Work package 2: the CDS-software, OptimiseRx Intervention
Evaluating the effectiveness and cost-effectiveness of an intervention involving the introduction of a set of prescribing safety indicators to computerised clinical decision support (CDS) software (OptimiseRx) in reducing hazardous prescribing in general practices
Objectives
- Determine the effectiveness and cost effectiveness of the CDS-software, OptimiseRx, in reducing hazardous prescribing in general practices
- Determine whether Optimise Rx is associated with a reduction in rates of hazardous prescribing, hospitalisation, and all-cause mortality
- Determine the cost from the perspective of the NHS, and the incremental cost her hazardous prescribing event avoided
- Determine the incremental cost for QALY generated by OptimiseRx for a subset of seven key prescribing indications (which are also used in WP3)
Setting and participants
- Setting: general practices in England that use TPP SystemOne and contribute to the ResearchOne database
- Recruitment: all practices in ResearchOne have already consented for use of their data for research purposes
Methods
- Design: interrupted time series study (24 months prior and 12 months post implementation)
- Data collection: ResearchOne will provide pseudoanonymised data for practicing general practices. Data will need to be linked to HES and ONS
Outcomes
- Primary: the number and proportion of patients in each general practice exposed to at least one type of hazardous prescribing
- Secondary: rates of hospitalisation and all-cause mortality
WP2 team members
- Professor Niels Peek (Lead)
- Professor Darren Ashcroft
- Dr Sarah Armstrong
- Professor Tony Avery
- Professor Bruce Guthrie
- Dr Pearl Mok
- Dr Sarah Rodgers
- Professor Tjeerd van Staa
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