Contact

• workSchool of Veterinary Medicine and Science
  Sutton Bonington Campus
  Sutton Bonington
  Leicestershire
  LE12 5RD
  UK
• work0115 951 6797
• Victoria.James@nottingham.ac.uk

Biography

Victoria obtained a PhD in genetics from the University of Leicester in 2007. Following her PhD studies, she pursued postdoctoral training in the fields of molecular and cell biology. Victoria was awarded the prestigious JG Graves Research Fellowship in 2012, which she held at the University of Sheffield Cancer Research Centre until joining the University of Nottingham as a lecturer in 2014. Victoria now splits her time between research and teaching and is an active member of the University of Nottingham's Cancer Research Priority Area.

Teaching Summary

Victoria is involved in teaching on a range of undergraduate and postgraduate courses offered by the University of Nottingham. Victoria's teaching philosophy centres on student interaction and… read more

Research Summary

Victoria's research is focussed on understanding the complex mechanisms that lead to cancer progression and metastasis. Her group investigates how extracellular communication, via RNA and proteins,… read more

Selected Publications

• PROBERT C, DOTTORINI T, SPEAKMAN A, HUNT S, NAFEE T, FAZELI A, WOOD S, BROWN JE and JAMES V, 2018. Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis. Oncogene. 38(10), 1751-1763
• ES-HAGHI, MASOUMEH, GODAKUMARA, KASUN, HALING, ANNIKA, LATTEKIVI, FREDDY, LAVRITS, ARINA, VIIL, JANELI, ANDRONOWSKA, ANETA, NAFEE, TAMER, JAMES, VICTORIA, JAAKMA, ULLE, SALUMETS, ANDRES and FAZELI, ALIREZA, 2019. Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk. Cell communication and signaling : CCS. 17(1), 146
• KLETUKHINA, SEVINDZH, NEUSTROEVA, OLGA, JAMES, VICTORIA, RIZVANOV, ALBERT and GOMZIKOVA, MARINA, 2019. Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition. International journal of molecular sciences. 20(19),
• CHULPANOVA DS, SOLOVYEVA VV, JAMES V, ARKHIPOVA SS, GOMZIKOVA MO, GARANINA EE, AKHMETZYANOVA ER, TAZETDINOVA LG, KHAIBOULLINA SF and RIZVANOV AA, 2020. Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro. Bioengineering (Basel, Switzerland). 7(2),

• View all publications

Applications for PhD positions are invited all year round from exceptional graduates to study the contribution of extra-cellular communication and non-coding RNAs to cancer progression and metastasis.

Funding Notes:

Candidates interested in joining the lab to work in this research area can contact Dr James by sending an e-mail to victoria.james@nottingham.ac.uk. Currently positions are only available to self-funded students. There are a number of international studentships available to international applicants: see http://www.nottingham.ac.uk/InternationalOffice/prospective-students/scholarships/index.aspx.

Victoria is involved in teaching on a range of undergraduate and postgraduate courses offered by the University of Nottingham. Victoria's teaching philosophy centres on student interaction and engagement, implemented through the integration of technology and traditional teaching strategies.

Current Research

Victoria's research is focussed on understanding the complex mechanisms that lead to cancer progression and metastasis. Her group investigates how extracellular communication, via RNA and proteins, promotes cancer progression and the adaption of the metastatic niche, with the aim of identifying novel markers to better stage and predict disease behaviour for the development of novel therapeutic strategies. Victoria has a specific interest in both primary and metastatic cancers of bone as well as cutaneous and other soft tissue tumours.

• CHULPANOVA DS, GILAZIEVA ZE, KLETUKHINA SK, AIMALETDINOV AM, GARANINA EE, JAMES V and RIZVANOV AA, 2021. Cytochalasin B-Induced Membrane Vesicles from Human Mesenchymal Stem Cells Overexpressing IL2 Are Able to Stimulate CD8+ T-Killers to Kill Human Triple Negative Breast Cancer Cells Biology. 10(2), 141
• GOMZIKOVA, M, JAMES, V and RIZVANOV, A, 2021. Mitochondria donation: current understanding and mitochondria transplantation strategies Frontiers in Cell and Developmental Biology. 9,
• OGURCOV, S, SHULMAN, L, GARANINA, E, BAICHURINA, I, KUZNETCOV, M, MASGUTOVA, G, KOSTENNIKOV, A, RIZVANOV, A, JAMES, V and MUKHAMEDSHINA, Y, 2021. lood serum cytokine levels in patients with subacute spinal cord injury: a pilot study to search for biomarkers of injury severity and level Brain Science. 11(3),
• KLETUKHINA, SK, NEUSTROEVA, OA, KURBANGALEAVA, SV, SALAFUTDINOV, II, ROGOV, AM, JAMES V, RIZVANOV, AA and GOMZIKOVA, MO, 2021. Storage stability and delivery potential of cytochalasin B induced membrane vesicles Biotechnology Reports. 30, e00616
• THOMAS J BROWN, 2021. The Role of Extracellular Vesicles in the Development of a Cancer Stem Cell Microenvironment Niche and Potential Therapeutic Targets Cancers. 13(10), 2435
• CHULPANOVA DS, SOLOVYEVA VV, JAMES V, ARKHIPOVA SS, GOMZIKOVA MO, GARANINA EE, AKHMETZYANOVA ER, TAZETDINOVA LG, KHAIBOULLINA SF and RIZVANOV AA, 2020. Human Mesenchymal Stem Cells Overexpressing Interleukin 2 Can Suppress Proliferation of Neuroblastoma Cells in Co-Culture and Activate Mononuclear Cells In Vitro. Bioengineering (Basel, Switzerland). 7(2),
• KITAEVA KV, PRUDNIKOV TS, GOMZIKOVA MO, KLETUKHINA SK, JAMES V and RIZANOV AA, 2019. Analysis of the interaction and proliferative activity of adenocarcinoma, peripheral blood mononuclear and mesenchymal stromal cells after co-cultivation in vitro BioNanoScience. 9, 502-509
• KLETUKHINA, SEVINDZH, NEUSTROEVA, OLGA, JAMES, VICTORIA, RIZVANOV, ALBERT and GOMZIKOVA, MARINA, 2019. Role of Mesenchymal Stem Cell-Derived Extracellular Vesicles in Epithelial-Mesenchymal Transition. International journal of molecular sciences. 20(19),
• ES-HAGHI, MASOUMEH, GODAKUMARA, KASUN, HALING, ANNIKA, LATTEKIVI, FREDDY, LAVRITS, ARINA, VIIL, JANELI, ANDRONOWSKA, ANETA, NAFEE, TAMER, JAMES, VICTORIA, JAAKMA, ULLE, SALUMETS, ANDRES and FAZELI, ALIREZA, 2019. Specific trophoblast transcripts transferred by extracellular vesicles affect gene expression in endometrial epithelial cells and may have a role in embryo-maternal crosstalk. Cell communication and signaling : CCS. 17(1), 146
• GOMZIKOVA MO, JAMES V and RIZVANOV AA, 2019. Therapeutic Application of Mesenchymal Stem Cells Derived Extracellular Vesicles for Immunomodulation. Frontiers in immunology. 10, 2663
• MUKHAMEDSHINA Y, SHULMAN I, OGURCOV S, KOSTENNIKOV A, ZAKIROVA E, AKHMETZYANOVA E, ROGOZHIN A, MASGUTOVA G, JAMES V, MASGUTOV R, LAVROV I and RIZVANOV A, 2019. Mesenchymal Stem Cell Therapy for Spinal Cord Contusion: A Comparative Study on Small and Large Animal Models. Biomolecules. 9(12),
• SHAIMARDANOVA AA, SOLOVYEVA VV, CHULPANOVA DS, JAMES V, KITAEVA KV and RIZVANOV AA, 2019. Extracellular vesicles in the diagnosis and treatment of central nervous system diseases. Neural regeneration research. 15(4), 586-596
• GALIEVA LR, JAMES V, MUKHAMEDSHINA YO and RIZVANOV AA, 2019. Therapeutic Potential of Extracellular Vesicles for the Treatment of Nerve Disorders. Frontiers in neuroscience. 13, 163
• CHULPANOVA, D.S., KITAEVA K.V., TAZETDINOVA L.G., JAMES V., RIZANOVA A.A. and SOLOVYEVA V.V., 2018. Application of Mesenchymal Stem Cells for Therapeutic Agent Delivery in Anti-tumor Treatment Frontiers in Pharmacology. 9, 259
• CHULPANOVA D.S, KITAEVA K.V, JAMES V, RIZANOV A.A and SOLOVYEVA V.V, 2018. Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment Therapeutic Prospects of Extracellular Vesicles in Cancer Treatment. 9, 1534
• PROBERT C, DOTTORINI T, SPEAKMAN A, HUNT S, NAFEE T, FAZELI A, WOOD S, BROWN JE and JAMES V, 2018. Communication of prostate cancer cells with bone cells via extracellular vesicle RNA; a potential mechanism of metastasis. Oncogene. 38(10), 1751-1763
• CATRIN S RUTLAND, SIMONE DE BROT, VICTORIA JAMES and NIGEL P MONGAN, 2017. Expression Mediated by Noncoding RNA in Cancer. In: JAYPROKAS CHAKRABARTI and SANGA MITRA, eds., Cancer and Noncoding RNAs 1. 1. Academic Press Elsevier. 359-366
• SIMONE DE BROT, CATRIN S RUTLAND, NIGEL P MONGAN and VICTORIA JAMES, 2017. Epigenetic control of microRNA expression and cancer. In: JAYPROKAS CHAKRABARTI and SANGA MITRA, eds., Cancer and Noncoding RNAs 1. 1. Academic Press Elsevier. 373-378
• MAJCHER V, GOODE A, JAMES V and LAYFIELD R, 2015. Autophagy receptor defects and ALS-FTLD. Molecular and Cellular Neuroscience. 66, 43-52
• JOSEPH INNS and VICTORIA JAMES, 2015. Circulating microRNAs for the Prediction of Metastasis in Breast Cancer Patients Diagnosed with Early Stage Disease The Breast. 24(4), 364-9
• DE BROT S, NTEKIM A, CARDENAS R, JAMES V, ALLEGRUCCI C, HEERY D, BATES DO, ODUM N, PERSSON JL and MONGAN NP, 2015. Regulation of vascular endothelial growth factor (VEGF) in prostate cancer. Endocrine-related cancer. 22(3), R107-23
• INNS J and JAMES V, 2015. Circulating microRNAs for the prediction of metastasis in breast cancer patients diagnosed with early stage disease. Breast (Edinburgh, Scotland). 24(4), 364-9
• FOXLER, D.E., BRIDGEM, K.S., JAMES, V., WEBB, T.M., MEE, M., WONG, S.C.K., FENG, Y., CONSTANTIN-THEODOSIU, D., PETURSDOTTIR, T.E., BJORNSSON, J., INGVARSSON, S., RATCLIFFE, P.J., LONGMORE, G.D. and SHARP, T.V., 2012. The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity Nature Cell Biology. 14(2), 201-208
• GONZALEZ-ESTEVEZ, C., FELIX, D. A., SMITH, M. D., PAPS, J., MORLEY, S. J., JAMES, V., SHARP, T. V. and ABOOBAKER, A. A., 2012. SMG-1 and mTORC1 act antagonistically to regulate response to injury and growth in planarians: PLoS Genet PLoS Genet. 8(3), e1002619
• JAMES V, WONG SCK and SHARP TV, 2012. MicroRNA-mediated gene silencing: are we close to a unifying model? Biomolecular Concepts. 3(1), 29-40
• JAMES V, WONG SC and SHARP TV, 2012. MicroRNA-mediated gene silencing: are we close to a unifying model? Biomolecular concepts. 3(1), 29-40
• FOXLER, D.E., JAMES, V., SHELTON, S.J., VALLIM, T.Q.D.A., SHAW, P.E. and SHARP, T.V., 2011. PU.1 is a major transcriptional activator of the tumour suppressor gene LIMD1 FEBS Letters. 585(7), 1089-1096
• BHATTI, I., LEE, A., JAMES, V., HALL, R. I., LUND, J. N., TUFARELLI, C., LOBO, D. N. and LARVIN, M., 2011. Knockdown of microRNA-21 inhibits proliferation and increases cell death by targeting programmed cell death 4 (PDCD4) in pancreatic ductal adenocarcinoma: J Gastrointest Surg J Gastrointest Surg. 15(1), 199-208
• JAMES, V., ZHANG, Y., FOXLER, D.E., DE MOOR, C.H., KONG, Y.W., WEBB, T.M., SELF, T.J., FENG, Y., LAGOS, D., CHU, C.-Y., RANA, T.M., MORLEY, S.J., LONGMORE, G.D., BUSHELL, M. and SHARP, T.V., 2010. LIM-domain proteins, LIMD1, Ajuba, and WTIP are required for microRNA-mediated gene silencing Proceedings of the National Academy of Sciences of the United States of America. 107(28), 12499-12504
• NASIM, MT, GHOURI, A, PATEL, B, JAMES, V, RUDARAKANCHANA, N, MORRELL, NW and TREMBATH, RC, 2008. Stoichiometric Imbalance In The Receptor Complex Contributes To Dysfunctional Bmpr-Ii Mediated Signalling In Pulmonary Arterial Hypertension Human Molecular Genetics. 17(11), 1683-1694
• JAMES, V. *, ALDRED, M. A. *, MACHADO, R. D.*, MORRELL, N. W. and TREMBATH, R. C., 2007. Characterization of the BMPR2 5'-untranslated region and a novel mutation in pulmonary hypertension: Am J Respir Crit Care Med Am J Respir Crit Care Med. 176(8), 819-24
• LONG, L, MACLEAN, MR, JEFFERY, TK, MORECROFT, I, YANG, XD, RUDARAKANCHANA, N, SOUTHWOOD, M, JAMES, V, TREMBATH, RC and MORRELL, NW, 2006. Serotonin Increases Susceptibility To Pulmonary Hypertension In Bmpr2-Deficient Mice Circulation Research. 98(6), 818-827
• MACHADO, RD, ALDRED, MA, JAMES, V, HARRISON, RE, PATEL, B, SCHWALBE, EC, GRUENIG, E, JANSSEN, B, KOEHLER, R, SEEGER, W, EICKELBERG, O, OLSCHEWSKI, H, ELLIOTT, CG, GLISSMEYER, E, CARLQUIST, J, KIM, M, TORBICKI, A, FIJALKOWSKA, A, SZEWCZYK, G, PARMA, J, ABRAMOWICZ, MJ, GALIE, N, MORISAKI, H, KYOTANI, S, NAKANISHI, N, MORISAKI, T, HUMBERT, M, SIMONNEAU, G, SITBON, O, SOUBRIER, F, COULET, F, MORRELL, NW and TREMBATH, RC, 2006. Mutations Of The Tgf-Beta Type Ii Receptor Bmpr2 In Pulmonary Arterial Hypertension Human Mutation. 27(2), 121-132
• ALDRED MA, VIJAYAKRISHNAN J, JAMES V, SOUBRIER F, GOMEZ-SANCHEZ MA, MARTENSSON G, GALIE N, MANES A, CORRIS P, SIMONNEAU G, HUMBERT M, MORRELL NW and TREMBATH RC, 2006. Bmpr2 Gene Rearrangements Account For A Significant Proportion Of Mutations In Familial And Idiopathic Pulmonary Arterial Hypertension. Human Mutation. 27(2), 212-3
• JAMES V*, MACHADO RD*, SOUTHWOOD M, HARRISON RE, ATKINSON C, STEWART S, MORRELL NW, TREMBATH RC, ALDRED MA., 2005. Investigation of second genetic hits at the BMPR2 locus as a modulator of disease progression in familial pulmonary arterial hypertension. Circulation. 111(5), 607-613