Physiological process of sepsis
Infection occurs - infectious cell releases toxins/mediators
White cell
responds
(monocyte)
Reaction initiates cytokines,
tumour necrosis factor and interleukins
More mediators released by TNF
and interleukins which affect the endothelial
lining - increasing capillary permeability
Tissue factor produced - produces prothrombin
which induces thrombin
Thrombin helps produce
clots in micro-vasculture
Platelets activated
- to address
endothelium injury
Fibrinolysis
Microvascular
coagulopathy
The stages of the physiological process of sepsis are outlined below:
- Infection occurs - infectious cell releases toxins/mediators
- White cell responds (monocyte)
- Reaction initiates cytokines, tumour necrosis factor and interleukins
- More mediators released by TNF and interleukins which affect the endothelial lining - increasing capillary permeability
- Tissue factor produced - produces prothrombin which induces thrombin
- Thrombin helps produce clots in micro-vasculture
- Platelets activated - to address endothelium injury
- Fibrinolysis
- Microvascular coagulopathy