Who's
Who (current group members; click here for the alumni
)
Me
I started my
own group here late in 2002. Before coming to Nottingham I was here in Oxford. And before that I
was here (also in Oxford). I enjoyed
the challenge, stress and endless worry about setting up my own lab and
research group and over the past 15 years have managed to keep training PhD
students, getting them good publications without a
huge amount of financial backing. If only the funding bodies of this world
took that into account!
Post-doctoral workers
James
Mitchell-White – James has been brought on board to spend the money on the
BBSRC grant “Channelling a path for substrates through a multidrug
transporter” while hopefully screening ABCG2 mutants for transport and
binding activity. Outside the lab, you can find him too close to the edge,
trying to take a good photo.
Research
Technician
Deb Briggs - Deb has
been working alongside my PhD students and project students for several
years now providing outstanding training of new group members and oversight
of the whole lab. If you can’t get any cloning to work……then Deb will get
it to work, probably first time.
Current Postgraduate Students
Ella Hutchison is an
MRes student who joined the group in October
2019. She is studying inhibitor binding and whether high affinity prevents
them from being transported.
Joe Morris is an MRes student who joined the group in February 2020, and
was just getting his hands dirty when the lab locked down for COVID-19.
Plenty of time for him to come back and finish his project.
Parth Kapoor is a
PhD student and Vice Chancellor’s Scholarship holder from India. Parth
joined the lab early in 2016 and has a project that also aims to understand
drug binding and
transport in ABCG2 by mutagenesis of TM helix 3. He’s handed in the thesis and
successfully defended his thesis on Zoom recently. Parth has already moved
on to bigger and better things with a job at OMass in Oxford.
.Previous
Group Members - all-time project student list here
Simon Caulton
– Simon was in the group for a relatively short period of time and worked
on a BBSRC/CBMNET funded project in collaboration with Lucite and Gill
Stephens (engineering) on the transcriptional regulation of bacterial
tolerance to organic esters. Since then he has moved to the lab of Andy
Lovering in Birmingham.
Hannan Azmir was an MRes student in the group who successfully defended her
thesis in May 2020. Her project was all about understanding interactions
between methionine and aromatic residues in ABCG2 and whether conservation
of those residues was an indication of importance in function. Hannan has
returned to Malaysia to continue her scientific career there.
Megan Cox. Meg’s
BBSRC DTP funded project took in mutagenesis studies in the multidrug
transporter ABCG2 to
demonstrate the functional importance of individual amino acid residues in
drug binding and transport. Meg now works at the Aston University and Meritics.
Aaron Horsey. Aaron
was a BBSRC DTP student under the supervision of Nick Holliday, Steve
Briddon and Ian Kerr. His PhD project has just been published and Aaron has
now started work at Sygnature Discovery
Sunehera Sarwat.
Sunehera joined the lab from the marvellously named North-South University
in Dhaka, Bangladesh. She carried out an MRes
project on ABCG2, kick-starting our purification of this transporter, and
has since moved to Cambridge to work for Wren Therapeutics
George Janes. George
was a BBSRC DTP student, working initially on plant transporters of auxin,
but then he diversified into the phosphate response. His main supervisors
are Leah Band and Tony Bishopp, both of whom are down on the Sutton Bonington campus.
Kelvin
Wong was a a student
jointly supervised with Nick Holliday. Kelvin is from Malaysia, and was a
graduate of the Nottingham:Malaysia
joint MPharm degree. Kelvin's work on ABCG2
using various microscopy and fluorescent technologies allowed us to
investigate oligomerization and function. He is
also a massive Manchester United fan so his mood on a Monday was always
predictable come full-time in the weekend football games. Kelvin graduated
in July 2015 and has a future as a technology consultant.
Christopher
Kay. Chris was originally an inheritance. He was in the lab of Sabrina Dyall until she went back to Mauritius in 2009, leaving
him to finish his project under my supervision. Chris finished his project
working on membrane insertion in the hydrogenosome
of the parasite Trichomonas vaginalis. and then continued in the lab as a research fellow,
publishing three papers in PLOS Neglected Tropical Diseases, FEBS Letters
and Bioscience Reports. Chris is a unique person. I know of no-one else who
builds their own solar heating system from scrap panels, their own home
microscopy unit, and regularly arrives with cakes baked with strange
ingredients (one recently with a bright green sponge, courtesy of pandan leaves). Chris is current a post-doctoral
researcher in Bristol.
Ayat Al-Ghafari. Ayat Al-Ghafari
("micro-Ayat") was a PhD student with myself and Beth Coyle
working on acute and chronic responess to
drug treatment in a model glioma cell line. After completing her
thesis she returned to Saudi Arabia where she now holds a senior faculty postion at KAU. Here she is moments after passing
her viva. The picture is the more remarkable for finally capturing Deb.
James Dorrian
successfully defended his thesis in late 2010.
Ameena
Haider - started early 2007, and worked on ABCG2 all the way through her
project, graduating in 2011. We’ve got one paper published in PLOS One, and
continue to work on some of the various tangents she started to explore.
Ameena joined the lab from Kuwait and after graduating has returned there
to take up an academic post.
David Carrier -
started 2005 on the Aux1, auxin transporter project. Nickname
"dangerous". Dave is a local lad, a graduate of Nottingham Trent
University, and a keen climber, which partially explains his nickname. Dave
defended his thesis in January 2010, and then worked for Beth Coyle as a
post-doc for a year, before taking up a technical post at Nottingham Trent
University. David is now a post-doc in Alison Baker's lab at the University
of Leeds, and it is great to see him working on ABC transporters at last!
In addition
to these three students, I have also been a co-supervisor for several
others who all had successful PhD projects in collaboration with various collagues. A few of these are mentioned below....
Wiyada Punjaruk. Wiya did her project in Beth Coyle's lab and produced a
collosal thesis on brain tumour cell lines. Her
thesis occupies about double the space of most of the others I have on my
shelf, and that is after Beth and I wielded the hatchet on several
chapters! Wiya has returned home to Thailand to
take up a Faculty position there.
Emily Crowley.
Nicknamed "squaredee" Emily was often
heard well before she was seen. Working on P-glycoprotein and TM12 in
particular (in a project I had with Richard Callaghan), she came up to
Nottingham to make many mutant isoforms, an occasional batch of Welsh cakes
and to break equipment. She's finished her PhD in late 2009 and has moved
to Italy to do a post-doc there.
Norliza
Tendot Abu Bakar, nicknamed "Liza" and
camera shy. Norliza worked up here at University
Park and primarily in the lab of Malcolm Bennett at Sutton Bonington. She had a "never say rest"
attitude to lab work, and after completion returned to Malaysia to take a
Faculty post there.
...and not forgetting all our project students,
who have always brought something to the table.
|
Name
|
Year
|
Project
|
Doing now?
|
Famous for...
|
|
Natalie
Jones
|
14/15
science
|
G2
mutants
|
PhD
in Edinburgh
|
modesty!
|
|
Lee
Armfield
|
14/15
science
|
G2
and cholesterol
|
PhD
in Oxford
|
|
|
Sophie
Tursunkanova
|
14/15
science
|
YFP_PGP
|
MSc
|
bring
in Kazakh chocolate, in fact any chocolate
|
|
Robin
Badger
|
14/15
BMedSci
|
G2
and drugs
|
Medical training
|
|
|
Dan
Hurry
|
14/15
BMedSci
|
G2
and drugs
|
Medical training
|
lots of questions....
|
|
Nyssa
Comber
|
13/14
BMedSci
|
G2
and antipsychotics
|
Medical training
|
her name!
|
|
David
Lee
|
13/14
BMedSci
|
G2
and antipsychotics
|
Medical training
|
|
|
Allen
Kim
|
13/14
science
|
SMALPs
and Pgp mutants
|
MSci
in London
|
bad
luck with cloning
|
|
Harry
Sherman
|
13/14
science
|
Pgp-GFP
|
PhD
student
|
nothing
"mate"
|
|
Megan
Cox
|
13/14
science
|
G2 mutants
|
PhD student
|
knowing when to bring in cakes
|
|
Tim
van der Gucht
|
12/13
Science
|
G2
and PIM1
|
|
|
|
Nam Hoang
|
12/13 Science
|
G2 and microtubules
|
|
|
|
Alison Macgregor and Chloe Williams
|
12/13 BMedSci
|
G2 and statins
|
Medical training
|
|
|
Chari Wariyapola
|
11/12 BMedSci
|
G2
and statins
|
Medical training
|
Stacks of 96-well
plates
|
|
Caroline Reed
|
Medical training
|
|
Sarah Hopkinson
|
11/12 science
|
Hup
proteins
|
|
Listening
to Chris
|
|
Nat Poulter
|
11/12 science
|
B6 and B10
|
corporate governance
|
More PCRs than you
shake stick at
|
|
Kathryn Wolhuter
|
11/12 science
|
A4 and
cholesterol
|
PhD student
|
Bizarre mutagenesis
results
|
|
Alice Marshall
|
10/11 science
|
G2 mutants
|
Pharma marketing
|
Trying to make stable
cell lines
|
|
Astrid Omell
|
10/11 science
|
Teaching
|
|
Mike Ridley
|
10/11 science
|
Stress and
resistance
|
MSc
|
Wearing a huge Royal
Navy overcoat in summer
|
|
Mary Gee
|
09/10 science students
|
dimerization
of ABCG2
|
medical student
|
fighting crime
|
|
Hannah Chilvers
|
PhD student
|
tidyness
|
|
Katherine Dixon
|
08/09 science students
|
ABCG2 mutagenesis
|
post-doc
|
|
|
Alice Goode
|
post-doc
|
|
Katherine Dixon
|
08/09 science students
|
ABCG2 mutagenesis
|
post-doc
|
|
|
Alice Goode
|
post-doc
|
skiing holidays
|
|
Kate Starr
|
07/08 science students
|
ABCG2 ATPase
|
medical student
|
man magnet
|
|
Amy Firth
|
ABCG2 linked dimers
|
|
|
|
Tom Wood
|
|
putting up
with Amy and Kate?
|
|
Jess Lawson
|
06-07
science students
|
P-gp
mutation analysis
|
|
the biggest
Excel spreadsheet ever.
|
|
Krishanu Baruah
|
LmrC
|
|
being a
Newcastle fan
|
|
Grace Chen
|
ABCA4 mutants
|
|
great plaque
assays and awful westerns (and buying me a huge Easter egg)
|
|
Simon Potter
|
06-07 medical students
|
literature project
|
|
eating all my
biscuits
|
|
Tom Chiddick
|
Pgp NBD
refolding
|
Kolmogorov-Smirnov
tests!
|
|
Pravisha Ravindra
|
|
Alex Burton
|
2006 summer
|
LmrC
|
|
cuvette usage
above and beyond the call of duty
|
|
Claire Kingswood
|
05-06
science student
|
brain tumour cell lines
|
|
breaking two
pipettes in half an hour
|
|
Alex Selwyn
|
05-06
medical student
|
Pgp NBD
|
|
weighing out
enough arginine for 5 litres at 4M, only to discover that it's insoluble
above 0.5M. So we now have 40 litres of the stuff in the cold room.
|
|
Anna Scorer
|
05-06 medical student
|
Pgp NBD
|
|
|
Talha Shahid
|
05 MSc
student
|
brain tumour cell lines
|
|
where to
start?
|
|
Helen Jeffery
|
04-05 science student
|
LmrC
|
|
do western blots
without antibodies
|
|
Claire Hodgson
|
04-05 science student
|
ABCE
|
|
proudly showing
off her soluble and purified protein...and then tipping it down the sink
accidentally.
|
|
Iain Irving
|
04-05 science student
|
EmrE
|
|
|
|
Jai Jani
|
04-05 medical student
|
NBD
|
|
trying to light
a bunsen burner with a gilson
|
|
William Grainger
|
04 summer student
|
LmrC
|
|
attempting to
dissolve maltose in "water" and failing to smell the fact that
his water was actually ethanol.
|
|
Tom Oliver
|
03-04 science student
|
EmrE
|
|
|
|
Tammy Mabley
|
03-04 science student
|
Pgp NBD
|
|
asking for a
black pen to draw lines on autoclave tape.
|
|
Hannah Stower
|
03 summer student
|
Pgp
mutants
|
|
exposing a
western blot to the white backing card and then putting that through the
developer machine.
|
|
Clare Walton
|
03 summer student
|
Pgp NBDs
|
|
|
|
Roz Holmes
|
03 summer student
|
ABCA4
|
|
foggy western
blots were a speciality
|
|
