Contact

• workRoom B20 Institute of Mental Health
  Jubilee Campus
  Wollaton Road
  Nottingham
  NG8 1BB
  UK
• Anto.Rajamani@nottingham.ac.uk

Biography

Anto is a clinically active researcher (clinical associate professor) in old age Psychiatry. He has 20 years of Psychiatric research experience and a broad spectrum of research expertise. He has a unique combination of expertise in clinical psychiatry, epidemiology, biostatistics, molecular genetics, RNA biology, and relevant bioinformatics. He has experience of designing and conducting translational research studies, qualitative research, meta-analyses, clinical trials, and epidemiological, pharmacogenetic, biomarker and next-generation sequencing studies. He has published more than 64 peer-reviewed research papers (Google scholar citations: 2918; h-index: 29; i-10 index: 47) so far. He has the experience of participating in journal editorial boards and research ethics committees. He has been serving as an associate editor of the official journal of the Scandinavian College of Neuropsychopharmacology, Acta Neuropsychiatrica, since 2012. Moreover, He has been serving the Academic Training Programme Director for Psychiatry in the University of Nottingham since 2021. He has been a regional (Midlands) lead of the Deep Dementia Phenotyping network, an international network for applying data science and artificial intelligence in dementia research.

Research Summary

Anto is a clinically active researcher in old age Psychiatry. He has more than 20 years of psychiatric research experience in conducting basic science studies, translational research, qualitative… read more

Recent Publications

• RAJKUMAR, A. P., BIDKHORI, G., SHOAIE, S., CLARKE, E., MORRIN, H., HYE, A., WILLIAMS, G., BALLARD, C., FRANCIS, P. and AARSLAND, D., 2020. Postmortem Cortical Transcriptomics of Lewy Body Dementia Reveal Mitochondrial Dysfunction and Lack of Neuroinflammation: Am J Geriatr Psychiatry Am J Geriatr Psychiatry. 28(1), 75-86
• PATERNOSTER, VEERLE, SVANBORG, MARIA, EDHAGER, ANDERS VALDEMAR, RAJKUMAR, ANTO P., EICKHARDT, ESBEN AHLBURG, PALLESEN, JONATAN, GROVE, JAKOB, QVIST, PER, FRYLAND, TUE, WEGENER, GREGERS, NYENGAARD, JENS RANDEL, MORS, OLE, PALMFELDT, JOHAN, BORGLUM, ANDERS DUPONT and CHRISTENSEN, JANE HVARREGAARD, 2019. Brain proteome changes in female Brd1(+/-) mice unmask dendritic spine pathology and show enrichment for schizophrenia risk NEUROBIOLOGY OF DISEASE. 124, 479-488
• FITZGERALD, JAMES M., PERERA, GAYAN, CHANG-TAVE, ALEXANDRA, PRICE, ANNABEL, RAJKUMAR, ANTO P., BHATTARAI, MANORAMA, O'BRIEN, JOHN T., BALLARD, CLIVE, AARSLAND, DAG, STEWART, ROBERT and MUELLER, CHRISTOPH, 2019. The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 20(5), 604-609
• RUAN, C. J., WANG, C. Y., TANG, Y. L., LIN, S. K., LEE, S. T., HONG, K. S., RAJKUMAR, A. P., JACOB, K. S. and DE LEON, J., 2019. Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13: J Clin Psychopharmacol J Clin Psychopharmacol. 39(6), 644-648

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Current Research

Anto is a clinically active researcher in old age Psychiatry. He has more than 20 years of psychiatric research experience in conducting basic science studies, translational research, qualitative studies, clinical trials, meta-analyses, and epidemiological, pharmacogenetic, biomarker, and next-generation sequencing studies. His research team focuses on molecular neurodegeneration, blood-based RNA biomarkers, and novel therapeutic targets of Dementia with Lewy Bodies (DLB) and dementia in Alzheimer's disease (AD). His principal aim is to improve the clinical diagnosis and management of people with dementia, especially those with DLB. Anto's research are funded by the Innovate UK, Dunhill Medical Trust, BBSRC, and Alzheimer's Research UK (Further details at https://orcid.org/my-orcid?orcid=0000-0003-3203-6326).

• RAJKUMAR, A. P., BIDKHORI, G., SHOAIE, S., CLARKE, E., MORRIN, H., HYE, A., WILLIAMS, G., BALLARD, C., FRANCIS, P. and AARSLAND, D., 2020. Postmortem Cortical Transcriptomics of Lewy Body Dementia Reveal Mitochondrial Dysfunction and Lack of Neuroinflammation: Am J Geriatr Psychiatry Am J Geriatr Psychiatry. 28(1), 75-86
• PATERNOSTER, VEERLE, SVANBORG, MARIA, EDHAGER, ANDERS VALDEMAR, RAJKUMAR, ANTO P., EICKHARDT, ESBEN AHLBURG, PALLESEN, JONATAN, GROVE, JAKOB, QVIST, PER, FRYLAND, TUE, WEGENER, GREGERS, NYENGAARD, JENS RANDEL, MORS, OLE, PALMFELDT, JOHAN, BORGLUM, ANDERS DUPONT and CHRISTENSEN, JANE HVARREGAARD, 2019. Brain proteome changes in female Brd1(+/-) mice unmask dendritic spine pathology and show enrichment for schizophrenia risk NEUROBIOLOGY OF DISEASE. 124, 479-488
• FITZGERALD, JAMES M., PERERA, GAYAN, CHANG-TAVE, ALEXANDRA, PRICE, ANNABEL, RAJKUMAR, ANTO P., BHATTARAI, MANORAMA, O'BRIEN, JOHN T., BALLARD, CLIVE, AARSLAND, DAG, STEWART, ROBERT and MUELLER, CHRISTOPH, 2019. The Incidence of Recorded Delirium Episodes Before and After Dementia Diagnosis: Differences Between Dementia With Lewy Bodies and Alzheimer's Disease JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 20(5), 604-609
• RUAN, C. J., WANG, C. Y., TANG, Y. L., LIN, S. K., LEE, S. T., HONG, K. S., RAJKUMAR, A. P., JACOB, K. S. and DE LEON, J., 2019. Exploring the Prevalence of Clozapine Phenotypic Poor Metabolizers in 4 Asian Samples: They Ranged Between 2% and 13: J Clin Psychopharmacol J Clin Psychopharmacol. 39(6), 644-648
• D'SOUZA, T. and RAJKUMAR, A. P., 2019. Systematic review of genetic variants associated with cognitive impairment and depressive symptoms in Parkinson's disease: Acta Neuropsychiatr Acta Neuropsychiatr. 1-13
• MUELLER, CHRISTOPH, RAJKUMAR, ANTO P., WAN, YI MIN, VELAYUDHAN, LATHA, FFYTCHE, DOMINIC, CHAUDHURI, KALLOL RAY and AARSLAND, DAG, 2018. Assessment and Management of Neuropsychiatric Symptoms in Parkinson's Disease CNS DRUGS. 32(7), 621-635
• MUELLER, CHRISTOPH, PERERA, GAYAN, RAJKUMAR, ANTO P, BHATTARAI, MANORAMA, PRICE, ANNABEL, O'BRIEN, JOHN T, BALLARD, CLIVE, STEWART, ROBERT and AARSLAND, DAG, 2018. Hospitalization in people with dementia with Lewy bodies: Frequency, duration, and cost implications. Alzheimer's & dementia (Amsterdam, Netherlands). 10, 143-152
• RAJKUMAR, ANTO P., PETIT, CHERYL P., RACHANA, ARUN, DEINDE, FUNMI, SHYAMSUNDAR, G., THANGADURAI, P. and JACOB, KURUTHUKULANGARA S., 2018. Correlates of self-reported, autobiographical, and mini-mental status examination defined memory deficits following electroconvulsive therapy in South India ASIAN JOURNAL OF PSYCHIATRY. 34, 47-53
• MORRIN, HAMILTON, FANG, TON, SERVANT, DONALD, AARSLAND, DAG and RAJKUMAR, ANTO P., 2018. Systematic review of the efficacy of non-pharmacological interventions in people with Lewy body dementia INTERNATIONAL PSYCHOGERIATRICS. 30(3), 395-407
• PATERNOSTER, VEERLE, RAJKUMAR, ANTO P., NYENGAARD, JENS RANDEL, BORGLUM, ANDERS DUPONT, GROVE, JAKOB and CHRISTENSEN, JANE HVARREGAARD, 2018. The importance of data structure in statistical analysis of dendritic spine morphology JOURNAL OF NEUROSCIENCE METHODS. 296, 93-98
• RAJAGOPAL, VEERA M., RAJKUMAR, ANTO P., JACOB, KURUTHUKULANGARA S. and JACOB, MOLLY, 2018. Gene-gene interaction between DRD4 and COMT modulates clinical response to clozapine in treatment-resistant schizophrenia PHARMACOGENETICS AND GENOMICS. 28(1), 31-35
• BHAMRA, M., RAJKUMAR, A. P., FFYTCHE, D. H. and KALAFATIS, C., 2018. Successful management of persistent distressing neuropsychiatric symptoms by clozapine in a patient suffering from dementia with Lewy bodies: BMJ Case Rep BMJ Case Rep. 2018,
• AARSLAND, DAG, RAJKUMAR, ANTO P. and HYE, ABDUL, 2017. Novel evidence associates higher plasma alpha-synuclein levels and cognitive impairment in Parkinson's disease JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 88(10), 808-808
• RAJKUMAR, ANTO P., HORSDAL, HENRIETTE THISTED, WIMBERLEY, THERESA, COHEN, DAN, MORS, OLE, BORGLUM, ANDERS D. and GASSE, CHRISTIANE, 2017. Endogenous and Antipsychotic-Related Risks for Diabetes Mellitus in Young People With Schizophrenia: A Danish Population-Based Cohort Study AMERICAN JOURNAL OF PSYCHIATRY. 174(7), 686-694
• QVIST, PER, CHRISTENSEN, JANE HVARREGAARD, VARDYA, IRINA, RAJKUMAR, ANTO PRAVEEN, MORK, ARNE, PATERNOSTER, VEERLE, FUCHTBAUER, ERNST-MARTIN, PALLESEN, JONATAN, FRYLAND, TUE, DYRVIG, MADS, HAUBERG, MADS ENGEL, LUNDSBERG, BIRGITTE, FEJGIN, KIM, NYEGAARD, METTE, JENSEN, KIMMO, NYENGAARD, JENS RANDEL, MORS, OLE, DIDRIKSEN, MICHAEL and BORGLUM, ANDERS DUPONT, 2017. The Schizophrenia-Associated BRD1 Gene Regulates Behavior, Neurotransmission, and Expression of Schizophrenia Risk Enriched Gene Sets in Mice BIOLOGICAL PSYCHIATRY. 82(1), 62-76
• RAJKUMAR, ANTO P., BALLARD, CLIVE, FOSSEY, JANE, ORRELL, MARTIN, MONIZ-COOK, ESME, WOODS, ROBERT T., MURRAY, JOANNA, WHITAKER, RHIANNON, STAFFORD, JANE, KNAPP, MARTIN, ROMEO, RENEE, WOODWARD-CARLTON, BARBARA, KHAN, ZUNERA, TESTAD, INGELIN and CORBETT, ANNE, 2017. Epidemiology of Pain in People With Dementia Living in Care Homes: Longitudinal Course, Prevalence, and Treatment Implications JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION. 18(5),
• QVIST, PER, RAJKUMAR, ANTO P., REDROBE, JOHN P., NYEGAARD, METTE, CHRISTENSEN, JANE H., MORS, OLE, WEGENER, GREGERS, DIDRIKSEN, MICHAEL and BORGLUM, ANDERS D., 2017. Mice heterozygous for an inactivated allele of the schizophrenia associated Brd1 gene display selective cognitive deficits with translational relevance to schizophrenia NEUROBIOLOGY OF LEARNING AND MEMORY. 141, 44-52
• RAJKUMAR AP, BALLARD C, FOSSEY J, CORBETT A, WOODS B, ORRELL M, PRAKASH R, MONIZ-COOK E and TESTAD I, 2016. Apathy and Its Response to Antipsychotic Review and Nonpharmacological Interventions in People With Dementia Living in Nursing Homes: WHELD, a Factorial Cluster Randomized Controlled Trial Journal of the American Medical Directors Association.
• BRINDA, ETHEL M., RAJKUMAR, ANTO P., ATTERMANN, JORN, GERDTHAM, ULF G., ENEMARK, ULRIKA and JACOB, KURUTHUKULANGARA S., 2016. Health, Social, and Economic Variables Associated with Depression Among Older People in Low and Middle Income Countries: World Health Organization Study on Global AGEing and Adult Health AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY. 24(12), 1196-1208
• RAJKUMAR, ANTO P., MOHAN, TITUS S. P. and THARYAN, PRATHAP, 2015. Lessons from the 2004 Asian tsunami: Nature, prevalence and determinants of prolonged grief disorder among tsunami survivors in South Indian coastal villages INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY. 61(7), 645-652
• RAJKUMAR, ANTO P., QVIST, PER, LAZARUS, ROSS, LESCAI, FRANCESCO, JU, JIA, NYEGAARD, METTE, MORS, OLE, BORGLUM, ANDERS D., LI, QIBIN and CHRISTENSEN, JANE H., 2015. Experimental validation of methods for differential gene expression analysis and sample pooling in RNA-seq BMC GENOMICS. 16,
• RAJKUMAR, ANTO P., SMITH, ALAN, GREAVES, SUKI, DUGGAL, ANITA and BANDYOPADHYAY, DIPANKAR, 2015. Does midlife obesity really lower dementia risk? LANCET DIABETES & ENDOCRINOLOGY. 3(7), 500-501
• BRINDA, ETHEL MARY, RAJKUMAR, ANTO P. and ENEMARK, ULRIKA, 2015. Association between gender inequality index and child mortality rates: a cross-national study of 138 countries BMC PUBLIC HEALTH. 15,
• RAJKUMAR, ANTO P., CHRISTENSEN, JANE H., MATTHEISEN, MANUEL, JACOBSEN, IBEN, BACHE, IBEN, PALLESEN, JONATAN, GROVE, JAKOB, QVIST, PER, MCQUILLIN, ANDREW, GURLING, HUGH M., TUMER, ZEYNEP, MORS, OLE and BORGLUM, ANDERS D., 2015. Analysis of t(9;17)(q33.2; q25.3) chromosomal breakpoint regions and genetic association reveals novel candidate genes for bipolar disorder BIPOLAR DISORDERS. 17(2), 205-211
• RAJKUMAR, A. P., SENTHILKUMAR, P., GAYATHRI, K., SHYAMSUNDAR, G. and JACOB, K. S., 2015. Associations Between the Macroeconomic Indicators and Suicide Rates in India: Two Ecological Studies: Indian J Psychol Med Indian J Psychol Med. 37(3), 277-81
• RAJAGOPAL, VEERAMANIKANDAN, SUNDARESAN, LAKSHMIKIRUPA, RAJKUMAR, ANTO P., CHITTYBABU, CHITHRA, KURUVILLA, ANJU, SRIVASTAVA, ALOK, BALASUBRAMANIAN, POONKUZHALI, JACOB, KURUTHUKULANGARA S. and JACOB, MOLLY, 2014. Genetic association between the DRD4 promoter polymorphism and clozapine-induced sialorrhea PSYCHIATRIC GENETICS. 24(6), 273-276
• BRINDA, ETHEL M., RAJKUMAR, ANTO P., ENEMARK, ULRIKA, ATTERMANN, JORN and JACOB, K. S., 2014. Cost and burden of informal caregiving of dependent older people in a rural Indian community BMC HEALTH SERVICES RESEARCH. 14,
• RAJKUMAR, A. P., BRINDA, E. M., DUBA, A. S., THANGADURAI, P. and JACOB, K. S., 2013. National suicide rates and mental health system indicators: An ecological study of 191 countries INTERNATIONAL JOURNAL OF LAW AND PSYCHIATRY. 36(5-6), 339-342
• RAJKUMAR, ANTO P., POONKUZHALI, B., KURUVILLA, ANJU, SRIVASTAVA, ALOK, JACOB, MOLLY and JACOB, K. S., 2013. Association between CYP1A2 gene single nucleotide polymorphisms and clinical responses to clozapine in patients with treatment-resistant schizophrenia ACTA NEUROPSYCHIATRICA. 25(1), 2-11
• RAJKUMAR, A. P., 2013. Anti-NMDA receptor encephalitis: clinical and research implications ACTA NEUROPSYCHIATRICA. 25(3), 125-127
• RAJKUMAR, A. P., MOHAN, T. S. P. and THARYAN, P., 2013. Lessons from the 2004 Asian tsunami: Epidemiological and nosological debates in the diagnosis of post-traumatic stress disorder in non-Western post-disaster communities INTERNATIONAL JOURNAL OF SOCIAL PSYCHIATRY. 59(2), 123-129
• RAJKUMAR, ANTO P., POONKUZHALI, BALASUBRAMANIAN, KURUVILLA, ANJU, JACOB, MOLLY and JACOB, KURUTHUKULANGARA S., 2013. Clinical predictors of serum clozapine levels in patients with treatment-resistant schizophrenia INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY. 28(1), 50-56
• RAJKUMAR, A. P., POONKUZHALI, B., KURUVILLA, A., SRIVASTAVA, A., JACOB, M. and JACOB, K. S., 2012. Outcome definitions and clinical predictors influence pharmacogenetic associations between HTR3A gene polymorphisms and response to clozapine in patients with schizophrenia PSYCHOPHARMACOLOGY. 224(3), 441-449
• JAYAPRAKASH, R R, RAJKUMAR, A P, NANDYAL, M, KURIAN, S and JACOB, K S, 2012. Dissociative stupor, mutism and amnesia in a young man. Indian journal of psychiatry. 54(2), 198-9
• BRINDA, E. M., RAJKUMAR, A. P., ENEMARK, U., PRINCE, M. and JACOB, K. S., 2012. Nature and determinants of out-of-pocket health expenditure among older people in a rural Indian community INTERNATIONAL PSYCHOGERIATRICS. 24(10), 1664-1673
• MERLIN, THANKA JEMI, RAJKUMAR, ANTO P., REEMA, S., TSHERINGLA, SHERAB, VELVIZHI, S. and JACOB, K. S., 2012. Construct validity and factor structure of Tamil version of Beck Cognitive Insight Scale to assess cognitive insight of patients with schizophrenia ACTA NEUROPSYCHIATRICA. 24(1), 43-49
• DUBA, A. S., RAJKUMAR, A. P., PRINCE, M. and JACOB, K. S., 2012. Determinants of disability among the elderly population in a rural south Indian community: the need to study local issues and contexts INTERNATIONAL PSYCHOGERIATRICS. 24(2), 333-341
• RAJKUMAR, A. P., CHITRA, C., BHUVANESHWARI, S., POONKUZHALI, B., KURUVILLA, A. and JACOB, K. S., 2011. Clinical Predictors of Response to Clozapine in Patients with Treatment Resistant Schizophrenia PSYCHOPHARMACOLOGY BULLETIN. 44(3), 51-65
• MANORANJITHAM, S. D., RAJKUMAR, A. P., THANGADURAI, P., PRASAD, J., JAYAKARAN, R. and JACOB, K. S., 2010. Risk factors for suicide in rural south India BRITISH JOURNAL OF PSYCHIATRY. 196(1), 26-30
• SHYAMSUNDAR, G., RAGHUTHAMAN, G., RAJKUMAR, ANTO P. and JACOB, K. S., 2009. Validation of memorial delirium assessment scale JOURNAL OF CRITICAL CARE. 24(4), 530-534
• RAJKUMAR, A. P., THANGODURAI, P., SENTHILKUMAR, P., GOYATHRI, K., PRINCE, M. and JACOB, K. S., 2009. Nature, prevalence and factors associated with depression among the elderly in a rural south Indian community INTERNATIONAL PSYCHOGERIATRICS. 21(2), 372-378
• SUGANTHAN, JONAS S., RAJKUMAR, ANTO P., JAGANNATH, C., PULIMOOD, SUSANNE A. and JACOB, K. S., 2009. Delusional parasitosis over dermatological morbidity: diagnostic and therapeutic challenges TROPICAL DOCTOR. 39(1), 49-50
• STANLEY, R., KURUVILLA, A., KUMAR, S., GAYATHRI, K., MATHEWS, P., ABRAHAM, V., RAJKUMAR, A. and JACOB, K. S., 2009. The Vellore screening instruments and strategies for the diagnosis of dementia in the community: Int Psychogeriatr Int Psychogeriatr. 21(3), 539-47
• RAJKUMAR, ANTO P., PREMKUMAR, TITUS S. and THARYAN, PRATHAP, 2008. Coping with the Asian tsunami: Perspectives from Tamil Nadu, India on the determinants of resilience in the face of adversity SOCIAL SCIENCE & MEDICINE. 67(5), 844-853
• RAJKUMAR, ANTO P. and JACOB, K. S., 2008. Are antidepressants safe during pregnancy? BRITISH JOURNAL OF PSYCHIATRY. 193(6), 508-508
• RAJKUMAR, A P and JEBARAJ, P, 2008. Chronic psychosis associated with vitamin B12 deficiency. The Journal of the Association of Physicians of India. 56, 115-6
• RAJKUMAR, ANTO P., YOVAN, SIMPSON, RAVEENDRAN, ANOOP L. and RUSSELL, PAUL SWAMIDHAS SUDHAKAR, 2008. Can only intelligent children do mind reading: The relationship between intelligence and theory of mind in 8 to 11 years old BEHAVIORAL AND BRAIN FUNCTIONS. 4,
• RAJKUMAR, A P, SARAVANAN, B and JACOB, K S, 2007. Voices of people who have received ECT. Indian journal of medical ethics. 4(4), 157-64
• RAJKUMAR, A P, JEBARAJ, P and THARYAN, P, 2007. Multi-drug overdose risperidone, ziprasidone, valproate, trihexyphenidyl, and clonazepam. The Journal of the Association of Physicians of India. 55, 146-8
• RAJKUMAR, ANTO P., SARAVANAN, B. and JACOB, K. S., 2006. Perspectives of patients and relatives about electroconvulsive therapy: A qualitative study from Vellore, India JOURNAL OF ECT. 22(4), 253-258