Publications
The links below take you to Pubmed
to read the abstract, but most are fully open access publications. If you
do see a paper you want to read but cannot get it for free then please
contact me ian.kerr@nottingham.ac.uk and I will
send you the pdf by return email.
2016-to date
2010-2015
2005-2009
2000-2004
1995-1999
prior to 1995
Recent papers
Mitchell-White,
JI, Stocker, T., Holliday, N, Briddon, SJ, Kerr, ID (2021). Analysis of Sequence
Divergence in Mammalian ABCGs Predicts a Structural Network of Residues
That Underlies Functional Divergence. Int J Mol Sci 22: 3012 https://doi.org/10.3390/ijms22063012
Taylor, L., Kerr, ID., Coyle B (2021) Y-box Binding Protein-1: A
Neglected Target in Pediatric Brain Tumors? Mol Cancer Res 19: 375-387. The publisher is a miserly one and charges 3K for open access even
for an invited review. So if you want to read this paper then please email me and I will send you a version of the paper.
Vaughan-Hirsch J, Tallerday EJ,
Burr CA, Hodgens C, Boeshore
SL, Beaver K, Melling A, Sari K, Kerr ID, Šimura
J, Ljung K, Xu D, Liang W, Bhosale R, Schaller
GE, Bishopp A, Kieber JJ (2021) Function of the pseudo phosphotransfer proteins has diverged between rice and
Arabidopsis. Plant J. doi: 10.1111/tpj.15156.
Online ahead of print.
Kerr, ID., Hutchison, E., Gerard, L., Aleidi, SM and
Gelissen, IC. (2021) Mammalian
ABCG-transporters, sterols and lipids: To bind perchance to transport? Biochim Biophys Acta Mol Cell Biol Lipids doi: 10.1016/j.bbalip.2020.158860
Linke F, Aldighieri M, Lourdusamy A, Grabowska AM, Stolnik S, Kerr
ID, Merry CLR, Coyle B (2021) 3D hydrogels reveal
medulloblastoma subgroup differences and identify extracellular matrix
subtypes that predict patient outcome. J Pathol. 253: 326-338
Khunweeraphong
N, Mitchell-White J, Szollosi D, Hussein T, Kuchler K, Kerr ID, Stockner T, Lee JY (2020)
Picky ABCG5/G8 and promiscuous ABCG2 - a tale of
fatty diets and drug toxicity. FEBS Lett. 594: 4035-4058.
Horsey AJ, Briggs DA, Holliday ND, Briddon SJ, Kerr ID Application of fluorescence correlation spectroscopy to study
substrate binding in styrene maleic acid lipid copolymer encapsulated ABCG2.
Biochim Biophys Acta Biomembr. 2020 1862:183218. doi:
10.1016/j.bbamem.2020.183218
Kapoor P, Briggs DA, Cox MH, Kerr ID. Disruption of the Unique ABCG-Family NBD:NBD
Interface Impacts Both Drug Transport and ATP Hydrolysis. Int J Mol Sci. 2020 21:E759. doi: 10.3390/ijms21030759
Carey Hulyer AR, Briggs DA, O'Mara ML, Kerr ID, Harmer
JR, Callaghan R. Cross-linking, DEER-spectroscopy and molecular
dynamics confirm the inward facing state of P-glycoprotein in a lipid
membrane. J. Struct. Biol. 2020 211:
107513
Al-Saad, R. Z. Kerr, I., Hume, A. N. In Vitro Fluorescence Resonance Energy Transfer-Based Assay Used to
Determine the Rab27-Effector-Binding Affinity Assay Drug Dev
Technol. 18: 180-194.
Sabnis, D.H., Storer, L.C.D., Liu, JF., Jackson, H.K., Kilday, J.P., Grundy, R.G., Kerr, I.D., Coyle, B. A role for ABCB1 in prognosis, invasion and drug resistance in
ependymoma. Scientific Reports 9: 10290
Heyes, N.D., Kapoor, P., Kerr, I.D. (2018) Polymorphisms of the multidrug pump ABCG2: a systematic review of
their effect on protein expression, function and drug pharmacokinetics.
Drug Metab Disp 46:1886-1899
Cox, M.H., Kapoor, P, Briggs, D.A., Kerr, I.D. (2018). Residues contributing to drug transport by ABCG2 are localised to
multiple drug-binding pockets. Biochemical Journal 475:
1553-1557
Janes, G., von Wangenheim, D., Cowling, S., Kerr, I.,
Band, L., French, A. P., and Bishopp, A. (2018) Cellular Patterning of Arabidopsis Roots Under Low
Phosphate Conditions, Frontiers in Plant Science 9, 1-11.
Mittra, R., Pavy, M.,
Subramanian, N. Georgem A.M., O’Mara, M.L., Kerr
I.D., & Callaghan, R. (2017). Location of contact residues in pharmacologically distinct drug
binding sites on P-glycoprotein. Biochemical pharmacology. 123,
19-28
Horsey, AJ, Cox, MH, Sarwat, S, Kerr, ID. The multidrug transporter ABCG2: still more questions than answers.
Biochemical Society Transactions 44: 824-830
Wong, K., Briddon, SJ.,
Holliday, ND & Kerr, ID. (2016) Plasma membrane dynamics and tetrameric organisation of ABCG2
transporters in mammalian cells revealed by single particle imaging
techniques. BBA Mol Cell Res 1863:
19-29.
2010-15
Al-Ghafari AB, Punjaruk, W,
Storer, LC, Carrier, DJ, Hussein, D, Coyle, B, Kerr
ID (2015) Long-term exposure to irinotecan reduces
cell migration in glioma cells. J. Neurooncol
127: 455-462
Theodoulou, F. L., and Kerr, I. D.
(2015) ABC transporter research: going strong 40 years
on, Biochemical Society Transactions 43, 1033-1040.
Coyle, B., Kessler, M., Sabnis, D. H., and Kerr,
I. D. (2015) ABCB1 in children's brain tumours,
Biochemical Society Transactions 43, 1018-1022.
Haider, AJ, Cox, MH, Jones, N, Goode, AJ, Bridge, KS,
Wong, K, Briggs, D, Kerr, ID Identification of residues in ABCG2 affecting protein trafficking
and drug transport, using co-evolutionary analysis of ABCG sequences
. (2015). Biosci Rep e00241
Darby, RAJ, Unsworth, A,
Brooks, S, Knapp, S, Kerr, ID, Callaghan R
Overcoming ABCG2-mediated drug resistance with imidzo-[1,2-b]-pyridazine based PIM1
kinase inhibitors (2015). Cancer Chemotherapy and Pharmacology 76: 853-864s
Othman RT, Kimishi I, Bradshaw
TD, Storer LC, Korshunov A, Pfister
SM, Grundy RG, Kerr ID,
Coyle B. Overcoming multiple drug resistance mechanisms in
medullobastoma (2014). Acta Neuropathol
Commun. 30: 57
van Wonderen
JH, McMahon RM, O'Mara ML, McDevitt CA, Thomson AJ, Kerr ID, Macmillan F, Callaghan R The Central Cavity Of Abcb1 Undergoes Alternating
Access During Atp Hydrolysis. (2014)
FEBS J . 281: 2190-2201
Wong, K., Ma, J., Rosthnie,
A.J., Biggin, P.C., Kerr, I.D. Towards an understanding of promiscuity in multidrug efflux pumps.
(2014) TiBS 39: 8-16
Pollock, N.L., McDevitt, C.A., Collins, R., Niesten, P.H.M., Prince, S., Kerr,
I.D., Ford, R.C., Callaghan, R.C. Improving the stability and function of purified
ABCB1 and ABCA4: The influence of membrane lipids (2014). BBA Biomembranes 1838: 134-147.
Kay, C., Lawler, K. Kerr, I.D. Analysis of the Sam50 translocase of Excavate
organisms supports evolution of divergent organelles from a common endosymbiotic event .
(2013). Biosci Rep 33: e00084s
De Marcos Lousa C, van Roermund CW, Postis VL, Dietrichs
D, Kerr ID, Wanders RJ, Baldwin SA, Baker A, Theodoulou
FL. Intrinsic acyl-CoA thioesterase
activity of a peroxisomal ATP binding cassette
transporter is required for transport and metabolism of fatty acids.
(2013). Proc Natl. Acad. Sci. 110: 1279-1284
Kay C, Lawler K, Self TJ, Dyall
SD, Kerr ID. Localisation of a family of complex-forming
ß-barrels in the T. vaginalis hydrogenosomal
membrane. (2012) FEBS Lett. 586:
4038-4045.
Kay C, Woodward KD, Lawler K, Self TJ, Dyall SD, Kerr
ID. The ATP-binding cassette proteins of the
deep-branching protozoan parasite Trichomonas vaginalis.
(2012) PLoS Negl Trop Dis. 6:e1693.
Haider
AJ, Briggs D, Self TJ, Chilvers HL, Holliday ND,
Kerr ID . Dimerization of ABCG2
Analysed by Bimolecular Fluorescence Complementation. (2011) PLOS One
6:e25818
Dorrian, JM, Briggs, DA, Ridley, ML, Layfield, R, Kerr, ID. Induction of a stress response
in Lactococcus lactis
is associated with a resistance to ribosomally
active antibiotics . (2011) FEBS Journal 278:
4015-24
De Smet I, Voss U, Lau S, Wilson M, Shao N, Timme RE, Swarup R, Kerr
I , Hodgman C, Bock R, Bennett M, Jürgens
G, Beeckman T. Unraveling
the evolution of auxin signaling . (2011)
Plant Physiol. 155:209-21.
Kerr ID,
Haider AJ, Gelissen IC. The ABCG family of
membrane-associated transporters: you don't have to be big to be mighty. (2011).
Br J Pharmacol 164: 1767-1779
Hussein
D, Punjaruk W, Storer LC, Shaw L, Ottoman R, Peet A, Miller S, Bandopadhyay
G, Heath R, Kumari R, Bowman KJ, Braker P, Rahman R, Jones GD, Watson S, Lowe J, Kerr ID
, Grundy RG, Coyle B.
Pediatric brain tumor
cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion .(2011). Neuro Oncol. 13:70-83.
Crowley
E, O'Mara ML,Kerr ID,
Callaghan R Transmembrane
helix 12 plays a pivotal role in coupling energy provision and drug binding
in ABCB1. (2010) FEBS J. 277:3974-85.
Kerr I.D., Jones P.M., George A.M. Multidrug efflux pumps:
the structures of prokaryotic ATP-binding cassette transporter efflux pumps
and implications for our understanding of eukaryotic P-glycoproteins and
homologues. (2010). FEBS
J. 277: 550-63.
2005-2009
Crowley,
E., L. O'Mara M, E. Reynolds, D. P. Tieleman, J.
Storm, I. D. Kerr and R. Callaghan (2009).
Transmembrane helix 12 modulates progression of the ATP catalytic cycle in
ABCB1 .Biochemistry: 48: 6249-58.
Dorrian,
J.M and Kerr, I.D. ( 2009) Can ABC proteins confer drug
resistance in micro-organisms without being export pumps? to be published in ABC
Transporters in Microorganisms , Horizon Press, 2009.
Kerr, I.D, Twycross, J.T.,
Carrier, D.J. (2009) Hormone Transport to be published in Plant Plasma Membrane Monographs, 2010.
Carrier,
D.J., Abu Bakar, N.T., Lawler, K., Dorrian, J.M., Haider, A., Bennett, M.J.,Kerr, I.D
.(2009). Heterologous expression
of a membrane-spanning auxin importer: Implications for functional analyses
of auxin transporters. Internaional Journal of Plant Genomics , 848145.
McDevitt, C. A., Collins, R., Kerr,
I. D ., and Callaghan, R. (2009) Purification
and structural analyses of ABCG2 , Advanced drug delivery reviews61: 57-65.
Chuthapisith, S., Bean, B. E.,
Cowley, G., Eremin, J. M., Samphao,
S., Layfield, R.,Kerr, I.
D.,
Wiseman, J., El-Sheemy, M., Sreenivasan,
T., and Eremin, O. (2009)
Annexins in human breast cancer: Possible
predictors of pathological response to neoadjuvant
chemotherapy, Eur J Cancer
45:1274-12
McDevitt,
C., E. Crowley, G. Hobbs, K. Starr, I. D.
Kerr and R.
Callaghan (2008). Is
ATP binding responsible for initiating drug translocation by the multidrug
transporter ABCG2? FEBS
Journal 275: 4354-4362.
Carrier,
D., N. T. Abu Bakar, R. Swarup, R. Callaghan, R. Napier, M. J. Bennett and I. D.
Kerr
(2008). The
binding of auxin to the Arabidopsis auxin influx transporter, AUX1 .Plant Physiol.148: 529-535.
Swarup, K., Benkova, E.,
Swarup, R., Casimiro, I., Péret,
B., Yang, Y., Carrier, D., Nielsen, E., De Smet,E,
Vanneste, S., Levesque, M. P., Parry, G., James,
N. , Calvo, V. , Ljung,
K., Kramer, E.M., Roberts, R., Graham, N., Marillonnet,
S. , Patel, K. , Jones, J.D.G., Taylor, C.G. , Schachtman,
D.P., May, S.T., Sandberg, G. , Benfey, P.,
Friml, J. , Kerr, I. , Beeckman,
T., Laplaze, L. and Bennett, M.J.. (2008) The
auxin influx carrier LAX3 facilitates lateral root emergence in Arabidopsis
Nature Cell Biology10:946-954.
Storm, J. Modok, S. O'Mara M, L. Tieleman, D. P.Kerr,
I.D. and
Callaghan, R. (2008). The
cytosolic region of TM6 in P-glycoprotein: topographical analysis and
functional perturbation by site directed labelling. Biochemistry 47:3615-3624.
Lawson, J., O'Mara, M.L., and I.D.
Kerr (2008)Structure-based
interpretation of the mutagenesis database for the nucleotide binding
domains of P-glycoprotein BBA Biomembranes
1778: 376-391 .
Callaghan, R., Crowley, E., Potter, S., and I.D.
Kerr (2008)
P-glycoprotein:
So Many Ways to Turn It On . Journal of Clinical Pharmacology 48:365-378.
Storm, J., M. O'Mara, E. Crowley, J. Peall, D. P. Tieleman, I.
D. Kerrand R. Callaghan (2007).
Residue G346 in transmembrane segment six is involved in inter-domain
communication in p-glycoprotein .Biochemistry46:9899-9910
Warner, D.J., Vadolia,
M., Laughton, C.A., Kerr, I.D., and Doughty, S.W. (2007).
Modelling
the Restoration of Wild-Type Dynamic Behaviour indelta-F508-CFTR by 1,3-Dipropyl-8-Cyclopentylxanthine .J. Mol. Graph. Model. 26:691-699.
Chuthapisith, S., Layfield, R.,
Kerr, I.D ., Hughes, C., Eremin,
O. (2007). Proteomic
profiling of MCF-7 breast cancer cells with chemoresistance
to different types of anti-cancer drugs . Int. J. Oncol. 30: 1545-1551
Chuthapisith, S., Layfield, R.,
Kerr, I.D. , and Eremin,
O. (2007). Principles
of proteomics and its applications in cancer. The Surgeon 5:14-22.
Kerr, I.D. and Bennett, M.J. (2007)New
insight into the biochemical mechanisms regulating auxin transport in
plants Biochemical
Journal 401:613-622.
McDevitt, C., Collins, R. F., Conway, M., Modok, S., Storm, J., Kerr,
I. D.,
Ford, R. C. & Callaghan, R. (2006)Purification
and 3-D structural analysis of oligomeric human
multidrug transporter ABCG2.Structure. 14:1623-32.
Clark, R., Kerr,
I.D., and
Callaghan, R. (2006) Multiple
drug binding sites on the R482G isoform of ABCG2.Br. J. Pharmacol.149:506-15.
Kerr, I.D. and Simpkins, N. (2006)ABC
transporters and isothiocyanates. Letters in
Drug Design and Discovery . 3:607-621.
Callaghan,
R. Ford, R.C. and Kerr, I.D.(2006)The translocation
mechanism of P-glycoprotein . FEBS Letters 580:1056-1063. DOI 10.1016/j.febslet.2006.11.083
.
Kerr, I.D., Reynolds, E.D., and Cove, J.H.
(2005).ABC proteins and
antibiotic drug resistance: is it all about transport? Biochem.
Soc. Trans.33:
1000-1002.
Rothnie, A., Storm, J. McMahon, R.,Taylor,
A., Kerr, I.D. and
Callaghan, R. (2005) The coupling mechanism of
P-glycoprotein involves residue L339 in the sixth membrane spanning
segment. FEBS Letters 579: 3984-3990. DOI:10.1016/j.febslet.2005.06.030
2000-2004
Campbell,
J. D., Deol, S. S., Ashcroft, F. M.,Kerr, I. D. & Sansom, M. S. P.
(2004)
Nucleotide dependent
conformational changes in HisP: molecular
dynamics simulations of an ABC transporter nucleotide binding domain.
, Biophys. J.87: 3703-3715. DOI:10.1529/biophysj.104.046870
Swarup,
R., Kargul, J., Marchant, A., Szadik,
D., Rahman, A., Mills, R., Yemm, A., May, S.,
Williams, L., Millner, P., Tsurumi, S., Moore, I., Napier, R., Kerr, I. D. & Bennett, M. J.
(2004)Structure-function
analysis of the presumptive Arabidopsis auxin permease
AUX1. Plant Cell.
16:3069-3083. DOI 10.1105/tpc.104.024737.
Rothnie,
A., Storm, J.,Campbell,
J., Linton, K.J., Kerr, I.D.
and Callaghan, R. (2004). The topography of
transmembrane segment six is altered during the catalytic cycle of P-glycoprotein.J.
Biol. Chem.279:34913-34921.
DOI: 10.174/jbc.M405336200.
Kerr, I.D. (2004).
Sequence analysis of
twin ATP binding cassette proteins involved in translational control,
antibiotic resistance and ribonuclease L inhibition. Biochem.
Biophys. Res. Comm. 315. 166-173. DOI: 10.1016/j.bbrc.2004.01.044.
Kerr, I.D ., Berridge, G., K. J. Linton,
C. F. Higgins, R. Callaghan (2003). Definition of domain
boundaries is critical to the expression of the nucleotide-binding domains
of P-glycoprotein.Eur. Biophys. J.32.644-654. DOI:
10.1007/s00249-003-0327-6.
.
Stenham, D. R., J. D. Campbell, M. S. P.
Sansom, C. F. Higgins,I. D. Kerr
and K. J. Linton (2003).An atomic detail model for
the human ATP binding cassette transporter, P-glycoprotein, derived from
disulphide cross-linking and homology modelling. FASEB J. 17.2287-2289. DOI
10.1096/fj.03-0107fje.
Gabriel
M.P., Storm, J., Rothnie, A., Taylor,
A., Linton K.J.,Kerr
I.D. and Callaghan, R. (2003)Communication between the
nucleotide binding domains of P-glycoprotein occurs via conformational
changes that involve residue 508 . Biochemistry 42. 7780-7789. DOI 10.1021/bi0341049.
Berridge,
G., J. A. Walker, R. Callaghan and Kerr, I.D. (2003).
The
nucleotide binding domains of P-glycoprotein: functional symmetry in the
isolated domain demonstrated by N-ethylmaleimide binding . Eur. J. Biochem.270. 1473-1492. DOI
10.146/j1432.1033.2003.03514.x.
Linton,
K.J., Rosenberg, M.F., Kerr, I.D.,and Higgins, C.F. (2003).
The structure of ABC Transporters. In. "ABC Proteins: From Bacteria to
Man", ed. I.B. Holland. S. Cole, K. Kuchler, C.F. Higgins. Academic
Press, London. p 65-80.
Kerr,I.
D. (2002).Structure and association
of ABC transporter nucleotide-binding domains.Biochim. Biophys.
Acta.1561: 47-64. DOI:10.1016/S0304-4157(01)00008-9.
Rosenberg,
M.F., Verlade, G., Ford, R. C., Martin, C.,
Berridge, G.,Kerr, I. D., Callaghan, R., Schmidlin, A., Wooding, C., Linton, K. J., and Higgins,
C. F. (2001).Major
conformational changes in the transmembrane domains of an ABC transporter,
the multidrug resistance P-glycoprotein, during the transport cycle .EMBO J.20:5615-5625.
Son,
H. S.,Kerr, I. D., and Sansom, M. S. (2000).Simulation studies on bacteriorhodopsin bundle of transmembranea-segments.Eur. Biophys. J.28: 663-673.
1995-1999
Kerr,
I. D., Ranatunga, K. M., and Sansom, M. S. P. (1999). The
voltage-gated potassium channel: sequence analysis and molecular modelling
of the pore domain.Perspectives in Drug Discovery and Design 15:
187-214.
Sansom,
M. S., Kerr,I.
D., Law, R., Davison, L., and Tieleman, D. P. (1998). Modelling the packing of
transmembrane helices: application to aquaporin-1 .Biochem. Soc. Trans.26: 509-515.
Ranatunga, K. M.,Kerr,
I. D.,
Adcock, C., Smith, G. R., and Sansom, M. S. (1998).Protein-water-ion
interactions in a model of the pore domain of a potassium channel: a
simulation study. Biochim. Biophys.
Acta 1370: 1-7.
Breed,
J., Kerr, I. D. , Molle,
G., Duclohier, H., and Sansom, M. S. (1997).Ion
channel stability and hydrogen bonding. Molecular modelling of channels
formed by synthetic alamethicin analogues.Biochim. Biophys.
Acta1330: 103-109.
Kerr,
I. D., and
Sansom, M. S. (1997).The pore-lining region of shaker voltage-gated
potassium channels: comparison of beta-barrel and alpa-helix
bundle models. Biophys. J. 73: 581-602.
Sansom,
M. S.,Kerr,
I. D., Smith,
G. R., and Son, H. S. (1997).The influenza A virus M2 channel: a molecular modeling and simulation study. Virology 233: 163-173.
Breed,
J., Biggin, P. C.,Kerr,
I. D. ,
Smart, O. S., and Sansom, M. S. (1997). Alamethicin
channels - modelling via restrained molecular dynamics simulations. Biochim. Biophys.
Acta 1325: 235-249.
Grice,
A. L.,Kerr,
I. D. , and
Sansom, M. S. (1997). Ion
channels formed by HIV-1 Vpu: a modelling and
simulation study .FEBS.
Lett 405: 299-304.
Schmitt,
J. D., Sansom, M. S., Kerr,I.
D., Lunt, G. G., and Eisenthal, R. (1997). Ferrocenoyl
derivatives of alamethicin: redox-sensitive ion
channels .Biochemistry 36:
1115-1122.
Cosette, P., Kerr, I. D., La Rocca, P., Duclohier, H. & Sansom, M.
S. P. (1997) Secondary structure of an isolated P-region from the
voltage-gated sodium channel: a molecular modelling/dynamics study. ,Biophysical Chemistry. 69 : 221-232.
Ponting,
C. P., and Kerr, I.
D. (1996). A novel family of phospholipase D
homologues that includes phospholipid synthases and putative endonucleases:
identification of duplicated repeats and potential active site residues .Protein Sci.5: 914-922.
Kerr,
I. D., Doak, D. G., Sankararamakrishnan,
R., Breed, J., and Sansom, M. S. (1996).Molecular modelling of Staphylococcald -toxin ion channels by restrained
molecular dynamics. Protein
Eng .9:
161-171.
Kerr,
I. D., Son, H. S., Sankararamakrishnan,
R., and Sansom, M. S. (1996).Molecular dynamics simulations of isolated
transmembrane helices of potassium channels.Biopolymers39: 503-515.
Sansom,
M. S.,Kerr, I.
D., Breed, J., and Sankararamakrishnan, R. (1996). Water in channel-like
cavities: structure and dynamics. Biophys. J.70:
693-702.
Breed,
J., Sankararamakrishnan, R.,Kerr,I.
D., and Sansom, M. S.
(1996).Molecular dynamics simulations of water within models of ion channels.Biophys. J.70: 1643-1661.
Mellor,I. R., Kerr,
I. D.,
Sansom, M. S. P., Sukumar, M., and Balaram, P. (1996). Voltage-activated ion channels
formed by a synthetica-helical peptide:- determination of channel stoichiometry and molecular
modelling of peptide conformation.Cell. Molec. Biol. Lett. 1: 325-336.
Sansom,
M. S. P., and Kerr, I.
D. (1995). Principles of membrane protein
structure. In "Biomembranes", A. Lee,
ed. (New York: JAI Press), pp. 29-78.
Sansom,
M. S., and Kerr, I.
D. (1995).Transbilayer
pores formed byb-barrels: molecular modeling of pore structures and properties. Biophys. J.69: 1334-1343.
Sansom,
M. S., Sankararamakrishnan, R., and Kerr,I.
D. (1995).Modelling membrane proteins using
structural restraints.Nat. Struct. Biol. 2: 624-631.
Kerr, I.
D., Dufourcq, J., Rice, J. A., Fredkin, D. R., and Sansom, M. S. (1995). Ion channel
formation by synthetic analogues of staphylococcal deta-toxin.Biochim. Biophys. Acta 1236: 219-227.
Sansom,
M. S., Son, H. S., Sankararamakrishnan, R.,Kerr, I. D. , and Breed, J.
(1995). Seven-helix bundles: molecular modeling
via restrained molecular dynamics. Biophys. J.68:
1295-1310.
Breed, J.,Kerr, I. D., Sankararamakrishnan, R., and Sansom, M. S. (1995).
Packing interactions of Aib-containing helices:
molecular modeling of parallel dimers of simple
hydrophobic helices and of alamethicin.Biopolymers 35: 639-655.
Kerr, I.
D. , and Sansom, M. S. (1995). Cation selectivity
in ion channels [Comment on: Nature 1994 Oct 6;371:516-9.
Nature 373: 112
pre-1995
Kerr, I.
D. , Sankararamakrishnan,
R., Smart, O. S., and Sansom, M. S. (1994). Parallel helix bundles and ion
channels: molecular modeling via simulated
annealing and restrained molecular dynamics . Biophys. J.67: 1501-1515.
Gazit, E., Bach, D.,Kerr, I. D., Sansom, M. S., Chejanovsky,
N., and Shai, Y. (1994). The alpha-5 segment of Bacillus thuringiensis d-endotoxin: in vitro activity, ion
channel formation and molecular modelling .Biochem. J. 304: 895-902.
Woolley,
G. A., Epand, R. M.,Kerr, I. D., Sansom, M. S., and Wallace, B. A.
(1994). Alamethicin pyromellitate:
an ion-activated channel-forming peptide. Biochemistry 33: 6850-58.
Haris, P. I., Ramesh, B., Sansom, M. S., Kerr, I. D., Srai, K. S., and Chapman, D. (1994). Studies of the
pore-forming domain of a voltage-gated potassium channel. Protein Eng.7: 255-262.
Sansom,
M. S., and Kerr, I. D. (1993).
Influenza virus M2 protein: a molecular modelling study of the ion channel. Protein Eng. 6: 65-74.
Kerr, I. D., and Sansom, M. S. (1993).Hydrophilic
surface maps of channel-forming peptides: analysis of amphipathic helices .Eur. Biophys.
J. 22: 269-277.
Sansom, M. S., Kerr, I. D. , and Mellor,
I. R. (1991). Ion
channels formed by amphipathic helical peptides. A molecular modelling
study. Eur. Biophys. J. 20: 229-240.
Howl, J., Kerr, I. D., Chan, C. H., and Wheatley, M. (1991). A
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