow AJ, Ramus SJ, Brenton JD. p53 and ovarian carcinoma survival: an Ovarian Tumor Tissue Analysis consortium study. J Pathol Clin Res., 2023, 9(3):208-222. doi.org/10.1002/cjp2.311

Storr SJ, Hoskin V, Aiyappa-Maudsley R, Ghaffari A, Varma S, Green A, Rakha E, Ellis IO, Greer PA, Martin SG. A retrospective analysis of ezrin protein and mRNA expression in breast cancer: Ezrin expression is associated with patient survival and survival of patients with receptor-positive disease. Cancer Med., 2023, 12(9):10908-10916. doi.org/10.1002/cam4.5802

Vasan R, Yadav J, Aiyappa-Maudsley R, Deen S, Storr SJ,Martin SG. High BMP7 expression is associated with poor prognosis in ovarian cancer. J Cell Mol Med., 2023, Sep 8. doi.org/10.1111/jcmm.17951

Aiyappa-Maudsley R, Storr SJ,Rakha EA,Green AR, Ellis IO, Martin SG. CYP2S1 and CYP2W1 expression is associated with patient survival in breast cancer. J Pathol Clin Res., 2022, 8(6):550-566. doi.org/10.1002/cjp2.291

Greener MR, Storr SJ. Exploring the role of DARPP-32 in addiction: a review of the current limitations of addiction treatment pathways and the role of DARPP-32 to improve them. NeuroSci., 2022, 3(3) :494-509. doi.org/10.3390/neurosci3030035

Yao A, Storr SJ, Inman M, Barwell L, Moody CJ, Martin SG. Cytotoxic and Radiosensitising Effects of a Novel Thioredoxin Reductase Inhibitor in Brain Cancers. Mol Neurobiol., 2022, 59(6):3546-3563. doi.org/10.1007/s12035-022-02808-4

Martin SG, Rakha E,Storr SJ. Quantifying Lymphatic Vessel Density in Human Tissue Samples. Methods Mol Biol., 2022, 2022:2441:183-189. doi.org/10.1007/978-1-0716-2059-5_14

Amanda Tatler

Cash E, Goodwin AT,Tatler AL. Adenosine receptor signalling as a driver of pulmonary fibrosis. Pharmacol Ther., 2023, 249:108504. doi.org/10.1016/j.pharmthera.2023.108504

Goodwin AT, John AE, Joseph C, Habgood A, Tatler AL, Susztak K, Palmer M, Offermanns S, Henderson NC, Jenkins RG. Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation. Development, 2023, 150(9):dev201046. doi.org/10.1242/dev.201046

Tatler AL. Asthmatic airway remodeling: long overlooked but too important to ignore. Ann Transl Med., 2023, 11(2):29. doi.org/10.21037/atm-22-5733

Calthorpe RJ, Poulter C, Smyth AR, Sharkey D, Bhatt J, Jenkins G, Tatler AL. Complex roles of TGF-β signaling pathways in lung development and bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol., 2023, 324(3):L285-L296. doi.org/10.1152/ajplung.00106.2021

Tatler AL, Philp CJ, Hill MR, Cox S, Bullock AM, Habgood A, John A, Middlewick R, Stephenson KE, Goodwin AT, Billington CK, O'Dea RD, Johnson SR, Brook BS. Differential remodeling in small and large murine airways revealed by novel whole lung airway analysis. Am J Physiol Lung Cell Mol Physiol., 2023, 324(3):L271-L284. doi.org/10.1152/ajplung.00034.2022

Goodwin AT, Noble PW, Tatler AL. Plasma cells: a feasible therapeutic target in pulmonary fibrosis? Eur Respir J., 2022, 60(5):2201748. doi.org/10.1183/13993003.01748-2022

Joseph C, Tatler AL. Pathobiology of Airway Remodeling in Asthma: The Emerging Role of Integrins. J Asthma Allergy, 2022, 15:595-610. doi.org/10.2147/jaa.s267222

Ramis J, Middlewick R, Pappalardo F, Cairns JT, Stewart ID, John AE, Naveed SU, Krishnan R, Miller S, Shaw DE, Brightling CE, Buttery L,Rose F, Jenkins G, Johnson SR,Tatler AL. Lysyl oxidase like 2 is increased in asthma and contributes to asthmatic airway remodelling. Eur Respir J., 2022, 60(1):2004361. doi.org/10.1183/13993003.04361-2020

Neil Thomas

Safo L, Abdelrazig S, Grosse-Honebrink A, Millat T, Henstra AM, Norman R, Thomas NR, Winzer K, Minton NP, Kim DH, Barrett DA. Quantitative Bioreactor Monitoring of Intracellular Bacterial Metabolites in Clostridiumautoethanogenum Using Liquid Chromatography-Isotope Dilution Mass Spectrometry. ACS Omega, 2021, 6(21):13518-13526. doi.org/10.1021/acsomega.0c05588

Chetty S, Armstrong T, Sharma Kharkwal S, Drewe WC, De Matteis CI, Evangelopoulos D, Bhakta S, Thomas NR. New InhA Inhibitors Based on Expanded Triclosan and Di-Triclosan Analogues to Develop a New Treatment for Tuberculosis. Pharmaceuticals (Basel), 2021, 14(4):361. doi.org/10.3390/ph14040361

Alexander Thompson

James JR, Curd J, Ashworth JC, Abuhantash M, Grundy M, Seedhouse CH, Arkill KP, Wright AJ, Merry CLR, Thompson A. Hydrogel-Based Pre-Clinical Evaluation of Repurposed FDA-Approved Drugs for AML. Int J Mol Sci., 2023, 24(4):4235. doi.org/10.3390/ijms24044235

Milborne B, Murrell L, Cardillo-Zallo I, Titman J, Briggs L, Scotchford C, Thompson A, Layfield R, Ahmed I. Developing Porous Ortho- and Pyrophosphate-Containing Glass Microspheres; Structural and Cytocompatibility Characterisation. Bioengineering (Basel), 2022, 9(11):611. doi.org/10.3390/bioengineering9110611

Huw Williams

Padilla C, Quero F, Pępczyńska M, Díaz-Calderon P, Acevedo JP, Byres N, Blaker JJ, MacNaughtan W, Williams HEL, Enrione J. Understanding the Molecular Conformation and Viscoelasticity of Low Sol-Gel Transition Temperature Gelatin Methacryloyl Suspensions. Int J Mol Sci., 2023, 24(8):7489. doi.org/10.3390/ijms24087489

Casella BM, Farmer JP, Nesheva DN, Williams HEL, Charlton SJ, Holliday ND, Laughton CA, Mistry SN. Design, Synthesis, and Application of Fluorescent Ligands Targeting the Intracellular Allosteric Binding Site of the CXC Chemokine Receptor 2. J Med Chem., 2023, 66(18):12911-12930. doi.org/10.1021/acs.jmedchem.3c00849

Yeo H, Linforth R, MacNaughtan W, Williams H, Hewson L, Fisk ID. Effect of sweeteners and carbonation on aroma partitioning and release in beverage systems. Food Res Int., 2023, 164:112373. doi.org/10.1016/j.foodres.2022.112373

Summers HS, Lewis W, Williams HEL,Bradshaw TD, Moody CJ, Stevens MFG. Discovery of new imidazotetrazinones with potential to overcome tumor resistance. Eur J Med Chem., 2023, 257:115507. doi.org/10.1016/j.ejmech.2023.115507

Furse S, Kusinski LC, Ray A, Glenn-Sansum C, Williams HEL, Koulman A, Meek CL. Relative Abundance of Lipid Metabolites in Spermatozoa across Three Compartments. Int J Mol Sci., 2022, 23(19):11655. doi.org/10.3390/ijms231911655

Furse S, Watkins AJ, Williams HEL, Snowden SG, Chiarugi D, Koulman A. Paternal nutritional programming of lipid metabolism is propagated through sperm and seminal plasma. Metabolomics, 2022, 18(2):13. doi.org/10.1007/s11306-022-01869-9

Griffiths RC, Smith FR, Long JE, Scott D, Williams HEL, Oldham NJ, Layfield R, Mitchell NJ. Site-Selective Installation of N^ϵ -Modified Sidechains into Peptide and Protein Scaffolds via Visible-Light-Mediated Desulfurative C-C Bond Formation. Angew Chem Int Ed Engl., 2022, 61(2):e202110223. doi.org/10.1002/anie.202110223

Brennan A, Layfield R, Long J, Williams HEL, Oldham NJ, Scott D, Searle MS. An ALS-associated variant of the autophagy receptor SQSTM1/p62 reprograms binding selectivity toward the autophagy-related hATG8 proteins. J Biol Chem., 2022, 298(2):101514. doi.org/10.1016/j.jbc.2021.101514

Paul Williams

He Y, Luckett J, Begines B, Dubern JF, Hook AL, Prina E, Rose FRAJ, Tuck CJ, Hague RJM, Irvine DJ, Williams P, Alexander MR, Wildman RD. Ink-jet 3D printing as a strategy for developing bespoke non-eluting biofilm resistant medical devices. Biomaterials, 2022, 281:121350. doi.org/10.1016/j.biomaterials.2021.121350

Murray EJ, Dubern JF, Chan WC, Chhabra SR, Williams P. A Pseudomonas aeruginosa PQS quorum-sensing system inhibitor with anti-staphylococcal activity sensitizes polymicrobial biofilms to tobramycin. Cell Chem Biol., 2022, 29(7):1187-1199.e6. doi.org/10.1016/j.chembiol.2022.02.007

Peng Z, Maciel-Guerra A, Baker M, Zhang X, Hu Y, Wang W, Rong J, Zhang J, Xue N, Barrow P, Renney D, Stekel D, Williams P, Liu L, Chen J, Li F, Dottorini T. Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming. PLoS Comput Biol., 2022, 18(3):e1010018. doi.org/10.1371/journal.pcbi.1010018

Webb K, Zain NMM, Stewart I, Fogarty A, Nash EF, Whitehouse JL, Smyth AR, Lilley AK, Knox A, Williams P, Cámara M, Bruce K, Barr HL. Porphyromonas pasteri and Prevotella nanceiensis in the sputum microbiota are associated with increased decline in lung function in individuals with cystic fibrosis. J Med Microbiol., 2022, 71(2):001481. doi.org/10.1099/jmm.0.001481

Dubern JF, Romero M, Mai-Prochnow A, Messina M, Trampari E, Gijzel HN, Chan KG, Carabelli AM, Barraud N, Lazenby J, Chen Y, Robertson S, Malone JG, Williams P,Heeb S, Cámara M. ToxR is a c-di-GMP binding protein that modulates surface-associated behaviour in Pseudomonas aeruginosa. NPJ Biofilms Microbiomes, 2022, 8(1):64. doi.org/10.1038/s41522-022-00325-9

Romero M, Mayer C, Heeb S, Wattanavaekin K, Cámara M, Otero A, Williams P. Mushroom-shaped structures formed in Acinetobacter baumannii biofilms grown in a roller bioreactor are associated with quorum sensing-dependent Csu-pilus assembly. Environ Microbiol., 2022, 24(9):4329-4339. doi.org/10.1111/1462-2920.15985

Webb K, Cámara M, Zain NMM, Halliday N, Bruce KD, Nash EF, Whitehouse JL, Knox A, Forrester D, Smyth AR, Williams P, Fogarty A, Barr HL. Novel detection of specific bacterial quorum sensing molecules in saliva: Potential non-invasive biomarkers for pulmonary Pseudomonas aeruginosa in cystic fibrosis. J Cyst Fibros., 2022, 21(4):626-629. doi.org/10.1016/j.jcf.2021.08.030

Dubern JF, Hook AL, Carabelli AM, Chang CY, Lewis-Lloyd CA, Luckett JC, Burroughs L, Dundas AA, Humes DJ, Irvine DJ, Alexander MR, Williams P. Discovery of a polymer resistant to bacterial biofilm, swarming, and encrustation. Sci Adv., 2023, 9(4):eadd7474. doi.org/10.1126/sciadv.add7474

Cuzzucoli Crucitti V, Ilchev A, Moore JC, Fowler HR, Dubern JF, Sanni O, Xue X, Husband BK, Dundas AA, Smith S, Wildman JL, Taresco V, Williams P, Alexander MR, Howdle SM, Wildman RD, Stockman RA, Irvine DJ. Predictive Molecular Design and Structure-Property Validation of Novel Terpene-Based, Sustainably Sourced Bacterial Biofilm-Resistant Materials. Biomacromolecules, 2023, 24(2):576-591. doi.org/10.1021/acs.biomac.2c00721

Wong S Y, Hook A L, Gardner W, Chang C-Y, Mei Y, Davies M C, Williams P, Alexander M R, Ballabio D, Muir B W, Winkler D A, Pigram P J. Exploring the Relationship between Polymer Surface Chemistry and Bacterial Attachment Using ToF-SIMS and Self-Organizing maps. Adv. Mater. Interfaces, 2023, 2202334. doi.org/10.1002/admi.202202334

Contreas L, Hook AL, Winkler DA, Figueredo G, Williams P,Laughton CA, Alexander MR, Williams PM. Linear Binary Classifier to Predict Bacterial Biofilm Formation on Polyacrylates. ACS Appl Mater Interfaces, 2023, 15(11):14155–63. doi.org/10.1021/acsami.2c23182

Dubern J-F, Halliday N, Camara M, Winzer K, Barrett DA, Hardie KR,Williams P. Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa. Microbiology (Reading), 2023, 169(4):001316. doi:10.1099/mic.0.001316

Bardelang P, Murray EJ, Blower I, Zandomeneghi S, Goode A, Hussain R, Kumari D, Siligardi G, Inoue K, Luckett J, Doutch J, Emsley J, Chan WC, Hill P, Williams P, Bonev BB. Conformational analysis and interaction of the Staphylococcus aureus transmembrane peptidase AgrB with its AgrD propeptide substrate. Frontiers in Chemistry, 2023, 11, 1113885. doi.org/10.3389/fchem.2023.1113885

Ottonello A, Wyllie JA, Yahiaoui O, Sun S, Koelln RA, Homer JA, Johnson RM, Murray E, Williams P, Bolla JR, Robinson CV, Fallon T, Soares da Costa TP, Moses JE. Shapeshifting bullvalene-linked vancomycin dimers as effective antibiotics against multidrug-resistant gram-positive bacteria. Proc Natl Acad Sci USA, 2023, 120(15):e2208737120. doi.org/10.1073/pnas.2208737120

Giallonardi G, Letizia M, Mellini M, Frangipani E, Halliday N, Heeb S, Cámara M, Visca P, Imperi F, Leoni L, Williams P, Rampioni G. Alkyl-quinolone-dependent quorum sensing controls prophage-mediated autolysis in Pseudomonas aeruginosa colony biofilms. Front Cell Infect Microbiol., 2023, 13:1183681. doi.org/10.3389/fcimb.2023.1183681

Khateb H, Hook AL, Kern S, Watts JA, Singh S, Jackson D, Marinez-Pomares L, Williams P, Alexander MR. Identification of Pseudomonas aeruginosa exopolysaccharide Psl in biofilms using 3D OrbiSIMS. Biointerphases, 2023, 18(3):031007. doi.org/10.1116/6.0002604

Williams P, Hill P, Bonev B, Chan WC. Quorum-sensing, intra- and inter-species competition in the staphylococci. Microbiology, 2023, 169(8), 001381. doi.org/10.1099/mic.0.001381

Mellini M, Letizia M, Caruso L, Guiducci A, Meneghini C, Heeb S,Williams P,Cámara M, Visca P, Imperi F, Leoni L, Rampioni G. RsaL-driven negative regulation promotes heterogeneity in Pseudomonas aeruginosa quorum sensing. mBio, 2023, e0203923.

doi.org/10.1128/mbio.02039-23

Klaus Winzer

Poulalier-Delavelle M, Baker JP, Millard J, Winzer K,Minton NP. Endogenous CRISPR/Cas systems for genome engineering in the acetogens Acetobacterium woodii and Clostridium autoethanogenum. Front Bioeng Biotechnol., 2023, 11:1213236. doi.org/10.3389/fbioe.2023.1213236

Humphreys JR, Bean Z, Twycross J, Winzer K. The Lanthipeptide Synthetase-like Protein CA_C0082 Is an Effector of Agr Quorum Sensing in Clostridium acetobutylicum. Microorganisms, 2023, 11(6):1460. doi.org/10.3390/microorganisms11061460

Dubern JF, Halliday N, Cámara M,Winzer K, Barrett DA, Hardie KR, Williams P. Growth rate and nutrient limitation as key drivers of extracellular quorum sensing signal molecule accumulation in Pseudomonas aeruginosa. Microbiology (Reading), 2023, 169(4):001316. doi.org/10.1099/mic.0.001316

Humphreys JR, Debebe BJ, Diggle SP, Winzer K. Clostridium beijerinckii strain degeneration is driven by the loss of Spo0A activity. Front Microbiol., 2023, 13:1075609. doi.org/10.3389/fmicb.2022.1075609

Wickham-Smith C, Malys N, Winzer K. Improving carbon monoxide tolerance of Cupriavidus necator H16 through adaptive laboratory evolution. Front Bioeng Biotechnol., 2023, 11:1178536. doi.org/10.3389/fbioe.2023.1178536

Tomi-Andrino C, Pandele A, Winzer K, King J, Rahman R, Kim DH. Metabolic modeling-based drug repurposing in Glioblastoma. Sci Rep., 2022, 12(1):11189. doi.org/10.1038/s41598-022-14721-w

Pearcy N, Garavaglia M, Millat T, Gilbert JP, Song Y, Hartman H, Woods C, Tomi-Andrino C, Reddy Bommareddy R, Cho BK, Fell DA, Poolman M, King JR, Winzer K, Twycross J, Minton NP. A genome-scale metabolic model of Cupriavidus necator H16 integrated with TraDIS and transcriptomic data reveals metabolic insights for biotechnological applications. PLoS Comput Biol., 2022, 18(5):e1010106. doi.org/10.1371/journal.pcbi.1010106

Woods C, Humphreys CM, Tomi-Andrino C, Henstra AM, Köpke M, Simpson SD, Winzer K,Minton NP. Required Gene Set for Autotrophic Growth of Clostridium autoethanogenum. Appl Environ Microbiol., 2022, 88(7):e0247921. doi.org/10.1128/aem.02479-21

Piatek P, Humphreys C, Raut MP, Wright PC, Simpson S, Köpke M, Minton NP,Winzer K. Agr Quorum Sensing influences the Wood-Ljungdahl pathway in Clostridium autoethanogenum. Sci Rep., 2022, 12(1):411. doi.org/10.1038/s41598-021-03999-x

Salinas A, McGregor C, Irorere V, Arenas-López C, Bommareddy RR, Winzer K,Minton NP, Kovács K. Metabolic engineering of Cupriavidus necator H16 for heterotrophic and autotrophic production of 3-hydroxypropionic acid. Metab Eng., 2022, 74:178-190. doi.org/10.1016/j.ymben.2022.10.014

Jing Yang

Qiu D, Cao C, Prasopthum A, Sun Z, Zhang S, Yang H, Xu Z, Tao J, Ai F, Yang J. Elucidating osseointegration in vivo in 3D printed scaffolds eliciting different foreign body responses. Mater Today Bio., 2023, 22:100771. doi.org/10.1016/j.mtbio.2023.100771

Mischa Zelzer

Teja Surikutchi B, Obenza-Otero R, Russo E, Zelzer M, Golán Cancela I, Costoya JA, Crecente Campo J, José Alonso M, Marlow M. Development of a nanocapsule-loaded hydrogel for drug delivery for intraperitoneal administration. Int J Pharm., 2022, 622:121828. doi.org/10.1016/j.ijpharm.2022.121828

Anderson HJ, Sahoo JK, Wells J, van Nuffel S, Dhowre HS, Oreffo ROC, Zelzer M, Ulijn RV, Dalby MJ. Cell-controlled dynamic surfaces for skeletal stem cell growth and differentiation. Sci Rep., 2022, 12(1):8165. doi.org/10.1038/s41598-022-12057-z

Bruggeman M, Zelzer M, Dong H, Stamboulis A. Processing and interpretation of core-electron XPS spectra of complex plasma-treated polyethylene-based surfaces using a theoretical peak model. Surf Interface Anal., 2022, 54:986–1007. doi.org/10.1002/sia.7125

Catania R, Onion D, Russo E, Zelzer M, Mantovani G, Huett A, Stolnik S. A mechanoresponsive nano-sized carrier achieves intracellular release of drug on external ultrasound stimulus. RSC Adv., 2022, 12(26):16561-16569. doi.org/10.1039/d2ra02307e

Taylor M, Simoes F, Smith J, Genapathy S, Canning A, Lledos M, Chan WC, Denning C, Scurr DJ, Steven RT, Spencer SJ, Shard AG, Alexander MR, Zelzer M. Quantifiable correlation of ToF-SIMS and XPS data from polymer surfaces with controlled amino acid and peptide content. Surf Interface Anal., 2022, 54(4), 417-432. doi.org/10.1002/sia.7052

Ying Zhang

Yang S, Zhu J, Zhou X, Zhang J, Li Q, Bian F, Zhu J, Yan T, Wang X, Zhang Y, Yang J, Jiang Y, Yang S. RNA-Guided DNA Transposition in Corynebacterium glutamicum and Bacillus subtilis. ACS Synth Biol., 2023, 12(7):2198-2202. doi.org/10.1021/acssynbio.3c00193

Omorotionmwan BB, Wang H, Baker JP, Gizynski K, Yoo M, Akaluka C, Zhang Y,Minton NP. Chromosomal engineering of inducible isopropanol- butanol-ethanol production in Clostridium acetobutylicum. Front Bioeng Biotechnol., 2023, 11:1218099. doi.org/10.3389/fbioe.2023.1218099

Millard J, Agius A, Zhang Y,Soucaille P, Minton NP. Exploitation of a Type 1 Toxin-Antitoxin System as an Inducible Counter-Selective Marker for Genome Editing in the Acetogen Eubacterium limosum. Microorganisms, 2023 May 10;11(5):1256. doi.org/10.3390/microorganisms11051256

Sheng L, Madika A, Lau MSH, Zhang Y,Minton NP. Metabolic engineering for the production of acetoin and 2,3-butanediol at elevated temperature in Parageobacillus thermoglucosidasius NCIMB 11955. Front Bioeng Biotechnol., 2023, 11:1191079. doi.org/10.3389/fbioe.2023.1191079

Claxton Stevens BH, Rumah BL, Stead CE, Zhang Y. A Complete Genome of the Alphaproteobacterial Methanotroph Methylocystis parvus OBBP. Microbiol Resour Announc., 2023, 12(4):e0007623. doi.org/10.1128/mra.00076-23

Rumah BL, Claxton Stevens BH, Yeboah JE, Stead CE, Harding EL, Minton NP,Zhang Y. In Vivo Genome Editing in Type I and II Methanotrophs Using a CRISPR/Cas9 System. ACS Synth Biol., 2023, 12(2):544-554. doi.org/10.1021/acssynbio.2c00554

Li Q, Sun M, Lv L, Zuo Y, Zhang S, Zhang Y, Yang S. Improving the Editing Efficiency of CRISPR-Cas9 by Reducing the Generation of Escapers Based on the Surviving Mechanism. ACS Synth Biol., 2023, 12(3):672-680. doi.org/10.1021/acssynbio.2c00619

Wen Z, Chen J, Yang Y, Zhang Y, Jiang Y, Yang S. Pilot-scale fermentation of 300 t/a total solvents from sweet sorghum stalk juice. Chem Eng J., 2023, 454(4):140534. doi.org/10.1016/j.cej.2022.140534

Madika A, Spencer J, Lau MSH, Sheng L, Zhang Y, Minton NP. pMTL60000: A modular plasmid vector series for Parageobacillus thermoglucosidasius strain engineering. J Microbiol Methods., 2022, 202:106600. doi.org/10.1016/j.mimet.2022.106600