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Featured research:
The first major study of its kind to characterise the problem of chronic oedema internationally.
Current research
Additional research by Professor Quere includes projects in the following areas:
Venous thromboembolism (VTE) disease
- Identification of new risk and aetiologic factors for VTE disease, through studies of associated rare diseases with a clinical phenotype
- Validation of tools and strategies for diagnosing VTE disease during clinical trials and in daily practice
- Evaluation of new anticoagulation and compression therapies for VTE disease
Lymphatic and venous post-thrombotic syndrome (PTS)
- Evaluation of strategies for treating lymphoedema
- Development of new tools for clinical assessment and clinical trials (3D-camera and phlebosthene projects)
Rare vascular diseases
- Study of the natural course and thrombotic complications of vascular abnormalities in adults and children
- Understanding the mechanisms of primary lymphoedema
- Development of genetic and phenotypic characterisation of children and adolescents with lymphoedema
Previous and ongoing research
New methods of treatment for lymphoedema and chronic oedema
Professor Christine Moffatt and Professor Isabelle Quere are also engaged in the development of new methods of treatment. These include compression systems, currently being evaluated in clinical studies at national and international level.
Improved methods of diagnosis and treatment for children with lymphoedema
A further joint focus of international research is the development of improved methods of diagnosis and treatment for children with primary lymphoedema, a rare disorder in which genetic forms are being defined.
Non-invasive assessment methods for peripheral vascular disease
New research at the centre is also examining methods of non-invasive assessment for peripheral vascular disease and early identification of cellulitis.
Developing a community chronic oedema pathway
Work in the UK is currently focusing on the development and validation of a community chronic oedema pathway with Leicester City Partnership Trust though an Innovate UK government-funded KTP grant. This includes:
- A four-country study to examine outcomes in patients receiving intensive treatment (CDT) for chronic oedema
- An MS study to determine the clinical impact of chronic oedema (survey and random sample clinical evaluation)
- A bariatric study to evaluate the impact of bariatric surgery on the development and resolution of chronic oedema
- An evaluation of chronic oedema and wounds in patients with spina bifida and an exploration of the impact on their families
- Development and evaluation of a community pathway for chronic oedema management
- Exploration of the implementation of a community care pathway using systems theory