Work package 1
Measuring serious harm, and economic impact, associated with hazardous prescribing
Objectives
- Determine the risk of serious harm, and economic impact, associated with hazardous prescribing
- Validate the algorithms that will be used to identify the serious harm outcomes in WP2 and WP3
- Develop a composite measure for the serious harm outcomes
- Develop the economic models that will be used to evaluate the cost-effectiveness of the interventions in WP2 and WP3
Methods
We will examine existing large population-based observational studies, and undertake one new GP-database cohort study
Outcomes
- The absolute attributable risk of serious harm associated with 11 specific types of hazardous prescribing
- Markov models to estimate the effect of hazardous prescribing on Quality-Adjusted-Life-Years (QALYs)
WP1 team members
- Professor Darren Ashcroft (lead)
- Professor Tony Avery
- Professor Rachel Elliott
- Professor Bruce Guthrie
- Dr Pearl Mok
- Dr Daniel Morales
- Professor Tjeerd van Staa
