School of Biosciences
 

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Ivan Campeotto

Assistant Professor in Microbial Biotechnology, Faculty of Science

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Biography

Career summary:

  • Senior Lecturer in Biochemistry at Nottingham Trent University
  • Wellcome Trust ISSF - Early Career Research Fellow at the Leicester Institute of Structural and Chemical Biology.
  • BTP Research Fellow at Pembroke College, University of Oxford.
  • Research Associate at the University of Oxford.
  • Research Associate at Imperial College London.
  • Research Associate at King's College London.
  • PhD in protein crystallography at the Astbury Centre for Structural Molecular Biology, University of Leeds with Prof. Simon Philips and Prof. Arwen Pearson
  • Degree and MRes in Industrial Biotechnology at the University of Padua (Italy)

Other roles:

Member of the CCP4 WG1 and WG2, Honorary Fellow at LISCB (University of Leicester), Visiting Lecturer (NTU), Editor Board Member of Scientific Reports and Frontiers in Microbiology

Expertise Summary

My group currently focuses on structure-based drug design and structure-guided vaccine development in the fields of Neglected Tropical Diseases (NTDs) and of emerging viruses, with main focus on Chagas disease.

To achieve this, we use protein crystallography as the main research tool in combination with cryo-EM, 2D NMR, HDX-MS and complementary biophysical techniques (ITC, BLI, SPR, DSF, DSC, CD etc.). My group has access to the Diamond Light Source (DLS) MX beamlines, Research Complex at Harwell and other synchrotrons in France (Soleil) and Germany (Petra and DESY). I am also involved in methods development for in situ serial crystallography, to trap intermediates of enzymes from human pathogens in collaboration with the VMXi team at DLS.

We use several expression systems for recombinant protein production: Escherichia coli, Vibrio natrigens, HEK293F cells, sf9 cells, Leishmania tarantulae and more recently Tobacco plants.

Teaching Summary

I am module leader for the UG course on "Fundamental in Immunology" (BIOS2010) which will start in October 2023 and will have particular focus on host-pathogen interactions and vaccines.

I am also module leader for the PG module "Research skills in Microbia Biotehcnology" (BIOS4125).

Research Summary

My main research stream lies in the design and production of immunogens from human and animal pathogens, for the generation of monoclonal antibodies, which we test for diagnostic and therapeutic… read more

Recent Publications

School of Biosciences

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Sutton Bonington Campus
Nr Loughborough
LE12 5RD, UK

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