School of Pharmacy

Publications in the Biomolecular Science and Medicinal Chemistry Division

Publications

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WITHERS, I.M., MAZANETZ, M.P., WANG, H., FISCHER, P.M. and LAUGHTON, C.A., 2008. Active site pressurization: a new tool for structure-guided drug design and other studies of protein flexibility Journal of Chemical Information and Modeling. 48(7), 1448-1454

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MAZANETZ, M.P., WITHERS, I.M., LAUGHTON, C.A. and FISCHER, P.M., 2008. Exploiting glycogen synthase kinase 3beta flexibility in molecular recognition. Biochemical Society Transactions. 36(1), 55-58

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WANG, S. and FISCHER, P.M., 2008. Cyclin-dependent kinase 9: a key transcriptional regulator and potential drug target in oncology, virology and cardiology Trends in Pharmacological Sciences. 29(6), 302-313

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PATWARDHAN, G, OLDHAM, N.J. and FISCHER, P.M., 2008. Structure-guided design of inhibitors of the eukaryotic initiation factor 4E (eIF4E) mRNA-cap interaction as anti-cancer agents In: European Journal of Cancer Supplements, Volume 6, Issue 9. 106 (In Press.)

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FISCHER, P.M., 2008. Computational chemistry approaches to drug discovery in signal transduction Biotechnology Journal. 3(4), 452-470

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FISCHER, P.M., 2008. Turning down tau phosphorylation Nature Chemical Biology. 4(8), 448-449

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FISCHER, P.M., 2008. Cell cycle inhibitors in cancer: current status and future directions. In: NEIDLE, S., ed., Cancer Drug Design and Discovery Academic Press. 253-283

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DEKKER, L.V., 2008. Novel approaches to drug discovery in signal transduction The Biotechnology Journal. 3(4), 428-429

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ASHRAF, S. and WALSH, D. A., 2008. Angiogenesis in osteoarthritis Curr Opin Rheumatol. 20(5), 573-80

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LIVERPOOL, T.B., HARRIS, S.A. and LAUGHTON, C.A., 2008. Supercoiling and denaturation of DNA loops Physical Review Letters. 100(23), 238103

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LAUGHTON, CHARLES A, LUISI, BEN F, PRATAP, J VENKATESH and CALLADINE, CHRIS R, 2008. A potential molecular switch in an alpha-helical coiled coil. Proteins. 70(1), 25-30

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JIRANUSORNKUL, SUPAT and LAUGHTON, CHARLES A, 2008. Destabilization of DNA duplexes by oxidative damage at guanine: implications for lesion recognition and repair. Journal Of The Royal Society Interface. 5 Suppl 3, S191-8

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GIRARD, PETER M, NIKJOO, HOOSHANG and LAUGHTON, CHARLES, 2008. Simulation of (125)I-based radioprobing experiments to study DNA quadruplex structure and topology. International Journal of Radiation Biology. 84(12), 1045-9

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CHENG, MAI-KIM, MODI, CHETNA, COOKSON, JENNIFER C, HUTCHINSON, IAN, HEALD, ROBERT A, MCCARROLL, ANDREW J, MISSAILIDIS, SOTIRIS, TANIOUS, FARIAL, WILSON, W DAVID, MERGNY, JEAN-LOUIS and LAUGHTON, CHARLES, 2008. Antitumor polycyclic acridines. 20. Search for DNA quadruplex binding selectivity in a series of 8,13-dimethylquino[4,3,2-kl]acridinium salts: telomere-targeted agents. Journal of Medicinal Chemistry. 51(4), 963-75

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HARRIS, S.A., LAUGHTON, C.A. and LIVERPOOL, T.B., 2008. Mapping the phase diagram of the writhe of DNA nanocircles using atomistic molecular dynamics simulations Nucleic Acids Research. 36(1), 21-29
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