Modelling DNA Chain Dynamics  

Project description

Whilst the dynamics of the DNA double helix are extremely complicated, a number of well-defined modes of vibration, such as twisting and bending, have been identified. At present the only accurate models of DNA dynamics involve large-scale simulations of molecular dynamics. Such approaches suffer two major drawbacks: they are only able to simulate short strands of DNA and only for extremely short periods (nanoseconds). the aim of this project is to develop simpler models that describe vibrations of the DNA double helix. The resulting systems of equations will be used to simulate the dynamics of longer chains of DNA over long timescales and, hence, allow larger-scale dynamics, such as the unzipping of the double helix, to be studied.